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Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

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Zoological Research 2024年第4期45卷 924-936页

作者： Ruo-Wen Guo Wen-Jing Xie Biao Yu Chao Song Xin-Miao Ji Xin-Yu Wang Mei Zhang Xin Zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of physical {1. and Information technology Anhui UniversityHefeiAnhui 230601China School of Life sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1.42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD *** diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic *** this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD *** indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in *** the AD mouse model APP/PS1.RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory *** examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1.mouse *** findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

关键词： lzheimer’s disease Rotating magnetic field Amyloid-β Cognitive function Alzheimer’s disease animal models

Bifunctional core–shell co-catalyst for boosting photocatalytic CO_(2) reduction to CH_(4)

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Nano Research 2024年第3期17卷 1259-1266页

作者： Fangxu Dai Mingming Zhang Jishu Han Zhenjiang Li Shouhua Feng Jun Xing Lei Wang Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China college of Materials {1. and Engineering Qingdao University of Science and TechnologyQingdao 266042China college of Environment and Safety Engineering Qingdao University of Science and TechnologyShandong Engineering Research Center for Marine Environment Corrosion and Safety ProtectionQingdao 266042China

Solar-light-driven CO_(2) reduction CO to CH_(4) and C2H6 is a complex process involving multiple elementary reactions and energy ***,achieving high CH_(4) activity and selectivity remains a significant ***,we integrate bifunctional Cu2O and Cu-MOF(MOF=metal-organic framework)core–shell co-catalysts(Cu2O@Cu-MOF)with semiconductor TiO_(2).Experiments and theoretical calculations demonstrate that Cu2O(Cu+facilitates charge separation)and Cu-MOF(Cu2+improves the CO_(2) adsorption and activation)in the core–shell structure have a synergistic effect on photocatalytic CO_(2) reduction,reducing the formation barrier of the key intermediate*COOH and**** photocatalyst exhibits high CH_(4) yield(366.0μmol·g^(-1.·h^(-1.),efficient electron transfer(3283μmol·g^(-1.·h^(-1.)and hydrocarbon selectivity(95.5%),which represents the highest activity of Cu-MOF-based catalysts in photocatalytic CO_(2) reduction *** work provides a strategy for designing efficient photocatalysts from the perspective of precise regulation of components.

关键词： bifunctional co-catalyst core–shell photocatalytic CO_(2)reduction

Realize ultralow-energy-consumption photo-synaptic device based on a single(Al,Ga)N nanowire for neuromorphic computing

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Nano Research 2024年第3期17卷 1933-1941页

作者： Xiushuo Gu Min Zhou Yukun Zhao Qianyi Zhang Jianya Zhang Yonglin Huang Shulong Lu college of Electronic and Optical Engineering&college of Flexible Electronics(Future technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China

The rapid development of artificial intelligence poses an urgent need for low-energy-consumption and small-sized artificial photonic ***,it is pretty novel to demonstrate a light-stimulated synaptic device based on a single(Al,Ga)N nanowire *** to the presence of vacancy defects in the single nanowire,the artificial synaptic device can simulate multiple functions of biological synapses under stimulation of both 31. and 365 nm light photons,including paired-pulse facilitation,spike timing dependent plasticity,and memory learning *** energy consumption of artificial synaptic device can be reduced as little as 5.58×1.^(-1.) J,which is close to that of the biological synapse in human ***,the synaptic device is demonstrated to have the high stability for both long-time stimulation and long-time *** on the experimental conductance of long-term potentiation and long-term depression,the simulated three-layer neural network can achieve a high recognition rate of 92%after only 1. training *** a brain-like behavior,the single-nanowire-based synaptic devices can promote the development of visual neuromorphic computing technology and artificial intelligence systems requiring ultralow energy consumption.

