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Alteration of heat shock protein 20 expression in preeclampticpatients and its effect in vascular and coagulation function

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Frontiers of Medicine 2018年第5期12卷 542-549页

作者： Fanfan Li Mengzhou He Meitao Yang Yao Fan Yun Chen Xi Xia Yin Xie Dongrui Deng Department of Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Ultrosonic Department Peking University Shenzhen Hospital Shenzhen 518035 China

Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulated coagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation and suppression of platelet aggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collected chorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20 and its phosphorylated form. Both HSP20 and phosphorylated HSP20 were downregulated in CPAs from women with PE. Comparison of the vasodilative ability of CPAs from the two groups showed impaired relaxation responses to acetyl choline in preeclamptic vessels. In addition to the reduced HSP20 in serum from women with PE, the platelet distribution width and mean platelet volume were also decreased, and the activated partial thromboplastin time and thromboplastin time were elevated. With regard to the vital roles of HSP20 in mediating vasorelaxation and coagulation function, the decreased HSP20 might contribute to the pathogenesis of PE.

关键词： preeclampsia heat shock protein 20 vascular relaxation coagulation-fibrinolytic system

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