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Biologic agents for anterior cruciate ligament healing: a systematic review

World Journal of Orthopedics 2016年第9期7卷 592-603页

作者： Berardo Di Matteo Markus Loibl Luca Andriolo Giuseppe Filardo Johannes Zellner Matthias Koch Peter Angele ⅰorthopaedic and traumatologic clinic - biomechanics and technology innovation laboratory Rizzoli Orthopaedic Institute Department of Trauma Surgery University Regensburg Medical Centre Sporthopaedicum Regensburg

AIM To systematically review the currently available literature concerning the application of biologic agents such as platelet-rich plasma(PRP) and stem cells to promote anterior cruciate ligament(ACL) *** A systematic review of the literature was performed on the use of biologic agents(i.e., PRP or stem cells) to favor ACL healing during reconstruction or repair. The following inclusion criteria for relevant articles were used: clinical reports of any level of evidence, written in English language, on the use of PRP or stem cells during ACL reconstruction/repair. Exclusion criteria were articles written in other languages, reviews, or studies analyzing other applications of PRP/stem cells in knee surgery not related to promoting ACL *** The database search identified 394 records that were screened. A total of 23 studies were included in the final analysis: In one paper stem cells were applied for ACL healing, in one paper there was a concomitant application of PRP and stem cells, whereas in the remaining21 papers PRP was used. Based on the ACL injury pattern, two papers investigated biologic agents in ACL partial tears whereas 21 papers in ACL *** at the quality of the available literature, 17 out of 21 studies dealing with ACL reconstruction were randomized controlled trials. Both studies on ACL repair were case *** There is a paucity of clinical trials investigating the role of stem cells in promoting ACL healing both in case of partial and complete tears. The role of PRP is still controversial and the only advantage emerging from the literature is related to a better graft maturation over time, without documenting beneficial effects in terms of clinical outcome, bone-graft integration and prevention of bony tunnel enlargement.

关键词： Platelet-rich plasma Growth factors Stem cells Anterior cruciate ligament reconstruction Anterior cruciate ligament repair Anterior cruciate ligament healing Sports medicine Regenerative medicine

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Biomechanical study on implantable and interventional medical devices

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Acta Mechanica Sinica 2021年第6期37卷 875-894,I0003页

作者： Lizhen Wang Xili Ding Wentao Feng Yuanming Gao Shudong Zhao Yubo Fan Key laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering Medicine Beihang UniversityBeijing100083China

Implants,including artificial joints,bone fixation devices,and other orthopedic implants,oral implants,and vascular interventional devices,are used to repair or replace human tissues or organs and restore their *** biodegradable implants have advantage of avoiding long-term complications(including bone stress shielding,restenosis,thrombosis,and secondary surgery)while remaining safe and productive,personalized biodegradable implants will be an irresistible trend in the clinic for implantable and interventional medical ***,innovation of personalized biodegradable implants faces several challenges,including the interaction between the implant and its surrounding tissues or cells,the coordination of structural strength of implants and its degradation,the topological microstructure of implant and its fatigue properties,reliability,and *** this review,we introduced critical progresses achieved in the fields related to implants,including mechanical properties of materials,interaction between implants and host tissue,effect of stress on degradation;furthermore,we highlighted the optimized design and manufacture of implants as well as the evaluation of their reliability.

关键词： biomechanics Implants Design Manufacture Evaluation

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The first technology can compete with piezoelectricity to harvest ultrasound energy for powering medical implants

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Science Bulletin 2019年第21期64卷 1565-1566页

作者： Han Ouyang Zhou Li CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China Beijing Advanced innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of Nanoscience and technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and technology Guangxi UniversityNanning 530004China

Sustainable operation of implanted medical devices is essential for clinic ***,limited battery capacity is a key challenge for most implantable medical electronics[1].Higher-capacity battery is not an ideal choice,because battery capacity is usually linearly dependent on battery volume[2].New energy harvesters have been developed as promising alternative solutions,which extracted energy from the ambient environment and biosystem for powering implantable devices[3],However,the energy reclaimed from body and ambient environment also have power lim让ation,such as thermal gradient and bioelectric *** ultrasound or RF energy into the body and generate electrical power by a converter is a reliable solution.

关键词： battery power ambient

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