关键词： single(Al Ga)N nanowire light-stimulated synaptic device low-energy-consumption neural network

Room-temperature ferrimagnetism and size-modulated electronic structures in two-dimensional cluster-based metal-organic frameworks

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science China Chemistry 2024年第4期67卷 1334-1340页

作者： Jing Cheng Xingxing Li Jinlong Yang Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for physical {1.s at the Microscale University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Cluster-assembled materials have attracted particular attention for their complex hierarchical structures and unique ***,the majority of cluster-based assemblies developed so far are either non-magnetic or only exhibit magnetic ordering with a relatively low Curie temperature,limiting their applications in ***,two-dimensional(2D)cluster-assembled materials with room-temperature magnetism remain highly *** this purpose,based on first principles calculations,we design a series of thermodynamically stable 2D cluster-based metal-organic frameworks(MOFs)Fe_(n)-(pyz)(n=1.6)by utilizing Fenmetal clusters as nodes and nitrogen-containing pyrazine ligands as organic *** 2D cluster-based MOFs exhibit robust ferrimagnetic ordering due to the strong d-p direct exchange interaction between d-electron spin of Fe_(n)(n=1.6)clusters and charge transfer-induced p-electron spin of pyrazine *** particular,the ferrimagnetic Curie temperatures are well above room temperature(up to 836 K).Additionally,altering the size of Fe_(n)clusters in Fe_(n)-(pyz)(n=1.6)MOFs results in diverse functional spintronic properties,including bipolar magnetic semiconductors,half semiconductors and Dirac half ***,these 2D assembled MOFs possess sizable magnetic anisotropy energies,up to 9.1. me V per formula.

关键词： metal-organic framework two-dimensional material half metal bipolar magnetic semiconductor magnet

Calculation and prediction of divertor detachment via impurity seeding by using one-dimensional model

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Chinese Physics B 2024年第8期33卷 370-379页

作者：周文杰刘晓菊邬潇河李邦石奇奇樊皓尘杨艳杰李国强 Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of science and {1. of China Hefei 230026China

Achieving the detachment of divertor can help to alleviate excessive heat load and sputtering problems on the target plates,thereby extending the lifetime of divertor components for fusion *** order to provide a fast but relatively reliable prediction of plasma parameters along the flux tube for future device design,a one-dimensional(1.)modeling code for the operating point of impurity seeded detached divertor is developed based on Python language,which is a fluid model based on previous work(Plasma *** 5804501.(201.)).The experimental observation of the onset of divertor detachment by neon(Ne)and argon(Ar)seeding in EAST is well reproduced by using the 1. modeling *** comparison between the 1. modeling and two-dimensional(2D)simulation by the SOLPS-ITER code for CFETR detachment operation with Ne and Ar seeding also shows that they are in good *** also predict the radiative power loss and corresponding impurity concentration requirement for achieving divertor detachment via different impurity seeding under high heating power conditions in EAST and CFETR phase II by using the 1. *** on the predictions,the optimized parameter space for divertor detachment operation on EAST and CFETR is also *** a simple but reliable 1. model can provide a reasonable parameter input for a detailed and accurate analysis by 2D or three-dimensional(3D)modeling tools through rapid parameter scanning.

关键词： divertor detachment impurity seeding one-dimensional modeling

THE LONG TIME BEHAVIOR OF THE FRACTIONAL ORNSTEIN-UHLENBECK PROCESS WITH LINEAR SELF-REPELLING DRIFT

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Acta Mathematica Scientia 2024年第2期44卷 671-685页

作者：夏晓宇闫理坦杨晴 college of Information {1. and technology Donghua UniversityShanghai201620China Department of Statistics College of ScienceDonghua UniversityShanghai201620China

Let B^(H) be a fractional Brownian motion with Hurst index 1.2≤H<*** this paper,we consider the equation(called the Ornstein-Uhlenbeck process with a linear self-repelling drift)dX_(t)^(H)=dB_(t)^(H)+σ X_(t)^(H)dt+v... 详细信息

Let B^(H) be a fractional Brownian motion with Hurst index 1.2≤H1.95,303:87–93).Our main aim is to study the large time behaviors of the *** show that the solution X^(H)diverges to infinity as t tends to infinity,and obtain the speed at which the process X^(H)diverges to infinity.

