检索结果-南通市图书馆

Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第1期25卷 5-12页

作者： Chen-Yao Deng Zhe Zhang Wen-Hao Tang Hui Jiang Department of Urology Third Hospital of Peking UniversityBeijing 100089China Department of Andrology Third Hospital of Peking UniversityBeijing 100089China Department of Human Sperm Bank Third Hospital of Peking UniversityBeijing 100089China

Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome,the azoospermia factor region(AZF).AZF microdeletions are the main structural chromosomal abnormalities that cause male *** reproductive technology(ART)has been used to overcome natural fertilization barriers,allowing infertile couples to have ***,these techniques increase the risk of vertical transmission of genetic *** widespread awareness of AZF microdeletions,the occurrence of de novo deletions and overexpression,as well as the expansion of AZF microdeletion vertical transmission,remains *** review summarizes the mechanism of AZF microdeletion and the function of the candidate genes in the AZF region and their corresponding clinical ***,vertical transmission cases of AZF microdeletions,the impact of vertical inheritance on male fertility,and the prospective direction of research in this field are also outlined.

关键词： azoospermia factor male infertility microdeletion vertical transmission

Semen extracellular vesicles mediate vertical transmission of subgroup J avian leukosis virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2022年第2期37卷 284-294页

作者： Liqin Liao Weiguo Chen Xiangyu Zhang Huanmin Zhang Aijun Li Yiming Yan Zi Xie Hongxing Li Wencheng Lin Jingyun Ma Xinheng Zhang Qingmei Xie Heyuan Branch Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and TechnologyCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China Guangdong Provincial Key Lab of Agro Animal Genomics and Molecular Breeding Guangzhou510642China USDA Agriculture Research ServiceAvian Disease and Oncology LaboratoryEast LansingMI48823USA College of Science and Engineering Jinan UniversityGuangzhou510632China Key Laboratory of Animal Health Aquaculture and Environmental Control GuangdongGuangzhou510642China Guangdong Engineering Research Center for Vector Vaccine of Animal Virus Guangzhou510642China

Subgroup J avian leukosis virus(ALV-J) is a highly oncogenic retrovirus that has been devastating the global poultry industry since the late 1990s. The major infection model of ALV-J is vertical transmission, which is responsible for the congenital infection of progeny from generation to generation. Increasing evidence has suggested that extracellular vesicles(EVs) derived from virus-infected cells or biological fluids have been thought to be vehicles of transmission for viruses. However, the role of EVs in infection and transmission of ALV-J remains obscure. In the present study, semen extracellular vesicles(SE) were isolated and purified from ALV-J-infected rooster seminal plasma(SE-ALV-J), which was shown to contain ALV-J genomic RNA and partial viral proteins, as determined by RNA sequencing, reverse transcription-quantitative PCR and Western blotting. Furthermore, SE-ALV-J was proved to be able to transmit ALV-J infection to host cells and establish productive *** importantly, artificial insemination experiments showed that SE-ALV-J transmitted ALV-J infection to SPF hens, and subsequently mediated vertical transmission of ALV-J from the SPF hens to the progeny chicks. Taken together, the results of the present study suggested that ALV-J utilized host semen extracellular vesicles as a novel means for vertical transmission, enhancing our understanding on mechanisms underlying ALV-J transmission.

关键词： Semen extracellular vesicles(SE) Subgroup J avian leukosis virus(ALV-J) Infection vertical transmission

vertical transmission of hepatitis B virus:propositions and future directions

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第23期134卷 2825-2831页

作者： Jin-Feng Liu Tian-Yan Chen Ying-Ren Zhao Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Shaanxi Clinical Research Center of Infectious Diseases Xi’anShaanxi 710061China.

