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Signal Transduction and Targeted Therapy 2022年第11期7卷 3987-3988页

作者： Maik Luu Alexander Visekruna Lehrstuhl für Zelluläre Immuntherapie Medizinische Klinik und Poliklinik IIUniversitätsklinikum WürzburgWürzburgGermany Institute for Medical Microbiology and Hygiene Philipps-UniversityMarburgGermany

In a recent study published in Nature,Delaunay and colleagues demonstrate that tRNA modifications in mitochondria have the potential to affect the synthesis of mitochondrial proteins involved in oxidative phosphorylation(OXPHOS),which drives the invasive spread of cancer *** inhibition of one particular RNA-modifying enzyme was sufficient to prevent the cancer cell invasion and dissemination.

关键词： invasion metastasis cancer

Diphenyl methane laxatives do not induce electrolyte imbalance

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Open Journal of Gastroenterology 2013年第5期3卷 272-275页

作者： Stefan Müller-Lissner Department of Internal Medicine Park-Klinik Weissensee Schonstrasse Berlin

Aim: To analyse whether there are changes in sodium and potassium serum levels during chronic treatment with the diphenyl methanes bisacodyl and sodium picosulfate. Methods: A literature search was done using PubMed, and the reference lists of pertinent papers were screened for additional studies. Only studies of at least 4 weeks duration were considered for further analysis. Results: Four relevant studies were identified. In three randomised controlled trials with 5 to 10 mg daily of bisacodyl or sodium picosulfate, respectively, over four weeks no electrolyte losses were found. Hypokalemia was also not a problem in a group of patients with paraplegia using bisacodyl suppositories for 2 to 34 years. Conclusions: Electrolyte losses, particularly hypokalemia, are not a problem when bisacodyl or sodium picosulfate are used long-term.

关键词： Laxative Bisacodyl Sodium Picosulfate Hyponatremia Hypokalemia

Enchondromas of Long Bones and Other Skeletal Lesions Found Incidentally Need Critical Evaluation, But Rarely Systematic Follow-Up

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Open Journal of Orthopedics 2022年第2期12卷 66-78页

作者： G. Ulrich Exner Pascal A. Schai Nadja Mamisch-Saupe Michael O. Kurrer Orthopaedie Zentrum Zuerich Zuerich Switzerland Luzerner Kantonsspital Wolhusen Wolhusen Switzerland Radiologie klinik Hirslanden Klinik Hirslanden Witellikerstr Zuerich Pathologikum Gemeinschaftspraxis für Pathologie Seefeldstr Zuerich

Purpose: Incidental bone lesions are a challenge for the specialist, who has to give recommendations for further management. This review of our cases will assist in the decision whether the lesion can be “neglected”, needs further active follow-up or direct initiation of treatment. Patients and Methods: 153 cases of incidental bone findings were presented to our musculoskeletal tumor service for evaluation from July 2008 through June 2021. 73 of them were cartilaginous tumors and 63 of these were diagnosed as enchondroma of a long bone based on X-Ray and MRI. Results: Follow-up imaging of the enchondroma patients was available for 35 patients at 1 to 13 years (mean 4.3 y), with no change in size except for one femoral diaphyseal enchondroma with increasing diameter from age 18 to 20 years. 14 additional patients answered written contact stating that they remained asymptomatic at 2 to 12 years (mean 5.6 y). None of the patients has been reported to the Swiss Confoederation Cancer Registry to have developed malignancy. Among the 10 other cartilaginous tumors were one chondrosarcoma grade II exhibiting different imaging, 3 non-long-bone localizations (pelvis, scapula and rib), 2 Ollier-type enchondromas, and 2 osteochondromas. Incidental findings other than cartilaginous tumors were fibrous dysplasia (n = 31), non-ossifying fibroma (n = 31) and 18 other “sporadic” entities. Conclusions: Incidentally found enchondromas not exhibiting aggressive features need no systematic follow-up and patients can be “discharged” with the advice to present, if symptoms would develop. This also applies to fibrous dysplasia and the other sporadic lesions. 6 cases with other diagnoses needed specific treatment.

