检索结果-南通市图书馆

Open Journal of Psychiatry 2012年第4期2卷 327-334页

作者： Wakako Umene-Nakano Reiji Yoshimura Hikaru Hori Asuka Katsuki Kenji Hayashi Chiharu Yoshii Atsuko Ikenouchi-Sugita Kiyokazu Atake Jun Nakamura Department of Psychiatry School of Medicine University of Occupational and Environmental Health Kitakyushu City Japan Department of Respiratory Medicine Wakamatsu Hospital of University of Occupational and Environmental Health Kitakyushu City Japan

Objective: The present study sought to determine changes in plasma levels of catecholamine metabolites and serum levels of brain-derived neurotorophic factor (BDNF) among smokers with schizophrenia who were treated with varenicline. Methods: We compared plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and serum BDNF levels across 4 groups, divided as follows: smokers with schizophrenia (S-Sc), nonsmokers with schizophrenia (NS-Sc), smokers who were otherwise healthy (S-HC) and nonsmokers who were otherwise healthy (NS-HC). In addition, we also examined plasma HVA and MHPG levels and serum BDNF levels prior to study initiation (T0) and 8 weeks after varenicline treatment (T8) in the S-Sc and S-HC groups. Results: Plasma HVA levels in the S-Sc group at T0 were significantly higher than in the NS-Sc, S-HC and NS-HC groups at the same time point (S-Sc at T0;7.6 ± 1.6 ng/mL, NS-Sc;4.8 ± 1.0 ng/mL, S-HC;4.3 ± 0.9 ng/mL, NS-HC;3.4 ± 1.4 ng/mL, p varenicline.

关键词： Schizophrenia BDNF HVA MHPG varenicline Smoking Cessation

Effect of varenicline on Detrusor Overactivity in Rat Model of Parkinson’s Disease Induced by Intranigral 6-Hydroxydopamine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Parkinson's Disease 2022年第1期11卷 1-10页

作者： Zeynep Mine Altunay Fatma Rüyal Tan Nermin Bölükbaşı Funda Fatma Bölükbaşı Hatip Izzettin Hatip-Al-Khatib Department of Neurosciences Health Sciences Institute Pamukkale University Denizli Turkey Pharmacology Department Faculty of Medicine Demiro&#287 lu Bilim University Istanbul Turkey Pharmacology Department Faculty of Medicine Pamukkale University Denizli Turkey

Background: Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Bladder dysfunction is the common non-motor symptom of PD, most often presenting with detrusor overactivity (DO). Treatment of DO is currently limited, poorly tolerated and sometimes ineffective. Bladder responses are not only mediated by muscarinic cholinergic receptors (mAChR) but also by nicotinic cholinergic receptors (nAChR). However, nicotinic receptor subtypes and functions in the bladder are not clearly identified. Purpose: This study aimed at investigating the effect of varenicline, an alpha7 full agonist and alpha4beta2/alpha3 partial agonist, on detrusor strips in rat PD model induced by substantia nigra injection of 6-hydroxydopamine. Method: The detrusor activity was studied in an isolated organ bath system. Results: In PD group, the detrusor activity was increased, whereas varenicline decreased the DO. Conclusion: Alpha7 nAChR agonists may have therapeutic potential in treatment of bladder overactivity in PD.

关键词： Nicotinic Cholinergic Receptors Overactive Bladder varenicline Parkinson Disease Alpha7 Nicotinic Cholinergic Receptor Agonists

Somnambulism: varenicline-Induced Sleep Driving

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2023年第7期12卷 213-217页

作者： Samer Alkhuja Monika Girgis Mohammad Ali Pravinkumar Patel Olutunde Odeyemi Department of Medicine The Commonwealth Medical College Lehigh Valley Health Network-Pocon Stroudsburg Pennsylvania USA

Background: varenicline, which is derived from the cytisine compound, is used to assess in smoking cessation. Sleep driving (SD) is often classified as a variant of somnambulism. Although, somnambulism has been reported as a side effect of varenicline, varenicline-induced sleep driving (VISD) has not been reported. Case Report: A 56-year-old man with a history of 35 pack year smoking who presented for smoking cessation counseling. Treatment with varenicline was initiated. In the following night, the patient drove to a shopping center and woke up in his car. varenicline was discontinued. SD has not been reported in the following nights. In a repeated attempt to stop smoking, treatment with varenicline was resumed by the patient. SD reoccurred in the following night. varenicline was discontinued indefinitely, and SD has not been reported.

关键词： varenicline Sleep Walking Arousal Parasomnia

新型高效口服戒烟新药varenicline

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

齐鲁药事 2005年第7期24卷 406-406页

辉瑞有限公司研制的瓦伦尼克林(varenicline)是金雀花碱(Cytisine)类药物，是第一种不含尼古丁的戒烟药。varenicline的作用在于激活烟碱受体，从而改变烟碱对其正常反应，让吸烟者误以为烟瘾已经得到满足。在500人历时7周的试验中，研... 详细信息

辉瑞有限公司研制的瓦伦尼克林(varenicline)是金雀花碱(Cytisine)类药物，是第一种不含尼古丁的戒烟药。varenicline的作用在于激活烟碱受体，从而改变烟碱对其正常反应，让吸烟者误以为烟瘾已经得到满足。在500人历时7周的试验中，研究者报告戒烟成功率达50％，而借助口香糖等物戒烟6个月后的成功率只有7％到10％。辉瑞公司称，这种戒烟药的副作用非常小。

关键词：戒烟药 varenicline 烟碱受体疾病控制

Tobacco cessation pharmacotherapy use among racial/ethnic minorities in the United States:Considerations for primary care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2017年第3期5卷 193-203页

作者： Monica Webb Hooper Michael Payne Kimberly A.Parkinson Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOHUSA

Pharmacotherapies for tobacco cessation are efficacious and recommended during quit ***/ethnic minorities in the United States are less likely to use medication-based aids for tobacco cessation,despite greater difficulty achieving long-term *** reasons for this include,among others,provider-and patient-level *** care clinicians play an important role in encouraging racial/ethnic minority tobacco users to use cessation *** better understand pharmacotherapy use,we conducted a narrative review of patient-lev-el factors that may determine uptake and *** review indicates that social and cultural factors impact pharmacotherapy use,including health care experiences,beliefs,perceptions,and *** proportion of individuals using pharmacotherapy during quit attempts and adhering to the full course of treatment may be enhanced with greater attention to the ethnocultural concerns of these *** appropriate assessment and brief advice delivered by primary care providers could yield significant benefits in population *** for treating racial/ethnic tobacco users with pharmacotherapy for cessation are offered.

关键词： Tobacco cessation pharmacotherapy racial/ethnic minorities primary care physician advice nicotine replacement therapy varenicline bupropion