胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研究了CEACAM8在胃癌预后中的作用。发现CEACAM8的过表达与胃癌患者的临床肿瘤分期和病理肿瘤分级显著相关。此外,CEACAM8 mRNA的高表达与胃癌患者较短的总生存期(OS)显著相关。总的来说,CEACAM8可能是胃癌患者生存的预后生物标志物。Gastric cancer directly affects human quality of life worldwide, and some members of the carcinoembryonic antigen-associated cell adhesion molecule (CEACAM) subfamily are not regulated in tumors. Little is known about the function of CEACAM8 in gastric cancer. In order to solve this problem, this study used UALCAN, Kaplan-Meier Plotter and metascape databases to study the role of CEACAM8 in the prognosis of gastric cancer. It was found that the overexpression of CEACAM8 was significantly correlated with the clinical tumor stage and pathological tumor grade of gastric cancer patients. In addition, high expression of CEACAM8 mRNA was significantly associated with shorter overall survival (OS) in patients with gastric cancer. Overall, CEACAM8 may be a prognostic biomarker for survival in patients with gastric cancer.
目的:近年来研究发现中性粒细胞与淋巴细胞比值可以预测急性缺血性卒中(AIS)患者的短期和长期预后。但其变化量(ΔNLR)与患者溶栓后24 h的出血转化(HT)及早期神经功能改善(ENI)的关系仍缺乏研究。本次研究旨在探讨ΔNLR与溶栓后24 h的HT和ENI的关系,及ΔNLR与不同TOAST分型的患者溶栓后早期结局的关系。方法:纳入接受静脉溶栓治疗的AIS患者234例。对患者进行TOAST分型。根据HT和ENI的有无将患者进行分组。结果:发生HT的患者溶栓后NLR升高更明显,出现ENI的患者溶栓后NLR降低更明显。动脉粥样硬化型与心源性栓塞型患者的ΔNLR无明显差异,但小动脉闭塞型患者与大动脉粥样硬化型轻型患者相比,ΔNLR有统计学差异。结论:ΔNLR是AIS患者溶栓后HT和ENI的独立影响因素,且小动脉闭塞型脑卒中患者的ΔNLR大于轻型大动脉粥样硬化型脑卒中患者的ΔNLR。Objective: Recent studies have shown that the neutrophil-to-lymphocyte ratio can predict the short- and long-term prognosis of patients with acute ischemic stroke (AIS). However, the association between the variation of neutrophil-to- lymphocyte ratio(ΔNLR) and the bleeding transformation (HT) as well as early neurological improvement (ENI) at 24 h after thrombolysis is still lacking. The purpose of the study was to investigate the correlation between ΔNLR and HT as well as ENI 24 h after thrombolytic therapy, and the relationship between ΔNLR and early outcomes after thrombolytic therapy in patients with different TOAST classifications. Methods: 234 patients with AIS who received intravenous thrombolysis were included. The patients were classified by TOAST classifications. Patients were grouped according to the presence or absence of HT and ENI. Results: The increase of NLR after thrombolysis was more obvious in patients with HT while the decrease of NLR was more obvious in patients with ENI. There was no significant difference in ΔNLR between patients with atherosclerotic type and those with cardiogenic embolization type, but there was a statistical difference in ΔNLR between patients with small artery occlusion type and those with large artery atherosclerosis mild type. Conclusion: ΔNLR was an independent influencing factor for HT and ENI in AIS patients after thrombolysis, and ΔNLR in small artery occlusive stroke patients was greater than that in patients of minor stroke of LAA group.
糖尿病痛性神经病变(PDN)是临床上常见的一类感觉性周围神经病变。在众多致病因素中,远端对称性多发性神经病变(DSPN)占据主导地位。而格林巴利综合征则是一种急性炎症性周围神经病,又称慢性炎症性脱髓鞘性多发神经根神经病(CIDP),是一种免疫介导的脱髓鞘性周围神经病。当糖尿病痛性神经病变与格林巴利综合征合并时,病情通常会变得更为复杂。首先,这两种疾病存在密切关联及潜在的共同病理生理机制。研究显示,在其发病进程中,免疫系统可能发挥着至关重要的作用。由于这两种疾病所表现出的症状可能会相互交织、彼此重叠,因此很容易造成误诊和漏诊的情况发生。明确它们各自独特的临床表现、神经电生理特点以及实验室检查指标的变化,有助于提高诊断的准确性。总之,对糖尿病痛性神经病变并发格林巴利的探讨不仅能加强我们对神经病变的理解,也能为病人提供更精确、更有成效的医疗策略,从而提升他们的生活品质。本研究通过综合文献综述,深入探讨了格林巴利综合征与糖尿病痛性神经病变的发病机制、临床表现、实验室检查方法及治疗方案,旨在促进这两种疾病的及早诊断与有效治疗。Diabetic painful neuropathy (PDN) is a common clinical class of sensory peripheral neuropathy. Among the many causative factors, distal symmetrical polyneuropathy (DSPN) dominates. The prevalence of PDN in the diabetic patient population is estimated to be as high as 16%, and 39% of patients in this group fail to receive timely and effective therapeutic measures. Whereas, Guillain-Barré syndrome is an acute inflammatory peripheral neuropathy, also known as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which is an immune-mediated demyelinating peripheral neuropathy. When diabetic painful neuropathy is combined with Guillain-Barré syndrome, the condition usually becomes more complex. First, there is a close association and potential common pathophysiologic mechanisms between these two diseases. Studies have shown that the immune system may play a crucial role in their pathogenesis. As the symptoms of these two diseases may be intertwined and overlap with each other, they can be easily misdiagnosed and underdiagnosed. Clarifying their unique clinical manifestations, neurophysiologic features, and changes in laboratory tests can help improve the accuracy of diagnosis. In conclusion, the exploration of diabetic painful neuropathy complicating Guillain-Barré will not only enhance our understanding of neuropathy, but also provide patients with more precise and productive medical strategies, thus improving their quality of life. In this study, through a comprehensive literature review, the pathogen
