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Altered Expression of Nicotinic Receptors in Perinatal Life Related to Prenatal Exposure to Toxics—An Overview of the research Carried Out on This Topic at the “lino rossi” research center of the Milan University

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Journal of Behavioral and Brain Science 2020年第10期10卷 420-431页

作者： Anna Maria Lavezzi “lino rossi” research center of the Milan University Milan Italy

The article aims to underline the impact of nicotine and pesticides on neuronal α7-nicotinic acetylcholine receptors expression in brainstem regions receiving cholinergic projections, given their fundamental role during the neuronal development. The in-depth histopathological/immunohistochemical examination of the autonomic nervous system performed at the “lino rossi” research center of the Milan University on a wide group of sudden unexpected fetal and infant deaths, highlighted the frequent hypodevelopment of brainstem structures checking the vital functions associated to altered expression of α7-nicotinic acetylcholine receptors and smoke absorption in pregnancy. A dysregulation of the catecholamine system was also observed in the cerebellar cortex of the same cases. However, in a not negligible percentage of sudden deaths with altered expression of α7-nicotinic receptors, the mothers never smoked but lived in rural areas. Specific analytical procedures showed the presence of agricultural pesticides in cerebral cortex samples of these victims. Therefore, it is possible to believe that the exposition to pesticides during pregnancy can produce the same harmful effects as nicotine on the nicotinic acetylcholine receptors. Moreover, alterations of α7-nicotinic acetylcholine receptors receptor expression were also detected in the lungs of many sudden perinatal death victims, allowing to consider even these findings as possible consequence of maternal exposure to toxic factors.

关键词： Nicotine Pesticides Endocrine Disruptor Compounds (EDCs) α7-Nicotinic Acetylcholine Receptors Neuropathology Sudden Infant Death Syndrome (SIDS) Sudden Intrauterine Unexplained Death (SIUDS)

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Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou Yan Shi Jing Xu Long Li Bin Shi Quansheng Ouyang Jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering research center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with lino_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes FillersLithium metal batteries

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具有增强界面稳定性的阻燃型电解液用于实际锂金属电池

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Science China Materials 2024年第3期67卷 804-815页

作者：寇骁航张娇龙李朝林李如宏阮挺婷王文辉 School of Materials Science and Engineering&research Institute of Interdisciplinary Science Dongguan University of TechnologyDongguan 523808China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhenShenzhen 518055China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou 310023China ZJU-Hangzhou Global Scientific and Technological Innovation center Zhejiang UniversityHangzhou 311215China

开发匹配高电压正极的锂金属电池是实现高能量存储系统的关键.因此,研发可以同时为锂金属负极和高电压正极产生稳定界面相的先进电解液非常必要.lino_(3)作为高效的固体电解质界面相添加剂被广泛应用于醚基电解液中,然而其在碳酸脂类电... 详细信息

开发匹配高电压正极的锂金属电池是实现高能量存储系统的关键.因此,研发可以同时为锂金属负极和高电压正极产生稳定界面相的先进电解液非常必要.lino_(3)作为高效的固体电解质界面相添加剂被广泛应用于醚基电解液中,然而其在碳酸脂类电解液中的低溶解性严重限制了其在高压锂金属电池中的应用.本文利用磷酸三甲酯助溶剂提高lino_(3)在碳酸乙基甲酯/氟代碳酸乙烯酯电解液中的溶解度,并赋予电解液阻燃性能.此外,通过添加双草酸硼酸锂(LiBOB)进一步提高正负极的界面稳定性.结果表明,该电解液对锂金属负极和高电压层状氧化物正极均具有较高的兼容性.在2.8–4.3 V电压范围内,Li||LiCoO_(2)和Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)电池在1.2 mA cm^(-2)电流密度下循环300周后的容量保持率分别为80.2%和84.2%.更令人惊喜的是,负/正极容量比为3.33的Li||NCM811电池在相同的充放电条件下循环150周后的容量保持率仍高达~80%.本论文对富含lino_(3)的阻燃型高压电解液的研究将为通过界面相调控研发安全的高比能锂金属电池提供理论指导.

