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机械辅助呼吸早产儿支气管内病原体依赖性炎症细胞因子及抗炎细胞因子:前瞻性队列研究

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世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 57-58页

作者： De Dooy J. Ieven M. Stevens W. 虎小毅 Dr.University Hospital AntwerpDepartment of pediatrics Division of NeonatologyWilrijkstraat 10B-2650 EdegemBelgium

细胞因子等炎症介质与呼吸道病原体之间的关系目前仍不明了。本前瞻性队列研究评估了141例机械辅助呼吸早产儿在出生时支气管内病原体侵袭情况。分析了脐血C反应蛋白(CRP)与呼吸道细胞因子免疫应答的关系。在所研究的141例早产儿中,有37... 详细信息

细胞因子等炎症介质与呼吸道病原体之间的关系目前仍不明了。本前瞻性队列研究评估了141例机械辅助呼吸早产儿在出生时支气管内病原体侵袭情况。分析了脐血C反应蛋白(CRP)与呼吸道细胞因子免疫应答的关系。在所研究的141例早产儿中,有37例(26%)

关键词：机械辅助呼吸支气管内抗炎细胞因子炎症细胞因子前瞻性队列研究炎症介质脐血免疫应答革兰阴性菌生时

1型糖尿病和早期微血管病的青少年患者补充维生素E对细胞内抗氧化酶合成的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 51-52页

作者： Chiarelli F. Santilli F. Sabatino G. 贺莉 Department of pediatrics University of Chieti Ospedale PoliclinicoVia dei Vestini 5I-66100 ChietiItaly

细胞内抗氧化酶合成(IAP)缺陷已在成人糖尿病肾病中得以证实。为了评价在患有1型糖尿病和有微血管病早期征象的青少年中,口服维生素E对IAP的影响, 笔者研究了12例青少年患者(年龄在11-21岁;糖尿病病程10-18年)。其中8例有视网膜病(病情... 详细信息

细胞内抗氧化酶合成(IAP)缺陷已在成人糖尿病肾病中得以证实。为了评价在患有1型糖尿病和有微血管病早期征象的青少年中,口服维生素E对IAP的影响, 笔者研究了12例青少年患者(年龄在11-21岁;糖尿病病程10-18年)。其中8例有视网膜病(病情分别为病变4例,增殖前病变3例,增殖性病变1例),4例有持续的微白蛋白尿症,并且7例同时有以上2种病变存在。通过组织活检和Dulbecco改良的伊格尔培养基培养,获得皮肤的成纤维细胞。在补充复合维生素E(600 mg, 2次/d)前后3个月测量CuZn过氧化物歧化酶(SOD)、

关键词：微血管病糖尿病肾病抗氧化酶增殖性病变过氧化物歧化酶视网膜病伊格尔成人糖尿病葡萄糖浓度蛋白尿症

吸入一氧化氮治疗胎粪吸入综合征时新生儿需要体外膜式人工氧合法治疗模式的指征

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 49-50页

作者： Friedlich P. Noori S. Stein J. 王经纬 Division of Neonatology Department of Pediatrics Childrens Hospital Los Angeles Los Angeles CA 90027 United States

