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Efficacy and Safety of 120-W Thulium：Yttrium-Aluminum-Garnet Vapoenucleation of Prostates Compared with Holmium Laser Enucleation of Prostates for Benign Prostatic Hyperplasia

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Chinese Medical Journal 2015年第7期128卷 884-889页

作者： Kai Hong Yu-Qing Liu Jian Lu Chun-Lei Xiao Yi Huang Lu-Lin Ma Department of Urology Peking University Third Hospital Beijing 100191 China

Background： This study compared the efficacy and safety between 120-W thulium：yttrium-aluminum-garnet （Tm：YAG） vapoenucleation of prostates （ThuVEP） and holmium laser enucleation of prostates （HoLEP） for patients with lower urinary tract symptoms （LUTS） due to benign prostatic hyperplasia （BPH）. Methods： A retrospective analysis of 88 consecutive patients with symptomatic BPH was carried out, who underwent either 120-W ThuVEP or HoLEP nonrandomly. Patient demographics and peri-operative and 12-month follow-up data were analyzed with the International Prostate Symptom Score （IPSS）, quality of life （QoL） score, maximum flow rate （Qmax）, postvoid residual urine volume （PVR）＋ and rates of peri-operative and late complications. Results： The patients in each group showed no significant difference in preoperative parameters. Compared with the HoLEP group, patients in the 120-W ThuVEP group required significantly shorter time for laser enucleation （58.3 ± 12.8 min vs. 70.5 ± 22.3 min, P = 0.003）, and resulted in a significant superiority in laser efficiency （resected prostate weight/laser enucleation time） for 120-W Tm：YAG laser compared to holmium：YAG laser （0.69 ± 0.18 vs. 0.61 ± 0.19, P = 0.048）. During 1, 6, and 12 months of follow-ups, the procedures did not demonstrate a significant difference in IPSS, QoL score, Qmax, or PVR （P 〉 0.05）. Mean peri-operative decrease of hemoglobin in the HoLEP group was similar to the ThuVEP group （ 17.1 ± 12.0 g/L vs. 15.2± 10.1 g/L, P = 0.415）. Early and late incidences of complications were low and did not differ significantly between the two groups of 120-W ThuVEP and HoLEP patients （P 〉 0.05）. Conclusions： 120-W ThuVEP and HoLEP are potent, safe and efficient modalities of minimally invasive surgeries for patients with LUTS due to BPH. Compared with HoLEP, 120-W TbuVEP offers advantages of reduction of laser enucleation time and improvement of laser efficiency.

关键词： Benign Prostatic Hyperplasia Holmium Lasers Laser Surgery Prostatectomy Thulium Transurethral

Hybrid Therapy Regimen for Helicobacter Pylori Eradication

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Chinese Medical Journal 2016年第8期129卷 992-999页

作者： Zhi-Qiang Song Jian Liu Li-Ya Zhou Department of Gastroenterology Peking University Third Hospital Beijing 100191 China

Objective：Helicobacterpylori （***） eradication remains a challenge with increasing antibiotic *** therapy has attracted widespread attention because of initial report with good efficacy and ***,many issues on hybrid therapy are still unclear such as the eradication efficacy,safety,compliance,influencing factors,correlation with antibiotic resistance,and comparison with other ***,a comprehensive review on the evidence of hybrid therapy for *** infection was *** Sources：The data used in this review were mainly from PubMed articles published in English up to September 30,2015,searching by the terms of＆quot;Helicobacterpylori＆quot; or ＆quot;***＆quot;,and ＆quot;hybrid＆quot;.Study Selection：Clinical research articles were selected mainly according to their level of relevance to this ***：Totally,1871 patients of 12 studies received hybrid *** eradication rates were 77.6-97.4% in intention-to-treat and 82.6-99.1% in per-protocol *** was 93.3-100.0%,overall adverse effects rate was 14.5-67.5%,and discontinued medication rate due to adverse effects was 0-6.7%.*** culture and sensitivity test were performed only in 13.3% *** analysis showed that the eradication rates with dual clarithromycin and metronidazole susceptible,isolated metronidazole or clarithromycin resistance,and dual clarithromycin and metronidazole resistance were 98.5%,97.6%,92.9%,and 80.0%,***,the efficacy,compliance,and safety of hybrid therapy were similar with sequential or concomitant ***,hybrid therapy might be superior to sequential therapy in ***：Hybrid therapy showed wide differences in the efficacy but consistently good compliance and safety across different *** clarithromycin and metronidazole resistance were the key factor to *** therapy was similar to sequential or concomitant therapy in the efficacy,safety,and complian