关键词： fractional Brownian motion stochastic difference equations rate of convergence asymptotic

Magnetocaloric effect and phase transition critical behavior of La0.75Sr0.25Mn0.9Co0.1.3 compound synthesized under the high pressure

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Tungsten 2024年第3期6卷 621-632页

作者： Jing Zhao Lei Gao Jian-Jun Zhao Wei Wei Hui-Qin Yun Ru Xing Huai-Jin Ma Xiang Jin Luo-Meng Chao School of physical {1. and technology Key Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region Baotou Teachers' College National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Physics and Electronic Information Inner Mongolia Normal University college of {1. Inner Mongolia University of Science and Technology

In this study,a novel method is proposed for producing perovskite rare-earth manganese oxide magnetic refrigeration materials that exhibit superior properties compared to similar *** maximum magnetic entropy change values for this sample are 1.44 and 3.75 J·kg-1.K-1.or magnetic fields of 2 and 7 T,***,its relative cooling power has been calculated to be 1.1.96 and 404.78 J·kg-1.indicating good *** results were obtained using the sample synthesized under a pressure of 4 GPa,and the sample has undergone a second phase *** critical behavior of the sample fits well with the mean field *** different magnetic fields,there is a significant overlap between the values of the maximum magnetic entropy change and the temperature-averaged entropy change,indicating that the refrigeration performance of the sample after high pressure can approach its maximum capability.

关键词： High-pressure synthesis Magnetocaloric effect Relative cooling power Magnetic phase transition

Effect of Three-High Rotary Piercing Process on Microstructure,Texture and Mechanical Properties of Magnesium Alloy Seamless Tube

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 953-968页

作者： Xiaofeng Ding Zehao Wu Tong Li Jianxun Chen Yuanhua Shuang Baosheng Liu Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan030024China college of Materials {1. and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China

Mg alloy seamless tubes(MASTs)were prepared through three-high rotary piercing process,effect of billet temperature,feed angle and plug advance on microstructure,texture and mechanical properties of tubes were *** effect on the deformation mechanism and improving mechanical properties mechanism of this process for MASTs were *** results show that the grain size could be refined to 1..3-31.1.of the initial grain size and the microstructure was more uniform due to the accumulation of *** formation of high strain gradient at the grain boundary activated the non-basal *** piercing process could change the grain orientation of as-extruded billet and eliminate the initial basal texture to produce new favorable *** the process could accelerate the continuous dynamic recrystallization *** piercing,yield strength of pierced tubes decreased by 6.7%,ultimate tensile strength(UTS)and elongation increased by 32.4 and 45%,respectively,at optimal *** plate-shapedβ_(1.-Mg_(1.)Al_(1.) orientation transformed from basal plates to prismatic plates,facilitating the increase in UTS and *** decrease size of nanoscale precipitates could reduce the cracking *** critical resolved shear stress ratios of pyramidal(1.−1.)slip and(1.−22)slip to basal slip for the sample including prismatic plates both decreased compared to that including basal *** could enhance the ductility of tube ***,grain boundary sliding could contribute to a better ductility via coordinating deformation and reducing stress concentration during piercing process.

关键词： Mg alloy tube Rotary piercing Microstructure Texture Mechanical properties

(4S,4'S)-2,2'-(4,6-Dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole]-Ni(II)Complexes Catalyzed Highly Enantioselective Nitrile Imine Cycloaddition Reactions

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有机化学 2024年第7期44卷 2315-2332页

作者： Cao Xixian You Jun Liu Qiye Liu Bo Yu Yanchao Wu Wenju Key Laboratory of Green Chemical Engineering and technology of {1. of Heilongjiang Province College of Materials Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150080

The Ni(II)-chiral(4S,4'S)-2,2'-(4,6-dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole](DBFOX/Ph)-catalyzed asymmetric 1.3-dipolar cycloadditions of nitrile imines to N-α,β-unsaturated acylpyrazoles was *** tactic rendered a facile and feasible route to prepare the optically active tetrasubstituted 5-3,5-dimethylpyrazole acyl dihydropyrazole cy-cloadducts bearing one or two contiguous stereocenters in good yields(up to 97%yield)with high regioselectivities(1.0%)and enantioselectivities(up to 97.5%ee).Following that,chiral cycloadducts could be obtained consistently in good chemical yields with excellent enantioselectivities within the gram scale process,additionally,toward five kinds of derivatization reac-tions like nucleophilic and reduction for further conversion of chiral cycloadducts to related chiral dihydropyrazole derivatives encompassing different substituents.

关键词： (4S,4'S)-2,2'-(4,6-dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole](DBFOX/Ph) 1.3-dipolar cycloaddition nitrile imines N-α,β-unsaturated acylpyrazole enantioselectivity electronic circular dichroism(ECD)calculation