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Efficacy of Raw Corn Starch in Insulinoma-Related Hypoglycemia:A Promising Supportive Therapy

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Chinese Medical Sciences Journal 2024年第2期39卷 102-110页

作者： Rong-Rong Li Wei Chen Xin-Hua Xiao Miao Yu Fan Ping Lian Duan department of Clinical Nutrition Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced *** We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively,and analyzed the therapeutic effects of the RCS intervention on blood glucose control,weight change,and its adverse *** The study population consisted of 24 cases of insulinoma patients,7 males and 1. females,aged 46.08±1..1. *** RCS-supplemented diet,all patients had frequent hypoglycemic episodes(2.51.3.88 times/week),concurrent with neuroglycopenia(in 83.3% of patients)and autonomic manifestations(in 75.0% of patients),with the median fasting blood glucose(FBG)of 2.70(interquartile range[IQR]:2.50-2.90)mmol/*** patients'weight increased by 0.38(IQR:0.05-0.65)kg per month,with 8(33.3%)cases developing overweight and 7(29.2%)cases developing *** patients maintained the RCS-supplemented diet until they underwent tumor resection(23 cases)and transarterial chemoembolization for liver metastases(1.case).For 1. patients receiving RCS throughout the day,the median FBG within one week of nutritional management was 4.30(IQR:3.30-5.70)mmol/L,which was a significant increase compared to pre-nutritional level[2.25(IQR:1.60-2.90)mmol/L;P1..Of them,1. patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment[3.20(IQR:2.60-3.95)mmol/L vs.2.1.(IQR:1.83-2.33)mmol/L;P1..Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management[3.50(IQR:2.50-3.65)mmol/L vs.2.20(IQR:1.80-2.60)mmol/L;P1.,but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in *** improvement in weight gain was observed upon RCS *** diarrhea(2 cases)and flatulence(1.case)occurred,and were relieved by reduction of RCS ***

关键词： corn starch hypoglycemia insulinoma nutrition therapy

Synergistic effects of plant hormones on spontaneous late-ripening mutant of'Jinghong'peach detected by transcriptome analysis

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Food Quality and Safety 2022年第1期6卷 68-80页

作者： Man Zhang Tingting Du Yarui Yin Hongyan Cao Zhihua Song Mao Ye Yating Liu Yanhong Shen Libin Zhang Qing Yang Dong Meng Junkai Wu Hebei Normal University of Science and Technology QinhuangdaoChina Hebei Key Laboratory of Horticultural Germplasm Excavation and Innovative Utilization QinhuangdaoChina The College of forestry Beijing Forestry UniversityBeijingChina Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beiling Forestry UniversityBeilingChina

Objectives:Peach(Prunus persica L.)is an ancient fruit tree that originated from *** is the climacteric fruit belonging to genus Prunus in family ***,which is produced during ripening,accelerates fruit softening,and therefore peaches cannot be stored for a long *** and Methods:To study the mechanism of fruit late ripening,transcriptome analysis of the fruit of a late-ripening mutant of'Jinghong'peach was performed to identify genes and pathways involved in fruit late ***:A total of 1.05,1.1.,and 2309 genes were found to be differentially expressed in W2_vs_M1.W3_vs_M2,and W3_vs_M3,*** enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis,starch and sucrose metabolism plant hormone signal transduction,flavonoid biosynthesis,and *** expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were ***:It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of‘Jinghong’peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening.

关键词： Peach late-ripening bud mutation transcriptome analysis plant hormones

Improved genetic distance-based spatial deployment can effectively minimize inbreeding in seed orchard

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Forest Ecosystems 2020年第1期7卷 117-124,126,125,127页

作者： Boning Yang Haihong Sun Jiandong Qi Shihui Niu Yousry AEl-Kassaby Wei Li Beijing Advanced Innovation Center for Tree Breeding by Molecular Design National Engineering Laboratory for Forest Tree BreedingCollege of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China Liaoning Research Institute of Sandy Land Control and Utilization Xihe DistrictFuxin City 123000Liaoning ProvinceChina College of Information Science and Technology Beijing Forestry UniversityBeijing 100083China department of Forest and Conservation Sciences Faculty of ForestryThe University of British Columbia2424 Main MallVancouverBritish Columbia V6T 1Z4Canada

