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中华神经科杂志 2010年第6期43卷 449-450页

作者：刘广志吉良润一北京大学人民医院神经内科 100044 九州大学神经内科福冈812-8582

视神经脊髓炎（NMO）是一种以视神经和脊髓受累为主要表现的中枢神经系统（CNS）脱髓鞘疾病，多为急性或亚急性起病，可呈单时相病程或复发-缓解的多相病程。以往无特异性检查指标用于诊断该病，主要依据临床表现、MRI和脑脊液检查等确诊。

关键词：水通道蛋白4 视神经脊髓炎检测抗体中枢神经系统脱髓鞘疾病脑脊液检查主要表现

Retroperitoneal fibrosis associated with immunoglobulin G4-related disease

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World Journal of Gastroenterology 2013年第1期19卷 35-41页

作者： Nao Fujimori Tetsuhide Ito Hisato Igarashi Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Lingaku Lee Masahiko Uchida Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

Retroperitoneal fibrosis is a rare disease characterized by the development of inflammation and fibrosis in the soft tissues of the retroperitoneum and other abdominal *** fibrosis can be of 2 types:idiopathic and *** recently advocated concept and diagnostic criteria of immunoglobulin G4(IgG4)-related disease,derived from research on autoimmune pancreatitis(AIP),has led to widespread recognition of retroperitoneal fibrosis as a condition caused by IgG4-related *** now know that previously diagnosed idiopathic retroperitoneal fibrosis includes IgG4-related disease;however,the actual prevalence is ***,some reports on AIP suggest that retroperitoneal fibrosis is concurrently found in about 10% of IgG4-related *** retroperitoneal fibrosis has no specific symptoms,diagnosis is primarily based on diagnostic imaging(computed tomography and magnetic resonance imaging),which is also useful in evaluating the effect of *** retroperitoneal fibrosis can occur at different times with other lesions of IgG4-related disease including ***,the IgG4 assay is recommended to diagnose idiopathic retroperitoneal *** serum IgG4 levels should be treated and monitored as a symptom of IgG4-related *** first line of treatment for retroperitoneal fibrosis is steroid therapy regardless of its *** patients with concurrent AIP,i.e.,IgG4-related retroperitoneal fibrosis,the starting dose of steroid is usually 30-40 mg/*** response to steroid therapy is generally *** most cases,the pancreatic lesion and retroperitoneal fibrosis improve after the initial ***,the epidemiology,treatment for recurring retroperitoneal fibrosis,and long-term prognosis are still largely *** analysis of such cases and research are necessary.

关键词： Autoimmune pancreatitis Extrapancreatic lesion Immunoglobulin G4 Immunoglobulin G4related disease Retroperitoneal fibrosis

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背"音说疑

汉语学习 1999年第5期 45-46页

作者：史有为日本亍279-8550千叶县浦安市明海大学

在日本家系中弹力纤维性假黄瘤和视网膜色素变性的ABCC6基因上发现新的基因突变

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 50-51页

作者： Yoshida S. Honda M. Yoshida A. 司冰心 Department of Ophthalmology Kyushu University Graduate School of MedicineFukuoka 812-8582 Japan

Purpose: To report a novel mutation of the ABCC6 gene in a Japanese family tha t had a case of pseudoxanthoma elasticum (PXE) another with PXE and retinitis pi gmentosa. Methods: Ophthalmologic examinations were performed, and the ABCC6 gen e was analysed by direct genomic sequencing. Results: Fundus examinations of the 48-year-old proband disclosed angioid streaks and a peud’orange apparance of the retina of the both eyes, whereas both of his 25-and 20-year-old daughter s had pigmentary degeneration and angioid streaks. In the sibilings, the mixed cone-rod ERG was almost nond etectable, whereas that of the proband was well-preserved. Molecular genetic an alysis revealed that the proband has a homozygous nonsense mutation at the 595 b p in the ABCC6, and the siblings were heterozygous for the same mutation. This m utation was not detected in Japanese subjects in the JSNP database (http:// snp. ***/). Conculsions: Our results demonstrated an association betwe en a novel mutation in the ABCC6 gene and PXE in a Japanese family.

