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中医药干预神经退行性疾病引起的认知功能障碍的分子机制

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生物化学与生物物理进展 2020年第8期47卷 729-742页

作者：张韬赵磊战锐苑桂红韩鸿宾崔德华北京大学第三医院磁共振技术与设备重点研究室北京100191 北京大学医学技术研究院北京100191 北京大学基础医学院北京100191

本文综述了中医药对阿尔茨海默病(Alzheimer’s disease,AD)和帕金森病(Parkinson’s disease,PD)引起的认知功能障碍抗炎作用分子机制的研究进展,并讨论了中医药(如伊桐苷、芒柄花素、和厚朴酚、甘露寡糖二酸和红花类黄酮提取物等)在... 详细信息

本文综述了中医药对阿尔茨海默病(Alzheimer’s disease,AD)和帕金森病(Parkinson’s disease,PD)引起的认知功能障碍抗炎作用分子机制的研究进展,并讨论了中医药(如伊桐苷、芒柄花素、和厚朴酚、甘露寡糖二酸和红花类黄酮提取物等)在干预神经退行性疾病中的作用机制,具体包括中医药影响Aβ的生成及聚集、tau磷酸化、肠-脑轴和肠道菌群的调节、自噬功能、小胶质细胞极化、细胞外间隙、神经发生和神经递质传递等.

关键词：阿尔茨海默病炎症 β-淀粉样蛋白 tau蛋白小胶质细胞极化细胞外间隙

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惰性气体原子间相互作用势比较研究

物理学报 2015年第14期64卷 122-131页

作者：孙素蓉王海兴北京航空航天大学宇航学院北京100191

原子间相互作用势是预测惰性气体输运性质的必要输入条件.文章对描述惰性气体原子间相互作用的Lennard-Jones势、指数排斥势、Hartree-Fock-Dispersion-B(HFD-B)势和唯象势的形式和特点进行了分析.基于Chapman-Enskog方法,计算得到了惰... 详细信息

原子间相互作用势是预测惰性气体输运性质的必要输入条件.文章对描述惰性气体原子间相互作用的Lennard-Jones势、指数排斥势、Hartree-Fock-Dispersion-B(HFD-B)势和唯象势的形式和特点进行了分析.基于Chapman-Enskog方法,计算得到了惰性气体在300—5000 K温度区间内基于四种原子相互作用势的黏性和热导率,并与文献报道的实验和理论计算结果进行了比较.研究结果表明,基于Hartree-Fock排斥理论与色散理论发展起来的HFD-B势能够合理反映惰性气体原子相互作用的趋势与特征,因而可以较好地预测惰性气体的宏观输运性质.

关键词：原子间作用势惰性气体输运性质

解整合素金属蛋白酶19(ADAM19)与子痫前期的相关性研究

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生物化学与生物物理进展 2011年第5期38卷 449-454页

作者：杨玲玲王静原鹏波赵扬玉王永清北京大学第三医院妇产科北京100191

通过对孕妇胎盘组织和外周血中解整合素金属蛋白酶19(ADAM19)的检测,探讨ADAM19与子痫前期发病的关系.将病人分为研究组(子痫前期组)和对照组(正常妊娠组),子痫前期组病人中早发型50例,晚发型44例,对照组病人50例.于临近分娩时取静脉血... 详细信息

通过对孕妇胎盘组织和外周血中解整合素金属蛋白酶19(ADAM19)的检测,探讨ADAM19与子痫前期发病的关系.将病人分为研究组(子痫前期组)和对照组(正常妊娠组),子痫前期组病人中早发型50例,晚发型44例,对照组病人50例.于临近分娩时取静脉血,分娩后取胎盘组织,应用免疫组织化学技术和免疫印迹技术对胎盘组织中ADAM19蛋白进行检测,用ELISA法检测两组血浆中ADAM19的水平.结果显示,胎盘组织中ADAM19分布在多种滋养层细胞中,包括细胞滋养层细胞、合体滋养层细胞和一些绒毛间质结缔组织细胞、毛细血管中,其阳性信号定位于细胞膜上和细胞质中;ADAM19的蛋白表达正常胎盘中为0.34±0.03,晚发型子痫前期组为0.53±0.02,早发型子痫前期组为0.82±0.03,三者间比较差异均有统计学意义(P0.05),早发型与晚发型子痫前期比较有统计学差异(P<0.001).结果表明,子痫前期胎盘组织中ADAM19过度表达可能与子痫前期的发生和发展有关,ADAM19有可能作为预测子痫前期发病的分子标志.

