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Electron probe microanalysis оf experimentally stimulated osteoarthrosis in dogs

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World Journal of Orthopedics 2017年第9期8卷 681-687页

作者： Tatyana Stupina Michael Shchudlo Michael Stepanov Laboratory of Morphology FSBI Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics"

AIM To develop methods of articular cartilage preparation for X-ray-electron probe microanalysis and to study its elements content in experimental *** Twenty dogs aged 2-8 years were divided in research(aged 2 years, induction of osteoarthrosis-IOA) and intact group. Intact group included three subgroups(aged 2, 5 and 8 years). Samples of cartilage after araldite saturation and pouring were partially cut into semithin sections stained with methylene blue and with methylene blue-basic fuchsin. Their smooth surfaces were investigated by X-ray-electron probe microanalysis. Spatial distribution of sulfur, calcium and phosphorus and their concentrations(weight %) were *** X-ray electron probe microanalysis revealed non-uniformsulfur distribution in cartilage of intact animals: Its content increases from superficial zone to deep one, this regularity was preserved in animals with IOA. Differences of IOA with spontaneous chondropathy were revealed. Spontaneous aging was characterized by calcium and phosphorus storage in deep and calcified zones and compensatory increase of sulfated glycosaminoglycans in intermediate and deep cartilage zones as evidenced by the metachromatic reaction and microanalysis data. Unlike spontaneous chondropathy connected with aging in experimentally stimulated osteoarthrosis more intensive storage of calcium but minor phosphorus in intermediate zone were marked. In IOA the calcified cartilage thinning and osteoclastic resorption are apparent with few changes of elements composition; the only difference from control is minority phosphorus *** The obtained results demonstrate specific tricks of X-ray electron probe microanalysis and its possibility in the research of mechanisms of articular cartilage alterations in osteoarthrosis.

关键词： Osteoarthrosis Articular cartilage Dog X-ray electron probe microanalysis

Benefits of Ilizarov automated bone distraction for nerves and articular cartilage in experimental leg lengthening

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World Journal of Orthopedics 2017年第9期8卷 688-696页

作者： Nathalia Shchudlo Tatyana Varsegova Tatyana Stupina Michael Shchudlo Marat Saifutdinov Andrey Yemanov Laboratory of Morphology FSBI Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics"

AIM To determine peculiarities of tissue responses to manual and automated Ilizarov bone distraction in nerves and articular *** Twenty-nine dogs were divided in two experimental groups: Group M-leg lengthening with manual distraction(1 mm/d in 4 steps), Group A-automated distraction(1 mm/d in 60 steps) and intact group. Animals were euthanized at the end of distraction, at 30 th day of fixation in apparatus and 30 d after the fixator removal. M-responses in gastrocnemius and tibialis anterior muscles were recorded, numerical histology of peronealand tibialis nerves and knee cartilage semi-thin sections, scanning electron microscopy and X-ray electron probe microanalysis were *** Better restoration of M-response amplitudes in leg muscles was noted in A-group. Fibrosis of epineurium with adipocytes loss in peroneal nerve, subperineurial edema and fibrosis of endoneurium in some fascicles of both nerves were noted only in M-group, shares of nerve fibers with atrophic and degenerative changes were bigger in M-group than in A-group. At the end of experiment morphometric parameters of nerve fibers in peroneal nerve were comparable with intact nerve only in A-group. Quantitative parameters of articular cartilage(thickness, volumetric densities of chondrocytes, percentages of isogenic clusters and empty cellular lacunas, contents of sulfur and calcium) were badly changed in M-group and less changed in *** Automated Ilizarov distraction is more safe method of orthopedic leg lengthening than manual distraction in points of nervous fibers survival and articular cartilage arthrotic changes.

关键词： Limb lengthening Articular cartilage Nerve Histomorphometry Dog

Assessment of palmar subcutaneous tissue vascularization in patients with Dupuytren's contracture

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World Journal of Orthopedics 2018年第9期9卷 130-137页

作者： Nathalia Shchudlo Tatyana Varsegova Tatyana Stupina Tamara Dolganova Michael Shchudlo Nathalia Shihaleva Vadim Kostin Clinics and Experimental Laboratory for Reconstructive Microsurgery and Hand Surgery Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics" Laboratory of Morphology of Federal State Budget Institution Russian Ilizarov Scientific Center "Restorative Traumatology and Orthopaedics"

AIM To investigate the structural and functional characte-ristics of palmar hypodermal tissue vascularization in Dupuytren's contracture patients of different *** Eighty-seven Dupuytren's contracture patients underwent partial fasciectomy. Twenty-two of them were less than 55 years old(Y-group, n = 22); the others were 55 and older(O-group, n = 65). In surgically excised representative tissue samples, a histomorphometric analysis of the perforating arteries of the palmar aponeurosis and stereologic analysis of hypodermis vascularity were performed. The method of laser flowmetry estimated the microcirculation of the skin of the *** Frequency of cases with rapid development of contracture(less than 5 years) was 13.6% in the Y-group and 40% in the O-group, P < 0.05. The external and luminal diameters of perforating arteries in palmar fascia were decreased more severely in Y. The thickness of intima increased three times compared with healthy control, and the intima/media relation also increased, especially in O. Increased numerical and volumetric micro-vessel densities in hypodermis, percentage of large vessels(more than 12 μm in diameter), and percentage of vessels with signs of periadventitial inflammatory infiltration were noted in Y. The percentage of vessels with adventitial fibrosis was greater in O than in Y. Base capillary flow in Y was increased compared to healthy control subjects and to O, and peak capillary flow was increased in comparison with *** Compared to the O-group, Y-group patients exhibited more severe constrictive remodeling of palmar fascia perforating arteries supplying hypodermis but more expressed compensatory changes of its capillarization.