关键词： Antibiotic Helicobacter pylori Resistance Therapy

外源核苷酸对干酪乳杆菌生长的促进作用及机制

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食品科学 2021年第22期42卷 201-207页

作者：丁婷李勇北京大学公共卫生学院北京100191

探究2种外源核苷酸,即5’-单磷酸胞苷(cytidine 5’-monophosphate,5’-CMP)和5’-单磷酸腺苷(adenosine 5’-monophosphate,5’-AMP)对干酪乳杆菌生长的促进作用,探究其对细菌生物被膜、胞外聚合物、粗提物群体感应抑制活性和抗食源致... 详细信息

探究2种外源核苷酸,即5’-单磷酸胞苷(cytidine 5’-monophosphate,5’-CMP)和5’-单磷酸腺苷(adenosine 5’-monophosphate,5’-AMP)对干酪乳杆菌生长的促进作用,探究其对细菌生物被膜、胞外聚合物、粗提物群体感应抑制活性和抗食源致病菌生物被膜活性的影响。结果发现,2种外源核苷酸对细菌的生长繁殖均有明显促进作用,刺激了细菌生物被膜和胞外聚合物的产生。此外还促进了干酪乳杆菌粗提物群体感应抑制活性和对志贺菌生物被膜的抑制作用。5’-CMP和5’-AMP可以作为细菌生长刺激物使用,在维护肠道健康方面具有广阔应用前景。

关键词：外源核苷酸干酪乳杆菌 5’-CMP 5’-AMP 生物被膜

Factors affecting proprioceptive recovery after anterior cruciate ligament reconstruction

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Chinese Medical Journal 2008年第22期121卷 2224-2228页

作者： ZHOU Mou-wang GU Li CHEN Ya-ping YU Chang-long AO Ying-fang HUANG Hong-shi YANG Yan-yan Department of Rehabilitation Medicine Peking University Third Hospital Beijing 100191 China Department of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background Proprioception plays an important role in knee movements. Since there are controversies surrounding the overall recovery time of proprioception following surgery, it is necessary to define the factors affecting proprioceptive recovery after anterior cruciate ligament （ACL） reconstruction and to investigate the relationship between proprioception and muscle strength. Methods A total of 36 patients who had their ACL reconstructed with a semitendinosus/gracilis graft （reconstructed group： 6 months post-surgery） and 13 healthy adults without any knee injury （control group） were included in the study. Knee proprioception was evaluated with a passive reproduction test. Isokinetic strength was measured using the Biodex System. Statistical analysis was used to compare proprioception of the reconstructed group versus the control group, and to define causal factors, including sex, hamstring/quadriceps ratio, and the course of injury before reconstruction, We also investigated the correlation between the passive reproduction error and quadriceps index. Results There was a significant difference in proprioception between the reconstructed and control groups （P 〈0.05）. When the course of injury before reconstruction was less than 4 months, there was a linear correlation with proprioception 6 months after the operation （r=0.713, P 〈0.05）. There was a positive correlation between post-surgery proprioception and the quadriceps index at 6 months post-surgery. Conclusions Impaired knee proprioception is observed 6 months after ACL reconstruction. Within 4 months of injury, early undertaking of reconstruction is associated with better proprioception outcome. Patients with enhanced proprioception have a better quadriceps index.

