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Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

World Journal of Gastroenterology 2020年第43期26卷 6810-6821页

作者： Jing Hu Yu-Mei Zhang Yi-Fan Miao Lv Zhu Xiao-Lin Yi Huan Chen Xi-Jing Yang Mei-Hua Wan Wen-Fu Tang Department of Integrative Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Traditional Chinese Medicine Xiang’an Hospital of Xiamen UniversityXiamen 361101Fujian ProvinceChina Animal Experiment Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis(SAP).These two complications can both lead to water metabolism and acid-base balance disorders,which could act as additional critical factors affecting the disease ***(AQPs),which can regulate the transmembrane water transport,have been proved to participate in the pathophysiological process of SAP and the associated complications,such as acute lung injury and acute kidney ***,exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this *** To determine whether Yue-Bi-Tang(YBT)can regulate the water metabolism in rats with severe acute pancreatitis via regulating the expression of *** Sprague-Dawley rats were randomly divided into three groups,sham operation group(SOG),model group(MG),and treatment group(TG).SAP was induced with 3.5%sodium taurocholate in the MG and *** in the TG were administered with YBT while SOG and MG rats were given the same volume of *** and tissue samples were harvested to detect serum inflammatory cytokines,histopathological changes,malondialdehyde and superoxide dismutase in the lung,and protein and mRNA expression of kidney injury molecule-1,α-smooth muscle actin,and vimentin in the kidney,and AQP1 and 4 in the lung,pancreas,and *** The serum interleukin-10,tumor necrosis factorα,and creatinine levels were higher in the MG than in the *** necrosis factorαlevel in the TG was lower than that in the *** level in lung tissues was higher than in the *** pathological scores and edema scores of the pancreas,lung,and kidney tissues in the MG were all higher than those in the SOG and *** protein expression of AQP4 in lung tissues and AQP1 in kidney tissues in the MG were higher than those in the SOG and *** expression of vimentin was s

关键词： Yue-Bi-Tang Aquaporins Sever acute pancreatitis Acute lung injury Acute kidney injury water metabolism

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water metabolism from lung,spleen and kidney

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TMR Theory and Hypothesis 2021年第3期4卷 499-504页

作者： Di Zhang Bei Jing Shi-quan Chang Xing Li Hui-mei Shi Ya-chun Zheng Yu Wang Guo-ping Zhao School of Traditional Chinese Medicine Jinan UniversityGuangzhou China Songzi Hospital of Traditional Chinese Medicine Hubei China

water and liquid are the material basis of human *** Chinese medicine believes that water and liquid metabolism is a very complex process that requires the synergy of the internal organs,but mainly the physiological functions of the lungs,spleen and *** the function or structure of the spleen,lungs,kidneys,or triple-burner is abnormal,it is easy to cause abnormalities in the body's water metabolism,which in turn leads to the production of pathological products such as damp phlegm.

关键词： lung spleen kidney water metabolism

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Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China

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Journal of Arid Land 2014年第3期6卷 311-323页

作者： LiNa XIE ChengCang MA HongYu GUO QingFang LI YuBao GAO Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University College of Life Sciences Nankai University

There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area （SLA） decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency （WUE） increased significantly. In addition, with the intensification of climatic drought stress, peroxidase （POD） and superoxide dismutase （SOD） activities in leaves increased significantly. As a result, the malondialdehyde （MDA） cont

关键词： adaptation climatic gradient morphological trait osmotic potential water state water metabolism antioxidative enzyme

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