关键词： Dupuytren’s contracture Laser Doppler flowmetry Hypodermis Histo-morphometry Palmar fascia

Open wedge re-correction high tibial osteotomy in an elderly patient with a varus angulated non-united dome-shaped high tibial osteotomy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1054-1058页

作者： Steffen SCHROTER Lukas KONSTANTINIDIS Tobias M. KRAUS Fabian STUBY Ulrich STOCKLE Thomas FREUDE Department of traumatology and Reconstructive Surgery BG Trauma Center Department of orthopaedics and Trauma Surgery University Medical Centre Freiburg

The high tibial osteotomy(HTO)is a wellestablished and commonly used treatment for younger and active patients with a medial unicompartmental osteoarthritis of the knee and varus *** aim of this technique is to shift the load to a functional lateral compartment in order to delay total knee *** dome-shaped HTO was introduced by Blaimont et al.(1975)and later popularized by Maquet(1980).Out of 118 cases,96 cases of overcorrection,13 cases of undercorrection,and 9 cases

关键词： HTO MPTA high

Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

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World Journal of Diabetes 2022年第12期13卷 1140-1153页

作者： Yan-Jun Hu Chen-Sheng Song Nan Jiang Division of orthopaedics and traumatology Department of OrthopaedicsSouthern Medical University Nanfang HospitalGuangzhou 510515Guangdong ProvinceChina

Diabetes mellitus has become a global health problem,and the number of patients with diabetic foot ulcers(DFU)is rapidly ***,DFU still poses great challenges to physicians,as the treatment is complex,with high risks of infection,recurrence,limb amputation,and even ***,a comprehensive understanding of DFU pathogenesis is of great *** this review,we summarized recent findings regarding the DFU development from the perspective of single-nucleotide variations(SNVs).Studies have shown that SNVs located in the genes encoding C-reactive protein,interleukin-6,tumor necrosis factor-alpha,stromal cell-derived factor-1,vascular endothelial growth factor,nuclear factor erythroid-2-related factor 2,sirtuin 1,intercellular adhesion molecule 1,monocyte chemoattractant protein-1,endothelial nitric oxide synthase,heat shock protein 70,hypoxia inducible factor 1 alpha,lysyl oxidase,intelectin 1,mitogen-activated protein kinase 14,toll-like receptors,osteoprotegerin,vitamin D receptor,and fibrinogen may be associated with the development of ***,considering the limitations of the present investigations,future multi-center studies with larger sample sizes,as well as in-depth mechanistic research are warranted.

关键词： Diabetic foot Diabetic foot ulcer Diabetic foot osteomyelitis Single nucleotide variations Narrative review

Intraarticular injections(corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis

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World Journal of Orthopedics 2014年第3期5卷 351-361页

作者： Egemen Ayhan Hayrettin Kesmezacar Isik Akgun Department of orthopaedics and traumatology Mersin UniversityMersin 33110Turkey Kaktus Health center Is-tanbul 34394Turkey

Osteoarthritis(OA)is a complex"whole joint"disease pursued by inflammatory mediators,rather than purely a process of"wear and tear".Besides cartilage degradation,synovitis,subchondral bone remodeling,degeneration of ligaments and menisci,and hypertrophy of the joint capsule take parts in the *** is the hallmark symptom of OA,but the extent to which structural pathology in OA contributes to the pain experience is still not well *** the knee OA,intraarticular(IA)injection(corticosteroids,viscosupplements,blood-derived products)is preferred as the last nonoperative modality,if the other conservative treatment modalities are *** corticosteroid injections provide short term reduction in OA pain and can be considered as an adjunct to core treatment for the relief of moderate to severe pain in people with *** hyaluronic acid(HA)injections might have efficacy and might provide pain reduction in mild OA of knee up to 24 *** for HA injections,the costeffectiveness is an important concern that patients must be informed about the efficacy of these *** more high-quality evidence is needed,recent studies indicate that IA platelet rich plasma injections are promising for relieving pain,improving knee function and quality of life,especially in younger patients,and in mild OA *** current literature and our experience indicate that IA injections are safe and have positive effects for patient ***,there is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage.

