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Verruciform xanthoma of the penis:report of a case

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Chinese Medical Journal 2004年第1期117卷 150-152页

作者：夏同礼李贵忠那彦群郭应禄 Institute of Urology First HospitalPeking University

Verruciform xanthoma, a rare and benign lesion that was first described by Shafer1 in 1971, occurs mainly in the oral mucosa, but extra-oral involvement includes the vulva,2,3 scrotum,4,5 penis,6-15 anal region16 and extremities.17,18 With sessile or pedunculated growth this lesion is small, asymptomatic, yellow-brown or red-orange in color, and flat. Clinically, verruciform xanthoma is likely to be misdiagnosed as papillomas and occasionally as verrucous or squamous cell carcinoma. It has a benign course and good prognosis. We report a case of verruciform xanthoma that occurred in the penis, a very rare location.

关键词： xanthoma penis histology

Bilateral Achilles Tendon xanthoma in an 18-Year-Old Patient

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Open Journal of Orthopedics 2017年第4期7卷 110-116页

作者： S. K. Venkatesh Gupta B. Sahithya S. P. Prashanth Department of Orthopaedics Mamata Medical College Khammam Telangana India

Background: xanthomas are rare, non-neoplastic lesions which occur due to defect in the LDL receptors leading to their accumulation in tendons and synovium. The prevalence of heterozygous familial hypercholesterolaemia (HFH) is approximately 1 in 500. Aim: To study a rare case of bilateral achilles tendon xanthoma and its functional outcome. Case Presentation: We presented a case of xanthoma over posterior aspect of both lower third legs just above the heel in an 18-year-old female, and diagnosis was confirmed by clinical examination ultrasound and MRI, for which subtotal resection was planned and further followed up. Postoperative treatment consisted of six weeks long leg cast immobilization. After 10 weeks the patient started walking without any difficulties. Conclusion: Subtotal resection of achilles tendon xanthoma has given a good functional outcome. There is no need for reconstruction of tendon in every case.

关键词： Achilles Tendon xanthoma Low Density Lipoprotein Magnetic Resonance Imaging Ultrasound

Histopathological, Immunohistochemical and Exfoliative Cytological Studies of Oral Verruciform xanthoma

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Open Journal of Stomatology 2014年第9期4卷 435-440页

作者： Tadahiko Utsunomiya Takashi Matsumoto Miyuki Morikawa Masaaki Suemitsu Hidekuni Tanaka Yasuto Ota Takaaki Saito Hirotsugu Yamamoto Kayo Kuyama Department of Diagnostic Pathology Nihon University Hospital at Matsudo Matsudo Japan Department of Oral Pathology Nihon University School of Dentistry at Matsudo Matsudo Japan Nihon University Tokyo Japan

Verruciform xanthoma is a rare tumor-like lesion, predominantly affecting the oral mucosa. Although several studies of verruciform xanthoma have been reported, the characteristic features and pathogenesis have not been fully clarified. The purpose of the present study is to perform immunohistochemical analysis using markers of proliferative cell activity and cytokeratins, and to perform comparative analysis between cytological and histological features in order to clarify the characteristic features of verruciform xanthomas. Histological findings showed exophitic proliferation of stratified squamous epithelium and accumulation of foamy macrophages between epithelial processes. Immunohistochemically, accumulated foamy cells showed positive immuno-reactivity for CD68, and positive cells were also present in the epithelium. Expression of pancy-tokeratin was observed in most layers of the epithelium, whereas cytokeratin 13 was also detected in prickle cell layers. Positive reactivity for Ki-67 was observed in epithelial cell nuclei. Positive reactivity was largely distributed in basal and/or parabasal cell layers, and the positive cell rate was 20%. In addition, exfoliative cytological findings showed hyperkeratotic epithelial cells with picnosis, thus suggesting the characteristics of hyperplastic epithelium in verruciforma, although foamy cells were not observed in the cytological specimens. These results suggest that benign morphological characteristics with local cellular immune response of verruciform xanthoma may be evaluated based on immunohistochemical expression of cytokeratin and Ki-67, as well as exfoliative cytological findings.

