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Feasibility of MRI in Patients with Non-Pacemaker/Defibrillator Metallic Devices and Abandoned Leads

Journal of biomedical Science and {1. 2021年第3期14卷 83-93页

作者： Prabhakaran P. Gopalakrishnan Loretta Gevenosky Robert W. W. Biederman Division of Cardiology Aultman Deuble Heart and Vascular Hospital Canton OH USA Cardiovascular MRI center Allegheny Health Network Cardiovascular Institute Pittsburgh PA USA

Objective: To evaluate feasibility of MRI in patients with non-pacemaker (PM)/Implantable cardioverter defibrillator (ICD) metallic devices and abandoned leads. Background: Relative safety of MRI performed using specified protocol has been established in MR non-conditional PM/ICDs. With limited safety data, many non-PM/ICD metallic devices and abandoned leads continue to be a contraindication for MRI. Methods: We retrospectively analyzed consecutive patients with extra-cardiac devices, non-programmable cardiac devices, and abandoned leads, who underwent MRI (GE 1.5 Tesla, WI) at a single tertiary care center over a span of 1. years. Scan protocol was designed to maintain specific absorption rate (SAR) Results: The cohort comprised 1.7 MRI exams representing 94 patients, with 1. patients having two or more scans. The devices consisted of: 23 vagal nerve stimulators (VNS), 22 implantable loop recorders, 1. spinal stimulators, 5 peripheral nerve stimulators, 3 bladder stimulators, 2 deep brain stimulators, 1.gastric stimulator, 1.bone stimulator, 1.WATCHMAN device, 22 abandoned PM/lCD leads and 1.VNS lead. There was no immediate (peri-MRI exam) morbidity or mortality. Patients did not report any discomfort, palpitations, heating, or sensation of device migration during the exam. Local follow-up data was available in 65% (1.0% for thoracic imaging) with a mean of 1.0 ± 475 days (median 1. days). No device malfunction was reported during follow-up. Conclusions: With appropriate precautions, MRI is feasible in patients with extracardiac devices, nonprogrammable cardiac devices, and abandoned leads.

关键词： MRI Safety Pacemaker Abandoned Leads Implantable Loop Recorder Extra-Cardiac Devices

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A Deep Learning Approach for Detecting Colorectal Cancer via Raman Spectra

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biomedical {1. Frontiers 2022年第1期3卷 149-158页

作者： Zheng Cao Xiang Pan Hongyun Yu Shiyuan Hua Da Wang Danny Z.Chen Min Zhou Jian Wu RealDoctor AI Research center College of Computer Science and TechnologyZhejiang UniversityChina Key Laboratory of Cancer Prevention and Intervention Ministry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineChina Institute of Translational Medicine and the Cancer Institute of the Second Affiliated Hospital Zhejiang University School of MedicineChina Department of Computer Science and engineering University of Notre DameUSA Second Affiliated Hospital School of Medicine and School of Public HealthZhejiang UniversityChina

Objective and Impact *** tumors from normal tissues is vital in the intraoperative diagnosis and pathological *** this work,we propose to utilize Raman spectroscopy as a novel modality in surgery to detect colorectal cancer *** spectra can reflect the substance components of the target ***,the feature peak is slight and hard to detect due to environmental *** a high-quality Raman spectroscopy dataset and developing effective deep learning detection methods are possibly viable ***,we collect a large Raman spectroscopy dataset from 26 colorectal cancer patients with the Raman shift ranging from 385 to 1.45 cm^(−1..Second,a one-dimensional residual convolutional neural network(1.-ResNet)architecture is designed to classify the tumor tissues of colorectal ***,we visualize and interpret the fingerprint peaks found by our deep learning *** results show that our deep learning method achieves 98.5%accuracy in the detection of colorectal cancer and outperforms traditional ***,Raman spectra are a novel modality for clinical detection of colorectal *** proposed ensemble 1.-ResNet could effectively classify the Raman spectra obtained from colorectal tumor tissues or normal tissues.

关键词： colorectal viable modality

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一种韧性的胃电信号传导速率估计方法

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中国生物医学工程学报 2007年第6期26卷 884-888,894页

作者：刘文红邱天爽林治钺 Richard W.McCallum 孙永梅大连理工大学电子与信息工程学院 Department of Medicine University of Kansas Medical Center CityKansas66160 USA

由于棘波和/或动作伪迹等因素的影响,实际测得的胃电信号常常具有脉冲性。根据分数低阶统计量理论,本研究提出一种基于最小平均p范数盲信道辨识的韧性时间延迟估计算法(BCILMP),对胃电信号传导速率进行估计。与最小均方误差时间延迟估... 详细信息

