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Wnt信号传导通路及其在肿瘤发生中的作用

世界华人消化杂志 2002年第10期10卷 1201-1205页

作者：张维刘爽徐宁志 Department of Biochemistry Case Western Reserve University10900 Euclid AvenueCleveland OH 44106 中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所细胞生物及分子生物学实验室

胚胎发育与肿瘤发生的关系甚密.近年来一直处于国际前沿研究热点的Wnt信号通路即是一个阐明二者关系的绝好例子.Wnt通路是一条十分保守的信号传导通路.从低等生物果蝇直至高等哺乳动物,其成员都具有高度的同源性.目前认为Wnt通路的组成... 详细信息

胚胎发育与肿瘤发生的关系甚密.近年来一直处于国际前沿研究热点的Wnt信号通路即是一个阐明二者关系的绝好例子.Wnt通路是一条十分保守的信号传导通路.从低等生物果蝇直至高等哺乳动物,其成员都具有高度的同源性.目前认为Wnt通路的组成主要包括:细胞外因子(Wnt)、跨膜受体(frizzled)、胞质蛋白(β-catenin)及核内转录因子(TCF)等一系列蛋白.当细胞外因子与受体结合后,通过一系列胞质蛋白的相互作用使β-catenin蛋白在胞质内累积进而入核与转录因子TCF共同作用激活靶基因的转录.Wnt通路的下游靶基因多数是参与细胞增生与凋亡的基因,如cylinD1、c-myc等.越来越多的研究结果表明,Wnt信号通路不仅在胚胎发育过程中起着至关重要的作用,而且与许多人类肿瘤的发生发展也具有密切关系.本文将着重介绍Wnt信号通路的组成及调控,并分析其在肿瘤发生过程中的作用机制.

关键词： Wnt信号传导通路调控肿瘤病因学

Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile

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Science China(Life Sciences) 2007年第1期50卷 125-134页

作者： GAO Lei1, LI Xia1,2, GUO Zheng1,2, ZHU MingZhu1, LI YanHui1 & RAO ShaoQi1,3 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 School of Biology Science and Technology, Tongji University, Shanghai 200092, China 3 Departments of Molecular Cardiology and Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 euclid avenue, Cleve-land, Ohio 44195, USA Department of Bioinformatics Harbin Medical University Harbin 150086 China Department of Bioinformatics Harbin Medical University Harbin 150086 China School of Biology Science and Technology Tongji University Shanghai 200092 China Department of Bioinformatics Harbin Medical University Harbin 150086 China Departments of Molecular Cardiology and Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

GESTs (gene expression similarity and taxonomy similarity), a gene functional prediction approach previously proposed by us, is based on gene expression similarity and concept similarity of functional classes defined in Gene Ontology (GO). In this paper, we extend this method to protein-protein interac-tion data by introducing several methods to filter the neighbors in protein interaction networks for a protein of unknown function(s). Unlike other conventional methods, the proposed approach automati-cally selects the most appropriate functional classes as specific as possible during the learning proc-ess, and calls on genes annotated to nearby classes to support the predictions to some small-sized specific classes in GO. Based on the yeast protein-protein interaction information from MIPS and a dataset of gene expression profiles, we assess the performances of our approach for predicting protein functions to “biology process” by three measures particularly designed for functional classes organ-ized in GO. Results show that our method is powerful for widely predicting gene functions with very specific functional terms. Based on the GO database published in December 2004, we predict some proteins whose functions were unknown at that time, and some of the predictions have been confirmed by the new SGD annotation data published in April, 2006.

关键词： gene expression profile protein-protein interaction Gene Ontology similarity gene function prediction

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ZnGeN_2晶体的结构和物性表征

电子显微学报 2006年第B8期25卷 9-10页

作者：杜奎 Bekele C Hayman C C Pirouz P Kash K 中国科学院金属研究所沈阳材料科学国家(联合)实验室 Case Western Reserve University 10900 Euclid AvenueClevelandOH44106USA Case

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胰管胸膜瘘:2例病例报道及文献综述

世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 3-4页

作者： Oh Y.S. Edmundowicz S. A. Jonnalagadda S. S. Azar R. R. 纪泛扑(译) 史敏(校) 不详 Dr. R.R. Azar Washington UniversitySchool of Medicine Campus Box 8124 660 South Euclid Avenue Saint Louis MO 63110 United States

Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopleural fistulas (79%versus 43%, respectively). Medical therapy with total parenteral nutrition, octreotide, and/or chest tube placement was successful in resolving the pancreaticopleural fistula in up to 33%of cases. None of the patients who underwent pancreatic duct stent and/or nasopancreatic drain placement required surgical intervention. Endoscopic retrograde cholangiopancreatography is the initial test of choice when the diagnosis of pancreaticopleural fistula is suspected. Early endoscopic intervention with pancreatic duct stent placement is recommended given its high success rate in fistula closure. Medical therapies are useful adjuncts to endoscopic therapy, but rarely result in pancreaticopleural fistula closure alone. Surgical interventions should only be considered after failure of endoscopic and medical therapies.