关键词： Li metal anode high voltage cathode flame-retardant electrolyte solid electrolyte interphase

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Methemoglobinemia—A biomarker and a link to ferric iron accumulation in Alzheimer’s disease

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Advances in Bioscience and Biotechnology 2014年第1期5卷 12-18页

作者： Lucijan Mohorovic Anna M. Lavezzi Sanja Stifter George Perry Djulija Malatestinic Vladimir Micovic Eris Materljan Herman Haller Oleg Petrovic “lino rossi” research center Department of Biomedical Sur-gical and Dental Science University of Milan Milan Italy Department of Biology University of Texas at San Antonio San Antonio USA Department of Environmental Medicine University of Rijeka School of Medicine Rijeka Croatia Department of Family Medicine University of Rijeka School of Medicine Rijeka Croatia Department of Gynecology and Obstetrics University of Rijeka School of Medicine Rijeka Croatia Department of Pathology University of Rijeka School of Medi-cine Rijeka Croatia Department of Social Medicine and Epidemiology University of Rijeka School of Medicine Rijeka Croatia

Understanding the mechanism of oxidative stress is likely to yield new insights regarding the pathogenesis of Alzheimer’s disease (AD). Our earlier work focused on the difference between hemoglobin and methemoglobin degradation, respectively leading to ferrous (Fe2+) iron, or ferric (Fe3+) iron. Methemoglobin has the role of carrier, the donor of cytotoxic and redox-active ferric (Fe3+) iron, which can directly accumulate and increase the rate of capillary endothelial cell apoptosis, and may cross into the brain parenchyma, to the astrocytes, glia, neurons, and other neuronal cells (neurovascular unit). This supposition helps us to understand the transport and neuronal accumulation process of ferric iron, and determine how iron is transported and accumulated intracellularly, identifiable as “Brain rust”. Earlier research found that the incidences of neonatal jaundice (p = 0.034), heart murmur (p = 0.011) and disorders such as dyslalia and learning/memory impairments (p = 0.002) were significantly higher in those children born from mothers with methemoglobinemia. Our hypothesis suggests that prenatal iron abnormalities could lead to greater neuronal death, the disease ageing process, and neurodegenerative disorders such as AD and other neurodegenerative diseases.

关键词： Alzheimer’s Disease (AD) Apoptosis Blood-Brain Barrier (BBB) Brain Capillary Ferric Iron Deposition Hemoglobin and Methemoglobin Catabolism Neurodegenerative Brain Disease SIDS

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Unsuspected imported malaria in a case of sudden infant death

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World Journal of Clinical Infectious Diseases 2014年第2期4卷 5-8页

作者： Teresa Pusiol Anna Maria Lavezzi Ferdinando Radice Graziella Alfonsi Luigi Matturri Institute of Anatomic Pathology Rovereto HospitalRovereto (Trento) 38068Italy Department of Biomedical Surgical and Dental Sciences"Lino Rossi" Research CenterUniversity of MilanMilan 20122Italy

Here we describe the case of a 4-mo-old female who died suddenly without any apparent cause that was initially mistaken as a case of sudden infant death syndrome. Histologic observation of brain sections revealed blue-black bodies in erythrocytes of the blood vessels, suggestive of specific stages of the hematic schizogonic cycle. Further examinations revealed hemozoin and hemosiderin deposits in the parenchyma of all organs, leading to the diagnosis of malaria by Plasmodium falciparum(P. falciparum). The death occurred in Italy, the native country of the infant, two weeks after a Christmas holiday spent in Pakistan, the parents' birthplace, which has a high malarial endemicity. As this case demonstrates, the diagnosis of malaria should always be considered as a differential diagnosis in subjects, including infants, that die unexpectedly after returning from P. falciparum endemic areas.

关键词： Parasitemia Plasmodium falciparum Protozoa Sudden infant death Unsuspected imported malaria

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Simultaneous Multi-Wavelength Observations of the TeV Blazar Mrk 421 during February-March,2003:X-Ray and NIR Correlated Variability

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Chinese Journal of Astronomy and Astrophysics 2008年第4期8卷 395-403页

作者： Alok C. Gupta B. S. Acharya Debanjan Bose Varsha R. Chitnis Jun-Hui Fan center for Astrophysics Guangzhou University Guangzhou 510006 China Tata Institute of Fundamental research Homi Bhabha Road Colaba Mumbai - 400 005 India Aryabhatta research Institute of Observational Sciences （ARIES） Manora Peak Nainital - 263129India

