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Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients

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Regenerative Biomaterials 2020年第1期7卷 29-34页

作者： Kefeng Luo Guoqiang Jiang Jinjin Zhu Bin Lu Jiye Lu Kai Zhang Xiumei Wang Fu-Zhai Cui Department of Orthopaedic Surgery The Affiliated Hospital of Medical School of Ningbo UniversityZhejiangChina Department of Orthopaedic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineZhejiangChina State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate)(PMMA)and mineralized collagen(MC)compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures(OVCFs)in patients aged over *** all,32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA(MC-PMMA)bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group,respectively,with an average age of over *** operation duration,intraoperative blood loss,hospital stay,oswestry disability index(ODI),visual analogue scale(VAS),anterior vertebral height(AVH),intermediate vertebral height(IVH)and posterior vertebral height(PVH)of injured vertebrae,vertebral computed tomography value,re-fracture rate of adjacent vertebrae,correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two *** the early post-operative period,the VAS,ODI,AVH and IVH in MC-PMMA group were comparable to those in the traditional PMMA ***,the MC-PMMA group showed better effects compared with the PMMA group 12months after ***,this new bone cement has superior clinic effects in the long term.

关键词： percutaneous vertebroplasty vertebral compression fractures PMMA bone cement mineralized collagen elderly patient

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Clinical observations of osteoporotic vertebral compression fractures by using mineralized collagen modified polymethylmethacrylate bone cement

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Regenerative Biomaterials 2017年第2期4卷 105-109页

作者： XiWang Jian-Ming Kou Yang Yue An-Ze Shao Xue-Jun Jia Jian-Wen Hou Chong Gao Zhi-Ye Qiu Xiu-Mei Wang Xi-Sheng Weng Department of Orthopedics The Second People’s Hospital of LianyungangNo.41 Hailian East RoadHaizhou DistrictLianyungang 222000China Institute for Regenerative Medicine and Biomimetic Materials Tsinghua UniversityHaidian DistrictBeijing 100084China Department of Orthopaedics Peking Union Medical College HospitalNo.1 ShuaifuyuanDongcheng DistrictBeijing 100730China

To investigate the clinical outcomes of the treatment of osteoporotic vertebral compression fractures(OVCFs)by using mineralized collagen(MC)modified polymethylmethacrylate(PMMA)bone cement.52 cases(52 vertebras)who sustained OVCF treated with MC modified PMMA bone cement from July 2014 to December 2015 were reviewed *** the cases(52 patients,52 vertebras)included 8 males and 44 females with an average age of 74.83(ranging from 57-to 90-years old).The visual analogue scale(VAS),vertebral body height,Cobb angle,CT values preand post-operation as well as incidence of complications were used to be *** the patients underwent the surgery were successfully followed-up with an average period of 13.54 months(ranging from 6 to 23 months).The patients can ambulate at the second day after the *** VAS scores 2 days after the operation and during the last follow-up were significantly decreased compared with that before the operation(Pvertebral height and local Cobb angle had significant recovery(P<0.05);the CT value of the treated vertebra significantly increased compared with that before the operation(P<0.05).MC with good osteogenic activity and degradation properties can effectively improve the mechanical properties and biocompatibility of the PMMA bone cement,thus obtain better clinical results.

关键词： mineralized collagen PMMA bone cement osteoporosis vertebral compression fractures

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Comment on “Outcomes of different minimally invasive surgical treatments for vertebral compression fractures: An observational study”

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World Journal of Clinical Cases 2022年第12期10卷 3966-3968页

作者： Long Ma Zhi-Wen Luo Ya-Ying Sun Department of Orthopedics The First People's Hospital of Pindingshan CityPingdingshan 467000Henan ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic ***,this is a valuable study that can provide a reference for clinical *** the other hand,we also noticed some points in the article and are willing to share our *** studies with a higher level of evidence can add more knowledge regarding relevant concerns.

关键词： vertebral compression fractures Osteoporosis Study design Observational study Randomize

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Kyphoplasty versus vertebroplasty for the treatment of malignant vertebral compression fractures caused by metastases： a retrospective study

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Chinese Medical Journal 2014年第8期127卷 1493-1496页

作者： Li Zhi Ni Caifang Chen Long Sun Zhiyong Yang Chao Zhao Xin Wang Yanwei Department of Interventional Radiology the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Orthopaedic Surgery the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of General Surgery the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background There are few comparative studies regarding kyphoplasty （KP） and vertebroplasty （VP） for the treatment of painful vertebral compression fractures （VCF） in patients with cancer. The purpose of this study is to retrospectively compare KP with VP in pain improvement, cement leakage incidence, and the cost of treatment of malignant VCE Methods We performed a retrospective study of clinical data for 80 patients with multiple spinal metastases, treated with KP in 42 cases and VP in 38. Visual analog scale （VAS） scores were collected pre-operatively, post-operatively, at 1 month, 6 months, and 1 year after treatment. Cement leakage was identified using fluoroscopy and CT scan. Total cost per patient was also collected. Results There was a significant difference between the pre- and post-operative VAS scores （7.4＋2.0 to 3.8＋1.6, P 〈0.001 in the KP group; 6.7＋2.4 to 3.7＋1.4, P 〈0.001 in the VP group）, and was maintained at 1-year follow-up （3.2＋1.4 in the KP group, 3.1＋1.3 in the VP group）. However, the difference in VAS score between these two groups was insignificant at baseline and every follow-up assessment post-operatively （P 〉0.05）. The incidence of cement leakage in the KP group was lower than that of the VP group （16.9% （14/83） vs 30.3% （23/76）, P 〈0.05）. However, none of the patients developed any symptoms. The length of postoperative hospital stay in the VP group was shorter than that of the KP group （（2.4＋1.3） vs （5.3＋1.9） days, P 〈0.05）. Total hospital cost in the KP group was much higher than that of the VP group （RMB Yuan 8 492_＋3 332 vs RMB Yuan 3 173~1 341, P〈0.01）. Conclusions VP and KP are both effective in providing pain relief for patients with cancer-related VCF. KP provides no greater degree of pain improvement. KP is associated with a lower rate of cement leakage compared with VP. VP is associated with lower cost and shorter postoperative hospital stay in China.

