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Dyslipidemia and H pylori in gastric xanthomatosis

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World Journal of Gastroenterology 2007年第34期13卷 4598-4601页

作者： Sun Young Yi Department of Internal Medicine School of Medicine Ewha Womans University Seoul 158-710 South Korea

AIM： To investigate the relationship among gastric xanthomatosis （GX）, Hpylori, dyslipidemia, and gastritis in Korea, a well-known Hpylori endemic area.METHODS： A total of 771 patients who had undergone gastroduodenoscopy by one endoscopist were included in this study. Among them, 54 patients with GX were assessed for Hpylori infection and their endoscopic characteristics and serum lipid profiles. The findings were compared with 54 age- and sex-matched control subjects without GX.RESULTS： The prevalence of GX was 7% （54/771） with no sex difference. GX was mainly single （64.8%） and located in the antrum （53.7%）. The mean diameter was 7 ± 3 mm. Mean body mass index （BMI） of patients with GX was 23.1 ± 2.8 and no one was above 30. Compared with the controls, lipid profiles of GX group showed significantly lower HDL-cholesterol （48.8 ± 12.3 vs 62.9 ± 40.5, P = 0.028） and higher LDL-cholesterol （112.9 ± 29.9 vs 95.9 ± 22.4, P = 0.032）. The level of total serum cholesterol, triglyceride and the existence of dyslipoproteinemia were not related to the presence of GX. However, GX showed a close relationship with endoscopically determined atrophic gastritis and histologic severity （24/53, 44.4% vs 8/54, 14.8%, P = 0.0082）. H pylori infection and bile reflux gastritis were not significantly related with GX.CONCLUSION： The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but lip, H pylori infection is not.

关键词： xanthomatosis Dyslipidemia H pylori Gastritis

Enlarged cauda equina nerve roots in Cerebrotendinous xanthomatosis

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Open Journal of Clinical Diagnostics 2011年第3期1卷 26-28页

作者： Peter Kalina 不详

CXT is a rare inherited autosomal recessive lipid storage disease due to the impaired metabolic pathway of cholesterol secondary to a deficiency in 27- sterol hydroxylase, an enzyme in the synthesis of chenodeoxycholic acid (CDCA), a primary bile acid. Abnormal bile acid synthesis leads to elevated plasma Cholestanol (a derivative of cholesterol) accumulation, especially in the lens, central nervous system (CNS) and tendons.

关键词： Cerebrotendinous xanthomatosis Cauda Equina Peripheral Neuropathy

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Chinese Journal of Traumatology 2001年第4期4卷 234-238页

作者：陈县城吴文乔沈洪武余水成 Department of Pathology Zhangzhou Municipal Hospital Zhangzhou 363000 China

Objective: To investigate the pathogenesis, exact nature, histologic feature of xanthogranulomatous interstitial nephritis (XGIN) as well as its significance in clinical medicine. Methods: The medical histories concerned were collected with diagnostic images including CT scanning, ultrasonography, intravenous urography (IVU) and laboratory data being synthesized by comparison with what was discovered during operations and pathologic examinations. Results: All patients were ever struck on their loins or backs by blunt violence over 4-12 years. The diseases were clinically diagnosed as “renal cancer” before, during and after operations, and treated with radical nephrectomy. Located at cortical parts, the tumor focus had penetrated the renal capsules and invaded other organs. However, immunohistochemistry demonstrated that the lesions were xanthogranulomas, not tumors, in which there were stacks of foam cells and lymphocytes with vast extends of fibrotic tissues obliterating the cortical interstitial structures. Urinary tracts yielded no bacterium, obstruction or calculus. Conclusions: XGIN is likely to be one kind of immunologic mediated granuloma following blunt renal trauma. It is imperative to clarify pathogenesis and character of this lesion so as to find out any approach to diagnosis and cure of such an unusual nephropathy.

关键词： Nephritis, interstitial xanthomatosis

Tumor biomarkers： help or mislead in the diagnosis of xanthogranulomatous cholecystitis？-analysis of serum CA 19-9,carcinoembryonic antigen, and CA 12-5

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Chinese Medical Journal 2013年第16期126卷 3044-3047页

作者： YU Hong YU Tu-nan CAI Xiu-jun Department of General Surgery Sir Run Run Shaw Hospital Schoolof Medicine Zhejiang University Hangzhou Zhejiang 310016China

Background Xanthogranulomatous cholecystitis （XGC） is a rare type of gallbladder *** other cholecystitis,it can be easily misdiagnosed as gallbladder cancer based on radiological *** response to misdiagnosis,extended surgical treatments are inappropriately given to patients,which is not beneficial to their health and/or *** this study,we set out to determine whether tumor biomarkers can help to avoid misdiagnosis in patients with *** Between January 2005 and January 2012,a total of 37 preoperative patients at Sir Run Run Shaw Hospital were suspicious of having gallbladder cancer and was pathologically confirmed to be XGC after surgical *** operations,all patients received a tumor biomarker test to verify diagnosis,which included serum CA 19-9,carcinoembryonic antigen （CEA）,and CA *** A measured amount （54.05％） of cases （20 in 37） had at least one elevation over the thresholds of CA 19-9 （37 IU/L）,CEA （5 ng/ml）,and CA 12-5 （35 IU/L）,which increased the suspicion of malignancy and consequently enhanced the difficulty to make right diagnosis of XGC as benign.45.95％ of cases （17 in 37） had an elevation in CA 19-9.2.70％of cases （one in 37） had an elevation in CEA and 24.32％ of cases （nine in 37） had an elevation in CA *** with Fisher＇s exact test discovered that the presence of common bile duct stone was a contributor to elevations of CA19-9 in patients with ***,even in cases without common bile duct stones,42.86％ of patients （nine in 21） had elevations of at least one tumor *** them,26.09％ of patients （six in 21） had elevations of CA 19-9,with the maximum of 536.29 IU/*** The elevations of tumor biomarkers in XGC were frequent,suggesting their inabilities to clarify the disease＇s nature,especially when there was a suspicion of gallbladder *** frozen pathology of gallbladder might be a possible ***,it is against the en bloc surgical principl

关键词： xanthomatosis CA 19-9 antigen gallbladder neoplasms