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New rat to mouse xenograft transplantation of endometrium as a model of human endometriosis

Animal Models and Experimental Medicine 2021年第3期4卷 268-277页

作者： Amir Abdolmaleki Cyrus Jalili Kamran Mansouri Mitra Bakhtiari Department of Anatomical Sciences Faculty of MedicineKermanshah University of Medical SciencesKermanshahIran Medical Biology Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshahIran

Background:Endometriosis can lead to *** there is no definitive treat-ment for endometriosis,animal modelling seems necessary to examine the possible *** endometrium cannot be separated for endometriosis *** addition,transplantation of uterus into the abdominal viscera to induce endometriosis causes organ *** this study,we defined a new model of en-dometriosis leading to separability of endometrium and a safe anatomical region for ***:Forty female mice were allocated to 5 groups:1,sham;2,allograft uterus transplantation of mice to anterior abdominal wall of mice;3,allograft uterus trans-plantation of mice to mesentery of mice;4,xenograft endometrial transplantation of rat to anterior abdominal wall of mice;5,xenograft endometrial transplantation of rat to mesentery of *** female rats with a previous pregnancy experience were selected and placed in the vicinity of male rats for 2 weeks to induce estrogen secre-tion and increase endometrial ***:In the 4th group of animals,compared to sham,the peritoneal concentrations of VEGF-A,TNF-α,NO,MDA,and serum levels of CA-125 and IL-37 were increased and total body weight was decreased,while weight and size of endometrial lesions were increased significantly(Pxenograft transplantation of endometrium from rat to anterior abdomi-nal wall of mice can potentially mimic human endometriosis morphologically,histo-logically,and genetically.

关键词： endometriosis endometrium mice rat xenograft transplantation

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