关键词： Oral Verruci Form xanthoma Histopathology Immunohistochemistry Exfoliative Cytology

Bilateral Tibial xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature

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International Journal of Clinical Medicine 2012年第3期3卷 234-237页

作者： Vallabhaneni Kalyan Chakravarthi E. Aruna Damera Naveen Chandra Rao Diddi Ranga Rao Department of Pathology Dr.PSIMS & RF Chinna Avutapalli India.

xanthoma of bone is a rare benign bone disorder. It radiologically presents as a lytic lesion, often with cortical expansion or disruption, mimics primary bone tumors and metastatic lesions. Histopathological study gives the definitive diagnosis. xanthoma of bilateral tibia in a normolipidemic patient is rare and not yet reported in literature. Here with we present one such rare case, with review of literature.

关键词： xanthoma Normolipidic Tibia Lytic Lesion

Bilateral primary xanthoma of the humeri with pathologic fractures: A case report

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World Journal of Radiology 2013年第9期5卷 345-348页

作者： Sayed Ali Alex Fedenko Ali B Syed George Matcuk Dakshesh Patel Chris Gottsegen Eric White Department of Radiology Temple University Hospital Department of Pathology University of Southern California Keck School of Medicine Department of Radiology University of Southern California Keck School of Medicine

xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign,with a narrow zone of transition and a sclerotic *** report the case of a 57-year-old woman with hyperlipidemia presenting with bilateral shoulder pain after minor *** and histopathologic investigation demonstrated intraosseous xanthoma with atypical features,including multifocality,a wide zone of transition and pathologic fractures-characteristics more commonly associated with aggressive lesions such as multiple myeloma or *** diagnosis,imaging,and histological appearance of xanthoma of bone are reviewed.

关键词： xanthoma Hyperlipidemia Pathologic fracture

Giant xanthogranuloma of the pelvis with S1 origin: Complete removal with only posterior approach, technical note

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World Journal of Clinical Cases 2015年第1期3卷 77-80页

作者： Nicola Marotta Alessandro Landi Cristina Mancarella Pierluigi Rocco Andrea Pietrantonio Gaspare Galati Antonio Bolognese Roberto Delfini Department of Neurology and Psychiatry Division of NeurosurgeryPoliclinico Umberto I "La Sapienza" Università di Roma00161 Rome Italy Department of General Surgery "Pietro Valdoni" Policlinico Umberto I "La Sapienza" Università di Roma 00161 Rome Italy

Xanthogranulomas(XG) are benign proliferative disorder of histiocytes, a non-Langerhans cell histiocytosis. Whose etiology is unknown. The nature of these lesions is controversial and could be either reactive or neoplastic;the presence of monoclonal cells does, however, favor the second hypothesis. Xanthogranuloma is frequently found in young adults and children(under 20 years old), mainly in the skin. In about 5%-10% of all Juvenile XG(JXG) cases xanthogranuloma are extracutaneous. Within this group, the site most frequently involved is the eye. Other involved organs are heart, liver, adrenals, oropharynx, lung, spleen, central nervous system and subcutaneous tissue, although involvement of the spine is uncommon. Isolated lesions involving the sacral region are extremely rare. To date, this is the first reported case of a giant JXG arising from S1 with extension into the pelvic region in an adult spine.

关键词： Xanthogranulomas Non-Langerhans cell histiocytosis Touton giant cells Congenital xanthoma Neurofibromatosis

Cutaneous markers of coronary artery disease

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World Journal of Cardiology 2010年第9期2卷 262-269页

作者： Shridhar Dwivedi Rajat Jhamb Department of Medicine/Preventive Cardiology University College of Medical Sciences University of Delhi and G.T.B. Hospital Delhi 110095 India

Coronary artery disease (CAD) is rapidly increasing in prevalence across the world and particularly in south Asians at a relatively younger age. As atherosclerosis starts in early childhood, the process of risk evaluation must start quite early. The present review addresses the issue of cutaneous markers associated with atherosclerosis, and the strengths and weaknesses of the markers in identifying early coronary atherosclerosis. A diligent search for such clinical markers, namely xanthelasma, xanthoma, arcus juvenilis, acanthosis nigricans, skin tags, ear lobe crease, nicotine stains, premature graying in smokers, hyperpigmented hands in betel quid sellers, central obesity, and signs of peripheral vascular disease may prove to be a rewarding exercise in identifying asymptomatic CAD in high risk individuals.

关键词： Cutaneous markers Coronary artery disease xanthoma Arcus juvenilis Acanthosis nigricans Nicotine