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Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications

World Journal of Stem Cells 2016年第10期8卷 332-341页

作者： Miruna Mihaela Micheu Ana-Maria Rosca Oana-Claudia Deleanu Department of Cardiology Clinical Emergency Hospital of Bucharest 014461 Bucharest Romania Department of Regenerative Medicine “Nicolae Simionescu” Institute for Cellular Biology and Pathology 050568 Bucharest Romania “Carol Davila” University of Medicine and Pharmacy 050474 Bucharest Romania “marius nasta” institute of pneumophtisiology bucharest 050159 Bucharest Romania

Obstructive sleep apnea syndrome(OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment. In this context, the recent advances that were made in stem cell biology knowledge and stem cell- based technologies hold a great promise for various medical conditions, including respiratory diseases. However, the investigation of the role of stem cells in OSAS is still recent and rather limited, requiring further studies, both in animal models and humans. The goal of this review is to summarize the current state of knowledge regarding both lung resident as well as circulating stem/progenitor cells and discuss existing controversies in the field in order to identify future research directions for clinical applications in OSAS. Also, the paper highlights the requisite for inter-institutional, multi-disciplinary research collaborations in order to achieve breakthrough results in the field.

关键词： Obstructive sleep apnea syndrome Continuous positive airway pressure therapy Lung resident stem/progenitor cells Circulating stem/progenitor cells Lung homeostasis

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