关键词： Incidental Bone Lesions Enchondroma Fibrous Dysplasia Non-Ossifying Fibroma

IN VIVO SOMATIC GENE TRANSFER WITH IkB AND TRUNCATED JUN DEPENDENCE OF TNF MEDIATED INTRAVASCULAR FIBRIN FORMATION ON NFkB AND AP-1

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Chinese Medical Journal 1995年第3期 82-82页

作者： Y Zhang Y Deng Th Luther M Muller B Chen R Ziegler PP Nawroth Medizinische klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt HeidelbergMedizinische Klinik I Universitdt Heidelberg

Recently it has been shown that induction of tissue factor (TF) by TNF in vitro is dependent on a concerted action of NFkB and AP-1. However it remains unknown, if TF can mediate intravascular fibrin formation and if NFkB and AP-1 are involved in intravascular fibrin formation in vivo. When mice with Meth-A sarcomas were injected with TNF; TF was expressed by vascular endothelium of the tumor,

关键词： TNF TF NFkB IN VIVO SOMATIC GENE TRANSFER WITH IkB AND TRUNCATED JUN DEPENDENCE OF TNF MEDIATED INTRAVASCULAR FIBRIN FORMATION ON NFkB AND AP-1 AP

Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population

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Journal of Geriatric Cardiology 2018年第9期15卷 559-566页

作者： Madeleine Eickhoff Stefanie Schupke Alexander Khandoga Julia Fabian Moritz Baquet David Jochheim David Grundmann Manuela Thienel Axel Bauer Hans Theiss Stefan Brunner Jorg Hausleiter Steffen Massberg Julinda Mehilli Department of Cardiology Munich University Clinic Ludwig-Maximilians University Munich Germany German Centre for Cardiovascular Research (DZHK) Partner Site Munich Heart Alliance Germany Deutsches Herzzentrum Miinchen Klinik fiir Herz- und Kreislauferkrankungen ISAResearch Center Munich Germany

Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. Methods SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention （PCI）： 463 patients ≥ 75 years and 868 patients 〈 75 years. Outcomes of interest were all-cause mortality at one and two years. Results A significant interaction of age and SYNTAX-score for mortality was observed at two-year （Pinteraction= 0.019） but not at one-year follow-up （Pinteraction= 0.594）. In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups （〈 75 years, hazard ratio （HR）： 1.43, 95% confidence intervals （CI）： 1.03-2.00, P = 0.034; and 〉 75 years, HR： 1.37, 95% CI： 1.01-1.85, P = 0.042）, but only two-year mortality among younger patients （〈 75 years, HR： 1.33, 95% CI： 1.01-1.76, P = 0.041; and ≥ 75 years, HR： 1.11, 95% CI： 0.87-1.41, P = 0.394）. SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients 〈 75 years （SYNTAX-score 〈 9, 3.8%; 9-20, 5.3%; 〉 20, 10.3%; P = 0.004） and 〉 75 years （SYNTAX-score 〈 11, 5.7%; 11-22.5, 16.1%; 〉 22.5, 18.7%; P = 0.003）, but two-year mortality only among patients 〈 75 years （SYNTAX-score 〈 9, 6.5%; 9-20, 7.6%; ≥ 20, 15%; P 〈 0.001） and not among ≥ 75 years old patients （SYNTAX-score 〈 11, 19.4%; 11-22.5, 26.3%; _〉 22.5, 27.9%; P = 0.138）. Conclusions Age modi- fies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients 〈 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients 〉 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate re

关键词： Age Mortality Percutaneous coronary intervention Syntax-score The elderly

CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection

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World Journal of Gastroenterology 2007年第31期13卷 4207-4213页

作者： Nina N Pawlowski Daniela Struck Katja Grollich Anja A Kühl Martin Zeitz Oliver Liesenfeld Jrg C Hoffmann Medizinische klinik I Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12200 Berlin Germany Institut für Mikrobiologie und Hygiene Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12203 Berlin Germany

To investigate whether bowel inflammation and/or parasite control is altered in the absence of the T cell adhesion molecule CD2.

关键词： CD2 IL-6 Ileitis Inflammatory bowel dis-ease Interferon-T Toxoplasma gondii

Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer

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World Journal of Gastroenterology 2006年第35期12卷 5635-5643页

作者： Michael Hpfner Andreas P Sutter Alexander Huether Viola Baradari Hans Scherübl Charité-Universittsmedizin Berlin Campus Benjamin Franklin Medical Clinic I Gastroenterology/Infectious Diseases/ Rheumatology Berlin Germany klinik für Gastroenterologie und Gastrointestinale Onkologie Vivantes-Klinikum Am Urban Dieffenbachstr. 1 Berlin 10967 Germany