关键词：解整合素金属蛋白酶19(ADAM19) 胎盘子痫前期

为健康发声,为科普赋能——天津全域科普背景下“健康科普好声音”品牌活动经验与思考

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天津科技 2024年第S1期51卷 87-90页

作者：沈文达李威潘怡解美秋薛晓丹张颖天津市疾病预防控制中心非传染病预防控制所天津300011 北京大学公共卫生学院社会医学与健康教育系北京100191

“健康科普好声音”暨全民健康生活方式科普演讲及科普展演大赛迄今已成功举办4届。大赛以施拉姆大众传播模式为理论基础,以“医防结合”全民健康生活方式行动为主题,凭借其“专业+科普”的广泛受众、“初赛+决赛”的科学赛制、“经典+... 详细信息

“健康科普好声音”暨全民健康生活方式科普演讲及科普展演大赛迄今已成功举办4届。大赛以施拉姆大众传播模式为理论基础,以“医防结合”全民健康生活方式行动为主题,凭借其“专业+科普”的广泛受众、“初赛+决赛”的科学赛制、“经典+新潮”的科普风格、“线下+线上”的立体宣传矩阵,作为健康科普领域成功案例入选天津市全域科普“四全”品牌宣传活动名单,产生了极大的社会影响力。通过回顾“健康科普好声音”大赛的发展轨迹,分析创新经验与成就,以期助力科普宣传工作。

关键词：全民健康全域科普经验

Circumspinal decompression through a single posterior incision to treat thoracolumbar disc herniation

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Chinese Medical Journal 2011年第23期124卷 3852-3857页

作者： QI Qiang CHEN Zhong-qiang LIU Ning GUO Zhao-qing SHI Ze-feng LIU Zhong-jun LIU Xiao-guang LI Wei-shi ZENG Yan SUN Chui-guo Department of Orthopaedics Peking University Third Hospital Beijing 100191 China

Various surgical approaches have been successfully used in the treatment of thoracolumbar disc herniation （TLDH）. Although the anterior transthoracic approach has a reputation for better visualization than the posterolateral and lateral approaches, it involves the manipulation of the thoracic and pulmonary structures. Thus, this approach is technically demanding and prone to compromising the respiratory system. An ideal approach would involve adequate visualization and be accomplished through the posterior midline approach that is familiar to spine surgeons. The objective of this retrospective preliminary clinical study was to introduce a new surgical procedure, circumspinal decompression through a single posterior incision, for the treatment of TLDH （T10/11-L1/2） and to evaluate the surgical outcome of this procedure by comparing it to the conventional anterior transthoracic approach. Methods In this study, 15 patients （10 males, 5 females; mean age 51 years） with symptomatic TLDH underwent the circumspinal decompression through a single posterior incision procedure between January 2008 and December 2009. Altogether, 17 herniated discs were excised, with 2 discs at T10/11, 4 discs at Tll/12, 5 discs at T12/L1 and 6 discs at L1/2. Of these patients, 13 were followed up with a mean follow-up period of 23.5 months. Clinical outcomes, including operative time, blood loss, perioperative complications, postoperative time of hospitalization, neurologic status improvement, back pain and correction of local kyphosis, were investigated by comparing these data with the results from patients who underwent the anterior transthoracic approach for TLDH during the same period. The patients＇ neurologic status was evaluated by a modified Japanese Orthopedic Association （JOA） scoring system of 11 points. Neurologic status improvement after the surgery was assessed by calculating the recovery rate, which was equal to the （postoperative JOA score-preoperative JOA score）/（11-preoperativ

关键词： thoracolumbar disc herniation circumspinal decompression thoracic spine

Prenatal diagnosis of Down syndrome using cell-free fetal DNA in amniotic fluid by quantitative fluorescent polymersase chain reaction

