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Journal of Clinical and Nursing Research 2024年第4期8卷 243-247页

作者： Guohui Zhang Juan Xu Qiong Peng Yalei Xu Shaochang Ma Guandu People’s Hospital of Kunming Kunming 650200China

Objective: To analyze the correlation between visceral fat area and insulin resistance index (HOMA-IR) in patients with type 2 diabetes mellitus (T2DM) and abdominal obesity and to provide a reference for screening and related research of such patients. Methods: Two hundred patients with T2DM admitted to Guandu People’s Hospital of Kunming were included. The study was carried out from October 2022 to December 2023. The patients were divided into three groups according to different abdominal visceral fat areas (VFA): Group A (n = 65) was less than 75cm2, Group B (n = 75) was 75-100 cm2, and Group C (n = 60) was greater than 100 cm2. The subjects in the three groups were all tested for glycated hemoglobin (HbA1c), fasting insulin (FINS), and fasting blood glucose (FPG). Height and weight were measured to calculate body mass index (BMI). The HOMA-IR and TYG (fasting triglyceride and glycemic index) were also calculated. Changes in the BMI, VFA, HOMA-IR, and TYG levels were observed in the three groups. Results: The VFA, BMI, HbA1c, FPG, FINS, HOMA-IR, and TYG of the patients all increased, with a more significant increase in the BMI, FINS, HOMA-IR, and TYG levels (P visceral fat area (VFA) as the dependent variable. The results showed that VFA was closely related to BMI, FINS, HOMA-IR, and TYG. Conclusion: Early reduction of VFA to reduce insulin resistance may be a better treatment and effective method for T2DM, providing powerful measures and new strategies for effective blood sugar control and early prevention in the treatment of metabolic diseases.

关键词： Type 2 diabetes Abdominal obesity visceral fat area Insulin resistance

Age-dependent Changes in Skeletal Muscle Mass and visceral fat area in a Chinese Population

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当代医学科学(英文) 2023年第4期43卷 838-844页

作者： Shu-jing JI Zhan-hong QIAN Pei-ying HU Fang-yao CHEN Health Management Center Health Promotion CenterZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou 310000China Department of Epidemiology and Biostatistics School of Public HealthXi'an Jiaotong University Health Science CenterXi'an 710061China

Objective:The present study was conducted to demonstrate the age-dependent changes in skeletal muscle mass and visceral fat area in a population of Chinese adults aged 30-92 years ***:A total of 6669 healthy Chinese men and 4494 healthy Chinese women aged 30-92 years old were assessed for their skeletal muscle mass and visceral fat ***:The results showed age-dependent decreases in the total skeletal muscle mass indexes in both men and women aged 40-92 years old as well as age-dependent increases in the visceral fat area in men aged 30-92 years old and in women aged 30-80 years *** regression models showed that the total skeletal muscle mass index was positively associated with the body mass index and negatively associated with the age and visceral fat area in both ***:The loss of skeletal muscle mass becomes obvious at approximately 50 years of age,and the visceral fat area commences to increase at approximately 40 years of age in this Chinese population.

关键词： skeletal muscle mass visceral fat area China aging

Postoperative excessive gain in visceral adipose tissue as well as body mass index are associated with adverse outcomes of an ileal pouch

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Gastroenterology Report 2017年第1期5卷 29-35,I0001,I0002页

作者： Ganglei Liu Xianrui Wu Yi Li Yuanyi Rui Luca Stocchi Feza HRemzi Bo Shen Department of Colorectal Surgery the Cleveland Clinic FoundationClevelandOHUSA Department of Geriatric Surgery the Second Xiangya HospitalCentral South UniversityChangshaChina Department of Gastroenterology/Hepatology the Cleveland Clinic FoundationClevelandOHUSA

