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The neuroimaging of neurodegenerative and vascular disease in the secondary prevention of cognitive decline

Neural Regeneration Research 2021年第8期16卷 1490-1499页

作者： Morgan J.Schaeffer Leona Chan Philip A.Barber Department of Clinical Neurosciences University of CalgaryCalgaryABCanada

Structural brain changes indicative of dementia occur up to 20 years before the onset of clinical symptoms. Efforts to modify the disease process after the onset of cognitive symptoms have been unsuccessful in recent years. Thus, future trials must begin during the preclinical phases of the disease before symptom onset. Age related cognitive decline is often the result of two coexisting brain pathologies: Alzheimer's disease(amyloid, tau, and neurodegeneration) and vascular disease. This review article highlights some of the common neuroimaging techniques used to visualize the accumulation of neurodegenerative and vascular pathologies during the preclinical stages of dementia such as structural magnetic resonance imaging, positron emission tomography, and white matter hyperintensities. We also describe some emerging neuroimaging techniques such as arterial spin labeling, diffusion tensor imaging, and quantitative susceptibility mapping. Recent literature suggests that structural imaging may be the most sensitive and cost-effective marker to detect cognitive decline, while molecular positron emission tomography is primarily useful for detecting disease specific pathology later in the disease process. Currently, the presence of vascular disease on magnetic resonance imaging provides a potential target for optimizing vascular risk reduction strategies, and the presence of vascular disease may be useful when combined with molecular and metabolic markers of neurodegeneration for identifying the risk of cognitive impairment.

关键词： amyloid arterial spin labeling cognitive decline dementia imaging magnetic resonance imaging positron emission tomography quantitative susceptibility mapping tau vascular disease white matter hyperintensities

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A bioinformatics method for predicting long noncoding RNAs associated with vascular disease

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Science China(Life Sciences) 2014年第8期57卷 852-857页

作者： LI JianWei GAO Cheng WANG YuChen MA Wei TU Jian WANG JunPei CHEN ZhenZhen KONG Wei CUI QingHua Laboratory of Translational Biomedicine Informatics School of Computer ScienceHebei University of Technology Department of Biomedical Informatics School of Basic Medical SciencesPeking University Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University MOE Key Laboratory of Cardiovascular Sciences Peking University

Long noncoding RNAs(lncRNAs)play important roles in human diseases including vascular *** the large number of lncRNAs,however,whether the majority of them are associated with vascular disease remains *** this purpose,here we present a genomic location based bioinformatics method to predict the lncRNAs associated with vascular *** applied the presented method to globally screen the human lncRNAs potentially involved in vascular *** a result,we predicted 3043 putative vascular disease associated *** test the accuracy of the method,we selected 10 lncRNAs predicted to be implicated in proliferation and migration of vascular smooth muscle cells(VSMCs)for further experimental *** results confirmed that eight of the 10 lncRNAs(80%)are *** result suggests that the presented method has a reliable prediction ***,the presented bioinformatics method and the predicted vascular disease associated lncRNAs together may provide helps for not only better understanding of the roles of lncRNAs in vascular disease but also the identification of novel molecules for the diagnosis and therapy of vascular disease.

关键词： vascular disease lncRNAs bioinformatics

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Extracellular matrix synthesis in vascular disease:hypertension,and atherosclerosis

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The Journal of Biomedical Research 2014年第1期28卷 25-39页

作者： Markella Ponticos Barbara D.Smith Centre for Rheumatology & Connective Tissue diseases Division of Medicine-InflammationRoyal Free & University College Medical SchoolUniversity College London Department of Biochemistry Boston University School of Medicine

Extracellular matrix （ECM） within the vascular network provides both a structural and regulatory role. The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network. Blood vessels are distended by blood pressure and, therefore, require ECM components with elasticity yet with enough tensile strength to resist rupture. The ECM is involved in conducting mechanical signals to cells. Most importantly, ECM regulates cellular function through chemical signaling by controlling activation and bioavail- ability of the growth factors. Cells respond to ECM by remodeling their microenvironment which becomes dys- regulated in vascular diseases such hypertension, restenosis and atherosclerosis. This review examines the cellu- lar and ECM components of vessels, with specific emphasis on the regulation of collagen type I and implications in vascular disease.

关键词： extracellular matrix vascular disease

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STIM1 and Orai1:novel targets for vascular diseases?

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Science China(Life Sciences) 2011年第8期54卷 780-785页

作者： Mohamed TREBAK Center for Cardiovascular Sciences Albany Medical College

The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking *** recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological ***,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.

