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Nano Research 2016年第6期9卷 1674-1681页

作者： Pauline Vitry Rolando Rebois Eric Bourillot Ariane Deniset-Besseau Marie-Joelle Virolle~ Eric Lesniewska Alexandre Dazzi ICB umr cnrs 6303 University ofBourgogne Franche Comte 21078 Dijon France LCP umr cnrs 8000 University Paris-Sud 91405 Orsay France 12bc umr cnrs 9198 University Paris-Sud 91190 Gif-Sur-Yvette France

We propose a new analytical approach combining vibrational spectroscopy and acoustic tomography for the detection and characterization of vesicles inside Streptomyces bacteria. Using atomic force microscopy and infrared spectroscopy （AFM-IR）, we detect the presence of triglyceride vesicles. Their sizes in depth are measured with high accuracy using mode synthesizing atomic force microscopy （MS-AFM）. We conducted a comparative study of AFM-IR and MS-AFM, and highlighted the advantages of the coupling of these techniques in having a full characterization （chemical, topographical, and volumetric） of a biological sample. With these complementary techniques, a complete access to the vesicle size distribution has been achieved with an accuracy of less than 50 nm. A 3D reconstruction of bacteria showing the in-depth distribution of vesicles is given to underline the great potential of the acoustic method.

关键词： nanoscale suDsurtace imaging atomic force microscop~ acoustic microscopy infrared microscopy biology

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Selecting and optimal sizing of hybridized energy storage systems for tidal energy integration into power grid

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 113-122页

作者： Seifeddine BEN ELGHALI Rachid OUTBIB Mohamed BENBOUZID LIS-umr cnrs 7020 University of Aix-Marseille umr cnrs 6027 IRDL University of Brest Shanghai Maritime University

The high penetration of renewable energy systems with fluctuating power generation into the electric grids affects considerably the electric power quality and supply ***, energy storage resources are used to deal with the challenges imposed by power variability and demand-supply *** main focus of this paper is to investigate the appropriate storage technologies and the capacity needed for a successful tidal power ***, a simplified sizing method, integrating an energy management strategy, is *** method allows the selection of the adequate storage technologies and determines the required least-cost storage capacity by considering their technological limits associated with different power *** optimal solutions given by the multi-objective evolutionary algorithm are presented and analyzed.

关键词： Tidal energy Energy storage system Optimal sizing Selection

Synthesis of two-dimensional lead sheets by spark discharge in liquid nitrogen

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Particuology 2018年第5期16卷 152-159页

作者： Ahmad Hamdan Hiba Kabbara Cedric Noel Jaafar Ghanbaja Abdelkrim Redjaimia Thierry Belmonte Universite de Lorraine lnstitutJean tamourUMR CNRS 7198Nancy F-54042France cnrs lnstitutJean LamourUMR CNRS 7198Nancy F-54042France

A simple method to synthesise hexagonal lead sheets,which belong to the class of two-dimensional materials,is *** objects are collected on a substrate located under two lead electrodes, between which nanosecond-pulsed spark discharges are ignited in liquid *** hexagonal sheets are single crystals produced by gas phase *** nitrogen completely evaporates,the sheets change to PbO2by oxidation in *** oxidation process induces stress that pleats the uppermost sheets or open cracks at the *** thickness of the individual objects typically varies from 4to *** the number of discharges is more than about 2000,in addition to sheets,two types of PbO2 sticks start to form:bundles composed of nanosticks (length 5p.m and diameter 50nm)and isolated sticks (length 20μm and diameter 500nm).These new nanostructures mainly form because of the way the discharge erodes the lead ***,anisotropic erosion driven by the orientation of the crystallographic planes of the lead crystals produces octahedra and nanosticks,and the nanosticks grow on the electrode surfaces as discharge *** about 2000discharges,the nanosticks are sufficiently long that they can be easily broken,probably by mechanical stress,and they fall onto the underlying substrate.

关键词： Discharge in hquids Plasma-surface interaction Nanopamcles Liquid nitrogen Lead

Best practices for model-based and simulation-aided engineering of power transmission and motion control systems

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Chinese Journal of Aeronautics 2019年第1期32卷 186-199页

作者： Jean-Charles MARE Institut Clément Ader (cnrs umr 5312)

This paper deals with the modelling and simulation of aircraft systems, in particular for power transmission and control. It is intended to review, propose and disseminate best practices for making model-based/simulation-aided engineering more efficient at any phase of the system life cycle. The proposals are aimed at creating value, not only by increasing the performance of the product under study but also by shortening the time to market, capitalizing knowledge, mitigating risks and facilitating concurrent engineering. The needs associated with the engineering activities are firstly identified to define a set of requirements for the models. Then, these requirements are used to drive the considerations leading to model development, focusing in particular on the process,modelled physical effects, modelling level, model architecting and concurrent engineering. The third part deals with the model implementation, giving special consideration to the different types of models, causalities, parameterization, implementation and verification. Each part is illustrated by examples related to safety critical actuators.