关键词：胆胰管造影术胸膜瘘管病例报道文献综述全胃肠外营养内镜逆行外科手术药物治疗鼻胰管引流支架置入术

Protective effect of unilateral vasospasm in the setting of HHH-associated posterior reversible encephalopathy syndrome:case report, review of the literature, and treatment considerations

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Chinese Neurosurgical Journal 2019年第1期5卷 47-55页

作者： Alankrita Raghavan Jordan Xu James M.Wright Christina Huang Wright Benjamin Miller Yin Hu School of Medicine Case Western Reserve University2109 Adelbert RoadClevelandOH 44106USA Department of Neurological Surgery University of California Irvine SOM1001 Health Sciences RdIrvineCA 92617USA Department of Neurological Surgery University Hospitals Cleveland Medical Center11100 Euclid AvenueClevelandOH 44106USA Department of Neurology University of Minnesota420 Delaware St SEMinneapolisMN 55455USA

Background:Hyperdynamic therapy,also called triple-H therapy,is the standard treatment and prophylaxis for aneurysmal-associated *** patients who are able to tolerate cardiopulmonary stressors induced by this therapy,it is of benefit as a modality for prevention and treatment of delayed ischemic neurologic ***,it can be a cause of significant cardiopulmonary or neurologic *** rare cases,it can be associated with posterior reversible encephalopathy syndrome(PRES),secondary to prolonged vasopressor and hypertensive *** presentation:We present the case of a patient with right-sided aneurysmal-associated vasospasm who,after 10 days of triple-H therapy,experienced a seizure and was found to have left-sided ***-sided vasospasm served as a protective mechanism from triple-H therapy-associated *** presented a treatment conundrum due to contradictory perfusion *** therapy was curtailed and in efforts to preserve local cerebral perfusion and vasodilation,local therapy with intrathecal nicardipine was *** present our case,a review of the literature,and management ***:Therapies that have conventionally functioned as second line treatments for aneurysmal subarachnoid hemorrhage(intra-arterial vasodilators and intrathecal vasodilators)may be beneficial as earlier treatments in the setting of vasospasm given the systemic difficulties and complications associated with HHH therapy in patients with PRES.

关键词： Subarachnoid hemorrhage Hyperdynamic therapy Posterior reversible encephalopathy syndrome

儿科学杂志——儿童苯丙胺盐混合物缓释剂的短期和长期心血管作用

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 58-58页

作者： Findling R. L. Biederman J. 李丹(译) University Hospitals of Cleveland 11100 Euclid Avenue Cleveland OH 44106-5080 United States

目的：评估苯丙胺盐混合物类扩展一缓释剂（MASXR；Adderall XR）的短期和长期心血管作用，这种药每日1次用于治疗6—12岁儿童注意缺陷多动障碍综合征（ADHD）。设计：在4周期间，双盲、随机、安慰剂对照、每日1次的10mg、20mg，和30mgM... 详细信息

目的：评估苯丙胺盐混合物类扩展一缓释剂（MASXR；Adderall XR）的短期和长期心血管作用，这种药每日1次用于治疗6—12岁儿童注意缺陷多动障碍综合征（ADHD）。设计：在4周期间，双盲、随机、安慰剂对照、每日1次的10mg、20mg，和30mgMASXR（n=580）的效应-剂量-滴定研究。在2年中，通过对568名受试者MASXR（10—30mg／d）的开放性标签延伸研究来评估这种药物的长期心血管效应。基线水平、短期研究期间每周及长期研究期间每月测定安静坐位血压和脉搏。结果：在短期治疗中，接受MASXR治疗的儿童血压、脉搏及由Bazett公式校正的QT间期的变化与接受安慰剂治疗组之间无差异。经过2年的MASXR治疗之后血压和脉搏的平均增加值无临床意义，而且无明显的剂量一效应关系。结论：以≤30mg／d剂量治疗时MASXR的长期和短期的心血管效应很弱。

关键词：心血管作用 2岁儿童缓释剂混合物苯丙胺注意缺陷多动障碍综合征儿科学 Adderall 安慰剂对照心血管效应

有或无心脏外科手术史患者肺静脉窦隔离术后心房扑动消融的必要性

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 53-53页

作者： Kilicaslan F. Verma A. Yamaji H. A. Natale Sect 腾增辉 Pacing and Electrophysiology Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States