AIM： To investigate the antineoplastic potency of the novel insulin-like growth factor 1 receptor （IGF-1R） tyrosine kinase inhibitor （TKI） NVP-AEW541 in cell lines and primary cell cultures of human colorectal cancer （CRC）. METHODS： Cells of primary colorectal carcinomas were from 8 patients. Immunostaining and crystal violet staining were used for analysis of growth factor receptor protein expression and detection of cell number changes, respectively. Cytotoxicity was determined by measuring the release of the cytoplasmic enzyme lactate dehydrogenase （LDH）. The proportion of apoptotic cells was determined by quantifying the percentage of sub-G1 （hypodiploid） cells. Cell cycle status reflected by the DNA content of the nuclei was detected by flow cytometry. RESULTS： NVP-AEW541 dose-dependently inhibited the proliferation of colorectal carcinoma cell lines and primary cell cultures by inducing apoptosis and cell cycle arrest. Apoptosis was characterized by caspase-3 activation and nuclear degradation. Cell cycle was arrested at the G1/S checkpoint. The NVP-AEW541-mediated cell cycle-related signaling involved the inactivation of Akt and extracellular signal-regulated kinase （ERK） 1/2, the upregulation of the cyclin-dependent kinase inhibitors p21^waf1/CIP1 and p27^kjp1, and the downregulation of the cell cycle promoter cyclin D1. Moreover, BAX was upregulated during NVP-AEW541-induced apoptosis, whereas Bcl-2 was downregulated. Measurement of LDH release showed that the antineoplastic effect of NVP-AEW541 was not due to general cytotoxicity of the compound. However, augmented antineoplastic effects were observed in combination treatments of NVP-AEW541 with either 5-FU, or the EGFR-antibody cetuximab, or the HMG-CoA-reductase inhibitor fluvastatin. CONCLUSION： IGF-1R-TK inhibition is a promising novel approach for either monoor combination treatment strategies of colorectal carcinoma and even for CRC chemoprevention.

关键词： Insulin-like growth factor receptor Tyrosine kinase Colorectal cancer Apoptosis Cell cycle arrest

EFFECTS OF ENDOTHELIN-1 RECEPTOR ANTAGONISTS BO123 AND BQ610

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Chinese Medical Journal 1995年第3期 72-72页

作者： H Han B Braeker S Neubauer G Ertl Medizinische Univ-klinik. Wurzburg Medizinische Univ-Klinik. WurzburgMedizinische Univ-Klinik. WurzburgMedizinische Univ-Klinik. Wurzburg

Using endothelin-1 (ET-1) antagonists BQ123 and BQ610. we tested whether endogenous ET-1 contributes to ischemia / re-perfusion injury in isolated. Langendorff rat hearts. BQ123 (7μg/min) and BQ610 (1.75μg/ min) did not affect mechanical function or coronary flow and shifted the dose-response curves for ET-1 (boluses of 4-400 pmol) significantly to the right. Isovolumic rat hearts were

关键词： BQ ET EFFECTS OF ENDOTHELIN-1 RECEPTOR ANTAGONISTS BO123 AND BQ610

Lipid lowering in patients 75 years and older

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World Journal of Cardiology 2021年第10期13卷 526-532页

作者： Umidakhon Makhmudova P Christian Schulze Harry R Davis Oliver Weingartner klinik fur Innere Medizin I Universitatsklinikum JenaJena 07747Germany Synergy Partners RD Solutions Synergy Partners RD SolutionsGaithersburgMD 20850United States

More than twenty years ago,knowledge about the importance of cholesterol absorption and the potential therapeutic effect of its inhibition led to the discovery and clinical application of the first and only cholesterol absorption inhibitor to date–*** then,ezetimibe has become a well-recognized player in lipid-lowering *** findings of IMPROVE-IT and EWTOPIA 75 imply that elderly patients over the age of 75 years in particular benefit from *** review summarizes the evidence,discusses the possible underlying pathophysiological mechanisms and calls for a change in future dyslipidemia guidelines.

关键词： Cholesterol Cholesterol absorption Cholesterol synthesis Ezetimibe Elderly

Endoscopic ultrasonography-guided endoscopic treatment of pancreatic pseudocysts and walled-off necrosis:New technical developments

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World Journal of Gastroenterology 2014年第43期20卷 16191-16196页

作者： Barbara Braden Christoph F Dietrich Translational Gastroenterology Unit Oxford University Hospitals NHS TrustOxford OX3 9DUUnited Kingdom Med.klinik 2 Caritas HospitalUhlandstr.797980 Bad MergentheimGermany

In the last decades,the treatment of pancreatic pseudocysts and necrosis occurring in the clinical context of acute and chronic pancreatitis has shifted towards minimally invasive endoscopic *** procedures can be avoided in many cases by using endoscopically placed,Endoscopic ultrasonography-guided techniques and *** ultrasound enables the placement of transmural plastic and metal stents or nasocystic tubes for the drainage of peripancreatic fluid *** development of selfexpanding metal stents and exchange free delivering systems have simplified the drainage of pancreatic fluid *** review will discuss available therapeutic techniques and new developments.

关键词： Pancreatic pseudocyst Walled-off necrosis Endoscopic ultrasonography-guided drainage Self-expanding metal stent Acute pancreatitis