检索结果-南通市图书馆

An in situ-forming polyzwitterion hydrogel: Towards vitreous substitute application

Bioactive Materials 2021年第10期6卷 3085-3096页

作者： Binbin He Jianhai Yang Yang Liu Xianhua Xie Huijie Hao Xiaoli Xing Wenguang Liu School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science Eye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin300384China

Development of a biostable and biosafe vitreous substitute is highly desirable,but remains a grand challenge.Herein,we propose a novel strategy for constructing a readily administered vitreous substitute based on a thiol-acrylate clickable polyzwitterion macromonomer.A biocompatible multivinyl polycarboxybetaine(PCB-OAA)macromonomer is designed and synthesized,and mixed with dithiothreitol(DTT)via a Michael addition reaction to form a hydrogel in vitreous cavity.This resultant PCB-OAA hydrogel exhibits controllable gelation time,super anti-fouling ability against proteins and cells,excellent biocompatibility,and approximate key parameters to human vitreous body including equilibrium water content,density,optical properties,modulus.Remarkably,outperforming clinically used silicone oil in biocompatibility,this rapidly formed hydrogel in the vitreous cavity of rabbit eyes remains stable in vitreous cavity,showing an appealing ability to prevent significantly inflammatory response,fibrosis and complications such as raised intraocular pressure(IOP),and cataract formation.This zwitterionic polymer hydrogel holds great potential as a vitreous substitute.

关键词： Zwitterion Hydrogel Anti-fouling vitreous substitute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel approach for 25-gauge transconjunctival sutureless vitrectomy to evaluate vitreous substitutes in rabbits

引用

国际眼科杂志:英文版 2023年第10期16卷 1568-1573页

作者： Rui-Jin Ran Ting Wang Meng-Ying Tao Yue-Qin Gou Ming Zhang Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology Minda Hospital of Hubei Minzu UniversityEnshi 445000Hubei ProvinceChina

AIM:To improve the standard three-port vitrectomy for establishing and evaluating an endotamponade model in rabbits.METHODS:Three ports were prepared near the third eyelid of rabbits,and the infusion port was placed at the inferior nasal quadrant with the inserted cannula linking with a self-designed handheld rigid infusion catheter.All right eyes of rabbits underwent a modified 25-gauge vitrectomy and were subsequently filled with balanced salt solution,silicone oil,and eight-arm polyethylene glycols(8-arm PEGs)hydrogel separately for comparison.Ophthalmic examinations were performed regularly to record the changes after the surgery.RESULTS:Successful vitrectomy was achieved among 44 chinchilla rabbits.The mean operation time was 4.51±1.25min.Four eyes(9.1%)presented limited lens touch and two eyes(4.5%)showed retinal touch during surgery.Incision leakage was found in three eyes(6.8%)after surgery.There was no endophthalmitis,hemorrhage,or retinal detachment during the observation period and ophthalmic examinations after the implantation of vitreous substitutes.CONCLUSION:The modified technique of the standard vitrectomy applied in the endotamponade model in rabbits shows excellent safety and practicality.

关键词： surgical technique endotamponade model vitreous substitute three-port vitrectomy rabbit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

vitreous substitutes: challenges and directions

引用

International Journal of Ophthalmology(English edition) 2015年第3期8卷 437-440页

作者： Qian-Ying Gao Yue Fu Yan-Nian Hui State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Department of Ophthalmology Xijing Hospital the Fourth Military Medical University

The natural vitreous body has a fine structure and complex functions. The imitation of the natural vitreous body by vitreous substitutes is a challenging work for both researchers and ophthalmologists. Gases, silicone oil, heavy silicone oil and hydrogels, particularly the former two vitreous substitutes are clinically widely used with certain complications. Those, however, are not real artificial vitreous due to lack of structure and function like the natural vitreous body. This article reviews the situations, challenges, and future directions in the development of vitreous substitutes, particularly the experimental and clinical use of a new artificial foldable capsular vitreous body.

关键词： vitreous substitute artificial vitreous foldable capsular vitreous body silicone oil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：