We report the result of simultaneous multi-wavelength observations of the TeV blazar Mrk 421 during February - March 2003. We observed Mrk 421 using the Pachmarhi Array of Cerenkov Telescopes （PACT） of Tata Institute of Fundamental research at Pachmarhi, India. Other simultaneous data were taken from the literature and public data archives. We have analyzed the high quality X-ray （2-20 keV） observations from the NASA rossi X-Ray Timing Explorer （RXTE）. We obtained a possible correlated variability between X-ray and J band （1.25 μ） near infrared （NIR） wavelength. This is the first case of X-ray and NIR correlated variability in Mrk 421 or any high energy peaked （HBL） blazar. The correlated variability reported here indicates a similar origin for the NIR and X-ray emissions. The emission is not affected much by the environment of the surrounding medium of the central engine of Mrk 421. The observations are consistent with the shock-in-jet model for the emissions.

关键词： galaxies active - galaxies blazars general - galaxies blazars individual Mrk 421

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Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells

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World Journal of Gastroenterology 2009年第36期15卷 4499-4510页

作者： Wei-Hong Hou Lisa rossi Ying Shan Jian-Yu Zheng Richard W Lambrecht Herbert L Bonkovsky The Cannon research center and the Liver Digestive Disease and Metabolism Laboratory Carolinas Medical Center Charlotte NC 28203 United States The University of North Carolina Charlotte NC 28223 United States Richard W Lambrecht Department of Medicin e University of Connecticut Health Center Farmington CT 06030 United States Department of Molecular Microbial & Structural Biology University of Connecticut Health Center Farmington CT 06030 United States The Cannon research center and the Liver Digestive Disease and Metabolism Laboratory Carolinas Medical Center Charlotte NC 28203 United States The University of North Carolina Charlotte 28223 United States The University of North Carolina Chapel Hill NC 27514 United States Departments of Medicine and Molecular Microbial & Structural Biology University of Connecticut Health Center Farmington CT 06030 United States Department of Medicine of the University of Massachusetts Medical School Worcester MA 01655 United States

AIM： To investigate effects of iron on oxidative stress, heme oxygenase-1 （HMOX1） and hepatitis C viral （HCV） expression in human hepatoma ceils stably expressing HCV proteins. METHODS： Effects of iron on oxidative stress, HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction, and protein levels by Western blots. RESULTS： Iron, in the form of ferric nitrilotriacetate,increased oxidative stress and upegulated HMOX1 gene expression. Iron did not affect mRNA or protein levels of Bach1, a repressor of HMOXl. Silencing the up-regulation of HMOXl nuclear factor-erythroid 2-related factor 2 （Nrf2） by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOXl mRNA levels. These iron effects were completely blocked by deferoxamine （DFO）. Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90% and protein by about 50% in the Con1 full length HCV replicon cells, whereas DFO increased them. CONCLUSION： Excess iron up-regulates HMOXl and down-regulates HCV gene expression in hepatoma cells. This probably mitigates liver injury caused by combined iron overload and HCV infection.

关键词： Deferoxamine Core protein of hepatitis Cvirus Hepatitis C Iron Heme oxygenase-1 Nuclearfactor-erythroid 2-related factor 2 Bachl Oxidativestress Nonstructural 5A protein of hepatitis C virus

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Endoscopic ultrasound radiofrequency ablation of pancreatic insulinoma in elderly patients:Three case reports

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World Journal of Clinical Cases 2022年第19期10卷 6514-6519页

作者： Gemma rossi Maria Chiara Petrone Gabriele Capurso Stefano Partelli Massimo Falconi Paolo Giorgio Arcidiacono Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy Department of Pancreatic Surgery Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy

BACKGROUND Endoscopic ultrasound(EUS)-guided radiofrequency ablation(RFA)has recently been proposed as a local treatment for functional pancreatic neuroendocrine neoplasms in patients unfit for surgery,in order to obtain clinical syndrome *** on the safety and long-term effectiveness of this approach are scarce,and EUS-RFA procedures are not *** SUMMARY The present case series reports 3 elderly patients with a pancreatic insulinoma and comorbidities,locally treated by EUS-guided RFA with clinical success in terms of hypoglycemic *** procedures were performed during deep sedation,under EUS control with a 19 G needle,an electrode 5-mm in size at a power of 30 W and multiple RFA applications during the same session in order to treat the whole area of the *** relief of symptoms was evident in 2 patients after the first EUS-RFA,while in the third patient a second endoscopic treatment was *** 3 patients are symptom-free without need of medications after 24 mo of follow-up with imaging follow-up showing no disease recurrence.A single adverse event of intraprocedural bleeding occurred,which was successfully treated *** EUS-RFA represents an effective and safe alternative to surgery for the treatment of insulinomas in elderly patients at high surgical ***,larger multicenter studies withlonger follow-up are needed in order to better assess its safety and clinical success.

