检索结果-南通市图书馆

有机化学 1999年第4期19卷 356-363页

作者：贾兰齐江焕峰中国科学院广州化学研究所广州510650

γ-氨基丁酸(GABA)类似物有着强烈而有趣的生理活性,有些已应用于中枢神经系统疾病的临床治疗。综述了近二十几年以来γ-氨基酸类似物的不同合成方法。

关键词： γ-氨基丁酸类似物合成氨基丁酸 GABA

nduced pluripotent stem cell （iPSCs） and their application n immunotherapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2014年第1期11卷 17-24页

作者： Zhengping Jiang Yanmei Han Xuetao Cao National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University Shanghai China

The ever-improving technology to generate induced pluripotent stem cells （iPSCs） has increased their potential use as novel candidates for disease modeling, drug screening, regenerative medicine and cell therapy. Indeed, iPSCs offer extensive capacity for self-renewal without the ethical concerns faced by embryonic stem cells （ESCs）. With respect to potential applications in the immune system, many studies provide evidence to support that there are exclusive advantages to using iPSCs over other systems. Both hematopoietic stem cells and several types of mature immune cells have successfully been reprogrammed to iPSCs and vice versa, paving a path toward our ability to effectively model patient-specific diseases and provide potentially alternative cell sources for transfusion medicine. Despite these potential advances, some limitations regarding the use of iPSCs in the clinic still remain, including the immunogenicity of iPSCs and their derivatives, which is currently under debate in the field. In this review, we mainly focus on discussing the recent progress being made in the latest differentiation methods and clinical implications of iPSCs with respect to the immune system. Additionally, current issues regarding the clinical application of iPSCs are addressed, especially the controversy surrounding immunogenicity, along with various other perspectives.

关键词： differentiation hematopoietic cell immunogenicity immunotherapy induced pluripotent stem cells

Afterword to varicocele and male infertility： curreni concepts and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第2期18卷 319-322页

作者： Sandro C Esteves Ashok Agarwal ANDROFERT Center for Male Reproduction Av.Dr. Heitor Penteado 1464 Campinas SP 13075-460Brazil American Center for Reproductive Medicine Cleveland Clinic 10681 Carnegie Avenue X-11Cleveland OH 44195 USA.

We summarize and comment on the topics discussed by the contributors to this Special Issue of Asian Journal of Andrology. The scope of varicocele covers a wide spectrum, including proteomics and metabolomics, hormonal control, interventional therapy, and assisted reproductive technology （ART）. The selection of topics demonstrates the exciting breadth of this thematic area and the opportunity research holds for both increasing the understanding and improving the reproductive health of males with varicocele.

关键词： @@

Buddy Study: Partners for better health in adolescents with type 2 diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2015年第18期6卷 1355-1362页

作者： Allison C Sylvetsky Radha Nandagopal Tammy T Nguyen Marisa R Abegg Mahathi Nagarur Paul Kaplowitz Kristina I Rother Section on Pediatric Diabetes and Metabolism NIDDKNational Institutes of Health Department of Exercise and Nutrition Sciences the George Washington University Division of Endocrinology Children’s National Medical Center

AIM: To investigate whether assigning young, healthy and motivated lay volunteer partners("buddies") to adolescents with type 2 diabetes improves hemoglobin A1c(HbA 1c). METHODS: Adolescents with type 2 diabetes were randomized to partnering with a "buddy" or to conventional treatment. During the initial screening visit, which coincided with a routine outpatient diabetes clinic visit, patients with type 2 diabetes underwent a physical examination, detailed medical history, laboratory measurement of HbA 1c, and completed two questionnaires(Pediatric Quality of Life Inventory and Children's Depression Inventory) to assess their overall quality of life and the presence of depressive symptoms. Patients were then randomized to the intervention(the buddy system) or conventional treatment(standard care). All patients were scheduled to return for followup at 3- and 6-mo after their initial visit. Hb A1 c was determined at all visits(i.e., at screening and at the 3- and 6-mo follow-up visits) and quality of life and depressive symptoms were evaluated at the screening visit and were reassessed at the 6-mo visit. RESULTS: Ten adolescents, recruited from a pool of approximately 200 adolescents, enrolled over a twoyear time period, leading to premature termination of the study. In contrast, we easily recruited motivated lay volunteers. We found no change in HbA 1c from the initial to the 6-mo visit in either group, yet our small sample size limited systematic assessment of this outcome. Participants repeatedly missed clinic appointments, failed to conduct self-glucose-monitoring and rarely brought their glucometers to clinic visits. Total quality of life scores(72.6 ± 6.06) at screening were similar to previously reported scores in adolescents with type 2 diabetes(75.7 ± 15.0) and lower than scores reported in normal-weight(81.2 ± 0.9), overweight(83.5 ± 1.8), and obese youths without diabetes(78.5 ± 1.8) or in adolescents with type 1 diabetes(80.5 ± 13.1). Among adolescents who

