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Effect of sequential nursing care combined with communication intervention on visual recovery and pain after cataract ultrasound emulsification

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World Journal of Clinical Cases 2024年第27期12卷 6087-6093页

作者： Jing-Cao Wang Qing Zhang Man-Rong Yu Yun-Xia Yang Hui-Min Jiang Department of Central Operating Room The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Ophthalmology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Cataracts are a common ophthalmic disease and postoperative vision recovery is crucial to patient quality of *** and efficient care models play an impor-tant role in promoting vision *** To evaluate the clinical effectiveness of procedural nursing care combined with communication intervention in vision recovery after cataract ultrasound *** A randomized controlled study was conducted on 100 patients with cataracts who underwent ultrasound emulsification *** were randomly assigned to an experimental group or a control *** experimental group received procedural nursing combined with Connect,Introduce,Communicate,Ask,Respond,Exit(CICARE)communication intervention,whereas the control group received conventional *** effectiveness of the nursing model was assessed by comparing differences in vision recovery,pain scores,and mental health status between the two *** It was found that over time the visual acuity of patients in both groups gradually recovered and patients in the experimental group had lower pain scores and superior mental health status than the control group(Pvision recovery in patients after cataract ultrasound emulsification.

关键词： Sequential nursing Communication intervention CICARE Cataract ultrasound emulsification vision restoration

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Optical delivery of multiple opsin-encoding genes leads to targeted expression and white-light activation

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Light(Science & Applications) 2015年第1期4卷 129-136页

作者： Kamal Dhakal Subrata Batabyal Weldon Wright Young-tae Kim Samarendra Mohanty Biophysics and Physiology Lab The University of Texas at ArlingtonArlingtonTXUSA NanoScope Technologies LLCArlingtonTXUSA Department of Bioengineering The University of Texas at ArlingtonArlingtonTXUSA

In photodegenerative diseases such as retinitis pigmentosa(RP)and age-related macular degeneration(AMD),progressive loss of vision occurs as a result of degeneration of the periphery of the retina and the macula,*** optogenetic stimulation-based approaches to vision restoration offer the advantages of cellular specificity,high resolution,and minimal invasiveness over electrode arrays;however,the clinical translation of optogenetic activation suffers from the lack of a method for the delivery of opsins into spatially targeted regions of a retina that has ***-targeted opsin delivery through viral or non-viral methods to non-photodegenerated retinal areas will perturb these already functioning retinal ***,viral methods are subject to limitations on the delivery of large plasmids,such as fusion constructs of multiple spectrally separated opsins(e.g.,channelrhodopsin-2(ChR2),chimeric opsin variants(C1V1),ReaChR),which can provide higher photo-excitability than can a single narrow-band opsin under ambient light ***,we report the ultrafast near-infrared laser-based spatially targeted transfection of single and multiple opsins and present a comparison with the opsin expression distribution achieved using another non-viral,but non-targeted,transfection method,*** evaluation of cells transfected with multiple opsins using the laser method revealed a significantly higher white-light-induced photocurrent than in cells expressing a single opsin(ChR2).The laser-assisted targeted delivery of multiple opsin-encoding genes to the peripheral retina/macula is ideal for sensitizing retinal areas that have degenerated,thus paving the way toward the restoration of lost vision in RP/AMD patients.

关键词： gene delivery optogenetics optoporation vision restoration

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