检索结果-南通市图书馆

国际感染病学（电子版） 2014年第4期3卷 179-186页

作者： Min Li Ren-tian Cai Cheng-yu Huang Nanjing University of Aeronautics and Astronautics Shanghai Public Health Clinical Center Fudan University Chongqing infectious disease Medical Center

Objective To enhance the quality of medical service for Chinese patients through research of service quality from Chinese medical personnel. Methods Serv Qual scale was used for infection medical staffs randomly by sampling questionnaire in Beijing, Shanghai, Chengdu, Chongqing, Guangzhou and Nanning. The data collected were entered and analyzed using SPSS 20.0. Statistical methods included frequency, factor analysis, reliability analysis, correlation analysis, independent samples t test, one-way analyses of variance, simultaneous regression analysis and structural equation model analysis. Results The Kaiser-Meyer-Olkin value for the factor analysis of the scale was 0.970. The Cronbach's α for the reliability analysis was 0.975. The Pearson correlation coefficients were 0.624-0.874 and statistically significant. Undergraduates felt good, Ph D students felt bad; the doctors felt bad; managers felt good. Standard 5 dimensions of the regression coefficients were positive, including empathy(β = 0.288), reliability(β = 0.241) impacting on perceived service quality mostly. The control ability and stability of the standard error of perceived service quality directly effected value were 0.646 and 0.382, respectively. Conclusions Medical staffs of infectious disease department have poor perception of service quality. Hospitals should improve awareness and of clinicians and deepen the reform of the medical care system.

关键词： Structural equation models infectious disease department Perception of service quality

维普期刊数据库

Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 431-440页

作者： Lian Liu Danyan Zhang Rong Fan Shipeng Cheng Jichao Yang Liyan Ma Zhiyang Ling Yaguang Zhang Jinlin Hou Xiaomei Wang Bing Sun Junqi Niu Shanghai Institute of Biochemistry and Cell Biology Centre for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China department of infectious disease Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Med-X Institute Centre for Immunological and Metabolic DiseasesThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong UniversityXi’an 710061China Hepatology department Centre of Infectious Diseases and Pathogen BiologyFirst Hospital of Jilin UniversityChangchun 130021China

It is critical to assess the extent and progression of liver fibrosis for patients to receive suitable treatments,but its diagnostic methods remain *** matrix protein 1(ECM1)has previously been reported to be a key factor in the induction and progression of liver ***,little is known about the use of ECM1 as a biomarker to evaluate *** a CCl_(4)-induced mouse model of liver fibrosis,the present study demonstrated that ECM1 decreased with gradually increasing *** biopsy as a reference,the serum ECM1 levels decreased with increasing fibrosis stage in 247 patients with liver fibrosis,but there were no significant changes between fibrosis stage 2 and stage 0–*** improve the performance of ECM1,age,platelet count,and ECM1 concentration were combined to calculate an EPA(ECM1-platelet-age)score(ranging from 0 to 10).The areas under the receiver operating characteristic curve of the EPA scores for the detection of F≥2,F≥3,and F4 were 0.6801,0.7377,and 0.8083,respectively,which showed a comparable or significantly greater diagnostic performance for assessing fibrosis than that of the AST/ALT ratio,APRI score,or FIB-4 *** HBV patients following antiviral treatment,the dynamics of the EPA score depended on the status of liver fibrosis *** accuracy of the EPA score in predicting fibrosis regression and progression was 66.00%and 71.43%,respectively,while that of the LSM,another useful method for monitoring hepatic fibrosis changes during treatment,was only 52.00%and 7.14%,*** with healthy controls,there were lower levels of serum ECM1 in HBV patients and individuals with HCV infection,MAFLD,ALD,PBC,and *** findings suggested that individuals with reduced ECM1 levels may have a risk of developing liver injury,and further examinations or medical care are *** conclusion,the ECM1-containing EPA score is a valuable noninvasive test for staging fibrosis and predicting the progression of liv

关键词： ECM1 EPA score noninvasive biomarker dynamic liver fibrosis injury

维普期刊数据库

Hepatitis B core-related antigen as a promising serological marker for monitoring hepatitis B virus cure

