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综合治疗中晚期前列腺癌的远期疗效分析

中华泌尿外科杂志 2003年第8期24卷 548-551页

作者：周桂霞张磊曾狄闻王晓雄杨东解放军总医院放疗科北京00853 解放军总医院泌尿外科北京00853

目的　总结综合治疗中晚期前列腺癌的远期疗效。　方法　 2 5 6例前列腺癌患者 ,C期 182例 ,D期 74例。腺癌 2 36例 ,鳞癌 7例 ,未分化癌 13例。Gleason评分 >6分者 2 0 2例。采用双睾切除加内分泌治疗和 (或 )放射治疗。　结果　 2 36... 详细信息

目的　总结综合治疗中晚期前列腺癌的远期疗效。　方法　 2 5 6例前列腺癌患者 ,C期 182例 ,D期 74例。腺癌 2 36例 ,鳞癌 7例 ,未分化癌 13例。Gleason评分 >6分者 2 0 2例。采用双睾切除加内分泌治疗和 (或 )放射治疗。　结果　 2 36例 (92 .2 % )患者PSA在短期内迅速下降至 2ng/ml以下 ;总 5、10、15年生存率为 4 8.8%、2 9.7%和 13.3% ,其中C期为 5 8.2 %、38.4 %和 17.7% ,D期为 2 5 .7%、6 .4 %和 0 ;C期与D期 5年与 10年生存率差异有显著性意义 (P <0 .0 0 5 ) ;照射剂量<70Gy者 5、10、15年生存率分别为 39.7%、7.7%、0 % ,≥ 70Gy者分别为 5 5 .9%、4 4 .1%和 2 1.6 % ,5年和 10年生存率差异有显著性意义 (P <0 .0 5 )。　结论　综合治疗是中晚期前列腺癌的主要治疗方法 ,临床分期、Gleason分级、照射剂量是影响长期生存的主要因素。

关键词：前列腺癌综合治疗双侧睾丸切除术放射治疗内分泌治疗

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基于蓝芽通讯的自动抄表系统

传感器技术 2004年第7期23卷 68-70页

作者：熊兆茵霍诗咏张子康蔡伟华谭锦荣澳门大学科技学院澳门00853

介绍一种使用蓝芽无线技术(Bluetooth)和现场可编程门数组(FPGA)数据控制的智能遥测读表系统,能自动量度仪表的资料并实时转送到计算机作数字辨识处理。该辨识系统是通过ANN仿脑神经网络而设计;论述了整个系统结构、运作原理、硬件设计... 详细信息

介绍一种使用蓝芽无线技术(Bluetooth)和现场可编程门数组(FPGA)数据控制的智能遥测读表系统,能自动量度仪表的资料并实时转送到计算机作数字辨识处理。该辨识系统是通过ANN仿脑神经网络而设计;论述了整个系统结构、运作原理、硬件设计及其测试结果。

关键词：蓝芽控制台遥测单元数字辨识模块

RADIOIMMUNOLOCALIZATION OF HUMAN MALIGNANT TUMORS WITH IN-111 LABELED MONOCLONAL ANTIBODY

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中华医学杂志(英文版) 1991年第12期104卷 999-1004页

作者：韩冰刘成贵方永鑫袁玫蒋彦永田嘉禾吴传初吴永慧刘元方 100853 Beijing PLA General Hospital 00853 Beijing PLA General Hospital Department of Technical Physics Peking University Beijing

An anti-human colon carcinoma monoclonal antibody 2C10 was radiolabeled with In-111 and studied in 15 patients with gastrointestinal and ovarian carcinoma. The labelling efficiency approached 100% and immunoactivity of the labeled antibody was over 75%. 2-3 mci (1 mg) In-111-2C10 was given to the patients intravenously and scintigraphy was performed 72 hours after administration with a gamma camera. Specimens were also scanned in some of the patients. The resected tumors and remote margin were examined immunohistocbemically. Positive scintigrapbic images were obtained in 12/15 patients with colorectal cancer (10) and ovarian cancer (2). Negative results were seen in the two patients with gastric cancer. The scintigraphic results of 10 patients were confirmed surgically and pathologically. The remaining 5 were confirmed by endoscopy, B-ultrasonography or X-ray CT. Most patients had been definitely diag nosed before imaging except one patient with metastatic focus from ovarian cancer to colon and one with recurrent colon cancer were first detected with RIAD, showing the unique advantage the latfer. The high background radioactivity in the liver, however, is a conspicuous problem to be solved.