由于棘波和/或动作伪迹等因素的影响,实际测得的胃电信号常常具有脉冲性。根据分数低阶统计量理论,本研究提出一种基于最小平均p范数盲信道辨识的韧性时间延迟估计算法(BCILMP),对胃电信号传导速率进行估计。与最小均方误差时间延迟估计算法(LMSTDE)比较,该算法在高斯和脉冲噪声环境下,均可以较好地估计出时间延迟,计算机仿真验证了其性能。运用该方法对四位胃轻瘫病人的胃电信号进行了传导速率的估计。结果表明:虽然胃轻瘫病人的胃慢波也由胃体大弯侧上1.3处向下端幽门处传播,但是其胃慢波的平均传导速率均比正常人的慢,速率的变化也不都是单调增加的。传导是胃电活动最重要的空间特征之一,时间延迟估计方法可以定量地评价胃慢波传导的速率和模式。

关键词：胃电活动(GEA) 胃轻瘫传导速率韧性时间延迟估计最小平均p范数

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Mechanism of Immune Hyporesponsiveness Induced by Recipientderived Immature Dendritic Cells in Rat Liver Transplantation

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Chinese Journal of biomedical {1.(English Edition) 2011年第1期20卷 36-46页

作者： LI Li ZHANG Sheng-ning RAN Jiang-hua LIU Jing LI Zhu ZHAO Yong-heng LI Lai-bang Department of Hepatobiliary Pancreatic Surgery First People ＇s Hospital of Kunming Kunming Medical CollegeLiver Transplantation Center of Organ Transplantation Institute of Yunnan Province Kunming 650011China

Objective： The use of donor-derived immature dendritic cells （imDC） has become a promising approach to induce immune tolerance or immune hyporesponsiveness. However, donor-derived imDC needs to be harvested for a few days and transfused into the recipient in 5-1. days before transplantation, which is practically impossible in a clinical setting where donor organs are mainly harvested from cadavers. Moreover, donor-derived imDC might be cleared by allogeneic reaction offsetting induced immune tolerance or immune hyporesponsiveness. In our study, we further explored the underlying mechanism of immune hyporesponsiveness induced by donor-antigen-unloaded recipient-derived imDC by transfusing these imDC into rats in 1.day before liver transplantation. This paper is to study the mechanism of immune hyporesponsiveness induced by donor-antigen-unloaded recipient-derived imDC and its protection of liver grafts in rats. Methods： 40 SD rats （donor） and 40 male Wistar rats （recipient） were randomly divided into 4 groups： control, cyclosporine A （CsA）, mature DC （mDC）, and imDC; with 1. SD rats and 1. Wistar rats for each group. Animal models of acute graft rejection were established with these rats. Corresponding treatments were given before or after transplantation. In the control group, Wistar rats received no treatment other than liver transplantation. In the CsA group, Wistar rats underwent liver transplantation plus CsA treatment （1. mg/kg·d） in the starting day 2 after transplantation. For the mDC group, recipient-derived mDC （1.× 1.^6/rat） were infused intravenously via the dorsal vein of the penis to recipient rats. For the imDC group, imDC （1. 1.^6/rat） were injected into recipient rats via the dorsal vein of the penis. In each group, 5 recipients were executed at 1. days after transplantation; the remaining five recipients were kept for the observation of survival time. Blood samples were collected for the measurement of ALT and TBIL; IL-2, IFN-γ, IL-4 and IL-1. and l

关键词： rat liver transplantation rejection immature dendritic cell immune hyporesponsiveness

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Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation

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Journal of biomedical Science and {1. 2010年第4期3卷 439-441页

作者： Karan Mittal Ramni Kaushal Rajashree Mashru Arti Thakkar I. S. F. College of Pharmacy center of Relevance and Excellence in Novel Drug Delivery Systems Pharmacy Department The Maharaja Sayajirao University of Baroda

Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of galanthamine hydrobromide (GH) in bulk and pharmaceutical formulation. First method is zero order UV spectrophotometry and second is 1.t derivative zero crossing spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drugs and marketed formulations. Absorbance was measured at 287 nm for zero order and 277.4 nm for first derivative. It obeyed Lambert-Beer’s law in the range of 30-80 μg mL-1. Both methods have good linearity (r2 = 0.9997) and accuracy found to be 1.0.5% and 1.1.2% for both methods respectively.

关键词： alanthamine Hydrobromide (GH) Zero Order UV-Spectrophotometry First Derivative Zero Crossing Spectrophotometry

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Observation of the effect of cleaning the smear layer and tubule plugs with SEM

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Chinese Journal of biomedical {1.(English Edition) 2001年第1期10卷 44-46页

作者： YU Dan-ni1.DONG Ya-li2 1.Department of stomatology of the 2nd Hospital of Tianjin Medical University,Tianjin 30021.,China 2 The Electron Microscope center of Tianjin Medical University, Tianjin 300070,China Department of stomatology of the 2nd Hospital of Tianjin Medical University Tianjin 300211China The Electron Microscope center of Tianjin Medical University Tianjin 300070China

To clean out the smear layer on teeth surface, and protect the teeth medulla, the experiment applied the study observing the cleanup of six groups of surface smear layer of dental caries and the tubule plugs reserving effect after using of different cavity cleansers with the help of SEM. The result implied that both the acidic preparations and chelator could clean out the smear layer on teeth surface in some way, but the later one could also reserve partial tubule plugs, which reduce the stimulation to the teeth medulla. So the chelator is better cleansers in clinical use.

