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vesicular drug delivery systems for oral absorption enhancement

Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui Zou Meng Cheng Kaili Hu Jianfang Feng Liangxing Tu Jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

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vesicular Li3V2(PO4)3/C hollow mesoporous microspheres as an efficient cathode material for lithium-ion batteries

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Nano Research 2019年第8期12卷 1937-1942页

作者： Hongxia Sun Haoran Du Mengkang Yu Kuangfu Huang Nan Yu Baoyou Geng College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular SolidsMinistry of EducationThe Key Laboratory oj Electrochemical Clean Energy of Anhui Higher Education InstitutesAnhui Normal UniversityNO. 189 South Jiuhua RoadWuhu 241002China

vesicular lithium vanadium phosphate/carbon hollow mesoporous microspheres were fabricated using a facile polyvinylpyrrolidone-assisted aerosol-spray-assisted method and subsequent heat-treatment. While changing the content of polyvinylpyrrolidone, we found that carbon content was adjustable on the surface of lithium vanadium phosphate. By optimizing the carbon content among the composites, the electrochemical performance can be enhanced significantly. The results of electrochemical performance tests suggested that the samples exhibited good cycle performance and high discharge capability in the voltages between 3.0-4.8 V. The observed excellent electrochemical performances could be attributed to the proper content of carbon coating and the vesicular hollow mesoporous microsphere structure, increasing the transmission rate of lithium ions and reducing the structural change during charging and discharging effectively.

关键词： U3V2(PO4)3 aerosol-spray-assisted approach polyvinylpyrrolidone vesicular hollow microsphere electrochemical properties

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vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 117-129页

作者： Shivani Verma Puneet Utreja Department of Pharmaceutics Rayat-Bahra College of Pharmacy I. K. Gujral Punjab Technical University Faculty of Pharmaceutical Sciences Department of Pharmaceutics PCTE Group of Institutes

Occurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome. When these antifungal agents are delivered topically using conventional formulations like creams and gels, they may cause various side effects like redness, burning, and swelling at the site of application. Therefore, various vesicular formulations(phospholipid based or non phospholipid based) have been explored by pharmaceutical scientists to treat skin fungal infections topically. vesicular formulation explored for the purpose are liposomes, ethosomes, transfersomes, transethosomes, niosomes, spanlastics, oleic acid vesicles, and *** formulations show various advantages like bioavailability enhancement of bioactives,high skin permeation power, no side effects at application site, dosing frequency reduction,and sustained drug release. Therefore, in the present article, we have discussed about the utility of various vesicular nanocarrier systems to treat skin fungal infections.

关键词： Conventional Nanoparticle Spanlastics Transfersomes vesicular

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A vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection

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Virologica Sinica 2019年第1期34卷 106-110页

作者： Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu Sidong Xiong Chunsheng Dong Jiangsu Key Laboratory of Infection and Immunity The Institutes of Biology and Medical SciencesSoochow University

Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural *** 2015.

关键词： VSV A vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection

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Endocytosis and vesicular Transport of Plasmid DNA in Cells During Electric Field-Mediated Gene Delivery

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医用生物力学 2019年第A1期34卷 12-13页

作者： Fan Yuan Department of Biomedical Engineering Duke University

Pulsed electric field has been used widely as a nonviral approach to improving gene delivery in basic and translational research[1-2].The technique has been called electrotransfection(ET),electroporation,electrogene transfer,and gene electroinjection in the literature [1,3].It has a great potential to improve clinical treatment of diseases through delivery of vaccines and therapeutic genes,genome and epigenome editing,and generation of human induced pluripotent stem cells for tissue engineering[1-3].During ET,extracellular transport of plasmid DNA(pDNA)relies on electrophoresis,which is critical for applications in ***,mechanisms of intracellular transport remain to be *** lack of understanding has hindered the translation of ET technology to the *** is well known that pulsed electric field can generate transient hydrophilic pores in the plasma membrane(i.e.,electroporation)that permit membrane-impermeant molecules to enter *** the pores have yet to be visualized directly under a microscope,the electric field-induced membrane permeabilization has been demonstrated through experimental measurements of electrical conductance of synthetic lipid membranes and plasma membranes,direct observation of fluorescent markers crossing the membranes facing both cathode and anode,and numerical simulations of the membrane permeabilization[1,3].Results from the simulations have predicted that the cutoff size of the pores is on the order of a few hundred nanometers,and the lifetime of the pores that are larger than 100 nm is on the order of 10 *** these data provide a solid evidence of the membrane permeabilization,recent studies have demonstrated that the generation of the pores is insufficient for ET[1,4].The reasons are as ***,the lifetime of the pores is several orders of magnitude shorter than the time scale for pDNA uptake,which is on the order of 10 ***,complex formation between pDNA and plasma membrane is a neces