关键词：视网膜色素变性 ABCC6 基因突变视网膜电图血管样条纹症视杆眼底检查眼视网膜先证者眼科检查

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一款柔性全自动吸塑成型机的研制

包装工程 2009年第12期30卷 56-58页

作者：耿明海郏银芳亍波宇环机械设备有限公司宁波315135

研制了一款柔性全自动吸塑成型机,相较于常见的全自动吸塑成型机,增加了纵向切割装置、切割输送装置、自动上料装置以及模具内横向封气装置。可在一副模具上生产任意长度的吸塑产品,并在横向按照产品长度要求自动找位切割并输出产品,实... 详细信息

研制了一款柔性全自动吸塑成型机,相较于常见的全自动吸塑成型机,增加了纵向切割装置、切割输送装置、自动上料装置以及模具内横向封气装置。可在一副模具上生产任意长度的吸塑产品,并在横向按照产品长度要求自动找位切割并输出产品,实现一机多用、一模多用,提高了吸塑成型机的使用效率和自动化程度。

关键词：全自动吸塑成型机柔性一机多用一模多用

日本的先天性巨结肠:在30年全国调查的基础上对3852例患者的分析

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 53-54页

作者： Suita S. Taguchi T. Ieiri S. Nakatsuji T. 肖莉 Department of Pediatric Surgery Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

The introduction of laparoscope and transanal endorectal pullthrough has caused a revolution in the operative procedures for Hirschsprung’s disease. To study the changing profile of Hirschsprung’s disease in Japan, the authors carried out a national survey. Patient data were collected in 3 phases: group 1, 1628 patients between 1978 and 1982; group 2, 1121 patients between 1988 and 1992; and group 3, 1103 patients between 1998 and 2002, respectively. The incidence was 1:4697, 1:5544, and 1:5343 and the male/female ratio was 3.0:1, 3.4:1, and 3.0:1 in each group, respectively. Patients weighing less than 2500 g at birth increased to 10.4%in group 3, whereas they were 6.5%in group 2 and 5.5%in group 1. The patients with a family history also increased to 6.0%in group 3, in comparison with 2.8%in group 2 and 3.0%in group 1. The incidence of associated anomalies increased over time, 11.1%in group 1, 16.3%in group 2, and 21.2%in group 3. Mutations of genes were found in 4 of the 23 patients examined. The extent of aganglionosis was almost the same in each group. Regarding the definitive operation, the procedures without laparotomy, including transanal endorectal pull-through, increased up to 42.6%in group 3 but 0%in groups 1 and 2. The frequency that a primary operation without stoma was performed also increased. The age at definitive operation decreased in group 3. The incidence of preoperative and postoperative enterocolitis also decreased over time. The mortality was decreased over time, 7.1%, 4.9%, and 3.0%for groups 1, 2, and 3, respectively. The authors analyzed 3852 Japanese patients over 3 decades. The ratio of patients with a low birth weight, associated anomalies, or a family history was increased in the last 10 years. A primary operation without laparotomy has thus become the procedure of choice for a definitive operation.

关键词：先天性巨结肠全国调查拖出术开腹手术小肠结肠炎神经节细胞直肠内发病状况基因突变性别比

Reflectance spectra analysis for mucous assessment

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 822-834页

作者： Toru Chiba Masaharu Murata Takahito Kawano Makoto Hashizume Tomohiko Akahoshi Pentax_LifeCare HOYA CorporationAkishima-shi 196-0012TokyoJapan Center for Advanced Medical Innovation Kyushu UniversityFukuoka-shi 812-8582FukuokaJapan Department of Disaster and Emergency Medicine Graduate School of Medical SciencesKyushu UniversityFukuoka_shi 812-8582FukuokaJapan

This review report represents an overview of research and development on medical hyperspectral imaging technology and its *** imaging technology is attracting attention as a new imaging modality for medical applications,especially in disease diagnosis and image-guided *** the recent advances in imaging,this technology provides an opportunity for twodimensional mapping of oxygen saturation(SatO2)of blood with high accuracy,spatial spectral imaging,and its analysis and provides detection and diagnostic information about the tissue physiology and *** imaging also provides information about tissue oxygenation,perfusion,and potential function during *** algorithm has been examined,and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame *** technology is expected to provide promising biomedical information in practical *** studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders,particularly malignant tumor *** use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