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Chinese Medical Journal 2014年第10期127卷 1897-1901页

作者： Wu Dan Chi Hongbin Shao Minjie Wu Yao Jin Hongyan Wu Baiyan Qiao Jie Department of Medical Genetics Peking University Health ScienceCenter Beijing 100191 China Reproductive Medicine Center Peking University Third Hospital Beijing 100191 China

Backgroud Amniotic fluid （AF） supernatant contains cell-free fetal DNA （cffDNA） *** study attempted to take advantage of cffDNA as a new material for prenatal diagnosis,which could be combined with simple quantitative fluorescent polymerase chain reaction （QF-PCR） to provide an ancillary method for the prenatal diagnosis of trisomy 21 *** AF supernatant samples were obtained from 27 women carrying euploid fetuses and 28 women carrying aneuploid fetuses with known cytogenetic *** blood samples of the parents were collected at the same *** tandem repeat （STR） fragments on chromosome 21 were amplified by *** condition and the parental source of the extra chromosome could be determined by the STR *** The sensitivity of the assay for the aneuploid was 93％（26/28; confidence interval,CI：77％-98％） and the specificity was 100％（26/26; CI：88％-100％）.The determination rate of the origin of the extra chromosome was 69％.The sensitivity and the specificity of the assay in the euploid were 100％（27/27）.Conclusions Trisomy 21 can be prenatally diagnosed by the QF-PCR method in AF *** karyotype analysis method greatly reduces the requirement for the specimen *** will be a benefit for early amniocentesis and could avoid pregnancy *** method may become an ancillary method for prenatal diagnosis of trisomy 21.

关键词： amniotic fluid supernatant cell-free fetal DNA fragment quantitative fluorescent polymerase chain reaction short tandem repeat analysis trisomy 21 syndrome

Enhancing interfacial stability in solid-state lithium batteries with polymer/garnet solid electrolyte and composite cathode framework

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Journal of Energy Chemistry 2021年第1期30卷 210-217,I0007页

作者： Long Chen Xiaoming Qiu Zhiming Bai Li-Zhen Fan Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Advanced Energy Materials and TechnologiesUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Advanced Chemical Energy Storage Technologies and Materials Research Institute of Chemical DefenseBeijing 100191China Shanxi Key Laboratory of New Energy Materials and Devices Taiyuan University of Technology030024China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The solid-state lithium battery is considered as an ideal next-generation energy storage device owing to its high safety,high energy density and low ***,the poor ionic conductivity of solid electrolyte and low interfacial stability has hindered the application of solid-state lithium ***,a flexible polymer/garnet solid electrolyte is prepared with poly(ethylene oxide),poly(vinylidene fluoride),Li6.75La3 Zr1.75Ta0.25O12,lithium bis(trifluoromethanesulfonyl)imide and oxalate,which exhibits an ionic conductivity of 2.0 ×10^(-4) S cm^(-1) at 55℃,improved mechanical property,wide electrochemical window(4.8 V ***/Li+),enhanced thermal *** acidic OX was introduced to inhibit the alkalinity reactions between Li6.75La3 Zr1.75Ta0.25O12 and poly(vinylidene fluoride).In order to improve the interfacial stability between cathode and electrolyte,an Al2 O3@LiNi0.5Co0.2Mn0.3O2 based composite cathode framework is also fabricated with poly(ethylene oxide) polymer and lithium salt as *** solid-state lithium battery assembled with polymer/garnet solid electrolyte and composite cathode framework demonstrates a high initial discharge capacity of 150.6 mAh g^(-1) and good capacity retention of 86.7% after 80 cycles at 0.2 C and 55℃,which provides a promising choice for achieving the stable electrode/electrolyte interfacial contact in solid-state lithium batteries.