关键词： Endocytosis vesicular Transport Plasmid DNA Cells During Electric Field-Mediated Gene Delivery DNA

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Mitochondrial Membranes Restitution Proceeds via vesicular Import from ER and Cytosol. Counterparts’ Resemblances and Variances in Mitochondria and Golgi Pathways

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Advances in Biological Chemistry 2017年第1期7卷 1-26页

作者： Amalia Slomiany Bronislaw L. Slomiany Rutgers Biomedical and Health Sciences School of Dental Medicine Newark USA

The processes of mitochondrial restitution are controlled by nuclear genes that encode proteins synthesized in ER and cytosol and delivered as organelle- and membrane-specific transport vesicles. The analysis of the transporters recovered from inner mitochondrial space (Mitosol) revealed that the ER-synthesized mitochondria-specific transport vesicles consist of two carriers, one remaining in outer mitochondrial membrane (OMM), and the other that transfers specific membrane segments to the inner mitochondrial membrane (IMM). The ER-assembled and IMM-committed membrane segments, while first integrated into OMM, undergo intra-mitochondrial lipid modification reflected in the synthesis of cardiolipin (CL) and inversion into Mitosol with load of IMM associated cytosolic proteins. Then, the CL-bedecked vesicles are released from OMM to Mitosol and upon contact with IMM fuse with the membrane, and the release of cytosolic cargo ensues. While ER-assembled mitochondria-specific transport vesicles fuse with OMM with the aid of the cytosolic, phosphatidylglycerol (PG)-specific phospholipase A2 (PLA2), the Mitosol-contained CL-specific PLA guides vesicles fusion with IMM. The described path of translocation of the membrane segments and the cytosol synthesized proteins into the designated mitochondrial compartments sustains growth and identity of OMM, IMM, maintains protein delivery for intra-mitochondrial lipid and protein modification in Mitosol, and ensures conformity of the cytosolic proteins cargo delivered to matrix.

关键词： Mitochondrial Restitution ER vesicular Transport Mitochondrial Membranes Cardiolipin Mitosol Vesicles

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Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice

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Chinese Medical Journal 2019年第14期132卷 1689-1699页

作者： Hong-Li Wang Ya-Xin Sun Xiao Liu Han Wang Yu-Nu Ma Yun-Ai Su Ji-Tao Li Tian-Mei Si National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital/Institute of Mental Health)and the Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China The Sixth People's Hospital of Hebei Province BaodingHebei 071000China

Background:Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental *** this study,we examined the effects of adolescent chronic social stress in aged mice on depressive behaviors and the excitatory-inhibitory (E/I) balance in stress-sensitive regions of the ***:Sixty-four adolescent,male C57BL/6 mice were randomly assigned to either the 7-week (from post-natal days 29 to 77) social instability stress (stress group,n =32) or normal housing conditions (control group,n =32).At 15 months of age,16 mice were randomly selected from each group for a series of behavioral tests,including two depression-related tasks (the sucrose preference test and the tail suspension test).Three days following the last behavioral test,eight mice were randomly selected from each group for immunohistochemical analyses to measure the cell density of parvalbumin (PV+)-and calretinin (CR+)-positive gamma-aminobutyric-acid (GABA)ergic inhibitory inter-neurons,and the expression levels of vesicular transporters of glutamate-1 (VGIuT1) and vesicular GABA transporter (VGAT) in three stress-sensitive regions of the brain (the medial pre-frontal cortex [mPFC],hippocampus,and amygdala).Results:Behaviorally,compared with the control group,adolescent chronic stress increased depression-like behaviors as shown in decreased sucrose preference (54.96 ± 1.97% vs.43.11 ± 2.85%,t(22)=3.417,P =0.003) and reduced latency to immobility in the tail suspension test (92.77 ± 25.08 s vs.33.14 ± 5.95 s,t(25)=2.394,P =0.025),but did not affect anxiety-like behaviors and pre-pulse *** the neurobiologic level,adolescent stress down-regulated PV+,not CR+,inter-neuron density in the mPFC (F(1,39)=19.30,P 10.09