As the use of inhaled nitric oxide (iNO) resulted in a decline in the need for extracorporeal membrane oxygenation (ECMO) in neonates with hypoxic respiratory failure, iNO has become an accepted treatment modality even in non-ECMO centers. However, because not all neonates respond to iNO, the timely identification and transfer of nonresponders to an ECMO center are important. Abstract: The objective of this study was to identify the risk factors predictive of the need of ECMO in neonates with hypoxic respiratory failure after the first 6 hours of iNO treatment in an ECMO center. Methods and Patient Population: Forty-nine patients with hypoxic respiratory failure transferred for iNO therapy and potential ECMO during a 2- year period were identified in this retrospective study. None of the patients had received iNO before admission. Strict clinical guidelines were used to standardize lung inflation, cardiovascular support, and iNO administration and weaning and to define treatment failure. The relationship between treatment failure (ie, the need for ECMO) and a set of suspected risk factors after 6 hours of iNO administration was examined by logistic regression analysis. Results: Twenty-two neonates responded to iNO(non-ECMO group)whereas 27 neonates failed and met ECMO criteria (ECMO group). There was no difference between the 2 groups in demographic data, ventilatory support, air leak syndrome at 6 hours of iNO treatment, and survival to discharge. However, the dose and duration of iNO therapy were predictive of the need for ECMO with an adjusted odds ratio of 1.12 (95% CI, 1.01- 1.25; P = .04) and 0.45 (95% CI, 0.27- 0.65; P = .0002), respectively. Conclusions: By the end of the first 6 hours of iNO treatment and under the specific conditions established by the use of the clinical guidelines, the dose and the duration of iNO administration were predictive of the probability for the need of ECMO in this patient population. Thus, one can establish a center-specific p

关键词：胎粪吸入综合征低氧性呼吸衰竭膜式肺通气临床指南存活情况对数回归气体渗人口学资料持续时间

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患人类开放性脊柱裂的新生儿的运动功能丧失

世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 58-59页

作者： Sival D.A. Van Weerden T.W. Vles J.S.H. 肖莉 Pediatric NeurologyDepartment of pediatrics University Hospital GroningenPO Box 30.0019713 GZ GroningenNetherlands

目的:患有开放性脊柱裂(SBA)的新生儿,其由马尾至脊膜脊髓膨出脊髓节段控制的腿部的运动会暂时性存在。这一对患SBA新生儿的研究的目的是确定腿部运动的存在是否表明了神经支配功能的完整性,以及腿部运动的消失是否是上运动神经元(从颅... 详细信息

目的:患有开放性脊柱裂(SBA)的新生儿,其由马尾至脊膜脊髓膨出脊髓节段控制的腿部的运动会暂时性存在。这一对患SBA新生儿的研究的目的是确定腿部运动的存在是否表明了神经支配功能的完整性,以及腿部运动的消失是否是上运动神经元(从颅脑起始到脊膜脊髓膨出处的轴索)和(或)下运动神经元(从马尾到脊膜脊髓膨出间)的功能障碍的结果。方法:研究出生后1 d(n=8)和7 d(n=10)的新生儿的腿部运动。

关键词：脊膜脊髓膨出上运动神经元脊柱裂脊髓节段出生后轴索脊柱节段神经支配胎儿外科检查法

Seroconversion of Hepatitis B Vaccine in Young Bangladeshi Children: A Tertiary Centre Experience

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World Journal of Vaccines 2021年第2期11卷 7-18页

作者： Salahuddin Mahmud Jahida Gulshan Farhana Tasneem Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology & Nutrition Bangladesh Institute of Child Health Dhaka Shishu(Children) Hospital Dhaka Bangladesh Institute of Statistical Research and Training University of Dhaka Dhaka Bangladesh Department of pediatrics BIHS General Hospital Diabetic Association of Bangladesh Dhaka Bangladesh

Background: Hepatitis B virus (HBV) infection is one of the most important global health problems and active immunization is the single most important and effective preventive measure against HBV infection. Several studied show that HBV carrier rate is between 2% - 7% in Bangladesh. Bangladesh introduced hepatitis B vaccination in children through Expanded Program on Immunization (EPI) in 2005 that includes 3 doses which starts from six weeks after birth. Currently booster vaccination is not recommended any more. However, many studies on different countries observed a declined level of HBs-antibody over a period of 3 - 6 years that may even reach to non-protective levels. Objective: To evaluate the status of seroconversion and seroprotection along with non-responders of EPI vaccinated children against HBV and to measure their antibody levels in different age groups. Methods: A cross sectional descriptive study was done in the department of Pediatric Gastroenterology, Hepatology & Nutrition, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh on 120 cases of EPI vaccinated children enrolled from January-December 2019 while attending the inpatient department without any liver problem. The development of Anti-HBs titre greater than or equal to 10 mIU/mL is considered as protective immunity and any titre less than 10 mIU/mL as non-protective following HBV vaccination. Results: Age of the children was 1 - 12 years with mean age of 5.6 ± 1.7 years and male: female ratio was 1.1:1. Among the children, 56 (46.6%) were from 1 - 5 years age, 36 (30.1%) children from 6 - 10 years age group and 27 (23.3%) children from 11 - 12 years age group. Out of 120 children, presence of Anti-HBs protective titre was in 63 (52.5%) children and non-protective level in 57 (47.5%) children. Among protective level, 34 (60.7%) children were in 1 - 5 years age group, 18 (50.0%) children in 6 - 10 years age group and 11 (39.3%) c