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ALTERATIONS OF ATRIAL NATRIURETIC FACTOR IN MAMMILLARY BODIES AND MEDIAN EMINENCE FROM HYPERTENSIVE AND EXPERIMENTAL BRAIN HEMORRHAGE RATS

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中华医学杂志(英文版) 1991年第10期104卷 838-841页

作者：王苏罗毅 100700 Beijing Neurology Department Beijing Army General Hospital 00853 Beijing Neurology Department General Hospital of PLA

The results of the present study demonstrate that atrial natriuretic factor (ANF) in the mammillary bodies has a dynamic change, while ANF in the median eminence is relatively constant in the course of the increase of blood pressure. It suggests that ANF in the mammillary bodies might take part in the regulation of blood pressure and ANF in the median eminence mainly participates in the functional regulation of the adenohypophysis.

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脂多糖诱导的小鼠腹腔巨噬细胞基因表达谱分析

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中华微生物学和免疫学杂志 2004年第10期24卷 773-777页

作者：李崇辉陈明易刘巨超臧传波徐迎新黄志强解放军总医院肝胆外科研究所北京00853 解放军总医院普通外科研究所北京00853

目的　利用基因芯片技术分析脂多糖 (LPS)活化的小鼠腹腔巨噬细胞基因表达谱 ,以更全面地了解LPS诱导的巨噬细胞反应。方法　以未刺激的和用 1mg/LLPS刺激的小鼠腹腔巨噬细胞制备3 3 P标记的cDNA探针 ,分别与含有 1176个已知基因的小鼠c... 详细信息

目的　利用基因芯片技术分析脂多糖 (LPS)活化的小鼠腹腔巨噬细胞基因表达谱 ,以更全面地了解LPS诱导的巨噬细胞反应。方法　以未刺激的和用 1mg/LLPS刺激的小鼠腹腔巨噬细胞制备3 3 P标记的cDNA探针 ,分别与含有 1176个已知基因的小鼠cDNA芯片杂交。结果　活化组和未刺激组间的 2倍差异表达基因为 118个 ,3倍差异表达基因为 6 9个 ,其中 4 4个上调 ,2 5个下调。转录因子、细胞内信号调节蛋白、炎症细胞因子和细胞凋亡相关基因的转录发生明显的调节变化。结论提供了LPS活化的巨噬细胞综合基因表达信息 ,并筛选出一些新的可能与LPS活化相关的基因。

关键词：小鼠腹腔巨噬细胞 LPS 基因表达谱脂多糖刺激差异表达基因诱导信号调节蛋白转录因子 cDNA芯片

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基于人脸识别的快速身份鉴定装置

传感器技术 2004年第5期23卷 39-41页

作者：林正谊王冠豪李嘉贤丁绍荣谭锦荣澳门大学科技学院澳门00853

介绍一种以智能卡起动的神经网络型人脸识别身份鉴定装置,通过整合电子式的智能卡技术和生物特征式的人脸识别技术与多项图像处理算法来进行身份鉴定,使得高达85%的准确辨识能于2s内完成。

关键词：人脸识别智能卡神经网络身份鉴定图像处理

Study of the continuum removal method for the Moon Mineralogy Mapper(M^3) and its application to Mare Humorum and Mare Nubium

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Research in Astronomy and Astrophysics 2016年第7期16卷 133-142页

作者： Xun-Yu Zhang Zi-Yuan Ouyang Xiao-Meng Zhang Yuan Chen Xiao Tang Ao-Ao Xu Ze-Sheng Tang Yun-Zhao Wu Space Science Institute Macao University of Science and Technology Macao 00853 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210023 China Key Laboratory of Planetary Sciences Chinese Academy of Sciences Nanjing 210008 China

