检索结果-南通市图书馆

Postoperative excessive gain in visceral adipose tissue as well as body mass index are associated with adverse outcomes of an ileal pouch

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2017年第1期5卷 29-35,I0001,I0002页

作者： Ganglei Liu Xianrui Wu Yi Li Yuanyi Rui Luca Stocchi Feza HRemzi Bo Shen Department of Colorectal Surgery the Cleveland Clinic FoundationClevelandOHUSA Department of Geriatric Surgery the Second Xiangya HospitalCentral South UniversityChangshaChina Department of Gastroenterology/Hepatology the Cleveland Clinic FoundationClevelandOHUSA

Background:There are no published studies on the impact of visceral adipose tissue(VAT)change on outcomes of restorative proctocolectomy and ileal pouch-anal anastomosis(IPAA).The aim of this historic cohort study was to evaluate the impact of excessive VAT gain on the outcomes of inflammatory bowel disease(IBD)patients with ***:We evaluated all eligible patients with at least two sequential CT scans after pouch construction from our prospectively maintained Pouchitis Registry between 2002 and *** visceral fat area(VFA)was measured on CT *** study group comprised patients with a significant VAT gain(>15%),and the control group was those *** adverse outcomes of the pouch were defined as the new development of chronic pouch inflammation(chronic pouchitis,chronic cuffitis or Crohn’s disease of the pouch),anastomotic sinus and the combination of above(the composite adverse outcome)or pouch failure,after the inception ***:Of 1564 patients in the Registry,59(3.8%)with at least 2 CT scans after pouch surgery were ***-nine patients(49.2%)were in the study group,and 30(50.8%)were in the control *** median duration from the inception to the latest CT was 552(range:31–2598)days for the entire *** compared the frequency of new chronic pouch inflammation(13.8%vs 3.3%,P=0.195),new pouch sinus(10.3%vs 0%,P=0.112),composite adverse pouch outcome(24.1%vs 3.3%,P=0.026)or pouch failure(10.3%vs 6.7%,P=0.671)between the two ***-Meier plot for time-to-pouch failure between the pouch patients with or without excessive body mass index(BMI)gain(>10%)showed statistical difference(P=0.011).Limited stepwise multivariate analysis showed that excessive VAT gain(odds ratio=12.608,95%confidence interval:1.190–133.538,P=0.035)was an independent risk factor for the adverse pouch ***:In this cohort of ileal pouch patients,excessive VAT gain as well as gain in BMI after pouch construction was found to be associated wit

关键词： inflammatory bowel disease ileal pouch pouch failure visceral adipose tissue visceral fat area

The role of visceral adipose tissue on improvement in insulin sensitivity following Roux-en-Y gastric bypass:a study in Chinese diabetic patients with mild and central obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2018年第4期6卷 298-303,I0002页

作者： Lei Zhao Liyong Zhu Zhihong Su Weizheng Li Pengzhou Li Yong Liu Shengping Liu Shaihong Zhu Department of General Surgery Third Xiangya HospitalCentral South UniversityNo 138 Tongzipo RoadChangshaHunan 410013China Department of Gastrointestinal Surgery First Affiliated HospitalUniversity of South ChinaNo 69 Chuanshan RoadHengyangHunan 421001China

Background:Most Chinese patients with type 2 diabetes mellitus(T2DM)have mild obesity and central *** obesity is combined with insulin *** aim of this study was to assess the effect of abdominal adipose tissue on insulin-sensitivity improvement after Roux-en-Y gastric bypass(RYGB)in Chinese diabetic patients with mild and central ***:Seventeen T2DM patients with a mean body mass index of 30.3 kg/m^(2) were scheduled for laparoscopic RYGB.A hyperinsulinemic-euglycemic clamp and dual-energy X-ray absorptiometry were performed prior to surgery and 3 months after *** primary end points were the correlations between insulin sensitivity and abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),before and 3 months after ***:Indices of peripheral insulin sensitivity,including glucose-disposal rate(M value)and glucose infusion rate,were significantly increased after ***-fat mass,VAT and SAT were significantly reduced after *** pre-operative M value was significantly correlated with VAT mass(r=–0.57,P=0.02),but not correlated with SAT mass.M value changes after RYGB were highly correlated with changes in VAT mass(r=–0.59,P=0.01),percentage of VAT mass(r=–0.66,P<0.01),VAT area(r=–0.56,P=0.02)and percentage of VAT area(r=–0.57,P=0.02).Conclusions:A significant correlation was observed between increased peripheral insulin sensitivity and decreased VAT following RYGB in Chinese patients with mild and central *** and SAT were significantly decreased with improved insulin sensitivity after *** mass may be considered as an indication for gastric bypass during patient selection.