关键词： Hepatitis B Virus Expanded Program on Immunization Immune Response Antibody Titre

川崎病时免疫球蛋白治疗的抵抗与血浆血小板活化因子乙酰水解酶基因的多态性有关

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 34-35页

作者： Minami T. Suzuki H. Takeuchi T. 郭战宏 Department of pediatrics Wakayama Medical University 811- 1 Kimiidera Wakayama 641- 0012 JapanDr.

To investigate whether reduced levels of plasma platelet-activating factor acetylhydrolase (PAF-AH) as a result of a genetic polymorphism are involved in the pathogenesis of Kawasaki disease (KD). Study design: The frequency of a V279F polymorphism (G/T transversion) in the PAF-AH gene was quantified in 76 Japanese children with KD and 112 healthy Japanese adults using the allele- specific polymerase chain reaction (PCR). Associations between genotype, clinical features, and resistance to intravenous immunoglobulin (IVIG) were investigated in the patients with KD. Plasma PAF-AH activity was measured by using [3H]- acetyl-PAF. Results: There were no significant differences in genotype frequency between patients and controls (P = .51). Compared with the GG (normal genotype) group, significantly more patients in the GT (heterozygous) + TT (homozygous deficient) group required additional IVIG (52% vs 14% , P = .001). The duration of fever and maximum serum C-reactive protein (CRP) levels also were significantly increased in the GT+ TT group (P = .012 and .036, respectively), whereas plasma PAF-AH activity was significantly lower (P < .0001). Conclusion: We conclude that the V279F polymorphism in the plasma PAF-AH gene and consequent enzymatic deficiency is one of the factors for IVIG nonresponse in Japanese patients with acute KD.

关键词：川崎病血小板活化因子免疫球蛋白乙酰水解酶多态性等位基因特异性聚合酶链反应发热持续时间静脉输注酶缺乏

中性粒细胞CD64是新生儿早期感染的敏感诊断标志

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 57-58页

作者： Ng P.C. 阿明 Department of pediatrics Clinical Sciences BuildingPrince of Wales Hospital Shatin N. T. HongKong

这项前瞻性研究的目的是为了评价中性粒细胞CD64表达对新生儿早期临床感染的诊断价值,并供以后研究进行参考对照。本研究将出生后72 h以内、怀疑受到感染的新生儿纳入观察对象。分别在0 h和24 h测定C-反应蛋白(CRP)和中性粒细胞CD64的... 详细信息

这项前瞻性研究的目的是为了评价中性粒细胞CD64表达对新生儿早期临床感染的诊断价值,并供以后研究进行参考对照。本研究将出生后72 h以内、怀疑受到感染的新生儿纳入观察对象。分别在0 h和24 h测定C-反应蛋白(CRP)和中性粒细胞CD64的表达水平。分别对CRP、CD64及这两个标志物联合对新生儿脓毒症预测的敏感性、特异性、阳性预测价值和阴性预测价值(NPV)进行了比较。

关键词： CD64 诊断标志预测价值早期临床出生后脓毒症早期感染中性粒细胞观察对象特异性

Diagnostic role of serum interleukin-18 in gastric cancer patients

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World Journal of Gastroenterology 2006年第28期12卷 4473-4477页

