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Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

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Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

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