关键词： Insulin sensitivity visceral adipose tissue gastric bypass hyperinsulinemic-euglycemic clamp type 2 diabetes mellitus non-morbid obesity

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

Characteristics and mechanisms of subcutaneous and visceral adipose tissue aging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 94-97页

作者： Peng Xu Yikai Wang Kai Liu Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Aging is one of the most significant health challenges worldwide and is a primary cause of chronic diseases and physiological *** the myriad changes that occur with aging,alterations in adipose tissue distribution and function have gained considerable attention because of their profound impact on metabolic health and overall *** adipose tissue(SAT)and visceral adipose tissue(VAT)are the two major depots of white adipose tissue,each with distinct roles in metabolism and *** the characteristics and underlying mechanisms of SAT and VAT is crucial for elucidating the aging process and developing strategies to promote healthy *** review focuses on delineating and analyzing the characteristics and intrinsic mechanisms underlying the aging of subcutaneous and visceral adipose tissue during the aging process,which can contribute to a better understanding of the aging process and enhance healthy aging.

关键词： White adipose tissue Subcutaneous adipose tissue visceral adipose tissue adipose tissue aging

Association of visceral adipose tissue with gout:Observational and Mendelian randomization analyses

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第19期137卷 2351-2357页

作者： Wenze Xiao Qi Wang Yining Liu Hui Zhang Hejian Zou Department of Rheumatology Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Department of Nephrology Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Human Phenome Institute Zhangjiang Fudan International Innovation CentreFudan UniversityShanghai 201203China Department of Rheumatology Huashan HospitalFudan UniversityShanghai 200000China

Background:The causal relationship between visceral adipose tissue(VAT)and gout is still *** aimed to examine the potential association between them using observational and Mendelian randomization(MR)***:In the observational analyses,a total of 11,967 participants(aged 39.5±11.5 years)were included from the National Health and Nutrition Examination *** regression models were used to investigate the association between VAT mass and the risk of *** two-sample MR analyses,211 VAT mass-related independent genetic variants(derived from genome-wide association studies in 325,153 UK biobank participants)were used as instrumental *** random-effects inverse-variance weighted(IVW)method was used as the primary *** sensitivity analyses were also performed to validate our ***:Observational analyses found that an increase in VAT mass(per standard deviation)was associated with a higher risk of gout after controlling for confounding factors(odds ratio[OR]=1.27,95%confidence intervals[CI]=1.11-1.45).The two-sample MR analyses demonstrated a causal relationship between increased VAT mass and the risk of gout in primary analyses(OR=1.78,95%CI=1.57-2.03).Sensitivity analyses also showed similar findings,including MR-Egger,weighted median,simple mode,weighted mode,and leave-one-out ***:Observational analyses showed a robust association of VAT mass with the risk of ***,MR analyses also provided evidence of a causal relationship between *** summary,our findings suggested that targeted interventions for VAT mass may be beneficial to prevent gout.

关键词： visceral adipose tissue Gout Observational analyses Mendelian randomization Causal relationship Epidemiology

Comprehensive association between plasma phospholipid fatty acids and body subcutaneous-to-visceral adipose tissue distribution in normal weight and overweight populations

在线全文

学校读者我要写书评

暂无评论

Comprehensive association between plasma phospholipid fatty ...

Critical visceral adipose tissue thresholds aassociated with type 2 diabetes mellitus in chinese population

第十二届全国营养科学大会

作者： Jingjing Jiao jieni Qiu Shankuan Zhu Chronic Disease Research Institute Department of NutritionSchool of Public HealthZhejiang University School of Medicine

目的 The aim was to investigate the association between plasma phospholipid(PPL)fatty acid profiles and fat distribution in subjects.方法 Overall 102 of 1029 Chinese adults stratified by sex and body mass index(BMI)were enrolled,who received questionnaire survey,physical exam and magnetic resonance imaging(MRI)*** PPL fatty acids were analyzed by gas *** fat distribution including subcutaneous adipose tissue(SAT)and visceral adipose tissue(VAT)was measured by MRI.结果 PPL n-3 polyunsaturated fatty acids(PUFA)were inversely associated with SAT in normal weight *** n-6 PUFA were correlated with SAT and VAT in normal weight subjects,while PPL saturated fatty acids(SFA)were positively associated with SAT and VAT in overweight *** regression analysis revealed PPL n-6 PUFA positively correlated with SAT in normal weight subjects,but positively associated with VAT in overweight subjects after multiple covariate *** regression results showed PPL n-6 PUFA levels could be used to estimate the obese state.结论 PPL n-6 PUFA instead of n-3 PUFA and SFA as important predictors positively correlate with body SAT-toVAT distribution.

