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Molecular evolution and deorphanization of bitter taste receptors in a vampire bat

Integrative Zoology 2021年第5期16卷 659-669页

作者： Qin LU Hengwu JIAO Yi WANG Ngawang NORBU Huabin ZHAO Department of Ecology Tibetan Centre for Ecology and Conservation at WHU-TUHubei Key Laboratory of Cell HomeostasisCollege of Life SciencesWuhan UniversityWuhanChina Research Center for Ecology College of ScienceTibet UniversityLhasaChina

bats represent the largest dietary radiation in a single mammalian order,and have become an emerging model group for studying dietary *** receptor genes have proven to be molecular signatures of dietary diversification in *** example,all 3 extant species of vampire bats have lost many bitter taste receptor genes(Tas2rs)in association with their dietary shift from insectivory to ***,only 8 full-length Tas2rs were identified from the high-quality genome of the common vampire bat(Desmodus rotundus).However,it is presently unknown whether these bitter receptors are functional,since the sense of taste is less important in vampire bats,which have an extremely narrow diet and rely on other senses for acquiring ***,we applied a molecular evolutionary analysis of Tas2rs in the common vampire bat compared with non-vampire ***,we provided the first attempt to deorphanize all bitter receptors of the vampire bat using a cell-based *** found that all Tas2r genes in the vampire bat have a level of selective pressure similar to that in non-vampire bats,suggesting that this species must have retained some bitter taste *** demonstrated that 5 of the 8 bitter receptors in the vampire bat can be activated by some bitter compounds,and observed that the vampire bat generally can not detect naturally occurring bitter compounds examined in this *** study demonstrates functional retention of bitter taste in vampire bats as suggested by cell-based functional assays,calling for an in-depth study of extra-oral functions of bitter taste receptors.

关键词： bitter taste diet evolution selection vampire bat

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