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Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua M.Little Haochen Yang Tsai-Chun Chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

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Selected dietary plant-based proteins for growth and health response of Nile tilapia Oreochromis niloticus

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Aquaculture and Fisheries 2024年第1期9卷 3-19页

作者： Tzodoq Obrero Magbanua Janice Alano Ragaza Ateneo Aquatic and Fisheries Resources Laboratory Department of BiologySchool of Science and EngineeringAteneo de Manila UniversityKatipunan AvenueLoyola HeightsQuezon CityMetro Manila1108Philippines

Tilapia culture is one of the largest sectors of global *** the different species of tilapia,Nile tilapia(Oreochromis niloticus)is perhaps the top cultured *** production of Nile tilapia has been continually increasing throughout the years resulting in genetic *** tilapia strains with better growth performance and adaptive capability to survive in different culture conditions have been developed to alleviate the *** demand for Nile tilapia implies higher farming ***-based proteins are utilized as partial or complete fishmeal replacements to reduce feed ***,these proteins can adversely affect and alter growth and feed performance,carcass composition and indices,and gut and hepatic *** review discusses the use of seven plant-based proteins:namely,soybean,copra,pea,corn,palm kernel,microalgae,and seaweed as a Nile tilapia *** processing methods are employed to produce several types of plant-based *** plant-protein types,when utilized as an aquafeed ingredient,vary in its effect on the performance,hemato-immunological parameters,and gut and hepatic health of Nile *** have shown that Nile tilapia can effectively maximize plant-based protein diets based on the preparation method,type of plant source,amino acid supplementation,and inclusion levels of the plant *** readily available crops should be considered as primary protein sources for *** to the use of plant-based proteins as a main dietary protein are limiting amino acids,presence of anti-nutritional factors,and the competition between its demand as human food and as animal feed.

关键词： Nile tilapia Plant-based proteins Soybean proteins Copra proteins Pea proteins Corn proteins Palm kernel proteins Algal proteins

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Advancing immunosuppression in liver transplantation: A narrative review

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 441-448页

作者： Samuele Iesari Francesca Laura Nava Ilaria Elena Zais Laurent Coubeau Mariano Ferraresso Evaldo Favi Jan Lerut General Surgery and Kidney Transplantation Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico15 Via della Commenda20122 MilanItaly Institut de Recherche Expérimentale et Clinique Universitécatholique de Louvain10 Avenue Hippocrate1200 BrusselsBelgium Service de Chirurgie et Transplantation Abdominale Cliniques Universitaires Saint-Luc55 Avenue Hippocrate1200 BrusselsBelgium Department of Clinical Sciences and Community Health Universitàdegli Studi di Milano19 Via della Commenda20122 MilanItaly

Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation(LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solidorgan transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT. The research trajectories cover mechanisms to induce T-cell exhaustion, to inhibit co-stimulation, to mitigate non-antigen-specific inflammatory response, and, lastly, to minimize the development and action of donor-specific antibodies. Moreover, while cellular modulation techniques are complex, active research is underway to foster the action of T-regulatory cells, to induce tolerogenic dendritic cells, and to promote the function of B-regulatory cells. We herein discuss current lines of research in clinical immunosuppression, particularly focusing on possible applications in the LT setting.

关键词： Liver transplantation Immunosuppression Drug development Long-term results Clinical operational tolerance

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Natural variation of an autophagy-family gene among rice subspecies affects grain size and weight

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The Crop Journal 2024年第1期12卷 121-132页

作者： Shiying Huang Peng Wang Caijing Li Qingwen Zhou Tao Huang Yicong Cai Qin Cheng Hui Wang Qi Zhong Zhihao Chen Liping Chen Haohua He Jianmin Bian Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of Education.Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Weill Cornell Medical Immunology and Microbiology1300 York AvenueBox 62New YorkNY 10065USA

Elucidating the genetic basis of natural variation in grain size and weight among rice varieties can help breeders develop high-yielding *** identified a novel gene,GW3a(Grain Weight 3a)(LOC_Os03g27350),that affects rice grain size and ***3a mutants showed higher total starch content and dry matter accumulation than the wild type(WT),Nipponbare,suggesting that GW3a negatively regulates grain size and ***,our study found that GW3a interacted with OsATG8 by cleaving it,suggesting that GW3a may be involved in the assembly of autophagosomes and starch degradation in *** haplotype analysis of GW3a showed functional differences between indica and japonica *** together,we conclude that GW3a is expressed in the autophagosome pathway regulating starch metabolism in rice,affecting yield-related traits,such as grain size,grain weight and thousand grain weight(TGW).Our findings also shed new light on autophagy-mediated yield trait regulation,proposing a possible strategy for the genetic improvement of high-yield germplasm in rice.

