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Virus profile in children with acute respiratory infections with various severities in Beijing, China

Chinese Medical Journal 2014年第21期127卷 3706-3711页

作者： Zhu Runan Song Qinwei Qian Yuan Zhao Linqing Deng Jie Wang Fang Sun Yu Laboratory of Virology Capital Institute of Pediatrics Beijing 100020 China

Background Acute respiratory infection （ARI） is one of the most common infectious diseases in infants and young children *** study aimed to determine the virus profile in children with ARI presenting with different *** Clinical specimens collected from children with ARI in Beijing from September 2010 to March 2011 were investigated for 18 respiratory viruses using an xtag respiratory viral panel fast （RVP fast） *** Pearson chisquare analysis was used to identify statistical *** Of 270 cases from three groups of ARI patients,including Out-patients,In-patients and patients in the intensive care unit （ICU）,viruses were detected in 176 （65.2％） specimens with the RVP fast *** viral detection rate from the Out-patients group （50.0％） was significantly lower than that from the In-patients （71.1％） and ICU-patients （74.4％） *** virus distribution was different between the Out-patients group and the other hospitalized groups,while the virus detection rate and distribution characteristics were similar between the In-patients and ICU-patients *** coinfection rates of the Out-patients group,the In-patients group,and the ICU-patients group were 15.6％,50.0％ and 35.8％,*** addition to respiratory syncytial virus （RSV） and adenovirus （ADV）,human rhinovirus （HRV） was frequently detected from children with serious illnesses,followed by human metapneumovirus （hMPV）,human bocavirus （HBoV） and *** virus 3 （PIV3） was detected in children with lower respiratory illness,but rarely from those with serious illnesses in the ICU-patient *** In addition to so-called common respiratory viruses,virus detection in children with ARI should include those thoucht to be uncommon respiratory viruses,especially when there are severe ARI-related clinical illnesses.

关键词： respiratory viruses acute respiratory infections co-infection children xtag respiratory viral panel fast assay

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