关键词： anterior cruciate ligament reconstruction " proprioception " muscle strength

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中医五音疗法干预气虚质人群临床观察

河北中医 2024年第7期46卷 1065-1069,1073页

作者：高昭曾静吕品黄梦文王稼心彭艳文提桂香中国中医科学院广安门医院治未病中心北京100053 国家中医药管理局中国中医药科技发展中心北京100191

目的观察中医五音疗法对未病状态的气虚质人群的干预效果及安全性,为中医五音疗法在体质偏颇人群的应用提供循证医学证据。方法将76例气虚质患者按照随机数字表法分为2组,对照组38例予统一生活方式干预,治疗组38例在对照组干预基础上加... 详细信息

目的观察中医五音疗法对未病状态的气虚质人群的干预效果及安全性,为中医五音疗法在体质偏颇人群的应用提供循证医学证据。方法将76例气虚质患者按照随机数字表法分为2组,对照组38例予统一生活方式干预,治疗组38例在对照组干预基础上加中医五音疗法干预,2组均干预6个月。记录2组治疗前后中医气虚质评分、五脏病位维度气虚量表评分、简明健康调查量表(SF-36)评分、疲劳评定量表(FAI)评分;对2组进行安全性评价。结果最终共75例受试者完成全程干预,其中治疗组完成干预37例,对照组完成干预38例。2组治疗后气虚质各症状评分均较本组治疗前降低(P0.05),均未出现不良反应。结论生活方式结合中医五音疗法对气虚质人群干预效果明显,且安全性较高。

关键词：气虚质五音疗法治未病

Haptic rendering for dental training system

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Science in China(Series F) 2009年第3期52卷 529-546页

作者： WANG DangXiao ZHANG YuRu WANG Yong LU PeiJun ZHOU RenGe ZHOU WanLin State Key Laboratory of Virtual Reality Technology and Systems Beihang University Beijing 100191 China School and Hospital of Stomatology Peking University Beijing 100081 China

Immersion and interaction are two key features of virtual reality systems, which are especially important for medical applications. Based on the requirement of motor skill training in dental surgery, haptic rendering method based on triangle model is investigated in this paper. Multi-rate haptic rendering architecture is proposed to solve the contradiction between fidelity and efficiency requirements. Realtime collision detection algorithm based on spatial partition and time coherence is utilized to enable fast contact determination. Proxy-based collision response algorithm is proposed to compute surface contact point. Cutting force model based on piecewise contact transition model is proposed for dental drilling simulation during tooth preparation. Velocity-driven levels of detail haptic rendering algorithm is proposed to maintain high update rate for complex scenes with a large number of triangles. Hapticvisual collocated dental training prototype is established using half-mirror solution. Typical dental operations have been realized including dental caries exploration, detection of boundary within dental cross-section plane, and dental drilling during tooth preparation. The haptic rendering method is a fundamental technology to improve immersion and interaction of virtual reality training systems, which is useful not only in dental training, but also in other surgical training systems.

关键词： haptic rendering computer haptics haptic-visual collocation dental training hand-eye coordination

C-Type Antiferromagnetic Structure of Topological Semimetal CaMnSb_(2)

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Chinese Physics Letters 2024年第3期41卷 114-120页

作者：李博曾旭涛徐千惠杨帆项俊森钟恒扬邓司浩何伦华徐菊萍殷雯鲁兴业刘慧颖胜献雷金文涛 School of Physics Beihang UniversityBeijing 100191China Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Center for Advanced Quantum Studies and Department of Physics Beijing Normal UniversityBeijing 100875China Spallation Neutron Source Science Center Dongguan 523803China Songshan Lake Materials Laboratory Dongguan 523808China

Determination of the magnetic structure and confirmation of the presence or absence of inversion(P)and time reversal(Τ)symmetry is imperative for correctly understanding the topological magnetic *** highquality singl... 详细信息

