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Prevalence of Charles Bonnet syndrome in low vision:a systematic review and meta-analysis

Annals of Eye Science 2022年第2期7卷 80-92页

作者： Yousif Subhi Mads Assenholt Nielsen Daniel Andrew Richard Scott Lars Morten Holm Amardeep Singh Department of Ophthalmology RigshospitaletGlostrupDenmark Department of Clinical Research University of Southern DenmarkOdenseDenmark Faculty of Health and Medical Sciences University of CopenhagenKøbenhavnDenmark Department of Ophthalmology Waikato District Health BoardHamiltonNew Zealand

Background:Charles Bonnet syndrome(CBS)is characterized by vivid lifelike visual hallucinations and is typically seen in individuals with visual *** this systematic review,we summarize current knowledge on the prevalence of CBS in patients with low ***:We searched 11 literature databases on 21 April 2021 for studies on the prevalence of CBS in low vision *** protocol was registered in the PROSPERO database(***42021255021).Eligible studies were defined as those on a population of low vision patients wherein the prevalence of CBS was evaluated(without any further restriction on the method for diagnosis of CBS).No restriction was enforced on study design,but we expected observational cross-sectional studies due to the nature of our research *** authors independently extracted data and evaluated risk of bias of individual studies using the Agency for Healthcare Research and Quality checklist for cross-sectional *** underwent qualitative review in the text and quantitatively in a prevalence meta-analysis using the random-effects *** analysis was made to evaluate the robustness of the summary ***:We identified 11 studies,which summarized data on 4,521 individuals with visual *** of CBS was based on screening questions or interviews,which in positive cases often was explored in more detail with follow-up questions or *** studies either had normal mental state as a participant eligibility criterion or as a part of the diagnosis of *** pooled prevalence of CBS in low vision patients aged≥40 years was 19.7%(95%CI:13.8%to 26.4%).The sensitivity analysis showed certain robustness in the summary prevalence estimate wherein prevalence estimates ranged from 16.9%to 22.5%.Conclusions:CBS is a prevalent condition in patients with low vision at a rate of approximately one in five *** that an estimated 239 million individuals have moderate visual im

关键词： Charles Bonnet syndrome(CBS) visual hallucinations low vision

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