关键词： plasma phospholipid fatty acids polyunsaturated fatty acids fat distribution subcutaneous adipose tissue visceral adipose tissue magnetic resonance imaging

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Nanjing Medical University 2007年第1期21卷 15-20页

作者： Om Kumar Shrestha Department of Radiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029China

To compare intervertebral location L2-L3 with L4-L5 as landmarks for measuring abdominal fat distribution and to determine critical levels of visceral adipose tissue （VAT） at those planes, exceeding which may lead to the development of type 2 diabetes. Methods： Abdominal fat distribution was measured using computed tomography（CT） in 29 diabetics （19 male, 10 female） and 30 non-diabetics （18 male, 12 female）. CT images obtained at two intervertebral locations L2-L3 and L4-L5 were used to measure the areas of total fat, VAT and subcutaneous adipose tissue （SCAT） using slice thickness of 5mm and an attenuation range from -190 to -30 Hounsfield units （HU）. Data were analyzed using logistic regression and Receiver-operating characteristic （ROC） analysis. Results： At L2-L3, diabetes and obesity were correctly classified at 91.53% and 83.05% respectively, while at L4-L5, the same were correctly classified at 84.75% and 88.14% respectively. VAT compared to SCAT, had significantly higher correctly classified percent values for predicting diabetes in both measurement sites. At L2-L3, VAT≥177.29 cm2 or VAT ≥51.52% of the total fat area had the highest correctly classified value for predicting diabetes in men, while VAT ≥ 132.27 cm2 or VAT≥45.7% of the total fat area had the highest correctly classified value for predicting diabetes in women. At LA-L5, VAT≥ 130.82 cm2 or VAT≥45.5,$% of the total fat area had the highest correctly classified value for predicting diabetes in men, while VAT≥ 118.56 cm2 or VAT≥32.24% of the total fat area had the highest correctly classified value for predicting diabetes in women. Conclusion： L2-L3 plane is a better landmark for measuring abdominal fat distribution for predicting diabetes, while abdominal fat distribution measured at L4-L5 has better association with obesity. Regardless of the measurement site, VAT compared to SCAT, has significantly stronger association with diabetes.

关键词： visceral adipose tissue type 2 diabetes measurement computed tomography

Sex-and age-specific associations between abdominal fat and non-alcoholic fatty liver disease:a prospective cohort study

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2023年第11期15卷 33-42页

作者： Hongli Chen Yuexing Liu Dan Liu Yebei Liang Zhĳun Zhu Keqing Dong Huating Li Yuqian Bao Jiarui Wu Xuhong Hou Weiping Jia Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Key Clinical Center for Metabolic DiseaseShanghai 200233China General Practitioner Teams in Community Health Service Center of Nicheng Pudong New Area DistrictShanghai 201306China CAS Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Obesity is closely related to non-alcoholic fatty liver disease(NAFLD).Although sex differences in body fat distribution have been well demonstrated,little is known about the sex-specific associations between adipose tissue and the development of *** community-based cohort data,we evaluated the associations between magnetic resonance imaging quantified areas of abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),and incident NAFLD in 2830 participants(1205 males and 1625 females)aged 55–70 *** a 4.6-year median follow-up,the cumulative incidence rates of NAFLD increased with areas of VAT and SAT both in males and in *** analyses showed that the abovementioned positive associations were stronger in males than in females,especially in participants under 60 years *** contrast,these sex differences disappeared in those over 60 years ***,the risk of developing NAFLD increased non-linearly with increasing fat area in a sex-specific ***,sex-specific potential mediators,such as insulin resistance,lipid metabolism,inflammation,and adipokines,may exist in the associations between adipose tissue and *** study showed that the associations between abdominal fat and the risk of NAFLD were stratified by sex and age,highlighting the potential need for sex-and age-specific management of NAFLD.

关键词： visceral adipose tissue subcutaneous adipose tissue sex difference NAFLD incidence prospective study

Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 214-221页

作者： Fateheya Mohamed Metwally Hend Mohamed Rashad Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla Environmental and Occupational Medicine National Research CentreGizaEgypt Department of Hormones National Research CentreGizaEgypt Department of Zoology Faculty of ScienceAin Shams UniversityCairoEgypt Department of Research on Children with Special Needs National Research CentreGizaEgypt Department of Horticulture Crops Technology National Research CentreGizaEgypt

Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam.(M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral ***: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the m RNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real ***: The results showed that M. oleifera extract down-regulated m RNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ***: It is reasonable to assume that the anti-obesity, anti-atherogenic and antidiabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome.

关键词： Moringa oleifera Lam visceral adipose tissue Adipokines Gene expression Rats