关键词： ferromagnetic magnetic manganese

Recurrence of Helicobacter pylori infection:incidence and influential factors

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Chinese Medical Journal 2019年第7期132卷 765-771页

作者： Yan Xue Li-Ya Zhou Hao-Ping Lu Jin-Zhe Liu Department of Gastroenterology Peking University Third HospitalBeijing 100191China

Background:Helicobacter pylori(***)eradication has been widely *** recurrence rate of *** after eradication and its related factors are gaining more and more *** study aimed to determine the recurrence rate of *** infection after successful eradication,and analyze its influential ***:We prospectively studied 1050 patients with upper gastrointestinal symptoms who were diagnosed as *** infection by gastroscopy and underwent eradication therapies from April 2013 to January *** 13C-urea breath test(UBT)or Warthin-Starry(WS)staining was done at 8 to 12 weeks after the *** with successful eradication were followed by repeated UBT or gastroscopy at one year and 3 years after therapy,as well as,questionnaire *** was considered if the UBTs or WS staining of biopsy were ***-year and 3-year recurrence rates were calculated,and analyzed the differences between recurred patients and others in basic data,socio logical characteristics,***:A total of 743 patients finished the 1-year follow-up,and the 1-year recurrence rate was 1.75%.Of the 607 patients who finished the 3-year follow-up,28 patients recurred,and the 3-year recurrence rate was 4.61%.Analysis of variance showed that lowincome,poor hygiene condition of dining out place,and receiving invasive diagnoses or treatments were significant risk factors for *** infection *** regression analysis demonstrated that the combination of invasive diagnoses or treatments,the level of income,and the hygiene standard of dining out place were significant and independent influential factors of the recurrence of ***:The 1-year and 3-year recurrence rates of *** infection after eradication therapy are 1.75%and 4.61%.Lowincome,poor hygiene condition of dining out place,and a combination of invasive diagnoses or treatments are independent risk factors of *** recurrence.

关键词： Affecting factors Follow-up study Helicobacter pylori Recurrence

EFFICIENCY DECOMPOSITION WITH SHARED INPUTS AND OUTPUTS IN TWO-STAGE DEA

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Journal of Systems Science and Systems Engineering 2016年第1期25卷 23-38页

作者： Lin Li Qianzhi Dai Haijun Huang Shouyang Wang School of Economics andManagement Beihang University Beijing 100191 China Academy of Mathematics andSystems Science Chinese Academy of Sciences Beijing 100190 China Institute of Automation Chinese Academy of Sciences Beijing 100190 China

Data envelopment analysis （DEA） is an effective non-parametric method for measuring the relative efficiencies of decision making units （DMUs） with multiple inputs and outputs. In many real situations, the internal structure of DMUs is a two-stage network process with shared inputs used in both stages and common outputs produced by the both stages. For example, hospitals have a two-stage network structure. Stage 1 consumes resources such as information technology system, plant, equipment and admin personnel to generate outputs such as medical records, laundry and housekeeping. Stage 2 consumes the same set of resources used by stage 1 （named shared inputs） and the outputs generated by stage 1 （named intermediate measures） to provide patient services. Besides, some of outputs, for instance, patient satisfaction degrees, are generated by the two individual stages together （named shared outputs）. Since some of shared inputs and outputs are hard split up and allocated to each individual stage, it needs to develop two-stage DEA methods for evaluating the performance of two-stage network processes in such problems. This paper extends the centralized model to measure the DEA efficiency of the two-stage process with non split-table shared inputs and outputs. A weighted additive approach is used to combine the two individual stages. Moreover, additive efficiency decomposition models are developed to simultaneously evaluate the maximal and the minimal achievable efficiencies for the individual stages. Finally, an example of 17 city branches of China Construction Bank in Anhui Province is employed to illustrate the proposed approach.

关键词： Data envelopment analysis, efficiency decomposition shared inputs, shared outputs, centralized model