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Exercise attenuates bone mineral density loss during diet-induced weight loss in adults with overweight and obesity:A systematic review and meta-analysis

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Journal of Sport and Health Science 2021年第5期10卷 550-559页

作者： Jakub Mesinovic Paul Jansons Ayse Zengin Barbora de Courten Alexander J.Rodriguez Robin M.Daly Peter R.Ebeling David Scott Department of Medicine School of Clinical Sciences at Monash HealthMonash UniversityClaytonVIA 3168Australia Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityBurwoodVIA 2134Australia School of Medical and Health Sciences Edith Cowan UniversityPerthWA 6027Australia Department of Medicine and Australian Institute of Musculoskeletal Science Melbourne Medical SchoolWestern CampusUniversity of MelbourneSt AlbansVIA 3021Australia

Background:weight-loss-induced fat loss improves cardiometabolic health in individuals with overweight and obesity;however,weight loss can also result in bone loss and increased fracture risk.weight-loss-induced bone loss may be attenuated with exercise.Our aim was to compare changes in bone mineral density(BMD)in adults with overweight and obesity who undertook diet-induced weight loss alone or in combination with exercise.Methods:We included randomized controlled trials(RCTs)in adults with overweight or obesity(aged-18 years;body mass index-25 kg/m^(2))that prescribed diet-induced weight loss alone or in combination with supervised exercise,and measured any bone structural parameters.Risk of bias was assessed using the Cochrane Risk of Bias tool.Random-effects meta-analyses determined mean changes and net mean differences(95%confidence intervals(95%CIs))in the percentage of areal BMD(aBMD)change between groups.Results:We included 9 RCTs.Diet-induced weight loss led to significant losses in femoral neck aBMD(mean change:-1.73%(95%CI:-2.39%to-1.07%),plosses were significantly greater in the diet-induced weight loss group compared to the exercise plus diet-induced weight loss group(net difference:-0.88%(95%CI:-1.73%to-0.03%));however,there were no differences in aBMD changes at any other skeletal site:total hip(-1.96%(95%CI:-4.59%to 0.68%))and lumbar spine(-0.48%(95%CI:-1.81%to 0.86%)).aBMD changes did not differ significantly according to exercise modality(resistance exercise,aerobic exercise,or a combination of the two)during diet-induced weight loss.Conclusion:Diet-induced weight loss led to greater femoral neck bone loss compared to diet-induced weight loss plus exercise.Bone loss at the total hip and lumbar spine was not attenuated by exercise during diet-induced weight loss.The lack of consistent skeletal benefits may be due to the insufficient duration and/or training intensities of most exercise interventions.Additional RCTs

关键词： Bone mass Exercise Obesity Overweight weight loss

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Does weight loss affect the center of pressure of children with obesity: a follow-up study

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Journal of Leather Science and Engineering 2022年第1期4卷 121-129页

作者： Linshan Zhang Shiyang Yan Ruoyi Li Weihua Dan Luming Yang National Engineering Research Center of Clean Technology in Leather Indus-try ChengduChina Key Laboratory of Leather Chemistry and Engineering(Sichuan University) Ministry of EducationChengduChina

Background:Children with obesity were found to show the greater postural instability compared to the normal-weighted children.However,it’s still unclear if their altered postural control ability would recover towards normal pat-tern after weight loss.The purpose of this study was to investigate the effect of weight loss on the center of pressure(COP)for obese children.Method:Totally 147 children were conducted a follow-up study in three years.A total number of 22 participants aged 7-13 years were recruited for their remission of obesity problem after 36 months.Their dynamic plantar pressure data were collected by Footscan pressure plate.The normalized time of four sub-phases,displacements and velocities of COP in anterior-posterior(AP)and medial-lateral(ML)directions were calculated to perform the Kolmogorov-Smirnov test and paired sample t test for statistical analyses.Results:After weight loss,children’s normalized time of forefoot contact phase(FFCP)increased significantly,and their duration of flat foot phase(FFP)decreased significantly.They also exhibited the more medial and posterior ori-entated COP path after weight loss.In ML-direction,the COP displacement during FFP and FFPOP increased,and the COP velocity during FFPOP increased.In AP-direction,COP velocity during FFP and FFPOP increased.Conclusions:The findings indicated that weight loss would have effects on the COP characteristics and postural stability for obese children.COP trajectory can provide essential information for evaluating foot function.The findings may be useful for obese children,medical staff,and healthcare physician.

