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Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

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Virologica Sinica 2023年第1期38卷 128-141页

作者： Jian Chen Jian Liu Zhilu Chen Daobin Feng Cuisong Zhu Jun Fan Shuye Zhang Xiaoyan Zhang Jianqing Xu Clinical Center for Bio-Therapy Zhongshan HospitalFudan University(Xiamen Branch)Shanghai200032China Center for Infectious Disease Research Science of Life SciencesWestlake UniversityHangzhou310024China Shanghai Public Health Clinical Center&Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai201508China

Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public *** the risk of a potential IAV pandemic,it is increasingly important to better understand virushost interactions and develop new anti-viral ***,we reported nonmuscle myosin IIA(MYH9)-mediated regulation of IAV ***9 depletion caused a profound inhibition of IAV infection by reducing viral attachment and internalization in human lung epithelial ***,overexpression of MYH9 also led to a significant reduction in viral productive ***,overexpression of MYH9 retained viral attachment,internalization,or uncoating,but suppressed the viral ribonucleoprotein(vRNP)activity in a minigenome *** analyses found that excess MYH9 might interrupt the formation of vRNP by interacting with the viral nucleoprotein(NP)and result in the reduction of the completed vRNP in the nucleus,thereby inhibiting subsequent viral RNA transcription and ***,we discovered that MYH9 can interact with IAV NP protein and engage in the regulation of vRNP complexes,thereby involving viral *** findings enlighten new mechanistic insights into the complicated interface of host-IAV interactions,ultimately making it an attractive target for the generation of antiviral drugs.

关键词： Myosin IIA(MYH9) Influenza A virus(IAV) vRNP activity virus-host interactions virus entry

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host preference of the major strains of Plum pox virus--Opinions based on regional and world-wide sequence data

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Journal of Integrative Agriculture 2017年第3期16卷 510-515页

作者： Nina Sihelská Miroslav Glasa Zdeno W Subr Biomedical Research Center Institute of Virology Slovak Academy of Sciences Bratislava 84505 Slovak Republic

Plum pox virus（PPV）causes sharka-the most serious viral disease of stone fruit *** is wide spread in Europe and Mediterranean Basin,its incidence has been further approved in Asia and both *** PPV strains have been recognized until now（PPV-D,PPV-M,PPV-Rec,PPV-EA,PPV-C,PPV-T,PPV-W,PPV-CR,and PPV-An）,forming molecularly distinct entities,however,only partially differentiable by their biological or epidemiological *** most strict virus-host linkages under natural conditions have been detected for strains naturally infecting cherries（PPV-C and PPV-CR）.However,although less stringent but still clear host preference is observed also for three epidemiologically most important strains（PPV-D/plum/apricot,PPV-M/peach,and PPV-Rec/plum）.So far no genetic marker has been mapped in the PPV genome,which responsibility for the host specificity/preference could be explicitly *** this review,we focus on the host preference of three major PPV strains as evidenced by analysis of an extensive dataset of PPV isolates of Slovak and world-wide ***,we discuss several performed relevant experiments and further possible research procedures aimed to better understand the genetic determinants and mechanisms of the host preference of this potyvirus.

关键词： sharka Prunus virus-host interactions

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