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Effect of cream, prepared with Tripterygium wilfordii Hook F and other four medicinals, on joint pain and swelling in patients with rheumatoid arthritis: a double-blinded, randomized, placebo controlled clinical trial

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Journal of Traditional Chinese Medicine 2019年第1期39卷 89-96页

作者： Jiao Juan Wei Chengchung Tang Xiaopo Gong Xun Yin Haibo Jiang Quan Department of Rheumatology Guang'anmen Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing 100053China Division of Allergy Immunology and RheumatologyChung Shan Medical University HospitalInstitute of MedicineChung Shan Medical UniversityGraduate Institute of Intergrated MedicineChina Medical UniversityTaichung 40201Taiwan China

OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Nalrii Sulfas), Chuanxiong(Rhizoma Chuanxiong), stir-frying with liquid adjuvant Ruxiang(Olibanum), and stir-frying with liquid adjuvant Moyao(Myrrh).METHODS: Patients were 1∶1 randomized to addon TwHF cream twice a day or placebo for 4 *** primary endpoint was achievement rate of20% improvement in American College of Rheuma-tology criteria(ACR20) at week 4. Secondary endpoints were ACR50, 28-joint count Disease Activity Score(DAS28) improvement and safety *** analyses were performed using intention to treat analysis(ITT) ***: A total of 70 active RA patients were enrolled. At week 4, the ACR20 was 34.3%(12/35) in TwHF cream group and 11.4%(4/35) in placebo group(P = 0.015). Similarly, a higher ACR50 responder proportion was seen in TwHF cream group with 17.1%(6/35) comparing to it in placebo group with 2.9%(1/35)(P = 0.046). The TwHF cream group also had more improvement than the placebo group on DAS28-ESR(1.1 vs 0.5, P = 0.001), DAS28-CRP(1.4 vs 0.7, P = 0.001), tender joint count(5.5 vs2.6, P = 0.018), swollen joint count(3.5 vs 1.6, P =0.003) and Physician's global assessment(25.8 vs13.0, P = 0.002), as well as C-reactive protein(11.2 vs 2.7, P = 0.048). Except 2 skin allergy events in TwHF cream group, no other substantive adverse events were ***: On the short term, TwHF cream is likely to be an effective and safety complimentary treatment in patients with active RA.

关键词： Tripterygium wilfordii Arthritis,rheumatoid External therapy Randomized controlled trial

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Tripterygium　wilfordii：　Structure，Chemistry　and　Activityof　Male　Antifertility　Constituents

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Journal of Reproduction and Contraception 1994年第2期5卷 245-254页

作者： SAMatlin ABelenguer VEStacey SZQian YXu JWZhang JKMSanders SRAmor CMPearc ChemistryDepartment WarwickUniversityCoventryUK DepartmentsofBasicMedicalResearchandPhytochemistry JiangsuFamilyPlanningInstituteNanjingPeople＇sRepublicofChina UniversityChemicalLaboratoryLensfieldRoadCambridge UK

ＴｒｉｐｔｅｒｙｇｉｕｍＷｉｌｆｏｒｄｉｉ：Ｓｔｒｕｃｔｕｒｅ，ＣｈｅｍｉｓｔｒｙａｎｄＡｃｔｉｖｉｔｙｏｆＭａｌｅＡｎｔｉｆｅｒｔｉｌｉｔｙＣｏｎｓｔｉｔｕｅｎｔｓＳＡＭａｔｌｉｎ；ＡＢｅｌｅｎｇｕｅｒ；ＶＥＳｔａ... 详细信息

ＴｒｉｐｔｅｒｙｇｉｕｍＷｉｌｆｏｒｄｉｉ：Ｓｔｒｕｃｔｕｒｅ，ＣｈｅｍｉｓｔｒｙａｎｄＡｃｔｉｖｉｔｙｏｆＭａｌｅＡｎｔｉｆｅｒｔｉｌｉｔｙＣｏｎｓｔｉｔｕｅｎｔｓＳＡＭａｔｌｉｎ；ＡＢｅｌｅｎｇｕｅｒ；ＶＥＳｔａｃｅｙ；ＳＺＱｉａｎ；ＹＸｕ；ＪＷ...