关键词： Adolescence Aging Depression Inter-neuron Stress vesicular glutamate transporter-1

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Bidirectional regulation of Ca^(2+) in exo–endocytosis coupling

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Science China(Life Sciences) 2018年第12期61卷 1583-1585页

作者： Qian Song Mingzhu Huang Bianbian Wang Xinjiang Kang Changhe Wang Center for Mitochondrial Biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology and Frontier Institute of Science and Technology Xi'an Jiaotong University College of Life Sciences Liaocheng University DOE-Key Lab of Medical Electrophysiology Institute of Cardiovascular Research Southwest Medical University

vesicular exocytosis is a key process involved in neurotransmitter release,whereas vesicle recycling is critical for the homeostasis of plasma membrane structures and the maintenance of ***^2+ regulates several fundamental cellular processes(Zhu et al.,2016,Xiong and Zhu,2016).Especially,Ca^2+ influx plays a dual role of triggering vesicular exocytosis and modulating compensatory endocytosis in neurons and endocrine cells.

关键词： vesicular exocytosis key process

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Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord

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Neuroscience Bulletin 2019年第4期35卷 637-648页

作者： Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen South China Research Center for Acupuncture and Moxibustion Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou 510006 China College of Basic Medical Science Guangzhou University of Chinese Medicine Guangzhou 510006 China The First Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510006 China Graduate College Guangzhou University of Chinese Medicine Guangzhou 510006 China

Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous *** immunopotentiator thymosin alpha-1(Tal)has recently been reported to have anti-inflammatory and neuroprotective functions in ***,how Tα1 affects inflammatory pain remains *** the present study,intraperitoneal injection of Tal attenuated complete Freund's adjuvant(CFA)-induced pain hypersensitivity,and decreased the up-regulation of pro-inflammatory cytokines(TNF-α,IL-1β,and IL-6)in inflamed skin and the spinal *** found that CFA-induced peripheral inflammation evoked strong microglial activation,but the effect was reversed by Tα***,Tα1 reversed the CFA-induced up-regulation of vesicular glutamate transporter(VGLUT)and down-regulated the vesicular γ-aminobutyric acid transporter(VGAT)in the spinal *** together,these results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microgliainduced pro-inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal cord.

关键词： Thymosin alpha-1 Cytokine Microglia vesicular glutamate transporter type 2 vesicular γ-aminobutyric acid transporter

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Transverse myelitis after infection with varicella zoster virus in patient with normal immunity: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10308-10314页

作者： Daehun Yun Soo Young Cho Wan Ju Eun Hyoung Seo Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Varicella zoster virus(VZV)is a human neurotropic and double-stranded DNA alpha-herpes *** infection with VZV usually occurs during childhood,manifesting as *** of latent VZV can lead to various neurological complications,including transverse myelitis(TM);although cases of the latter are very rare,particularly in newly active VZV *** SUMMARY We report here an unusual case of TM in a middle-aged adult immunocompetent patient that developed concomitant to an active VZV *** 46-year-old male presented with painful vesicular eruption on his left chest that had steadily progressed to involvement of his back over a 3-d *** fluid testing was denied,but findings from magnetic resonance imaging and collective symptomology indicated *** was administered antiviral drugs and corticosteroids immediately but his symptom improvement waxed and waned,necessitating multiple hospital *** about a month of repeated treatments,he was deemed sufficiently improved for hospital discharge to *** VZV myelitis should be suspected when a patient visits the outpatient pain clinic with herpes zoster showing neurological symptoms.

关键词： Herpes zoster Postherpetic neuralgia Transverse myelitis Varicella zoster virus Motor weakness vesicular Pain Case report

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