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Study on ultrasonic spray technology for the coating of vascular stent

Science China(Technological Sciences) 2011年第12期54卷 3358-3370页

作者： YI Hong HUANG Jie GU XingZhong NI ZhongHua Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical Engineering Southeast University Nanjing 210096 China

The ultrasonic spray technology is studied by the method of theoretical derivation, CFD simulation, spray particle diameter detection and analysis, and experimental analysis. And the ultrasonic spray process for the coating of vascular stent is also optimized. Firstly, the ultrasonic atomization physical model is established and the equation of atomization particle diameter is derived. Secondly, the ultrasonic atomization process is simulated by the CFD method, and shows three atomization patterns： incomplete atomization pattern, critical atomization pattern and jet atomization pattem. The critical amplitude and power equation for ultrasonic atomization is derived. Thirdly, experiment is conducted to study the influence of parameters including power, gas pressure, and surface tension. The results show that the spray is stable though few particles are likely to collide each other during spray moving, and the droplet diameter is about 10μm. The Rosin-Rammler distribution equation for ultrasonic spray is created, and the uniform index number is between 7.11 and 11.48. The uniformity of spray particle diameter, the efficiency of adjustment and the energy consumption are better than traditional spray technology. Lastly, the ultrasonic spray process parameters for stent coating are optimized to eliminate the common defects and obtain fine coating.

关键词： vascular stent ultrasonic atomization spray process particle size surface coating

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Structural and mechanical aspects of hypoeutectic Zn–Mg binary alloys for biodegradable vascular stent applications

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Bioactive Materials 2021年第1期6卷 26-44页

作者： W.Pachla S.Przybysz A.Jarzębska M.Bieda K.Sztwiertnia M.Kulczyk J.Skiba Institute of High Pressure Physics Polish Academy of Sciences UNIPRESSWarszawaPoland Institute of Metallurgy and Materials Science Polish Academy of SciencesKrakowPoland

The study is concerned with the mechanical properties of Zn and three Zn–Mg double alloys with Mg concentrations:0.5%,1.0%and 1.5%in the form of rods with a diameter of 5 mm as potential materials for use in biodegradable medical implants,such as vascular *** materials were cast,next conventionally hot extruded at 250°C and finally,hydrostatically extruded(HE)at ambient *** HE process was carried at liquid nitrogen temperature or in combination with the ECAP *** HE,the microstructure of the alloys was made up of fine-grainedαZn of mean grain size~1μm in a 2-phase coat of 50–200 nm nanograins of the fineαZn+Mg2Zn11 *** 3 to 4-fold reduction of grain size as a result of HE allowed an increase in yield strength from 100%to over 200%,elongation to fracture from 100%to thirty fold and hardness over 50%compared to the best literature results for similar *** accounted for elongation to fracture in case of Zn-0.5 Mg alloy and hardness in case of Zn-1.5 Mg alloy,both of which fell by 20%.For the Zn-0.5 Mg and Zn–1Mg alloys,after immersion tests,no corrosive degradation of plasticity was *** these properties was the result of generating large plastic deformations at ambient temperature due to the application of high pressure forming with the cumulative HE *** results showed that Zn–Mg binary alloys after HE have mechanical and corrosive characteristics,qualifying them for applications in biodegradable implants,including vascular stents.

关键词： Biodegradable Zn alloys Hydrostatic extrusion Microstructure Mechanical properties vascular stent

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vascular stent as a treatment for refractory cervical stenosis

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Chinese Medical Journal 2014年第5期127卷 986-987页

作者： Yang Jie Zhu Lan Lang Jinghe Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing 100730 China

Cervical stenosis is a clinical condition involving partial or complete obstruction of the endocervical *** 1996,Bauldauf proposed that the definition of cervical stenosis is a cervical canal into which a 2.5# Hegar dilator cannot be inserted.1 Acquired cervical stenosis can be a complication of surgical procedures such as conization,trachelectomy,and *** is a serious complication because of the clinical repercussions,which can include amenorrhea,hematometra,dysmenorrhea,infertility,infection,and *** surgical techniques are used in dilation and cervix ***,in some cases,unsuccessful dilation with refractory recurrent stenosis may lead to hysterectomy.A successful case in which a self-expanding nitinol vascular stent was used to treat cervical stenosis was described by Grund et al.2 Here we report two additional cases in which vascular stents were used to treat patients with recurrent cervical stenosis after cervical surgeries.

关键词： cervical stenosis vascular stent dilatation cervical leiomyoma conization

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Extracellular matrix and nitric oxide based functional coatings for vascular stents

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Engineered Regeneration 2022年第2期3卷 149-153页

作者： Quhan Cheng Muhammad Shafiq Muhammad Rafique Li Shen Xiumei Mo Kai Wang Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China.