关键词： Tripterygium Antifertility Chemistry Constituents Male Structure Activityof wilfordii and

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United observation and analysis of the effect of tripterygium wilfordii on sex hormone levels, apoptosis in ovary and bone metabolism in female rats

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Journal of Hainan Medical University 2018年第14期24卷 5-8页

作者： Jie Liu Qian Zhang Ying Chen Rehabilitation Department the Sixth Affiliated Hospital of Xinjiang Medical UniversityUrumchiXinjiang830002 Department of Respiratory Medicine Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous RegionUrumchiXinjiang830000

Objective:To study the effect of tripterygium wilfordii on sex hormone levels, apoptosis in ovary and bone metabolism in female ***: Adult female SD rats were chosen as experimental animals and divided into model group and control group, model group were made into premature ovarian failure models through intragastric administration of tripterygium wilfordii, and control group were given intragastric administration of same dose of normal saline. Serum was collected 14 d after model making to determine the contents of sex hormones and bone metabolism markers, ovarian tissue was collected to determine the expression of apoptosis genes and tibial tissue was collected to determine the expression of bone metabolism marker ***: FSH, LH,β-CTX and TRACP5b levels in serum of model group were significantly higher than those of control group whereas E2, PINP and N-MID levels were significantly lower than those of control group;Fas, FasL, APAF-1 and Caspase-3 mRNA expression in ovarian tissue of model group were significantly higher than those of control group whereas Bcl-2 and XIAP mRNA expression were significantly lower than those of control group;RUNX2, BAP and OPG mRNA expression in bone tissue of model group were significantly lower than those of control group whereas RANKL and RANK mRNA expression were significantly higher than those of control ***:There are sex hormone changes, apoptosis aggravation in ovarian tissue and systemic bone metabolism disorder in rat model with tripterygium wilfordii-induced premature ovarian failure.

关键词： Premature ovarian failure Tripterygium wilfordii Sex hormone Apoptosis Bone metabolism

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The　Complementarity　of　Pharmacologic　Action　between　Tripterygium　wilfordii　and　Prednisone

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Chinese Journal of Integrative Medicine 1997年第2期3卷 97-97页

作者：胡大伟刘沛霖 Tongji Hospital Tongji Medical University Wuhan

Ｔｈｅ　Ｃｏｍｐｌｅｍｅｎｔａｒｉｔｙ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｉｃ　Ａｃｔｉｏｎ　ｂｅｔｗｅｅｎ　Ｔｒｉｐｔｅｒｙｇｉｕｍ　Ｗｉｌｆｏｒｄｉｉ　ａｎｄ　ＰｒｅｄｎｉｓｏｎｅＨＵＤａ－ｗｅｉ；ＬＩＵＰｅｉ－ｌｉｎ... 详细信息

Ｔｈｅ　Ｃｏｍｐｌｅｍｅｎｔａｒｉｔｙ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｉｃ　Ａｃｔｉｏｎ　ｂｅｔｗｅｅｎ　Ｔｒｉｐｔｅｒｙｇｉｕｍ　Ｗｉｌｆｏｒｄｉｉ　ａｎｄ　ＰｒｅｄｎｉｓｏｎｅＨＵＤａ－ｗｅｉ；ＬＩＵＰｅｉ－ｌｉｎ（ＴｏｎｇｊｉＨｏｓｐｉｔａｌ，Ｔ...

关键词： Tripterygium Pharmacologic Prednisone The Action wilfordii and between of

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Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity

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Chinese Journal of Natural Medicines 2020年第3期18卷 196-205页

作者： SHEN Qing-Qing WANG Jing-Jing ROY Debmalya SUN Li-Xin JIANG Zhen-Zhou ZHANG Lu-Yong HUANG Xin Jiangsu Key Laboratory of Drug Screening China Pharmaceutical UniversityNanjing 210009China Jiangsu Center for Pharmacodynamics Research and Evaluation China Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China Center for Drug Screening and Pharmacodynamics Evaluation School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China

With the internationally growing popularity of traditional Chinese medicine(TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephritis. Transporters in renal proximal tubule are believed to be critical in the disposition of xenobiotics. In this review, we provide information on the alteration of renal transporters by nephrotoxic TCMs, which may be helpful for understanding the nephrotoxic mechanism of TCMs and reducing adverse effects. Studies have proven that when administering nephrotoxic TCMs, the expression or function of renal transporters is altered, especially organic anion transporter 1 and 3. The alteration of these transporters may enhance the accumulation of toxic drugs or the dysfunction of endogenous toxins and subsequently sensitize the kidney to ***-related drug combination and clinical biomarkers supervision to avoid the risk of future toxicity are proposed.