关键词： Li6.75La3Zr1.75Ta0.25O12 Polymer/garnet solid electrolyte Interfacial stability Composite cathode framework Lithium metal batteries

Intraoperative monitoring for safety of total hip arthroplasty using third-generation cementing technique

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Chinese Medical Journal 2009年第2期122卷 174-177页

作者： LI Zi-jian ZHANG Ke YANG Hong LIU Yan LU Jing-qiao Department of Orthopedics Peking University Third Hospital Beijing 100191 China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191 China

Background Controversies on the safety of the cement application between cemented and uncemented total hip arthroplasty （THA） have been existing for decades. The purpose of this study was to observe the changes in mean arterial pressure （MAP）, heart rate （HR） and oxygen pressure （PaO2） during cemented THA, and to evaluate the intraoperative safety of using the third-generation cementing technique and investigate whether the intraoperative risk is higher in acute femoral neck fracture patients than non-traumatic patients. Methods Forty-two patients who underwent cemented THA between November 2005 and September 2007 were prospectively included in this study. The third-generation cementing technique as vacuum mixing and pulsatile lavage was used strictly. The MAP and HR were monitored and documented during each operation. Blood gas analysis was performed at exposure, cup implantation, stem implantation and wound closure. MAP, HR and PaO2 were compared between pre- and post-cement application. Comparisons of MAP, HR and PaO2 between patients with acute femoral neck fracture and non-traumatic patiens were performed as well. Results No intraoperative cardiopulmonary complication occurred in these cases. No obvious changes were observed in MAP, HR and PaO2 after cement application. There was no significant difference in MAP, HR and PaO2 between acute femoral fracture patients （18 patients） and non-traumatic patients （24 patients）. Conclusions The results of this study suggested that the invasive blood pressure monitoring and blood gas analysis are essential for patients undergoing cemented THA, especially for patients with femoral neck fracture. The third-generation cementing technique is safe to use in THA. Chin Med J 2009; 122（2）： 174-177

关键词： arthroplasty hip bone cement monitoring intraoperative

Assessing Cardiovascular Health Using Life＇s Simple 7 in a Chinese Population Undergoing Stroke Prevention

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Chinese Medical Journal 2015年第18期128卷 2450-2456页

作者： QiongYang Bin Zhang Pan Deng Lu Chen Jing-Ran Wang Dong-Sheng Fan Department of Neurology Peking University Third Hospital Beijing 100191 China

Background： The American Heart Association/American Stroke Association proposed a metric called Life＇s Simple 7 （LS7） to define cardiovascular health （CVH）. The presence of a large number of ideal components of CVH is associated with lower cardiovascular disease and all-cause mortality. We aimed to assess CVH using LS7 in a Chinese population undergoing primary and secondary stroke prevention. Methods： Patients with either ischemic stroke or cardiovascular risk factors were enrolled in the study from October 2010 to July 2013. LS7 components were scored as poor （0 points）, intermediate （1 point）, or ideal （2 points）. The overall LS7 score was categorized as inadequate （0-4）, average （5-9）, or optimal （10-14） CVH. The Chi-square test, Mann-Whitney U-test, and Kruskal-Wallis test were used. Results： In total, 706 patients were enrolled. （1） The distribution of the overall LS7 score （n = 255） indicated that 9.4%, 82.4%, and 8.2% of the patients had inadequate, average, and optimal CVH, respectively. The proportion of patients with optimal CVH undergoing secondary stroke prevention was lower than that for patients undergoing primary stroke prevention （3.8% vs. 12.8%, P = 0,005）. The vast laaajority of participants （76.1%） presented with 〈2 ideal health components. （2） The proportions of patients with poor, intermediate, and ideal status, respectively, lbr the following LS7 components were assessed： Total cholesterol （n = 275; 5.1%, 73.8%, and 21.1%）, blood pressure （11 = 351 ; 32.5%. 59.0%, and 8.5%）, blood glucose （n = 280; 9.3%, 39.6%, and 51.1%）, physical activity （n = 540; 90.7%, 8.7%, and 0.6%）, diet （n = 524; 0.2%. 92.4%, and 7.4%）, smoking （n = 619： 20.7%, 2.9%, and 76.4%）, and body mass index （n = 259; 6.6%, 35.5%, and 57.9%）. Conclusions： Few Chinese patients undergoing stroke prevention had optimal CVH （determined using LS7）. Additionally, fewer patients undergoing secondary prevention had optimal CVH than those undergoing primary prevention. In particular, ph

关键词： Cardiovascular Health Life's Simple 7 Lifestyle, Risk Factors Stroke Prevention