关键词： weight loss Obesity Children Center of pressure Postural stability

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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains unexplored.AIM To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.METHODS The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work group.This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI.The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers.Patients with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were included.The index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation chemotherapy.This study evaluated associations between overall survival(OS),SIRI and weight loss.RESULTS A total of 50 patients were included.66%of these patients were male and the median age was 66 years.Metastasis sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple locations.Regarding the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI levels.This difference was statistically significant(P<0.000).For patients with a SIRI<2.3×10^(3)/L,those who did not

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index weight loss

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Analysis of weight loss, metabolism, and anti-reflux effect of sleeve gastrectomy combined with fundoplication as treatment of obesity complicated by gastroesophageal reflux disease

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Chinese Journal of Gastrointestinal Surgery 2024年第5期27卷 478-485页

作者： Li X. Aikebaier A. Aliyeguli A. Pierdiwasi M. Maimaitiaili M. Wang H. Yusujiang T. Adili M. Kelimu A. Graduate School Xinjiang Medical University Urumqi 830054 China Department of Minimally Invasive Hernia and Abdominal Surgery People's Hospital of Xinjiang Autonomous Region Urumqi 830011 China Institute of General Surgery and Minimally Invasive Surgery Xinjiang Uygur Autonomous Region Urumqi 830011 China Clinical Research Center for Gastroesophageal Reflux Disease and weight loss and Metabolic Surgery Xinjiang Uygur Autonomous Region Urumqi 830011 China

Objective To explore the weight-loss, metabolism, and anti-reflux effect of laparoscopic sleeve gastrectomy combined with fundoplication (SGFD) as treatment of obesity complicated by gastroesophageal reflux disease (GERD) with the aim of identifying the best treatment for such patients. Methods This was a retrospective cohort study. Relevant clinical data of 140 patients with obesity (body mass index≥30 kg/m2) complicated by GERD (confirmed by preoperative GerdQ score, gastroscope, upper gastrointestinal radiography, 24-hour pH monitoring of esophagus, and high-resolution esophageal manometry) who had undergone bariatric surgery in the Minimally Invasive Surgery, Hernia and Abdominal Surgery Department of the People's Hospital of Xinjiang Uygur Autonomous Region from January 2019 to February 2023 were collected. The participants were allocated to the following groups according to surgical procedure performed: sleeve gastrectomy group (SG group, 92 cases) versus SGFD (SGFD group, 48 cases). SGFD, a new type of anti-reflux weight loss surgery that achieves both anti-reflux and weight loss effects by a procedure involving "cutting first and then folding", was developed by our team. In this study, our main aim was to compare and analyze differences in outcomes between the SG and SGFD groups in terms of weight loss and improvements in metabolism and reflux 3 and 6 months postoperatively. Results The 140 patients comprised 50 men and 90 women of average age 36.0±9.6 years and preoperative body mass index (BMI) (38.5±6.5) kg/m2. The average preoperative GERD score was 10.2±1.6. There were no significant differences in baseline characteristics between the SGFD and SG groups (all P>0.05). There were also no significant differences in postoperative hospital stay, intraoperative blood loss, or postoperative complications between the two groups (all P>0.05). However, the operation time was longer in the SGFD than SG group (137.5±10.5 minutes vs. 105.3± 12.6 minutes, t= -15.131, P<0.001). Compared with preoperative values, fa