关键词： Diabetes mellitus type 2 Quality of life Adolescent Hemoglobin A1c Social support

辅助生殖门诊泌尿生殖道支原体感染及耐药性分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国卫生检验杂志 2014年第21期24卷 3165-3167页

作者：泰淑红王鹏徐豪施志欣郑州大学第三附属医院(河南省妇幼保健院)检验科河南郑州450052

目的了解本地区辅助生殖门诊泌尿生殖道支原体感染及耐药状况。方法收集2012年7月-2013年6月在本院生殖中心就诊并检测支原体的样本共2 223例(女性610例,男性1 613例),分析感染率及药敏结果。结果辅助生殖门诊病人支原体阳性率为33.47%... 详细信息

目的了解本地区辅助生殖门诊泌尿生殖道支原体感染及耐药状况。方法收集2012年7月-2013年6月在本院生殖中心就诊并检测支原体的样本共2 223例(女性610例,男性1 613例),分析感染率及药敏结果。结果辅助生殖门诊病人支原体阳性率为33.47%,女性(50.82%)高于男性(26.91%)。感染构成,单纯Uu感染90.32%;单纯Mh感染1.08%,混合感染8.6%。药敏显示单独Uu感染的耐药情况较混合感染及单独Mh感染时轻,四环素类抗生素对绝大多数支原体敏感。结论在辅助生殖门诊就诊并检测支原体的女性约1/2支原体阳性,男性约1/4支原体阳性,Uu是主要致病菌。四环素类抗生素作为首选用药,但在治疗时还应同时结合抗生素药敏结果调整用药。

关键词：辅助生殖门诊解脲脲原体人型支原体感染率耐药性

在线全文

学校读者我要写书评

暂无评论

从大气下陷论治慢性病经验举隅

中华中医药杂志 2012年第6期27卷 1596-1598页

作者：范逸品曹洪欣中国中医科学院基础理论研究所北京100700

慢性病具有起病隐匿、病因复杂、反复发作、迁延难愈等特点。随着社会发展、环境因素及生活方式的变化,慢性病已逐渐成为威胁人类健康的首要原因。文章叙述了大气和大气下陷概念及病机特点,提出大气下陷与慢性病密切相关,以病毒性心肌... 详细信息

慢性病具有起病隐匿、病因复杂、反复发作、迁延难愈等特点。随着社会发展、环境因素及生活方式的变化,慢性病已逐渐成为威胁人类健康的首要原因。文章叙述了大气和大气下陷概念及病机特点,提出大气下陷与慢性病密切相关,以病毒性心肌炎后遗症与进行性肌营养不良治疗为例,证实了从大气下陷论治慢性病的疗效并分析了益气升陷法的优势作用。

关键词：慢性病大气下陷益气升陷临床应用

Application of Kaiser Sepsis Calculator in culture-positive infants with early onset sepsis

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2021年第4期17卷 429-433页

作者： Gretchen Kopec Marc Collin Anirudha Das Department of Neonatology University of Illinois College of MedicinePeoria campusPeoriaUSA Department of Neonatology MetroHealth Medical CenterClevelandUSA Department of Neonatology Cleveland Clinic Children’s Hospital9500 Euclid AvenueClevelandOH44195USA