目的:探讨预后营养指数(Prognostic Nutritional Index, PNI)与急诊ICU老年脓毒症患者死亡相关性及对老年脓毒症患者死亡的评估价值。方法:采用回顾性分析方法,分析2021年1月至2024年7月康复大学青岛医院东院区急诊ICU收治的老年脓毒症患者(年龄 ≥ 65岁)的基本信息和实验室检查数据。根据患者的住院结局将其分为生存组和死亡组,比较两组的一般资料和实验室数据。单因素和多因素Logistic回归分析PNI与老年脓毒症患者死亡的关系。绘制受试者工作曲线(Receiver operating characteristic, ROC)和计算曲线下面积(area under the curve, AUC)评估PNI的预测效能。结果:共纳入133例患者,生存组92例,死亡组41例,病死率为30.8%。生存组白蛋白、PNI、总蛋白、血小板均显著高于死亡组,具有统计学意义(P Objectives: To explore the correlation between Prognostic Nutritional Index (PNI) and mortality in elderly sepsis patients in the emergency department, as well as its evaluation value for mortality in elderly sepsis patients. Method: A retrospective analysis was conducted to analyze the basic information and laboratory test data of elderly sepsis patients (aged ≥ 65 years) admitted to the Emergency ICU of the East Campus of Qingdao Hospital of Rehabilitation University from January 2021 to July 2024. According to the hospitalization outcome, they were divided into a survival group and a death group, and their general information and laboratory data were compared between the two groups. Single-factor and multi-factor logistic regression analyses were used to assess the relationship between PNI and the death of elderly patients with sepsis. Receiver operating characteristic (ROC) and calculate area under the curve (AUC) are drawn to evaluate the predictive performance of PNI. Result: A total of 133 patients were included, with 92 in the survival group and 41 in the death group, resulting in a mortality rate of 30.8%. The survival group had significantly higher levels of albumin, PNI, total protein, and platelets than the death group, with statistical significance (P < 0.05). The SOFA, APACHE II scores, and urea nitrogen levels in the death group were significantly higher than those in the survival group, and the differences were statistically significant (P < 0.05). Univariate logistic regression analysis showed that PNI, SOFA score, APACHE II score, total protein, albumin
目的:探究膝关节骨性关节炎(Knee osteo arthritis, KOA)患者单个股四头肌回声强度与临床严重程度的关系。方法:招募2023年10月至2024年05月在青岛大学附属医院就诊的55例单侧KOA患者,使用肌骨超声评估股四头肌(Quadriceps Femoris, QF)回声强度(Echo Intensity, EI),EI包括直接测得EI及使用皮下脂肪校正后的EI。膝关节损伤和骨关节炎结果评分(Knee Injury and Osteoarthritis Outcome Score, KOOS)用于评估患者膝关节功能及症状。5次起坐试验、起立行走测试以及5米步行测试用于评估患者运动功能。采用相关分析及回归分析,以阐明股四头肌EI与KOA患者临床严重程度之间的关系。结果:与健侧相比,KOA患者患侧股四头肌四块肌肉的EI均明显增高(p Objective: To investigate the relationship between the echo intensity (EI) of the quadriceps femoris (QF) muscle and clinical severity in patients with knee osteoarthritis (KOA). Methods: Fifty-five unilateral KOA patients were recruited, and the EI of the QF muscle was assessed using musculoskeletal ultrasound, incorporating both the direct measurement of EI and the subcutaneous fat-corrected EI. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to evaluate knee joint function and symptoms, while the 5-times sit-to-stand test (5CST), timed up and go test (TUG), and 5-meter walk test (5MWT) were employed to assess motor function. Results: The EI of the affected quadriceps femoris in KOA patients was significantly higher than that of the unaffected side (p < 0.05). Specifically, the vastus medialis (VM) showed a strong correlation with motor function as well as with KOOS domains covering symptoms, pain, and activities of daily living (ADL). Multiple regression analysis revealed that the corrected EI of the VM was significantly associated with KOOS symptoms [B = −0.157;95% CI, −0.247 to −0.066;p = 0.001], pain [B = −0.200;95% CI, −0.349 to −0.051;p = 0.009], ADL [B = −0.214;95% CI, −0.327 to −0.100;p < 0.001], 5CST [B = −0.028;95% CI, 0.012 to 0.044;p = 0.001], and 5MWT [B = 0.013;95% CI, 0.001 to 0.025;p = 0.032]. Furthermore, the corrected EI of the rectus intermedius (RI) was significantly associated with KOOS symptoms [B = −0.122;95% CI, −0.229 to −0.015;p = 0.026] and TUG [B = 0.019;95% CI, 0.002 to 0.035;p = 0.029]. Similarly, the corrected EI of the rectus femoris (RF) was
维普期刊数据库
同方期刊数据库
暂无评论