关键词： Diffuse reflectance spectroscopy Endoscopy Hemoglobin saturation Hypoxia Gastrointestinal cancer Tumor

Titanium membrane layered between fluvastatin-loaded poly(lactic-co-glycolic)acid for guided bone regeneration

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Regenerative Biomaterials 2022年第1期9卷 816-826页

作者： Akihiro Furuhashi Yunia Dwi Rakhmatia Yasunori Ayukawa Kiyoshi Koyano Section of Implant and Rehabilitative Dentistry Division of Oral RehabilitationFaculty of Dental ScienceKyushu UniversityHigashiFukuoka-ku 812-8582Japan Division of Advanced Dental Devices and Therapeutics Faculty of Dental ScienceKyushu UniversityHigashiFukuoka-ku 812-8582Japan Department of Prosthodontic Faculty of DentistryPadjadjaran UniversityKota BandungJawa Barat 40132Indonesia

The aimof this study was to investigate titaniummembranes(TMs)layered between poly(lactic-co-glycolic acid)(PLGA)containing fluvastatin(FS)for use in guided bone *** consisting of PLGA,FS-containing PLGA(PLGA–FS),TM layered between PLGA(TM–PLGA)and TM layered between FS-containing PLGA(TM–PLGA–FS)were prepared,and their mechanical and chemical properties were *** TM groups showed statistically significant differences,in terms of tensile strength and elastic modulus,when compared to the PLGA *** release of FS was demonstrated to be higher in the TM–PLGA–FS group than the PLGA–FS group after Day *** effect of membrane implantation on the calvaria of Wistar rats was measured using micro-computed tomography(micro-CT)and morphometrical analyses,as well as histological *** 4weeks,the TM–PLGA–FS and TM–PLGA groups were found to have lower bone mineral density but higher bone formation,when compared to the control and PLGA *** 8weeks,the use of TM–PLGA–FS membranes significantly enhanced bone formation in the calvaria model,compared to the other *** results suggest that a TM layered between PLGA containing FS potentially enhances bone formation,thus showing good potential as a GBR membrane.

关键词： titanium mesh PLGA statin guided bone regeneration(GBR)

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中期妊娠胎盘前置状态出血9例的超声诊断

中国超声医学杂志 1991年第2期7卷 64-65页

作者：张良庆 812江南医院

中期妊娠(12至24周)无诱因阴道流血,临床多以各种流产收治,但前置胎盘是出血原因之一。因中期妊娠前置胎盘绝大多数是一种过渡状态,其处置与预后也不同于妊娠晚期的前置胎盘,所以,我们客观称此为胎盘前置状态。本文收集分析了我院近年来... 详细信息

中期妊娠(12至24周)无诱因阴道流血,临床多以各种流产收治,但前置胎盘是出血原因之一。因中期妊娠前置胎盘绝大多数是一种过渡状态,其处置与预后也不同于妊娠晚期的前置胎盘,所以,我们客观称此为胎盘前置状态。本文收集分析了我院近年来由B超确诊的9例典型资料,提出中期妊娠胎盘前置状态出血的诊断及超声特征表现。

关键词：胎盘前置超声前置胎盘分娩合并症中期妊娠子宫内口

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刻苦学业务力争变内行

天津教育 1979年第3期 2-3页

作者：王如喜华安亍中学党支部书记

粉碎“四人帮”后,教育战线拨乱反正,学校的教学工作又恢复了应有的中心地位,我们不再耽心被打棍子、扣帽子,可以理直气壮地抓教学了。新的形势使人心情舒畅,但对我说也产生了新的压力、新的矛盾。我从一九五五年师范学校毕业后,直到一... 详细信息

粉碎“四人帮”后,教育战线拨乱反正,学校的教学工作又恢复了应有的中心地位,我们不再耽心被打棍子、扣帽子,可以理直气壮地抓教学了。新的形势使人心情舒畅,但对我说也产生了新的压力、新的矛盾。我从一九五五年师范学校毕业后,直到一九七三年才接触学校工作,没有教学实践,不会抓教学,“不会抓”成了突出的矛盾。怎么办?在新形势的鼓舞下,唯一的办法是下狠心学习业务知识,学习教学规律,学习管理方法,只有这样才有可能从外行变成内行。

关键词： “四人帮” 学习英语