Background Kaiser Sepsis Calculator(KSC)reduces antibiotic use,testing and intravenous infiltrates but there are concerns about the missed early onset sepsis(EOS)*** sought to apply the KSC score for culture-positive infants retrospectively in infants born in the last 10 years in our *** In a retrospective cohort study,the comparison groups were divided into Group A(no antibiotics recommended by KSC)and Group B(antibiotics recommended).Results Overall,17/24(71%)infants would have been started on antibiotics per KSC but 7/24(29%)would *** initial EOS risk was not significantly different between the groups(Group A *** B:0.44 vs.0.76,P=0.41),but the final risk score was(0.33 vs.9.41,P<0.001).In Group A(no antibiotics),3/7 infants became symptomatic between 9 and 42 *** There may be a potential delay in starting antibiotics in infants that are asymptomatic at birth while using KSC.

关键词： Early onset sepsis EOS Kaiser Sepsis Calculator Neonatal sepsis Neonate Newborn Blood culture

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小檗碱的药理研究及临床应用

中国医院药学杂志 1991年第12期11卷 538-539页

作者：谢义明同济医科大学附属同济医院武汉430003

小檗碱通过竞争性阻断α-肾上腺能受体增强心房收缩力,起到抗心律失常和降血压的作用;通过促进胰岛β细胞修复和增生,使胰岛素释放增加,同时抑制糖元异生,和(或)促进糖酵解,产生降血糖的作用,通过抗胃肠道粘膜细菌感染治疗溃疡性胃肠道... 详细信息

小檗碱通过竞争性阻断α-肾上腺能受体增强心房收缩力,起到抗心律失常和降血压的作用;通过促进胰岛β细胞修复和增生,使胰岛素释放增加,同时抑制糖元异生,和(或)促进糖酵解,产生降血糖的作用,通过抗胃肠道粘膜细菌感染治疗溃疡性胃肠道炎。因此,小檗碱临床应用前景广泛。

关键词：小檗碱药理临床应用

Advances in murine models of breast cancer bone disease

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 158-177页

作者： Penelope D.Ottewell Michelle A.Lawson Department of Oncology and Metabolism Mellanby Centre for Bone ResearchUniversity of SheffieldSheffield S102RXUK

Bone is the most prevalent metastatic site for breast cancer affecting~70%of patients with late-stage *** for this condition currently focus on controlling disease progression and limiting tumour-induced damage to bone,thereby playing a valuable role in increasing quality of ***,limited understanding of the interplay between tumour cells and their environment during bone metastasis has impeded the development of curative *** unravel the complex genetic and phenotypic alterations that occur during this process,it would be helpful to have a model in which tumours develop spontaneously at the primary site,spread to bone,undergo a dormancy phase and then,after a fixed timeframe,become re-activated to form osteolytic/mixed lesions in the *** humans,spontaneous metastasis of primary mammary tumours to bone is rare in mice and no syngeneic models of oestrogen receptor positive disease have been *** there is no single model that authentically reproduces all of the genetic and phenotypic changes representative of human bone metastasis,this review discusses the traditional and novel mouse models that are used to study bone metastasis from breast ***,this review focuses on advances that have been made towards making these models more closely related to human disease in an attempt to help researchers select the correct model(s)for their experimental needs with the aim of improving translational efficacy between the laboratory and the clinic.

关键词： Breast cancer bone metastasis mouse models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meet Guest Editor

Asian Journal of Andrology 2024年第6期26卷 F0002-F0002页

Urology from 1989,and a specialist in Microsurgery and Experimental surgery from *** May 1995 to February 2005,*** served as the Assistant in Urology at the Urological clinic,University of Trieste(Trieste,Italy).He did the different training periods abroad in 1992,1994,2000 and 2004,respectively,for learning in laparoscopic *** 2005 to 2015,he was Associate Professor at the University of Trieste;and from 2015 to 2020,he holds the same role at the Urological clinic.

关键词： surgery holds techniques.