关键词： SEM, smear layer, tubule plugs, cavity cleansers

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Computational cytometer based on magnetically modulated coherent imaging and deep learning

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Light(Science & Applications) 2019年第1期8卷 385-399页

作者： Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong Bijie Bai Donghyuk Kim Alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin Hatice Ceylan Koydemir Omai B.Garner Dino Di Carlo Aydogan Ozcan Electrical and Computer engineering Department University of CaliforniaLos AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Physics and Astronomy University of ToledoToledoOH 43606USA Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Yale School of Medicine New HavenCT 06510USA Department of Biochemistry University of CaliforniaLos AngelesCA 90095USA Department of Pathology and Laboratory Medicine University of CaliforniaLos AngelesCA 90095USA Department of Mechanical and Aerospace engineering University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer center University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Detecting rare cells within blood has numerous applications in disease *** rare cell detection techniques are typically hindered by their high cost and low ***,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic *** demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood *** serial dilution experiments,we quantified the limit of detection(LoD)as 1. cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same *** compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

关键词： rare magnetic speckle

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Small P values may not yield robust findings:an example using REST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1..

关键词：帕金森病 precise correction

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抗血管生成致内皮细胞释放外泌体促进肿瘤血管形成

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医用生物力学 2019年第A1期34卷 50-50页

作者：曾烨 Bingmei MFu 四川大学华西基础医学与法医学院生物医学工程研究室成都610041 Department of biomedical {1. The City College of the City University of New YorkNew York10031USA

抗血管生成疗法(anti-angiogenic therapies,AATs)被用于多种恶性癌症的治疗,其临床疗效因继发性的肿瘤血管形成(vasculogenesis)和肿瘤生长而受限[1.3]。本研究试图揭示AATs治疗后肿瘤血管生成和肿瘤生长的分子机制。首先,将微小RNA-9(... 详细信息

抗血管生成疗法(anti-angiogenic therapies,AATs)被用于多种恶性癌症的治疗,其临床疗效因继发性的肿瘤血管形成(vasculogenesis)和肿瘤生长而受限[1.3]。本研究试图揭示AATs治疗后肿瘤血管生成和肿瘤生长的分子机制。首先,将微小RNA-9(microRN A-9,miR-9)转染至人脐静脉内皮细胞,以模拟肝癌中的肿瘤相关性内皮细胞[4-5],探讨AATs对内皮细胞的影响及其作用机制。发现,抗血管生成抑制剂凡德他尼(vandetanib)完全抑制了miR-9诱导的血管生成,并促进了人脐静脉内皮细胞的自噬,同时,还诱导了富血管生成因子(vascular endothelial growth factor,VEGF)外泌体的释放。这些富VEGF外泌体可显著促进内皮血管生成和肝癌细胞血管生成拟态,促进肝癌在裸鼠体内的生长。抗自噬也可以抑制血管内皮细胞的血管生成,但是与AATs相似,自噬抑制剂3-MA促进了富VEGF外泌体的释放。体外实验表明,抑制外泌体的释放,或使用VEGF中和性抗体处理富VEGF外泌体,可以显著抑制肿瘤细胞的血管生成拟态。由此可见,AATs和抗自噬后的肿瘤血管形成和肿瘤生长是内皮细胞和肿瘤细胞相互作用的结果,由富VEGF的外泌体所介导。此外,内皮细胞miR-9表达水平受流体剪切力调控。力学因素在抗血管生成致内皮细胞释放外泌体促进肿瘤血管形成中的作用及机制有待深入探究。

关键词：肿瘤血管形成肿瘤生长抗血管生成外泌体内皮细胞

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Application of a continuous respiratory sound monitoring system in thoracic surgery

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The Journal of biomedical Research 2021年第6期35卷 491-494页

作者： Hong Wang Alper Toker Ghulam Abbas Le Yi Wang Department of Anesthesiology West Virginia UniversityMorgantownWV 26506USA Department of Cardiovascular and Thoracic Surgery West Virginia UniversityMorgantownWV 26506USA Department of Thoracic Surgery West Virginia UniversityMorgantownWV 26506USA Department of Electrical and Computer engineering Wayne State UniversityDetroitMI 48202USA.

Dear Editor,We would like to present a novel system for monitoring double-lumen tube(DTL)positions in thoracic surgery by respiratory sounds at the trachea and the bronchi,based on our previously described methodology,algorithms,and patented technology[1.2].Most thoracic surgeries require one-lung ventilation(OLV).A DLT or a bronchial blocker(BB)is the most common means for managing *** DLT or BB malposition is a critical issue that needs to be accurately and promptly detected to prevent the incidence of hypoxemia and unintended re-expansion of operated lung during OLV[3-4].A multi-center study of 21.7 patients requiring OLV during thoracic surgery revealed that DLTs were used in 95%of patients with a malposition rate of 1.%,and BBs were used in 5%of patients with a malposition rate of 33%[5].

关键词： thoracic surgery respiratory

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