关键词： Anti reflux Fundopli-cation Gastroesophageal reflux disease Metabolism Obesity Sleeve gastrectomy weight loss

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Apatite formation and weight loss study in EDMed perforated AZ31 Mg-alloy

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Journal of Magnesium and Alloys 2017年第3期5卷 362-367页

作者： Randeep Singh Gill Kamal Kumar Uma Batra Department of Mechanical Engineering PEC University of TechnologyChandigarh 160012India Department of Materials and Metallurgy Engineering PEC University of TechnologyChandigarh 160012India

Porous structures are highly preferred for bone regeneration and high tissue in-growth.In present work,electrical discharge drilling(EDD),a thermal erosion process was used to produce through holes in Mg-alloys to fabricate perforated structure similar to open cell porous structure in extruded AZ31.Apatite formation and weight loss study was conducted for 7 days,14 days and 21 days after immersion tests in SBF solution.The perforated structure in AZ31 with 26 through micro-holes provides 72%increase in surface area but with marginally 4%higher weight loss as compare to non-perforated structure.Comparing perforated and non-perforated samples of Mg-alloy,it was well observed that perforated structure forms high volume of apatite as compared to non-perforated structure.Scanning electron microscopic(SEM)study revealed that in perforated structure,drilled holes retain their circularity after 21 days of immersion test and distinct corrosion phenomenon occur at localized sites.

关键词： Mg-alloys AZ31 Perforated structure Electrical discharge drilling Apatite formation weight loss

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Liver decompensation after rapid weight loss from semaglutide in a patient with non-alcoholic steatohepatitis -associated cirrhosis

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World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew Peverelle Jonathan Ng James Peverelle Ryan D.Hirsch Adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (NASH). remains a paucity of safety data in the vulnerable NASHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with NASHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver Disease-Na (MELD-Na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELD-Na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists weight loss

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weight loss and Gastrointestinal Symptoms in Advanced Cancer Patients Treated with Platinum-based Chemotherapy

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Journal of Nutritional Oncology 2020年第2期5卷 97-104页

作者： Hui Gao Dong Bo Liu Jin Tong Jing Han Bo Liu Si Xian Zhu Liu Huang Ying Yao Shi Ying Yu Qiang Fu Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Peripherally Inserted Central Venous Catheters(PICC) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective This study assessed the weight loss changes and gastrointestinal symptoms in patients with advanced tumors receiving platinum-containing chemotherapy.Methods We retrospectively reviewed 297 patients with advanced cancers[124 gastrointestinal(GI)cancer patients,119 lung cancer patients and 54 head and neck cancer(HNC)patients]receiving first-line chemotherapy at Tongji Hospital.The patients’changes in body weight,body mass index(BMI),and biochemical parameters(serum haemoglobin and albumin levels)were compared before and after two chemotherapy cycles.Results More than half[54.88%(163/297)]of the patients had experienced unintentional weight loss in the 6 months before chemotherapy,and weight loss≥5%and≥10%of the body mass was noted in 35.69%and 20.20%of the patients,respectively.After two cycles of platinum-based chemotherapy,the proportions of patients with a>5%reduction in body weight among patients with GI,lung,and head and neck cancers were 47.5%(59/124),44.53%(53/119),and 46.2%(25/54),respectively.The patients with GI and lung cancers were more vulnerable to extreme weight loss(≥10%)than those with HNC(P=0.025).The serum hemoglobin levels were also remarkably decreased relative to those before chemotherapy(all Pweight loss experienced anorexia and vomiting(OR=12.21 and 3.61,P=0.008 and 0.047,respectively).Conclusions For advanced cancer patients receiving platinum-based chemotherapy,the GI symptoms are the major factor related to their nutritional status.Appropriate nutritional screening,evaluation and treatment should be applied during the treatment of cancer in order to reduce GI symptoms and improve the patient’s nutritional status.