Cardiovascular diseases cause huge morbidity and mortality ***,vascular stents have been most frequently used to treat cardiovascular diseases thanks to their effectiveness at dilating blood vessels and main-taining the circulation of ***,stent expansion leads to endothelium injury posing thrombogenic and in-stent restenosis(ISR).In addition,the bioinertness and an acute lack of endothelium-like function on the surface of implanted vascular stents compromise their *** coatings of vascular stents to mimic endothelium-and extracellular matrix(ECM)-like functions could prevent thrombosis,inhibit the over-growth of smooth muscle cells(SMCs),and promote the rapid restoration of native endothelium,hence effec-tively suppressing stent-related ***,ECM-based coatings including a multitude of bioactive molecular,such as growth factors,heparin,hyaluronic acid(HA)and so on,have been proven to play important effects on regulating ECs/SMCs behavior and improving blood compatibility of ***,nitric oxide(NO),which is fundamental to the endothelium-mediated anti-thrombogenesity,anti-intimal hyperplasia and anti-inflammation,has been leveraged to improve vascular stent ***,this review will highlight different strategies and biological role of ECM and NO based functional coatings on vascular ***,some potential important factors for stents development are suggested as well.

关键词： vascular stent Nitric oxide Extracellular matrix Functional coating

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Biocompatibility of vascular stents manufactured using metal injection molding in animal experiments

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Transactions of Nonferrous Metals Society of China 2022年第2期32卷 569-580页

作者： Chang SHU Hao HE Bo-wen FAN Jie-hua LI Tun WANG Dong-yang LI Yi-min LI Hao HE Department of vascular Surgery Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of vascular Surgery Fuwai HospitalChinese Academy of Medical ScienceBeijing 100037China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Microelectronic and Materials Engineering Guangxi University of Science and TechnologyLiuzhou 545006China

This study aimed to evaluate the feasibility and safety of a novel stent manufactured by metal injection molding(MIM)in clinical practice through animal *** stents were prepared using powder injection molding technology to considerably improve material *** influence of MIM carbon impurity variation on the mechanical properties and corrosion resistance of 316L stainless steel was *** vitro cytotoxicity and animal transplantation tests were also carried out to evaluate the safety of MIM *** results showed that the performance of 316L stainless steel was very sensitive to the carbon *** fluctuations should be precisely controlled during *** MIM stents were successfully implanted into the aortas of the dogs,and the MIM 316L stents had no significant *** novel intravascular stent manufactured using MIM can maintain a stable form and structure with fast endothelialization of the luminal surface of the stent and ensure long-term patency in an animal *** novel intravascular stent manufactured using MIM demonstrates favorable structural,physical,and chemical stability,as well as biocompatibility,offering promising application in clinical practice.

关键词： vascular stent metal injection molding cytotoxicity test animal experiment biocompatibility

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Zinc(Ⅱ)metal-organic framework eluting titanium implant as propulsive agent to boost the endothelium regeneration

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 123-131页

作者： Wen Liu Xiaoyu Wang Ying Li Shihai Xia Wencheng Zhang Yakai Feng School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China College of Materials Science and Engineering Qingdao UniversityQingdao 266071China Department of Hepatopancreatobiliary and Splenic Medicine Affiliated HospitalLogistics University of People’s Armed Police ForceTianjin 300162China Department of Physiology and Pathophysiology Logistics University of Chinese People’s Armed Police ForceTianjin 300309China Frontiers Science Center for Synthetic Biology Tianjin UniversityTianjin 300072China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China

The advent of antiproliferative drug-eluting vascular stents can dramatically reduce in-stent restenosis via inhibiting the hyperproliferation of vascular smooth muscle ***,the antiproliferative drugs also restrain the repair of the injured endothelial layer,which in turn leads to the very later in-stent *** points that competent endothelium plays a critical role in guaranteeing the long-term patency via maintaining vascular *** the regeneration of endothelium on the implanted vascular stents could be rendered as a promising strategy to reduce stent implantation *** this regard,bioactive zinc(II)metal-organic framework modified with endothelial cell-targeting Arg-Glu-Asp-Val peptide was embedded in poly(lactide-co-caprolactone)to serve as a functional coating on the surface of titanium substrate,which can promote the proliferation and migration of endothelial *** in vitro cell experiments revealed that the zinc(II)metal-organic framework embedded in the polymer coating was able to modulate the behaviors of endothelial cells owing to the bioactive effects of zinc ion and *** results confirmed that zinc(II)metal-organic framework eluting coating represented a new possibility for promoting the repair of the damaged endothelium with potential clinical implications in vascular-related biomaterials and tissue engineering applications.

关键词： Zinc(II)metal-organic framework vascular stent REDV peptide endothelium regeneration coating

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