Background:Inbreeding in seed orchards is expected to increase with the advancement of breeding cycles,which results in the delivery of crops with suboptimal genetic gain,reduced genetic diversity,and lower seed ***,a genetic distance-dependent method for clonal spatial deployment in seed orchards was developed and demonstrated,which reduced the inbreeding *** method’s main evaluation parameter of inbreeding is the genetic distance among individuals and the deployment method used an improved adaptive parallel genetic algorithm(IAPGA)based on Python *** inbreeding-prone Chinese Mongolian pine breeding population material originating from a single natural population,the proposed method was compared to a traditional orchard design and a distance-based design;namely,complete randomized block(RCB)and optimum neighborhood(ONA)designs,***:With the advancement of selective breeding cycles,group separation among orchard related individuals is expected to *** on the genetic distance among individuals,the IAPGA design was superior in significantly reducing the inbreeding level as compared to the two existing designs,confirming its suitability to advanced-generation orchards where relatedness among parents is *** the 1.t,2nd,and mixed generations clonal deployment schemes,the IAPGA design produced lower inbreeding with 87.22%,81.49%,and 87.23%of RCB,and 92.78%,91.30%,and 91.67%of ONA designs,***:The IAPGA clonal deployment proposed in this study has the obvious advantage of controlling inbreeding,and it is expected to be used in clonal deployment in seed orchards on a *** studies are needed to focus on the actual states of pollen dispersal and mating in seed orchards,and more assumptions should be taken into account for the optimized deployment method.

关键词： Seed orchard Deployment Inbreeding Genetic distance Clone SSR

Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong LI Li-yan WU Yu-huang TAN Yin-feng CHEN Long LIU Pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan Provincial Key Lab of Research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=1.),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 1. mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1.in BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(P1..The number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(P1..DMS pre-treatment decreased the levels of TNF-α,IL-6 and IL-1.(P1..Meanwhile,DMS activated the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(P1..Conclusions:DMS attenuated LPS-induced ALI in mice through repairing endothelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

Characterization of Curing and Bonding of Wood with Adhesive Mixtures of Liquefied Wood and Hexamethylenediamine

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Journal of Renewable Materials 2023年第2期11卷 991-1001页

作者： JureŽigon VitŠeda PetrČermák MilanŠernek department of Wood Science and Technology Biotechnical FacultyUniversity of LjubljanaLjubljana1000Slovenia department of Wood Science and Technology Faculty of Forestry and Wood TechnologyMendel University in BrnoBrno61300Czech Republic

Various crosslinking agents can be added to the formulations of natural-based adhesives for wood bonding in order to achieve better durability and higher strength of the formed *** the present study,the effect of hexamethylenediamine(HMDA)addition on the performance of liquefied wood(LW)adhesive for wood bonding is *** scanning calorimetry showed the improved thermal stability and crosslinking of the LW adhesive with *** intensified presence of amide linkages(C–N bonds)was found in LW+HMDA with attenuated total reflection Fourier transform infrared *** of the bonded joints using an automated bonding evaluation system showed that a higher press temperature resulted in stronger bonds for both types of ***,the addition of HMDA to LW adhesive improved the bond strength of the joints and accelerated the crosslinking of the ***,with a tensile shear strength of(6.76±2.1.)N×mm^(−2)(for LW)and(6.89±2.1.)N×mm^(−2)(for LW+HMDA),both adhesives were found to be unsuitable for interior non-structural *** addition,the acidity of LW resulted in relatively high wood failure(70%)in the adhesive joints *** crosslinking of LW with HMDA was reflected in improved resistance of LW+HMDA adhesive joints to water *** conclusion,HMDA is a promising additive for improving the adhesive performance of LW adhesives.

关键词： Adhesive bonding hexamethylenediamine liquefied wood

Evolution and geographic effects of high-speed rail in East Asia： An accessibility approach

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Journal of Geographical Sciences 2017年第5期27卷 515-532页

作者：金凤君焦敬娟齐元静杨宇 Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China School of Economics and Management Beijing Jiaotong University Beijing 100044 China School of Soil and Water Conservation Beijing Forestry University Beijing 100083 China

The rapid development of high-speed rail（HSR） is influencing regional development, regional structure, commuting, and regional integration. East Asia is the region with the world＇s first and largest current operating and planned HSR network. In this paper, we examine the evolutionary mechanism and impacts on the transport circle and accessibility of HSR in East Asia. The results indicate that the HSR network first follows a ＂core-core＂ model and then forms a corridor in Japan, South Korea, and China Taiwan, but then forms a complete network in China Mainland. The current operating HSR lines are mostly distributed in regions with developed economies and dense populations, and more than half of the population and GDP in China can be served by HSR within 1.hour＇s travel time. The planned HSR network will expand to the western region of China and Japan and the southern region of South Korea. The development of the current operating and planned HSR network considerably enlarges the transport circle of core cities, especially cities along trunk HSR lines. This 1.h transport circle of core cities has formed continuous regions in the Yangtze River Delta, the Pearl River Delta, Tokyo, Seoul, and along trunk HSR lines. The HSR network will bring about substantial improvement in accessiblity, but also increase the inequality of nodal accessibility in China Mainland. Spatially, the spatial patterns of the weighted shortest travel time of cities in China Mainland, Japan, and South Korea all present the ＂core-peripheral structure＂, taking Zhengzhou, Tokyo, and Seoul, respectively, as core cities, and cities located along the trunk HSR lines gain large improvement in accessibility.