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 18-28页

作者： Yue Qiu Qiao Tang Xiao-Qing Liu Yun-Ling Xue Yi Zeng Peng Hu department of infectious diseases Institute for Viral HepatitisThe Key Laboratory of Molecular Biology for Infectious DiseasesChinese Ministry of EducationThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Hepatitis B virus(HBV)infection is a global health *** current sequen-tial endpoints for the treatment of HBV infection include viral suppression,hepatitis B e antigen(HBeAg)seroconversion,functional cure,and covalently closed circular DNA(cccDNA)*** hepatitis B core-related antigen(HBcrAg)is an emerging HBV marker comprising three components:HBeAg,hepatitis B core antigen,and *** responds well to the transcriptional activity of cccDNA in the patient's liver and is a promising alternative marker for serolo-gical *** is a strong correlation,and a decrease in its level corresponds to sustained viral *** patients with chronic hepatitis B(CHB),serum HBcrAg levels are good predictors of HBeAg seroconversion(both spontaneous and after antiviral therapy),particularly in HBeAg-positive *** low baseline HBcrAg levels and decreasing levels early in antiviral therapy favored HBsAg seroconversion,which may serve as a good surrogate option for treatment *** this review,we summarize the role of serum HBcrAg in the treat-ment of ***,long-term continuous monitoring of serum HBcrAg levels contributes to the clinical management of patients with CHB and optimizes the choice of treatment regimen,making it a promising marker for monitoring HBV cure.

关键词： Hepatitis B Hepatitis B core-related antigen Hepatitis B surface antigen Hepatitis B virus DNA Covalently closed circular DNA Hepatitis B virus cure

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong Gong Min Zhang department of infectious diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and department of infectious diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)^(+)CD8^(+)T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5^(+)CD8^(+)T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×10^(4) copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8^(+)T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5^(+)CD8^(+)T cells compared to healthy controls(P<0.01).Notably,CXCR5^(+)CD8^(+)T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 level

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Construction of a lightweight, bispecific human antibody based on the bovine nano knob domain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第3期 877-879页

作者： Siling Wang Yizhen Wang Xiuting Chen Wenling Jiang Zheng Chen Huixian Shang Zhiyong Li Zizheng Zheng Ningshao Xia State Key Laboratory of Vaccines for infectious diseases Xiang An Biomedicine Laboratory Department of Laboratory Medicine School of Public Health Xiamen University National Institute of Diagnostics and Vaccine Development in infectious diseases State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine Research NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology School of Public Health School of Life Sciences Xiamen University department of Laboratory Medicine The First Affiliated Hospital of Xiamen University

Dear Editors,Bispecific antibodies (bsAbs), which possess the unique ability to bind to two different antigens simultaneously (Labrijn et al., 2019), have emerged as powerful tools in the field of cancer immunotherapy and pathogen prevention. Their design and production are of great significance, as they can enhance the effectiveness of targeted therapy by improving the accuracy and efficiency of attacks against multiple targets.

关键词：

同方期刊数据库

Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunctionassociated steatohepatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 178-182页

作者： Guo-E Gou Ting Li Chen-Rui Liu Ting Meng Ya-Ping Li department of infectious diseases Xi'an Jiaotong University Second Affiliated HospitalXi’an 710004Shaanxi ProvinceChina

Helicobacter pylori(***)infection is a known inducer of various gastroin-testinal diseases,including gastritis,gastric ulcers,and gastric ***,in recent years,research on the potential association between *** infection and metabolic dysfunction-associated steatohepatitis(MASH)has been *** large-scale multicenter study,covering more than 360 hospitals across 26 medical systems in the United States,systematically evaluated the association between *** infection and *** paper reviews the innovative aspects of this study,discusses its significance in the current research field of *** and liver diseases,analyzes potential molecular mechanisms,and suggests future research directions and therapeutic prospects.

关键词： Helicobacter pylori Metabolic dysfunction-associated steatohepatitis Gut-liver axis Insulin resistance

Gut microbiota in cancer initiation,development and therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Ruyi Zhang Xiang Zhang Harry Cheuk Hay Lau Jun Yu Institute of Digestive disease and department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

Cancer has long been associated with genetic and environmental factors,but recent studies reveal the important role of gut microbiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific microorganisms *** microbiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish microecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut microbiota may help manage side effects of cancer *** research is crucial to understand better how gut microbiota can be used to improve cancer prevention and treatment outcomes.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu department of Infection disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Innovative diagnostic tool aids screening for minimal hepatic encephalopathy in non-alcoholic cirrhosis patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 5-7页

作者： Ting Li Ya-Ping Li department of infectious diseases The Second Affiliated Hospital of Xi'an Jiaotong University(Xibei Hospital)Xi'an 710004Shaanxi ProvinceChina

In this editorial we comment on the article by Jiang et *** focus on the Ence-phalApp Stroop test which is an innovative,smartphone-based tool specifically designed for screening minimal hepatic encephalopathy(MHE)in cirrhosis *** MHE screening methods,while highly sensitive and specific,are often complex,time-consuming,and require controlled environmental con-ditions,limiting their widespread clinical *** EncephalApp Stroop test si-mplifies the screening process,enhances diagnostic efficiency,and is applicable across diverse cultural ***,the combination of additional bio-markers could further improve diagnostic *** its promising po-tential,more multicenter clinical studies are required to validate its effectiveness and applicability on a global scale.

关键词： EncephalApp Stroop test Minimal hepatic encephalopathy Cirrhosis biomarkers Diagnostic

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

维普期刊数据库