Chronic hepatitis B virus(HBV)infection due to vertical transmission remains a critical concern with regards to eliminating HBV *** of hepatitis B vaccine,the foundation to prevent perinatal and horizontal transmission,has reduced the prevalence of HBV by>80%.In countries where the hepatitis B immune globulin(HBIG)is available,such as China and the United States,the administration of HBIG and hepatitis B vaccine to the infants of mothers who are positive for hepatitis B surface antigen has become a standard practice and is effective in preventing vertical *** evidence on the efficacy and safety of antiviral prophylaxis during pregnancy indicates the probability of attaining the goal of the World Health Organization to eliminate hepatitis by *** this review,we discuss the transmission routes,diagnostic criteria,and preventive strategies for vertical transmission.A preventive program that includes screening before pregnancy,antiviral prophylaxis during pregnancy,and postpartum immunoprophylaxis provides“perfect strategies”to eliminate vertical ***,there is still a notable gap between“perfect strategies”and real-world application,including insufficient coverage of timely birth dose vaccine and the efficacy and necessity of HBIG,especially in mothers who are negative for hepatitis B envelope *** particular,there is a clear need for a comprehensive long-term safety profile of antiviral ***,feasible and cost-effective preventive strategies need to be determined across *** also needs to be scaled up to meet the demands for prophylaxis and prevalence targets.

关键词： Hepatitis B virus vertical transmission Immunoprophylaxis Antiviral prophylaxis

Prevention of vertical transmission of hepatitis B virus infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero Veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi Department of Medicine and Surgery University of ParmaParma 43121Italy Department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy Department Neurofarba University of FlorenceFlorence 50129Italy Department Neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis Tenofovir alafenamide fumarate

vertical transmission of the Yq AZFc microdeletion from father to son over two or three generations in infertile Han Chinese families

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第2期12卷 240-246页

作者： Xiao-Bin Zhu Yu-Lin Liu Wei Zhang Ping Ping Xiao-Rong Cao Yong Liu Yi-Ran Huang Zheng Li Shanghai Human Sperm Bank Renji Hospital Shanghai Institute of Andrology Shanghai Jiao Tong University School ofMedicine Shanghai 200001 China

This study was carried out to analyze the vertical transmission of Yq AZFc microdeletions from father to son in infertile Han Chinese families to investigate genetic factors and family background affecting fertility *** peripheral blood of infertile males in 19 Han families was extracted and screened with modified multiplex polymerase chain reaction （PCR）. Family trees were drawn according to fertility status and clinical characteristics of the subjects. The vertical transmission of Yq AZFc microdeletions was detected in six cases of 19 investigated families （31.6%,6/19）. Although both fathers and sons showed a similar type of Yq AZFc deletion,the fathers were fertile,whereas the sons were infertile and showed severe oligozoospermia. The vertical transmission of Yq AZFc microdeletion from fertile fathers to infertile sons over generations is not rare. This has different effects on fertility status in fathers and sons in Han Chinese families. Both genetic factors and family background affect spermatogenetic phenotypes.

关键词： infertility microdeletion vertical transmission Y chromosome

Mechanisms and Prevention of vertical transmission in Chronic Viral Hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2017年第2期5卷 119-129页

作者： Marianna G.Mavilia George Y.Wu Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT USA

vertical transmission (VT) is the primary route of transmission of viral hepatitis in *** rate of VT ranges from 1-28% with hepatitis B virus (HBV) and 3-15% with hepatitis C virus (HCV).VT for both viruses can occur during the intrauterine or peripartum *** of HBV primarily occurs by intrauterine transmission (IUT).Hepatitis B surface antigen is unable to cross the placenta and,therefore,relies on processes like transplacental leakage,placental infection,cellular transmission by peripheral blood mononuclear cells,and germline *** can also infect the fetus by *** viruses also have the potential for transmission during delivery,when there is increase chance of maternal-fetal blood *** and HCV share some common risk factors for VT,including maternal viral load,human immunodeficiency virus co-infection and neonatal *** of VT differs greatly between HBV and *** are several alternatives for prevention of HBV VT,including antiviral medications during the third trimester of pregnancy and HBV vaccine,as well as hepatitis B immunoglobulin administration to infants *** contrast,there are no preventative interventions available for *** these differences,the key to prevention with both viruses is screening women prior to and during pregnancy.