关键词： calcium signaling calcium channels Orail STIM1 CRAC channels vascular disease

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Mirror writing in elderly patients with Alzheimer disease and vascular dementia

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Neural Regeneration Research 2007年第4期2卷 248-250页

作者： Xinde Wang Dantao Peng Xiaojie Cai Shuhua Li Department of Neurology Beijing Hospital Ministry of Health Beijing 100730 China

BACKGROUND： The results showed that mirror writing （MW） was correlated with the development of written language, so that MW examination may be one of methods to examine the intelligence of elderly people. OBJECTIVE： To study the MW in elderly patients with Alzheimer disease （AD） and vascular dementia （VaD） and take appropriate scale for their evaluation. DESIGN： Taking the written portion of the Chinese Aphasia Examination Scale （1994） for assessment. SETTING： Department of Neurology, Neuropsychological Laboratory, Beijing Hospital. PARTICIPANTS： From March 1998 to January 2001, 33 patients with AD, 30 patients with VaD admitted into Department of Neurology, Beijing Hospital was enrolled into study. Criteria according to the Diagnostic and Statistical Manual of Mental Disorder, 4^th edition （DSM-Ⅳ）, published by the American Psychiatric Association was used to diagnose AD, while criteria according to the National Institute of Neurological Disorders and Stroke-Association Internationale pour 1a Recherche et 1＇ Enseignement en Neurosciences （NINDS-AIREN） and Alzheimer disease Diagnostic and Treatment Center （ADDCT） were used for diagnosis of VaD. AD group contained 19 males and 14 females aged 60 - 83 years. Twenty-eight males and 2 females, aged 60 - 87 years made up the VaD group. The 63 healthy elderly subjects matched on age and education as controls were enrolled into study. The matched controls were categorized AD control （n =33） and VaD control （n =30）. All patients and controls were understanding and agree with all items of assessment. METHODS： MW examination, Mini Mental State Examination （MMSE）, Hachinski Ischemic Scale, the Global Deterioration Scale （GDS） were examined in all subjects. ① Use the written potion of the Chinese Aphasia examination Scale （1994）, patient using MW for 91% - 100% of dictation had complete MW, those using MW for 51% - 90% of dictation had severe MW, those using MW for 11% - 50% had moderate MW, those using MW for 1% - 10

关键词： Alzheimer disease vascular disease Mirror writing

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Histone deacetylases:Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis

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Genes & diseases 2024年第6期11卷 351-366页

作者： Hanyi Yang Kai Guo Peng Ding Jiayi Ning Yimeng Zhang Yuanyong Wang Zhaoyang Wang Guanglin Liu Changjian Shao Minghong Pan Zhiqiang Ma Xiaolong Yan Jing Han Department of Ophthalmology Tangdu HospitalThe Air Force Military Medical UniversityXi'anShaanxi 710038China Xi'an Medical University Xi'anShaanxi 710086China Department of Thoracic Surgery Shaanxi Provincial People's HospitalThe Third Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710068China Department of Thoracic Surgery Tangdu HospitalThe Air Force Military Medical UniversityXi'anShaanxi710038China Department of Medical Oncology Senior Department of OncologyChinese PLA General HospitalThe FifthMedical CenterBeijing100853China

tHistone deacetylases(HDACs)are proteases that play a key role in chromosome structural modification and gene expression regulation,and the involvement of HDACs in can-cer,the nervous system,and the metabolic and immune system has been well *** understanding of the function of HDACs in the vascular system has recently progressed,and a significant variety of HDAC inhibitors have been shown to be effective in the treatment of vascular ***,few reviews have focused on the role of HDACs in the vascular *** this study,the role of HDACs in the regulation of the vascular system mainly involving endothelial cells and vascular smooth muscle cells was discussed based on recent updates,and the role of HDACs in different vascular pathogenesis was summarized as ***,the therapeutic effects and prospects of HDAC inhibitors were also addressed in this review.

关键词： Deacetylation Endothelial cells Histone deacetylase vascular disease vascular smooth muscle cells

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vascular restoration therapy and bioresorbable vascular scaffold

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Regenerative Biomaterials 2014年第1期1卷 49-55页

作者： Yunbing Wang Xingdong Zhang National Engineering Research Center For Biomaterials Sichuan UniversityChengdu 610064China

This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s,metallic bare metal stent and metallic drug-eluting stent technologies in 1990s and 2000s,to bioresorbable vascular scaffold(BVS)technology in large-scale development in recent *** history,the current stage,the challenges and the future of BVS development are discussed in detail as the best available approach for vascular restoration *** criteria of materials selection,design and processing principles of BVS,and the corresponding clinical trial results are also summarized in this article.