关键词： Actuator Aerospace Architecture Causality Modelling Motion control Power transmission Simulation

Self-assembly of colloidal polymers from two-patch silica nanoparticles

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Nano Research 2020年第12期13卷 3371-3376页

作者： Weiya Li Bin Liu Céline Hubert Adeline Perro Etienne Duguet Serge Ravaine cnrs CRPPUMR 5031Univ.BordeauxPessac33600France cnrs ICMCBUMR 5026Univ.BordeauxPessac33600France cnrs Bordeaux INPISMUMR 5255Univ.BordeauxTalence33400France

We report the formation of colloidal polymers consisting of disk-like silica nanoparticles(NPs)with polystyrene(PS)chains at the bottom of their two cavities assembled through reduction of the solvent quality for the PS chains and linked by hydrophobic *** show that this NPs assembly exhibits a two-stage process involving reaction-controlled polymerization and diffusion-controlled *** polymer networks are produced by the incorporation of three-patch NPs,which serve as branching points between the colloidal *** co-assembling preformed homopolymers composed of patchy NPs of different sizes or surface chemical groups,block copolymers are also *** study provides insight into the process of self-assembly of two-patch NPs by precisely designing the components to generate colloidal analogues of linear macromolecular chains.

关键词： colloidal polymers nanoparticles patchy self-assembly

The Rain on Underground Porous Media Part Ⅰ:Analysis of a Richards Model

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 193-212页

作者： Christine BERNARDI Adel BLOUZA Linda EL ALAOUI Laboratoire Jacques-Louis Lions CNRS & Université Pierre et Marie CurieBC 1874 Place Jussieu75252 Paris Cedex 05France Laboratoire de Mathématiques Raphaёl Salem(umr 6085 cnrs) Université de RouenAvenue de l'UniversitéBP 1276801 Saint-tienne-du-RouvrayFrance Universit Paris 13 Sorbonne Paris CitLAGACNRS(UMR 7539)F-93430VilletaneuseFrance

The Richards equation models the water flow in a partially saturated underground porous medium under the *** it rains on the surface,boundary conditions of Signorini type must be considered on this part of the *** authors first study this problem which results into a variational inequality and then propose a discretization by an implicit Euler's scheme in time and finite elements in *** convergence of this discretization leads to the well-posedness of the problem.

关键词： Richards equation, Porous media, Euler's implicit scheme, Finite element discretization Parabolic variational inequality

Molecular Simulations using Spherical Harmonics

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Chinese Journal of Chemistry 2003年第10期21卷 1252-1255页

作者：蔡文生徐佳维邵学广 MAIGRET Bernard Department of Chemistry umr 7565 cnrs/UHP

Computer aided drug design is to develop a chemical that binds to a target macromolecule known to play a key role in a disease state. In recognition of ligands by their protein receptors, molecular surfaces are often used because they represent the interacting part of molecules and they should reflex the complementarity between ligand and receptor. However, assessing the surface complementarity by searching all relative position of two surfaces is often computationally expensive. The complementarity of lobe hole is very important in protein ligand interactions. Spherical harmonic models based on expansions of spherical harmonic functions were used as a fingerprint to approximate the binding cavity and the ligand, respectively. This defines a new way to identify the complementarity between lobes and holes. The advantage of this method is that two spherical harmonic surfaces to be compared can be defined separately. This method can be used as a filter to eliminate candidates among a large number of conformations, and it will speed up the docking procedure. Therefore, it is possible to select complementary ligands or complementary conformations of a ligand and the macromolecules, by comparing their fingerprints previously stored in a database.

关键词： molecular surface shape complementarity molecular docking molecular recognition spherical harmonics

The contribution of solid-state chemistry in the determination of multicomponent phase diagrams

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Rare Metals 2006年第5期25卷 576-581页

作者： Jean Claude Tedenac Franck Gascoin Didier Ravot Université Montpellier 2 LPMC-umr-cnrs-5617 MontpellierFrance

For a long period of time, the determination of phase diagrams was only supported by experiments related to thermal effects or thermodynamic measurements： thermal analysis, calorimetric measurements, vapor pressures, and EMF measurements. As a matter of fact, solid-solid transformations were not so accurately determined and could not be taken into account in the system＇s analysis. First, X-ray diffraction methods were used as a support for the thermal analysis. Second, the implementation of novel tools in structural analysis （for example, the Rietveld method） has permitted to increase the knowledge of phase stability. Finally, modeling the phases using a Calphad method needed increasingly more structural results to determine and better understand the phase diagrams. On the other hand, the Calphad method has been widely developed for metallic systems, for oxide systems, and in the past 10 years, for some semi-conductor systems, for example, gallium arsenide, cadmium telluride, and lead telluride systems. In such applications, it is very important to bring point defects in the modeling of the phases to map the defects as a function of the chemical composition. Owing to its complexity, this characteristic, the knowledge of which is crucial for the understanding and the control of potential physical applications, was ignored in the previous assessment of semi-conductor systems.

关键词： thermodynamic modeling solid-state chemistry phase diagram