Objectives: The aim of this study was to assess the incidence of atrial flutter(AFL) after pulmonary vein antrum isolation(PVAI) in patients with previous cardiac surgery(PCS) in comparison to patients without PCS and to assess the need for AFL ablation in both groups. Background: Atrial fibrillation(AF) and AFL often co- exist. Pulmonary vein antrum isolation may be sufficient to control both arrhythmias. However, in patients with PCS, atrial incisions, cannulations, and scar areas may cause AFL recurrence despite elimination of pulmonary vein triggers. Methods: Data from 1,345 patients who had PVAI were analyzed. Patients with a history of AFL ablation and patients who had concomitant AFL ablation during PVAI were excluded from analysis. Sixty- three patients constituted the PCS group(Group 1, age 57± 13 years, 12 female) and 1,062 patients constituted the non- PCS group(Group 2, age 55± 12 years, 212 female). Patients in Group 1 had larger left atria, higher incidence of AFL pre- PVAI, and lower ejection fraction. Results: There was no significant difference in post- PVAI AF recurrence between Groups 1 and 2, but AFL incidence after PVAI was higher in Group 1(33% vs. 4% , p< 0.0001). Ablation of AFL in Group 1 patients resulted in an 86% acute success rate and 11% recurrence over a mean follow- up of 357± 201 days. Conclusions: In patients with PCS, post- PVAI AF recurrence is similar to patients without PCS. However, history of PCS is associated with a higher recurrence of AFL after PVAI. In a significant number of patients with PCS, AFL ablation is required to achieve a cure.

关键词：心房扑动心脏外科手术窦隔心房颤动复发率射血分数插管术左心房

多支冠状动脉疾病且曾行冠状动脉搭桥术的患者中血运重建方法的预测因素和经皮冠状动脉介入术或再次冠状动脉搭桥术的长期预后

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 50-50页

作者： Brener S.J. Lytle B.W. Casserly I.P. 王亭忠 Department of Cardiovascular Medicine Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States

Aims: The optimal revascularization strategy in patients with symptomatic multivessel coronary artery disease(CAD) and previous coronary artery bypass grafting(CABG) remains unknown. Methods and results: We evaluated all patients with previous CABG undergoing isolated, non- emergency multivessel revascularization between 1 January 1995 and 31 December 2000. The analysis concentrated on the independent predictors of the revascularization method, as well as on long- term mortality and its predictors, after calculating a propensity score for the method of revascularization. There were 2191 patients(1487 with reoperation and 704 with percutaneous coronary intervention, PCI) in the study. The most important factors in choosing reoperation were presence of more diseased or occluded grafts, previous infarction, lower ejection fraction(EF), longer interval from first CABG, and more total occlusions of native arteries, as well as absence of a patent mammary graft. The distribution of the propensity score was skewed towards the two extremes. At 5 years, the unadjusted cumulative survival was 79.5% for CABG and 75.3% for PCI, P=0.008. After adjustment for the propensity score for PCI vs. CABG, PCI was associated with a hazard ratio of 1.47(0.94- 2.28), P=0.09. The most powerful predictors of mortality were higher age and lower EF. Conclusion: The choice of the revascularization method in patients with previous CABG is dictated mostly by anatomical considerations and less by clinical characteristics. In contrast, clinical characteristics predominantly affect long- term outcome, whereas the method of revascularization has a limited effect. A randomized clinical trial addressing this important segment of the population with ischaemic heart disease is warranted.

关键词：经皮冠状动脉介入术冠状动脉搭桥术独立预测因素冠状动脉疾病血运重建重建方法再次手术患者长期预后 CABG

三尖瓣瓣环成形术后三尖瓣反流复发或残余功能性反流的决定因素

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 42-42页

作者： Fukuda S. Gillinov A.M. McCarthy P.M. T. Shiota 刘相飞 Department of Cardiovascular Medicine Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195United StatesDr

背景:经瓣环成形术修复的三尖瓣(TV)的耐久性有限。为改善TV修复的结果,有必要明确瓣环成形术后复发或残余TV反流(TR)的机制。本研究旨在查明TV瓣环成形术后中期结果的超声心动图决定因素。方法和结果:本项研究纳入39例功能性TR患者,分... 详细信息

背景:经瓣环成形术修复的三尖瓣(TV)的耐久性有限。为改善TV修复的结果,有必要明确瓣环成形术后复发或残余TV反流(TR)的机制。本研究旨在查明TV瓣环成形术后中期结果的超声心动图决定因素。方法和结果:本项研究纳入39例功能性TR患者,分别在TV瓣环成形术前、术后早期(5±2d)和术后>1年(20±6个月)行超声心动图检查。

关键词：瓣环成形术三尖瓣反流超声心动图前瓣叶本项外科治疗策略于术射血分数随访过程压力影响