作者： Duangporn Thong-Ngam Pisit Tangkijvanich Rungsun Lerknimitr Varocha Mahachai Apiradee Theamboonlers Yong Poovorawan Department of Physiology Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand Department of Biochemistry Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand Department of Medicine Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand Viral Hepatitis Research Unit Department of PediatricsFaculty of MedicineChulalongkorn UniversityBangkok10330Thailand

AIM： To determine the current status in various aspects of gastric cancer patients and to find out the clinical correlation with prognostic role of serum interleukins in Thai patients. METHODS： Sixty-eight patients were enrolled in this study at King Chulalongkorn Memorial Hospital during April 2003 to May 2005. Gastric cancer was histologically proven in 51 patients and gastric ulcer in 17 patients. Serum IL-6, IL-10, IL-12, and IL-18 levels were measured by enzyme-linked immunosorbent assay （ELISA）. RESULTS： There were 26 males （55.32%） and 21 females （44.68%） with their age ranging from 33 to 85 years （mean age 64.49 ± 13.83 years）. The common presentations were weight loss （41.2%）, dyspepsia （39.2%）, and upper gastrointestinal bleeding （15.7%）. A total of 35.3% gastric cancer patients and 6.3% of gastric ulcer patients were smokers （P = 0.029）. Moreover, 32.4% of gastric cancer patients and 6.3% of gastric ulcer patients were alcoholic drinkers （P = 0.044）. Lesion location was pyloric-antrum in 39.4%, gastric body in 39.4%, upper stomach in 12.2% and entire stomach in 6.1% of the patients. H pylori infection was detected in 44.4%. The poorly-differentiated adenocarcinoma was the most common pathologic finding （60.7%）. Surgical treatment was performed in 44.1% patients （total gastrectomy in 5.9%, subtotal gastrectomy in 32.4% and palliative bypass surgery in 5.9%）. Systemic chemotherapy was given as an adjuvant therapy in 8.8% patients. Carcinomatosis peritoneii were found in 18.8% patients. The mean survival time was 13.03 ± 9.75 mo. The IL-18 level in gastric cancer patient group （58.54 ± 43.96 pg/mL） was significantly higher than that in gastric ulcer patient group （30.84± 11.18 pg/mL）（P = 0.0001）（95% CI was 42.20, 13.19）. The cut point of IL-18 for diagnosis of gastric cancer was 40 pg/mL, the positive predictive value was 92.31%. The IL-6 level in gastric cancer patients with distant metastasis （20.21 ±9.37 pg/mL） was significantly higher than that in thos

关键词： Interleukin Gastric cancer Diagnostic marker

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全球控制传染病的心路历程

美国医学会杂志（中文版） 2005年第4期24卷 247-252页

作者： Alexandra Minna Stem Howard Markel 马凌云（译）崔德健（校） Center for the History of Medicine Department of Obstetrics and Gynecology and Program in Amedcan Culture Department of pediatrics and Communicable Diseases and Department of History 不详

展望21世纪，许多观察家把世界各国通力协作控制传染病视为全球化以及国际经贸、交通、人口流动领域最新变革的必然结果。某些国际卫生组织成立的初衷纯粹是为了遏制传染病的流行，了解这些机构的创建史及其规章制度有助于更加深入地理... 详细信息

展望21世纪，许多观察家把世界各国通力协作控制传染病视为全球化以及国际经贸、交通、人口流动领域最新变革的必然结果。某些国际卫生组织成立的初衷纯粹是为了遏制传染病的流行，了解这些机构的创建史及其规章制度有助于更加深入地理解当前启动的全球健康项目。本文回顾了全球控制传染病的3个时期（1851—1881年、1881—1945年、1945年至今），探讨了各国如何通过坚实的财政鼓励机制以及强烈的人道主义情结向传染病控制项目和国内外基础设施建设投放资金，得出了一些结论。

关键词：全球控制传染病心路历程国际卫生组织基础设施建设 21世纪人口流动健康项目规章制度