关键词： Grain size GW3a Autophagy Starch content

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Modelling the viscoplastic behaviour of Callovo-Oxfordian claystone with consideration of damage effect

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 303-316页

作者： Hao Wang Yu-Jun Cui Minh Ngoc Vu Jean Talandier Ecole des Ponts ParisTech Laboratoire Navier/CERMES6 et 8 avenue Blaise PascalMarne La Vallée cedex 277455France Andra R&D DepartmentChâtenay-Malabry92290France

In order to evaluate the performance of deep geological disposal of radioactive waste,an underground research laboratory(URL)was constructed by Andra in the Callovo-Oxfordian(COx)claystone formation at the Meuse/Haute-Marne(MHM).The construction of URL induced the excavation damage of host formations,and the ventilation in the galleries desaturated the host formation close to the gallery ***,it is expected that the mechanical behaviour of COx claystone is *** study presents a constitutive model developed to describe the viscoplastic behaviour of unsaturated and damaged COx *** this model,the unsaturation effect is considered by adopting the Bishop effective stress and the van Genuchten(VG)water retention *** terms of the viscoplastic behaviour,the nonstationary flow surface(NSFS)theory for unsaturated soils is used with consideration of the coupled effects of strain rate and suction on the yield stress.A progressive hardening law is ***,a non-associated flow rule is used,which is similar to that in Barcelona basic model(BBM).In addition,to describe the damage effect induced by suction change and viscoplastic loading,a damage function is defined based on the crack volume *** damage function contains two variables:unsaturated effective stress and viscoplastic volumetric strain,with the related parameters determined based on the mercury intrusion porosimetry(MIP)*** the model validation,different tests on COx claystone under different loading paths are *** between experimental and simulated results indicated that the present model is able to well describe the viscoplastic behaviour of damaged COx claystone,including swelling/shrinkage,triaxial extension and compression,and triaxial creep.

关键词： Callovo-Oxfordian(COx)claystone Excavation damage Time-dependent behaviour Suction Viscoplastic model

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Radiative capture of proton through the ^(14)N(p,γ)^(15)O reaction at low energy

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Chinese Physics C 2024年第4期48卷 183-192页

作者： B.F.Irgaziev Abdul Kabir Jameel-Un Nabi National University of Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan

The CNO cycle is the main source of energy in stars more massive than our *** process defines the energy production,the duration of which can be used to determine the lifetime of massive *** cycle is an important tool for determining the age of globular *** proton capture via p+^(14)N→^(15)O+γ,at energies of astrophysical interest,is an important process in the CNO *** this project,we apply a potential model to describe both non-resonant and resonant reactions in the channels where radiative capture occurs through electric E1 *** employed the R-matrix method to describe the ongoing reactions via M1 resonant transitions,when it was not possible to correctly reproduce the experimental data using the potential *** partial components of the astrophysical S-factor are calculated for all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-factor at zero energy(S(0))agrees well with earlier reported values for all transition types considered in this *** on the value of the total astrophysical S-factor,depending on the collision energy,we calculate the nuclear reaction rates for p+^(14)N→^(15)O+γ.The computed rates agree well with the results reported in the NACRE II Collaboration and most recent existing measurements.

关键词： CNO cycle potential model R-matrix method cross-section astrophysical S-factor nuclear rates.

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Application of artifcial intelligence in cataract management:current and future directions

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Eye and Vision 2024年第1期10卷 21-30页

作者： Laura Gutierrez Jane Sujuan Lim Li Lian Foo Wei Yan Ng Michelle Yip Gilbert Yong San Lim Melissa Hsing Yi Wong Allan Fong Mohamad Rosman Jodhbir Singth Mehta Haotian Lin Darren Shu Jeng Ting Daniel Shu Wei Ting Singapore Eye Research Institute SingaporeSingapore Singapore National Eye Center 11 Third Hospital AvenueSingapore 168751Singapore Academic Ophthalmology School of MedicineUniversity of NottinghamNottinghamUK Zhongshan Ophthalmic Center Sun Yet Sen UniversityGuangzhouChina

The rise of artifcial intelligence(AI)has brought breakthroughs in many areas of *** ophthalmology,AI has delivered robust results in the screening and detection of diabetic retinopathy,age-related macular degeneration,glaucoma,and retinopathy of *** management is another feld that can beneft from greater AI *** is the leading cause of reversible visual impairment with a rising global clinical *** diagnosis,monitoring,and surgical management are necessary to address this *** addition,patients in large developing countries often sufer from limited access to tertiary care,a problem further exacerbated by the ongoing COVID-19 *** on the other hand,can help transform cataract management by improving automation,efcacy and overcoming geographical ***,AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus *** utilizes a deep-learning,convolutional neural network(CNN)to detect and classify referable cataracts ***,some of the latest intraocular lens formulas have used AI to enhance prediction accuracy,achieving superior postoperative refractive results compared to traditional ***,AI can be used to augment cataract surgical skill training by identifying diferent phases of cataract surgery on video and to optimize operating theater workfows by accurately predicting the duration of surgical ***,some AI CNN models are able to efectively predict the progression of posterior capsule opacifcation and eventual need for YAG laser *** advances in AI could transform cataract management and enable delivery of efcient ophthalmic *** key challenges include ethical management of data,ensuring data security and privacy,demonstrating clinically acceptable performance,improving the generalizability of AI models across heterogeneous populations,and improving the trust of e