关键词： weight loss Platinum-based chemotherapy Gastrointestinal symptoms Hemoglobin

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Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic weight loss

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 230-238页

作者： Violeta B.Popov Joseph K.Lim Division of Gastroenterology New York University School of Medicine New York NY USA Yale Liver Center Section of Digestive Diseases Yale University School of Medicine New Haven CT USA

Nonalcoholic fatty liver disease (NAFLD) represents a rapidly growing cause of chronic liver disease in the United States and is associated with significant morbidity and mortality,including progression to liver cirrhosis and hepatocellular carcinoma.NAFLD comprises a spectrum of liver conditions,ranging from simple steatosis to steatosis with inflammation (steatohepatitis) and progressive fibrosis.weight loss represents a first line therapeutic modality for the management of NAFLD.Herein,we review the evidence base for medical,surgical,and endoscopic approaches to weight loss and their potential impact on the natural history of NAFLD.

关键词： Fatty liver Nonalcoholic steatohepatitis weight loss Exercise Pharmacotherapy Endoscopic therapy Bariatric surgery

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Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice

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Journal of Animal Science and Biotechnology 2012年第3期3卷 136-142页

作者： Keith N Haffer Braasch Biotech LLC 421 Rose AvenueGarrestonSD 570303-0430USA

The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity （DIO） model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations （JH17 ＆ JH]8） of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the week and food intake was measured weekly. At week 6 6 week study. Body weights were measured two times a mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 （IGF-1） were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JHI7 ＆ JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses （〉 1：500,000 titer）. IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates （mean 440.4 ng/mL） when compared with PBS controls （mean 365.6 ng/mL）. Vaccination with either JH17 or JH18 chimeric -somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls （P 〈 0.0001）, even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin antibodies at 6 weeks was correlative with the w

关键词： Obesity Treatment Vaccines weight loss weight management

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Effect of weight loss on In Vitro Fertilization Treatment Outcome

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Reproductive and Developmental Medicine 2017年第4期1卷 210-215页

作者： Jing-Yan Song Shan Xiang Zhen-Gao Sun Department of Gynecology of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanShandong 250011China Reproductive Medicine Center of Integration of Traditional and Western Medicine The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinanShandong 250011China

Background:To assess the effect of weight loss in overweight and/or obese women on the in vitro fertilization(IVF)treatment outcome before IVF cycles by a systematic review and meta-analysis of clinical trials.Methods:Systematic review and meta-analysis of randomized controlled trials(RCTs)and cohort studies were conducted.Systematic literature searches were conducted,and all randomized trials that evaluated the impact of weight loss in IVF treatment cycles were included in the study.Study selection,quality estimation,and data extractions were performed independently and in duplicate.Results:A total of 924 patients were enrolled in seven studies;the effects of weight loss on the IVF treatment outcome before the IVF treatment cycle were assessed.The clinical pregnancy rate(risk ratio[RR]:1.61,95%confidence interval[CI]:1.15-2.27),miscarriage rate(RR:0.56,95%CI:0.34-0.93),and live birth rate(RR:1.86,95%CI:1.41-2.45)had a statistically significant difference between the intervention and control group.No significant differences were observed in the number of oocytes retrieved(weighted mean difference[WMD]:0.84,95%CI:−0.12-1.79),gonadotropin consumption(WMD:2.59,95%CI:−6.61-1.42),or the duration of stimulation(WMD:−0.46,95%CI:−1.64-0.71).Conclusions:Before IVF treatment,obese and overweight women should lose weight by physical activity and/or dietary management because weight loss can improve pregnancy rate,reduce miscarriage rate,and meliorate live birth rate.At the same time,further prospective RCTs are required to establish which methods of weight loss are most suited to this purpose,as well as determining whether cut points for body mass index need to be recommended before accessing IVF.

关键词： Dietary Management In Vitro Fertilization Obesity weight loss

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