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Clinical and Laboratory Features, and quality of life Assessment in wheat Dependent Exercise-induced anaphylaxis Patients from central china

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第3期36卷 410-415页

作者：陈浩黄南李文静董翔祁姗姗王有娜刘光辉祝戎飞 Department of allergy Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

wheat dependent exercise-induced anaphylaxis（WDEIA） is a rare but potentially severe food allergy caused by the combination of wheat ingestion and physical exercise. The impact of WDEIA on quality of life（QOL） is unclear. This study characterized the clinical and laboratory features and investigated the QOL in WDEIA patients from central china. Twenty-eight WDEIA patients were analyzed, and QOL was measured by validated Chinese version Food allergy quality of life Questionnaire-Adult Form（FAQLQ-AF） and Food allergy Independent Measure（FAIM） after obtaining the diagnosis. The results showed that half of the patients were females. The median onset age was 37 years old. The symptoms occurred within 1 h after wheat ingestion（26/28）. Symptoms of anaphylaxis included cutaneous（26/28）, respiratory（11/28）, gastro-intestinal（5/28） and cardiovascular manifestations（27/28）. Skin prick tests were positive to salt soluble（89.3%） and salt insoluble wheat allergen extracts（100%）. Positive rate to wheat, gluten and omega-5 gliadin specific Ig E was 64.3%, 92.9% and 92.9% respectively. Specific Ig E to omega-5 gliadin with a cut-off value 0.83 KU/L offered highly efficient diagnostic criterion for WDEIA（sensitivity： 89.3%; and specificity： 88.9%）. The mean scores of FAQLQ-AF and FAIM were 4.70 and 4.98 respectively and level of anti-omega-5 gliadin Ig E had positive correlations with FAQLQ scores. Thereby, WDEIA is commonly found in mid-age adults. In most cases, multi-organs especially skin and cardiovascular systems are involved. Salt insoluble wheat allergen skin test and serum specific Ig E to gluten and omega-5 gliadin help to diagnose WDEIA. QOL in WDEIA patients is severely impaired.

关键词： wheat allergy anaphylaxis ige quality of life central china

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