The absorption band center of visible and near infrared reflectance spectra is a key spectral parameter for lunar mineralogical studies, especially for the mafic minerals（olivine and pyroxene） of mare basalts, which have two obvious absorption bands at 1000 nm（Band I） and 2000 nm（Band II）. Removal of the continuum from spectra, which was developed by Clark and Roush and used to isolate the particular absorption feature, is necessary to estimate this parameter. The Moon Mineralogy Mapper（M3） data are widely used for lunar mineral identification. However, M3 data show a residual thermal effect, which interferes with the continuum removal, and systematic differences exist among optical data taken during different optical periods. This study investigated a suitable continuum removal method and compared the difference between two sets of M3 data taken during different optical periods, Optical Period 1B（OP1B）and Optical Period 2A（OP2A）. Two programs for continuum removal are reported in this paper. Generally,a program respectively constructs two straight lines across Band I and Band II to remove the continuum,which is recommended for locating band centers, because it can find the same Band I center with different right endpoints. The optimal right endpoint for continuum removal is mainly dominated by two optical period data at approximately 2480 and 2560 nm for OP1 B and OP2 A data, respectively. The band center values derived from OP1 B data are smaller than those derived from OP2 A data in Band I but larger in Band II, especially for the spectra using longer right endpoints（〉2600 nm）. This may be due to the spectral slopes of OP1 B data being steeper than those of OP2 A data in Band I but gentler in Band II. These results were applied to Mare Humorum and Mare Nubium, and the measurements were found to mainly vary from intermediate- to high-Ca pyroxene.

关键词： techniques spectroscopic methods data analysis instrumentation spectrographs

THE ROLE OF KUPFFER CELLS IN THE DEVELOPMENT OF HEPATIC DYSFUNCTION DURING SEPSIS

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中华医学杂志(英文版) 1992年第1期105卷 34-38页

作者：孟宪钧邱宝安李新建宋旭华 100853 Beijing Institute of Basic Medical Sciences General Hospital of PLA 00853 Beijing Institute of Basic Medical Sciences General Hospital of PLA

The effect of Kupffer cell blockade on hepaticfunction during sepsis was evaluated in this *** palmitate suspension 100 mg/100 g adminis-tered intravenously suppressed the phagocytic activityas the phagocytic index K decreased from 0.0493±0.0089 to 0.0150±0.0035 in *** was producedby the method of cecal ligation and needling perfora-tion (CLP).At the end of 15 hours after CLP thehepatic adenosine triphosphate(ATP)level and ketonebody ratio decreased *** in ratspretreated with methyl palmitate 24 hours prior toCLP,the ATP level returned to the normal controllevel (1.6906±0.06-2.2323±0.13 μmol/g) andketone body ratio remained at significantly higher val-ues (0.26 to 0.68).After CLP, the liver lipoperoxide(LPO) concentration increased and glutathione (GSH)contents decreased significantly. When the septic ratswere pretreated with methyl palmitate,both the LPOand GSH returned to the normal control level(62.69±1.7 to 44.62±2.12 and 159.85±9.7 to 222.27±11.34).It is concluded that the hepatic dysfunction ismodulated at least to a greater extent by many of thetoxic mediators released by the activated Kupffer cellsduring sepsis.

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明清之际文人的山水游历“适性”观

厦门大学学报（哲学社会科学版） 2011年第3期61卷 49-55页

作者：王子超陈力鸥澳门科技大学国际旅游学院澳门00853

明代中期兴起的王阳明心学思想,张扬了人的个性和主体性的心学思潮,引起对人之本性的思考。心学的兴起促进了自然人性论和文学性灵说的崛起,同时也促使文人的山水游历观念发生重大变革,引发了一场对逸游败德论进行解构和颠覆的思想运动... 详细信息

明代中期兴起的王阳明心学思想,张扬了人的个性和主体性的心学思潮,引起对人之本性的思考。心学的兴起促进了自然人性论和文学性灵说的崛起,同时也促使文人的山水游历观念发生重大变革,引发了一场对逸游败德论进行解构和颠覆的思想运动,形成了山水游历的"适性"观。山水游历的"适性"观具体表现在:在胜境之中游目骋怀、直抒胸臆;于山水间娱乐性情,让心与自然得到高度会通;以"狂放"的方式体悟自然,体会至上乐趣。

关键词：明清文人心学山水游历 “适性”观