关键词： Artifcial intelligence Telemedicine Cataract Cataract screening Cataract surgery IOL calculations Biometry Machine learning

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Temporally consistent video colorization with deep feature propagation and self-regularization learning

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Computational Visual Media 2024年第2期10卷 375-395页

作者： Yihao Liu Hengyuan Zhao Kelvin CKChan Xintao Wang Chen Change Loy Yu Qiao Chao Dong Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Electrical&Computer Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798 Applied Research Center Tencent PCGShenzhenChina

Video colorization is a challenging and highly ill-posed *** recent years have witnessed remarkable progress in single image colorization,there is relatively less research effort on video colorization,and existing methods always suffer from severe flickering artifacts(temporal inconsistency)or unsatisfactory *** address this problem from a new perspective,by jointly considering colorization and temporal consistency in a unified ***,we propose a novel temporally consistent video colorization(TCVC)*** effectively propagates frame-level deep features in a bidirectional way to enhance the temporal consistency of ***,TCVC introduces a self-regularization learning(SRL)scheme to minimize the differences in predictions obtained using different time *** does not require any ground-truth color videos for training and can further improve temporal *** demonstrate that our method can not only provide visually pleasing colorized video,but also with clearly better temporal consistency than state-of-the-art methods.A video demo is provided at https://***/watch?v=c7dczMs-olE,while code is available at https://***/lyh-18/TCVC-Tem porally-Consistent-Video-Colorization.

关键词： video colorization temporal consistency feature propagation self-regularization

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Situational Analysis of Malaria Incidence Under Integrated Malaria Service in Hotspot Township-Minbya Township,Rakhine State,Myanmar,2017–2020

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China CDC weekly 2024年第17期6卷 374-377页

作者： Aung Than Oo Hong Chen ASEAN Centre for Biodiversity Ringgold standard institution D.M.Lantican AvenueUniversity of the Philippines Los Baños LagunaLos BañosPhilippines Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Malaria is a significant public health concern and tropical disease,particularly affecting Myanmar within the Greater Mekong *** annual parasite index(API)exceeds 1 per 10,000 population in the northern seven townships of Rakhine State,with Minbya Township designated as a highburden area for malaria by the World Health Organization(WHO)Myanmar and the National Malaria Control Programme(NMCP).Since 2017,the Malaria reduction intensification plan has been in place in this township to combat the high disease transmission *** study aims to assess the malaria epidemiology in Minbya Township from 2017 to 2020 under the intensification plan for elimination,as well as to evaluate the effectiveness of the integrated strategy in reducing cases in hotspot ***:The study utilized a surveillance study design to collect secondary data from the Malaria surveillance system(MSS)and the epidemiologic monitoring dashboard of Minbya Township,Maruk-U District,located in Rakhine ***:Since 2017,the Malaria prevention and control(P&C)Program in Minbya Township has successfully decreased malaria morbidity,eliminated malaria-related deaths,and bolstered malaria testing capabilities through the participation of village health volunteers(VHVs).Approximately 87%of malaria prevention and control services are executed by the township’s malaria elimination and disease control programs,with additional support from *** API dropped from 13 in 2017 to 2.5 in 2020,with Plasmodium vivax being the most prevalent malaria species,accounting for 55%of ***:The study suggests that early diagnosis and promotion of artemisinin-based combination treatment(ACT),along with strategic planning including expanding active case detection in rural health centers and implementing a communitybasedcommunitybased integrated healthcare approach,are effective and efficient strategies for malaria elimination.

关键词： Malaria prevention epidemiology

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A survey on multi-agent reinforcement learning and its application

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Journal of Automation and Intelligence 2024年第2期3卷 73-91页

作者： Zepeng Ning Lihua Xie School of Electrical and Electronic Engineering Nanyang Technological UniversityNanyang Avenue639798Singapore

Multi-agent reinforcement learning(MARL)has been a rapidly evolving *** paper presents a comprehensive survey of MARL and its *** trace the historical evolution of MARL,highlight its progress,and discuss related survey ***,we review the existing works addressing inherent challenges and those focusing on diverse *** representative stochastic games,MARL means,spatial forms of MARL,and task classification are *** then conduct an in-depth exploration of a variety of challenges encountered in MARL *** also address critical operational aspects,such as hyperparameter tuning and computational complexity,which are pivotal in practical implementations of ***,we make a thorough overview of the applications of MARL to intelligent machines and devices,chemical engineering,biotechnology,healthcare,and societal issues,which highlights the extensive potential and relevance of MARL within both current and future technological *** survey also encompasses a detailed examination of benchmark environments used in MARL research,which are instrumental in evaluating MARL algorithms and demonstrate the adaptability of MARL to diverse application *** the end,we give our prospect for MARL and discuss their related techniques and potential future applications.

关键词： Benchmark environments Multi-agent reinforcement learning Multi-agent systems Stochastic games

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