关键词： bioresorbable vascular scaffold vascular restoration therapy vascular reparative therapy vascular disease bioresorbable/biodegradable material drug-eluting stent drug-eluting biodegradable stent drug-eluting bioresorbable scaffold

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CEUS: A new imaging approach for postoperative vascular complications after right-lobe LDLT

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World Journal of Gastroenterology 2009年第29期15卷 3670-3675页

作者： Yan Luo Yu-Ting Fan Qiang Lu Bo Li Tian-Fu Wen Zhong-Wei Zhang Department of Sonography West China Hospital Sichuan University Chengdu 610041Sichuan Province China Liver TransplantationCenter West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM: To investigate contrast-enhanced ultrasound (CEUS) for early diagnosis of postoperative vascular complications after right-lobe living donor liver transplantation (RLDLT). METHODS: The ultrasonography results of 172 patients who underwent RLDLT in West China Hospital, Sichuan University from January 2005 to June 2008 were analyzed retrospectively. Among these 172 patients, 16 patients' hepatic artery flow and two patients' portal vein flow was not observed by Doppler ultrasound, and 10 patients' bridging vein flow was not shown by Doppler ultrasound and there was a regional inhomogeneous echo in the liver parenchyma upon 2D ultrasound. Thus, CEUS examination was performed in these 28 patients. RESULTS: Among the 16 patients without hepatic artery flow at Doppler ultrasound, CEUS showed nine cases of slender hepatic artery, six of hepatic arterial thrombosis that was confirmed by digital subtraction angiography and/or surgery, and one of hepatic arterial occlusion with formation of lateral branches. Among the two patients without portal vein flow at Doppler ultrasound, CEUS showed one case of hematoma compression and one of portal vein thrombosis,and both were confirmed by surgery. Among the 10 patients without bridging vein flow and with liver parenchyma inhomogeneous echo, CEUS showed regionally poor perfusion in the inhomogeneous area, two of which were confirmed by enhanced computed tomography (CT), but no more additional information about bridging vein flow was provided by enhanced CT. CONCLUSION: CEUS may be a new approach for early diagnosis of postoperative vascular complications after RLDLT, and it can be performed at the bedside.

关键词： Contrast-enhanced ultrasound Livingdonor liver transplantation Postoperative complication vascular disease

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IMPAIRED ANGIOGENESIS FOLLOWING HIND-LIMB ISCHEMIA IN DIABETES MELLITUS MICE

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Chinese Medical Sciences Journal 2007年第4期22卷 232-237页

作者： Yong-jun Li Heng Guan Surovi Hazarika Chang-wei Liu Brain H Annex Department of vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Division of Cardiology Department of Medicine Durham VA and Duke University Medical Center Durham North Carolina 27710 USA

Objective To investigate vascular endothelial growth factor(VEGF) and its signaling pathway spontaneous response in type 2 diabetes mellitus(T2DM) mice to surgery-induced hind-limb *** Sixty mice were randomly divided into two groups,one was fed with normal chow as control,and another was fed with high fat diet to induce *** weeks later,mice were surgically induced to hind-limb *** flow restoration was monitored with laser Doppler perfusion *** anterior muscle was collected after 3 days of hind-limb *** mRNA and protein expressions were analyzed using real-time PCR and ELISA;expressions of VEGF downstream signal molecules and receptors were analyzed using Western blotting and RT-PCR,*** Perfusion recovery 10,20,30 days after ischemia was significantly attenuated in T2DM compared with control group(P<0.05).T2DM impaired VEGF signaling pathway although VEGF levels increased in T2DM *** ischemia,T2DM group had a comparable increase in VEGF expression compared with control group,but still had an impaired VEGF signaling *** VEGF signaling pathway is abnormal in T2DM mice,although VEGF had a response to the ischemic stimulation.

关键词： vascular disease diabetes mellitus angiogenesis vascular endothelial growth factor

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Diffuse arterial atherosclerosis presenting with acute ischemic gastritis: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8357-8363页

作者： Rui-Yao Wei Jia-Hui Zhu Xiang Li Jian-Yong Wu Jun-Wei Liu Department of Traditional Chinese Medicine The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Gastroenterology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Gastroenterology Songyang Chinese Medicine HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Ischemic gastritis is a clinically rare disease with high mortality that infrequently reported in the medical literature and under-recognized clinically and *** diagnosis and treatment can only be achieved through upper gastrointestinal endoscopy after symptoms *** SUMMARY A 68-year-old woman with a history of intracranial aneurysm developed dizziness,chest tightness and unconsciousness for 2 *** tomography angiography showed diffuse coronary atherosclerosis,moderate to severe stenosis in the proximal end of the left anterior descending branch,multiple calcified plaques in the proximal end of the circumflex branch and right coronary artery,and mild to moderate *** patient also developed diffuse atherosclerosis in the splenic and mesenteric arteries,with mild lumen stenosis and athero-sclerosis in the abdominal aorta and its *** showed submucosal congestion and damage of the entire gastric mucosa,of which the fundus and body of the stomach were most seriously *** mucosa was swollen,with a deep purple color,surface erosion and dark red oozing *** examination showed bleeding and necrosis of the gastric mucosa,with residual contours of the gastric glands,consistent with ischemic *** Ischemic gastritis is a rare disease that may be difficult to diagnose as its symptoms may be similar to those of other gastrointestinal *** is usually based on endoscopic and pathological examinations,which show insufficient blood supply to the gastric mucosa leading to mucosal damage and necrosis.

关键词： Ischemic gastritis Endoscopy Pathological examination Atherosclerosis vascular disease Case report

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