关键词： Endoscopic ultrasound Radiofrequency ablation Insulinomas Neuroendocrine neoplasms Ablative therapies Case report

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A high efficiency electrolyte enables robust inorganic–organic solid electrolyte interfaces for fast Li metal anode

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Science Bulletin 2021年第9期66卷 897-903,M0004页

作者： Feilong Qiu Siyun Ren Xueping Zhang Ping He Haoshen Zhou center of Energy Storage Materials&Technology College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional MaterialsNational Laboratory of Solid-State Microstructures and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Energy Technology research Institute National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba 3058568Japan

Developing a high-rate Li metal anode with superior reversibility is a prerequisite for fast-charging Li metal ***,the build-up of large concentration gradients under high current density leads to inhomogeneous Li deposition and unstable passivation layers of Li metal,resulting in lower Coulombic *** we report a concentrated dual-salts LiFSI-lino_(3)/DOL electrolyte to improve the high-rate performance of Li metal *** Li salts help passivate the fresh Li deposition ***,DOL contributes to the formation of flexible organic layers that can accommodate the rapid volume change of Li metal upon *** metal in the electrolyte remains stable over 240 cycles with the average Coulombic efficiency of 99.14%under a high current density of 8.0 mA cm^(-2).

关键词： Lithium metal anode Concentrated electrolyte Coulombic efficiency Edge effect

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Synthesizing an inorganic-rich solid electrolyte interphase by tailoring solvent chemistry in carbonate electrolyte for enabling high-voltage lithium metal batteries

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Journal of Energy Chemistry 2023年第7期82卷 475-483,I0010页

作者： Qiwen Ran Hongyuan Zhao Jintao Liu Lei Li Qiang Hu Fuquan Nie Xingquan Liu Sridhar Kormarneni School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Department of Ecosystem Science and Management and Materials research Institute 204 Energy and the Environment LaboratoryThe Pennsylvania State UniversityUniversity ParkPA 16802USA research center for Electrochemistry and Energy Engineering Henan Institute of Science and TechnologyXinxiang 453003HenanChina

High-voltage(>4.0 V)lithium metal battery(LBM)is considered to be one of the most promising candidates for next-generation high-energy ***,the commercial carbonate electrolyte delivers a poor compatibility with Li metal anode,and its organic dominated solid electrolyte interphase(SEI)shows a low interfacial energy and a slow Li^(+)diffusion *** this work,an inorganic LiF-Li_(3)N rich SEI is designed to enable high-voltage LBM by introducing nano-cubic LiF and lino_(3)into1 M LiPF_(6)ethylene carbonate(EC)/dimethyl carbonate(DMC)(v:v=1:1)***,the unique nano-cubic structure of as-synthetized LiF particles achieves its high concentration dissolution in carbonate electrolyte to enhance the interfacial energy of *** addition,tetramethylene sulfolane(TMS)is used as a carrier solvent to dissolve lino_(3)in the carbonate electrolyte,thereby deriving a Li_(3)N-rich *** a result,the as-designed electrolyte shows a high average Li plating/striping CE of 98.3%after 100 cycles at 0.5 m A cm^(-2)/0.5 mA h cm^(-2).Furthermore,it also enables the ultrathin Li(~50μm)‖LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM,4.4 mA h cm^(-2))full cell to deliver a high-capacity retention of 80.4%after 100 cycles with an outstanding average CE of 99.7%.Notably,the practical application prospect of the modified electrolyte is also estimated in LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)‖Li pouch cell with an energy density of 261.2 W h kg^(-1).This work sheds light on the internal mechanism of Li^(+)transport within the inorganic dominated SEI and provides a simple approach to stabilize the high-voltage LMBs.

关键词： Li metal battery Carbonate electrolyte Nano-cubic LiF lino_(3) Tetramethylene sulfolane

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