关键词： spinal metastases vertebral compression fractures kyphoplasty vertebroplasty

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Risk factors for new vertebral compression fractures after percutaneous vertebroplasty:Qualitative evidence synthesized from a systematic review

Risk factors for new vertebral compression fractures after p...

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第25届全国脊柱脊髓学术会议暨2013年贵州省骨科年会

作者：邢丹马信龙马剑雄王杰陈阳杨阳朱少文马宝意冯睿天津医科大学总医院骨科天津市天津医院骨科

*** identify the risk factors for new vertebral compression fractures(VCFs)in patients after percutaneous vertebroplasty(PVP)and to grade the evidence according to the quality of included *** is an effective procedure for the treatment of VCFs.A major concern after PVP in patients with osteoporosis is the occurrence of new VCFs in the untreated *** risk factors for new VCFs after PVP reported thus far remain *** risk factors have neither been well identified or *** present systematic review was performed to identify the risk factors for new VCFs after ***-interventional studies evaluating the risk factors for new VCFs of patients with osteoporosis after PVP were searched in Medline,Embase,Sciencedirect and OVID database(all to Nov 2012).Only observational studies with eligible data were *** of included studies was assessed by a modified quality assessment tool,which was previously designed forobservational *** effects of studies were combined with the study quality score using a model of best-evidence ***.24 observational studies involving 3789 patients were *** articles published between 2004 and *** to the quality assessment criteria for included studies,8 studies were deemed as high quality studies,6 as moderate quality studies,and10 as low quality *** were strong evidence for 3 risk factors,including lower BMD,lower BMI,intradiscal cement leakage,and vertebral height *** also identified 6moderate-evidence factors including lower BMI,number of preexisting vertebral fractures,thoracolumbar junction in initial VCFs,cement distraction,older age,and number of treated *** factors were classified into the limited evidence risk *** there is no conclusive evidence for new VCFs of patients with osteoporosis after PVP procedure,these data provide evidence to guide the surgeon and develo

关键词： vertebral compression fractures osteoporosis risk factor vertebroplasy systematic review

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Risk factors for new vertebral compression fractures after percutaneous vertebroplasty:Qualitative evidence synthesized from a systematic review

Risk factors for new vertebral compression fractures after p...

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第二十届全国中西医结合骨伤科学术研讨会、第二届中国医师协会中西医结合医师分会骨伤科学术年会、第十九届浙江省中西医结合骨伤科专业委员会学术年会

作者： Dan Xing XinLong Ma Yang Chen WeiGuo Xu Yang Yang ShaoWen Zhu JianXiong Ma Jie Wang Department of Orthopaedics Institute Tianjin Hospital Department of Orthopaedics Tianjin Medical University General Hospital

Objective To identify the risk factors for new vertebral compression fractures(VCFs) in patients after percutaneous vertebroplasty(PVP) and to grade the evidence according to the quality of included studies. Background PVP is an effective procedure for the treatment of VCFs.A major concern after PVP in patients with osteoporosis is the occurrence of new VCFs in the untreated *** risk factors for new VCFs after PVP reported thus far remain *** risk factors have neither been well identified or summarised. The present systematic review was performed to identify the risk factors for new VCFs after PVP. Methods Non-interventional studies evaluating the risk factors for new VCFs of patients with osteoporosis after PVP were searched in Medline,Embase,Sciencedirect and OVID database(all to Nov 2012).Only observational studies with eligible data were *** of included studies was assessed by a modified quality assessment tool,which was previously designed for observational *** effects of studies were combined with the study quality score using a model of best-evidence synthesis. Results 24 observational studies involving 3789 patients were *** articles published between 2004 and *** to the quality assessment criteria for included studies,8 studies were deemed as high quality studies,6 as moderate quality studies,and 10 as low quality *** were strong evidence for 3 risk factors,including lower BMD,lower BMI,intradiscal cement leakage,and vertebral height restoration. We also identified 6 moderate-evidence factors including lower BMI,number of preexisting vertebral fractures, thoracolumbar junction in initial VCFs,cement distraction,older age,and number of treated *** factors were classified into the limited evidence risk factors. Conclusion Whilst there is no conclusive evidence for new VCFs of patients with osteoporosis after PVP procedure,these data provide evidence to guide the surgeo

关键词： vertebral compression fractures osteoporosis risk factor vertebroplasy systematic review

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