关键词： Intraarticular injections Corticosteroid Hyaluronic acid Platelet rich plasma Knee osteoarthritis Viscosupplementation

Flexible healable electromagnetic-interference-shielding bioelastichydrogel nanocomposite for machine learning-assisted highlysensitive sensing bioelectrode

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Aggregate

Aggregate 2024年第5期5卷 220-232页

作者： Yunfei Zhang Zehui Li Zhishan Xu Mingyue Xiao Yue Yuan Xiaolong Jia Rui Shi Liqun Zhang Pengbo Wan College of Materials Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijingChina National center for orthopaedics Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijingChina

The prosperous evolution of conductive hydrogel-based skin sensors is attract-ing tremendous attention ***,it remains a great challenge to simultaneously integrate excellent mechanical strength,desirable electrical conduc-tivity,admirable sensing performance,and brilliant healability in hydrogel-based skin sensors for high-performance diagnostic healthcare sensing and wearable human-machine interface,as well as robust photothermal performance for promptly intelligent photothermal therapy followed by the medical diagnosis and superior electromagnetic interference(EMI)shielding performance for personal ***,aﬂexible healable MXene hydrogel-based skin sensor is prepared through a delicate combination of MXene(Ti_(3)C_(2)T_(x))nanosheets network with the polymeric *** as-prepared skin sensor is featured with signiﬁcantly enhanced mechanical,conducting,and sensing performances,along with robust self-healability,good biocompatibility,and reliable injectability,enabling ultrasensitive human motion monitoring and teeny electrophysiological signals *** a fron-tier technology in artiﬁcial intelligence,machine learning can facilitate to efﬁciently and precisely identify the electromyography signals produced by various human motions(such as variableﬁnger gestures)with up to 99.5%accuracy,afﬁrming the reliability of the machine learning-assisted gesture identiﬁcation with great poten-tial in smart personalized healthcare and human-machine ***,the MXene hydrogel-based skin sensor displays prominent EMI shielding performance,demonstrating the great promise of effective personal protection.

关键词： electromagnetic interference shielding healable hydrogel nanocomposite machine learning ultrasensi-tive human-interactive sensing

Ilizarov bone transport combined with the Masquelet technique for bone defects of various etiologies (preliminary results)

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World Journal of Orthopedics 2022年第3期13卷 278-288页

作者： Dmitry Y Borzunov Sergey N Kolchin Denis S Mokhovikov Tatiana A Malkova Department of Taumatology and Orthopedics Ural State Medical UniversityEkaterinburg 620109Russia Orthopaedic Department 4 Ilizarov National Medical Research Center for Traumatology and OrthopaedicsKurgan 640014Russia Department of Medical Information and Analysis Ilizarov National Medical Research Center for Traumatology and OrthopaedicsKurgan 640014Russia

BACKGROUND The Ilizarov bone transport(IBT)and the Masquelet induced membrane technique(IMT)have specific merits and shortcomings,but numerous studies have shown their efficacy in the management of extensive long-bone defects of various etiologies,including congenital *** their strong benefits seems a promising strategy to enhance bone regeneration and reduce the risk of refractures in the management of post-traumatic and congenital defects and nonunion that failed to respond to other *** To combine IBT and IMT for the management of severe tibial defects and pseudarthrosis,and present preliminary results of this technological *** Seven adults with post-traumatic tibial defects(subgroup A)and nine children(subgroup B)with congenital pseudarthrosis of the tibia(CPT)were treated with the combination of IMT and IBT after the failure of previous *** mean number of previous surgeries was 2.0±0.2 in subgroup A and 3.3±0.7 in subgroup *** 1 included Ilizarov frame placement and spacer introduction into the defect to generate the induced membrane which remained in the interfragmental gap after spacer *** 2 was an osteotomy and bone transport of the fragment through the tunnel in the induced membrane,its compression and docking for consolidation without *** outcomes were retrospectively studied after a mean follow-up of 20.8±2.7 mo in subgroup A and 25.3±2.3 mo in subgroup *** The“true defect”after resection was 13.3±1.7%in subgroup A and 31.0±3.0%in subgroup B relative to the contralateral *** completion of treatment,defects were filled by 75.4±10.6%and 34.6±4.2%,*** duration of external fixation was 397±9.2 and 270.1±16.3 d,including spacer retention time of 42.4±4.5 and 55.8±6.6 d,in subgroups A and B,*** infection was not *** complications were several cases of pin-tract infection and regenerate deformity in both *** regener

关键词： Ilizarov bone transport Induced membrane technique Post-traumatic tibial defect Congenital pseudarthrosis of the tibia Distraction osteogenesis Regeneration

Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification

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Journal of Materials Science & Technology 2024年第1期168卷 250-264页

作者： Xiaotong Zhao Jiali Hu Jingjun Nie Dafu Chen Gaowu Qin Erlin Zhang Key Lab.for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research center for Metallic Wires Northeastern UniversityShenyang 110819China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing 100035China

Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical *** the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface *** superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the *** gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against ***),owing primarily to direct contact sterilization of Cu_(2)O/*** most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control *** coating extract also signifi-cantly stimulated in vitro angiogenesis *** rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO *** of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.

关键词： Titanium-copper alloy Titanium-nitride-oxide(TiNxOy) Cu^(2+)release Antibacterial property Cell compatibility