关键词： Traditional Chinese medicine Nephrotoxicity Renal tubular epithelial cell Organic anion transporter Aristolochic acid Tripterygium wilfordii Hook.f. Rheum officinale Baill

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Triptolide, A Potential Autophagy Modulator

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Chinese Journal of Integrative Medicine 2019年第3期25卷 233-240页

作者： WEI Yan-ming WANG Yong-hui XUE Hui-qing LUAN Zhi-hua LIU Bi-wang REN Jin-hong Experimental Management Centre Shanxi University of Chinese Medicine

As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator.

关键词： triptolide autophagy apoptosis Tripterygium wilfordii Hook F

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老鹳草膏对佐剂性关节炎大鼠血清VEGF和TGF-β1表达的影响

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湖北农业科学 2014年第9期53卷 2111-2113页

作者：万永霞王汉海冯道俊山东省高校生物化学与分子生物学重点实验室/潍坊学院生物与农业工程学院山东潍坊261061

为观察老鹳草(Geranium wilfordii Maxim)膏对佐剂性关节炎(AA)大鼠模型血清细胞因子VEGF、TGF-β1含量的影响,探讨老鹳草对类风湿性关节炎的作用机理,试验将SD大鼠尾根部皮内注射完全弗氏佐剂(CFA)造模,将造模成功的AA大鼠随机分为3组... 详细信息

为观察老鹳草(Geranium wilfordii Maxim)膏对佐剂性关节炎(AA)大鼠模型血清细胞因子VEGF、TGF-β1含量的影响,探讨老鹳草对类风湿性关节炎的作用机理,试验将SD大鼠尾根部皮内注射完全弗氏佐剂(CFA)造模,将造模成功的AA大鼠随机分为3组,于第10天开始分别以生理盐水(模型对照组)、老鹳草膏(老鹳草膏组)和MTX(MTX组)处理各试验组,同时设置空白对照组。第45天乙醚麻醉后眼底采血、ELISA法检测血清中VEGF、TGF-β1的浓度。结果表明,与模型对照组和MTX组相比,老鹳草膏可显著降低AA大鼠血清异常升高的VEGF水平,提高血清TGF-β1含量。表明老鹳草可改善大鼠足关节状态,具有免疫调节功能,有助于机体恢复免疫稳定状态。

关键词：佐剂性关节炎老鹳草(Geranium wilfordii Maxim)膏细胞因子甲氨蝶呤

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雷公藤种子发芽特性研究

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湖北农业科学 2018年第A2期57卷 143-145页

作者：刘三波龚达林魏民张赟陈友丽喻芬王永聪马骏王学奎华润三九(黄石)药业有限公司湖北黄石435003 华润三九医药股份有限公司广东深圳518110 华中农业大学植物科学技术学院武汉430070

为研究雷公藤(Tripterygium. wilfordii Hook. f.)种子的发芽特性,观察雷公藤种子的外观性状及测定种子千粒重、净度、含水率、发芽率等指标,为雷公藤的种子繁育及规范化种植提供理论依据。雷公藤种子的长度明显大于宽度,长宽比接近3∶1... 详细信息

为研究雷公藤(Tripterygium. wilfordii Hook. f.)种子的发芽特性,观察雷公藤种子的外观性状及测定种子千粒重、净度、含水率、发芽率等指标,为雷公藤的种子繁育及规范化种植提供理论依据。雷公藤种子的长度明显大于宽度,长宽比接近3∶1,种子棕褐色,供试种子净度为98.4%,千粒重12.428 0 g,含水率为7.918%,平均发芽率为33.4%。果皮、浸泡时间、播种深度、播种基质等对种子发芽率的影响均显著。通过对雷公藤种子发芽特性的研究,发现雷公藤果皮对雷公藤种子具有萌发阻碍作用,播种前应该去除,而雷公藤种子播种前应浸泡12 h左右再进行播种,播种深度以3 cm为宜,不宜过浅或过深,土壤应选择沙质土壤进行播种,也可播种在营养土中,种苗长大后再移栽至大田种植。

关键词：雷公藤(Tripterygium. wilfordii Hook. f.) 种子千粒重种子性状

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雷公藤多苷药效机理及安全性研究概况

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安徽农业科学 2012年第30期40卷 14717-14718,14762页

作者：郝颖张兴国黎红佳扬言琛陈雨文西南交通大学中药研究所四川成都610031

雷公藤多苷具有抗炎、免疫调节及抗生育等作用,该文概述了雷公藤多苷的临床应用及其作用机理,同时总结归纳了其毒副作用和不良反应,为更安全和广泛的应用雷公藤多苷提供了理论和试验依据。

关键词：雷公藤(Tripterygium wilfordii Hook.f.) 多苷临床应用药效机理毒副作用

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