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Effects of remifentanil on intracellular Ca^2＋ and its transients induced by electrical stimulation and caffeine in rat ventricular myocytes

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Chinese Medical Journal 2009年第12期122卷 1439-1443页

作者： ZHANG Ye Michael G. Irwin LI Rui CHEN Zhi-wu Tak-Ming Wong Department of Anesthesiology Second Affiliated Hospital of Anhui Medical University Hefei Anhui 230601 China Department of Anesthesiology the-university of Hong Kong Hong Kong Claina Department of Anesthesiology First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China Departmen't of Physiology the University of Hong Kong Hong Kong China

Background Preconditioning with remifentanil confers cardioprotection. Since Ca^2＋ overload is a precipitating factor of injury, we determined the effects of remefentanil on intracellular Ca^2＋（[Ca^2＋]i） and its transients induced by electrical stimulation and caffeine, which reflects Ca^2＋ handling by Ca^2＋ handling proteins, in rat ventricular myocytes. Methods Freshly isolated adult male Sprague-Dawley rat myocytes were loaded with Fura-2/AM and [Ca]i was determined by spectrofluorometry. Remifentanil at 0.1-1000 μg/L was administered. Ten minutes after administration, either 0.2 Hz electrical stimulation was applied or 10 mmol/L caffeine was added. The [Ca^2＋]i, and the amplitude, time resting and 50% decay （t50） of both transients induced by electrical stimulation （E[Ca^2＋]i） and caffeine （C[Ca^2＋]i） were determined. Results Remifentanil （0.1-1000.0 μg/L） decreased the [Ca^2＋]i in a dose-dependent manner. It also decreased the amplitude of both transients dose-dependently. Furthermore, it increased the time to peak and tso of both transients dose-dependently. Conclusion Remifentanil reduced the [Ca^2＋]i and suppressed the transients induced by electrical stimulation and caffeine in rat ventricular myocytes.

关键词： remifentanil ventricular myocyte cytosolic-calcium opioid receptor

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