关键词： vertical transmission Hepatitis B Hepatitis C Mechanisms Prevention

Mathematical model of Zika virus with vertical transmission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2017年第2期2卷 244-267页

作者： F.B.Agusto S.Bewick W.F.Fagan Department of Ecology&Evolutionary Biology University of KansasLawrenceKS 66045United States Department of Biology University of MarylandCollege ParkMD 20742United States

Zika is a flavivirus transmitted to humans through either the bites of infected Aedes mosquitoes or sexual *** has been linked to congenital anomalies such as *** this paper,we analyze a new system of ordinary differential equations which incorporates human vertical transmission of Zika virus,the birth of babies with microcephaly and asymptomatically infected *** Zika model is locally and globally asymptotically stable when the basic reproduction number is less than *** model shows that asymptomatic individuals amplify the disease burden in the community,and the most important parameters for ZIKV spread are the death rate of mosquitoes,the mosquito biting rate,the mosquito recruitment rate,and the transmission per contact to mosquitoes and to adult *** exploration indicates that personal-protection is a more effective control strategy than mosquito-reduction *** also shows that delaying conception reduces the number of microcephaly cases,although this does little to prevent Zika transmission in the broader ***,by coupling aggressive vector control and personal protection use,it is possible to reduce both microcephaly and Zika transmission.2000 Mathematics Subject Classifications:92B05,93A30,93C15.

关键词： Zika virus vertical transmission Microcephaly Stability Control

Mathematics of dengue transmission dynamics:Roles of vector vertical transmission and temperature fluctuations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2018年第1期3卷 266-292页

作者： Rahim Taghikhani Abba B.Gumel School of Mathematical and Statistical Sciences Arizona State UniversityTempeAZUSA

A new deterministic model is designed and used to gain insight into the effect of seasonal variations in temperature and vector vertical transmission on the transmission dynamics of dengue *** model,which incorporates(among many other features)the dynamics of the immature dengue-competent mosquitoes,vertical transmission in the vector population,density-dependent larval mortality and temperature effects,is rigorously analysed and simulated using data relevant to the disease dynamics in Chiang Mai province of *** non-trivial disease-free equilibrium of the model is shown to be globallyasymptotically stable when the associated basic reproduction number of the model is less than *** simulations of the model,using data relevant to the disease dynamics in the Chiang Mai province of Thailand,show that vertical transmission in the vector population has only marginal impact on the disease dynamics,and that the effect of vertical transmission is temperature-dependent(in particular,the effect of vertical transmission on the disease dynamics increases for values of the mean monthly temperature in the range[16-28]℃,and decreases with increasing mean monthly temperature thereafter).It is further shown that dengue burden(as measured in terms of disease incidence)is maximized when the mean monthly temperature is in the range[26-28]℃(and dengue burden decreases for mean monthly temperature values above 28℃).Thus,this study suggests that anti-dengue control efforts should be intensified during the period when this temperature range is recorded in the Chiang Mai province(this occurs between June and August).

关键词： Dengue vertical transmission Temperature Stability Reproduction number

Analysis of a delayed epidemic model with non-monotonic incidence rate and vertical transmission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2014年第4期7卷 103-119页

作者： Jinhu Xu Wenxiong Xu Yicang Zhou School of Mathematics and Statistics Xi ' an Jiaotong University Xi'an 710049 P. R. China

A delayed SEIR epidemic model with vertical transmission and non-inonotonic incidence is formulated. The equilibria and the threshold of the model have been determined on the bases of the basic reproduction number. The local stability of disease-free equilib- rium and endemic equilibrium is established by analyzing the corresponding character- istic equations. By comparison arguments, it is proved that, if Ro 〈 1, the disease-free equilibrium is globally asymptotically stable. Whereas, the disease-free equilibrium is unstable if R0 〉 1. Moreover, we show that the disease is permanent if the basic repro- duction number is greater than one. Furthermore, the sufficient conditions are obtained for the global asymptotic stability of the endemic equilibrium when R0 〉 1.

关键词： SEIR epidemic model basic reproduction number vertical transmission permanent.