Background:There are no published studies on the impact of visceral adipose tissue(VAT)change on outcomes of restorative proctocolectomy and ileal pouch-anal anastomosis(IPAA).The aim of this historic cohort study was to evaluate the impact of excessive VAT gain on the outcomes of inflammatory bowel disease(IBD)patients with ***:We evaluated all eligible patients with at least two sequential CT scans after pouch construction from our prospectively maintained Pouchitis Registry between 2002 and *** visceral fat area(VFA)was measured on CT *** study group comprised patients with a significant VAT gain(>15%),and the control group was those *** adverse outcomes of the pouch were defined as the new development of chronic pouch inflammation(chronic pouchitis,chronic cuffitis or Crohn’s disease of the pouch),anastomotic sinus and the combination of above(the composite adverse outcome)or pouch failure,after the inception ***:Of 1564 patients in the Registry,59(3.8%)with at least 2 CT scans after pouch surgery were ***-nine patients(49.2%)were in the study group,and 30(50.8%)were in the control *** median duration from the inception to the latest CT was 552(range:31–2598)days for the entire *** compared the frequency of new chronic pouch inflammation(13.8%vs 3.3%,P=0.195),new pouch sinus(10.3%vs 0%,P=0.112),composite adverse pouch outcome(24.1%vs 3.3%,P=0.026)or pouch failure(10.3%vs 6.7%,P=0.671)between the two ***-Meier plot for time-to-pouch failure between the pouch patients with or without excessive body mass index(BMI)gain(>10%)showed statistical difference(P=0.011).Limited stepwise multivariate analysis showed that excessive VAT gain(odds ratio=12.608,95%confidence interval:1.190–133.538,P=0.035)was an independent risk factor for the adverse pouch ***:In this cohort of ileal pouch patients,excessive VAT gain as well as gain in BMI after pouch construction was found to be associated wit

关键词： inflammatory bowel disease ileal pouch pouch failure visceral adipose tissue visceral fat area

PNPLA3 rs738409 C>G Variant Influences the Association Between visceral fat and Significant Fibrosis in Biopsyproven Nonalcoholic fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 439-448页

作者： Gang Li Liang-Jie Tang Pei-Wu Zhu Ou-Yang Huang Rafael SRios Kenneth IZheng Sui-Dan Chen Hong-Lei Ma Giovanni Targher Christopher DByrne Xiao-Yan Pan Ming-Hua Zheng NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Laboratory Medicine the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Department of Endocrinology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:Intra-abdominal visceral fat accumulation and patatin-like phospholipase domain containing 3(PNPLA3)rs738409 G/C gene polymorphism confer a greater susceptibility to nonalcoholic fatty liver disease(NAFLD).We examined whether the relationship between visceral fat accumulation and liver disease severity may be influenced by PNPLA3 rs738409 ***:The variant of PNPLA3 rs738409 was genotyped within 523 Han individuals with biopsy-confirmed *** fat area(VFA)was measured by bioelectrical *** liver fibrosis(SF),defined as stage F≥2 on histology,was the outcome measure of ***:The distribution of PNPLA3 genotypes was CC:27.5%,CG:48.2%,and GG:24.3%.Higher VFA was associated with greater risk of having SF(adjusted-odds ratio[OR]:1.03;95%confidence interval[CI]:1.02–1.04,p<0.05),independent of potential *** subjects with the same VFA level,the risk of SF was greater among carriers of the rs738409 G genotype than among those who did *** analysis showed that PNPLA3 rs738409 significantly influenced the association between VFA and *** remained significantly associated with SF only among the rs738409 G-allele carriers(adjusted-OR:1.05;95%CI:1.03–1.08 for the GG group;and adjusted-OR:1.03;95%CI:1.01–1.04 for the GC group).There was a significant interaction between VFA and PNPLA3 rs738409 genotype(Pinteraction=0.004).Conclusions:PNPLA3 rs738409 G allele has a moderate effect on the association between VFA and risk of SF in adult individuals with biopsy-proven *** of the PNPLA3 rs738409 G allele and VFA interact to increase risk of SF。

关键词： Nonalcoholic fatty liver disease Significant fibrosis visceral fat area Single nucleotide polymorphism Metabolic dysfunction-associated fatty liver disease