关键词： high-speed rail East Asia evolutionary mechanism geographic effects accessibility

LSM6 promotes cell proliferation and migration regulated by HMGB1.in laryngeal squamous cell carcinoma

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Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li Hui Li Yao Tang Xia Gao Hong Chen Xiaoyun Qian Xiaohui Shen department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1.HMGB1.play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant ***,the function of HMGB1.and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing *** we found immunohistochemistry from 97 LSCC tissues showed HMGB1.was upreg-ulated,which was associated with poor ***1.knockdown could significantly inhibit wound closure and colony *** full-genome gene expression microarray was performed to investigate the *** knockdown of HMGB1.by siRNA,among the expressed differential genes,1. genes were ran-domly selected for ***,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation ***6 downregulation was dramatically promoted by HMGB1.knockdown,resulting in higher expression in LSCC ***,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony *** study indicated that HMGB1.promoted LSCC cell malig-nant phenotypes through regulation of *** anticipate that HMGB1.LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

Object registration for remote sensing images using robust kernel pattern vectors

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Science China(Information Sciences) 2012年第11期55卷 2611-2623页

作者： DING MingTao1.JIN Zi2,TIAN Zheng1.3,DUAN XiFa1.ZHAO Wei1.& YANG LiJuan1.1.0} of Applied Mathematics,Northwest Polytechnical University,Xi'an 71.072,China 2department of Statistics,University of British Columbia,3333-6356 Agricultural Road,Vancouver,BC V677 1.2,Canada 3State Key Laboratory of Remote Sensing Science,Institute of Remote Sensing Applications,Chinese Academy of Sciences,Bejing 1.01.1.China 1. department of Applied Mathematics Northwest Polytechnical University Xi’an 710072 China2. Department of Statistics University of British Columbia 3333-6356 Agricultural Road Vancouver BC V677 1Z2 Canada3. State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications Chinese Academy of Sciences Bejing 100101 China

The registration of multitemperal remote sensing images before and after a disaster is a challenging *** main reason is that there is a dearth of homologous features that can be used as tie points for registration of variform *** paper proposes a new registration method based on robust kernel pattern vector(KPV) for water objects in the remote sensing images,which have complex deformation before and after a *** show how the variform objects can be precisely registered using their robust kernel pattern vectors(RKPVs).The contribution can be divided into three ***,a novel shape descriptor,named as kernel pattern vector(KPV),is ***,a robust kernel principal component analysis(RKPCA) method is proposed,which can not only capture the common pattern of the variform objects but can also act as the Criterion for outlier ***,a registration approach is derived based on the implicit *** demonstrate the power of the proposed approach by comparing it with other existing methods using two real cases:one for lake monitoring in the Jiayu region,and the other for damage mapping of earthquake-induced barrier lake at Tangjiashan(2008 Wenchuan Earthquake).The results show that the method is effective in capturing the common structural pattern of the variform objects before and after a disaster.

关键词： remote sensing image object registration robust kernel pattern vectors(RKPVs) variform object outlier data effective

Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 1-14页

作者： Mengzhu Li Xiude Fan Jiajun Zhao Dawei Wang department of Endocrinology Shandong Provincial HospitalShandong UniversityJinanShandongChina Key Laboratory of Endocrine Glucose&Lipids Metabolism and Brain Aging Ministry of EducationDepartment of EndocrinologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of Endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina

Background and Aims:Stress granules(SGs)as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile *** carcinoma(HCC)is prone to be highly aggressive once diagnosed,which markedly reduces patient survival ***,it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis,which promotes individualized precision therapeutics in *** the pro-tumorigenic activity of SGs,it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes(SGGs).Methods:Bioinformatic analysis was employed to establish an SGG-based prognostic *** blotting and realtime polymerase chain reaction assays were used to assess the expression patterns of the related ***-of-function experiments were performed to analyze the effect of the SGGs on SG formation and cell ***:A four-SGG signature(KPNA2,MEX3A,WDR62,and SFN)targeting HCC was established and validated to exhibit a robust performance in predicting HCC ***,all four genes were further found to be highly expressed in human HCC *** important,we demonstrated that individually knocking down the four SGGs significantly reduced HCC cell proliferation and metastasis by compromising the SG formation ***:We developed an SGG-based predictive signature that can be used as an independent prognostic tool for *** strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2,MEX3A,WDR62,and SFN in HCC cells by regulating SG formation.

关键词： Hepatocellular carcinoma Stress granules Prognostic factor G3BP1