检索结果-南通市图书馆

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

在线全文

学校读者我要写书评

暂无评论

National Science Review 2021年第7期8卷 72-85页

作者： Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of Neuroscience School of Medicine Xiamen University National Institute for Data Science in Health and Medicine School of Medicine Xiamen University Cancer Research Center Department of Stomatology School of Medicine Xiamen University

Loss-of-function mutations in sorting nexin 14(SNX14) cause autosomal recessive spinocerebellar ataxia20, which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models. We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration. SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin, which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia, and compromised axonal integrity and mitochondrial function. Axonal transport disruption and mitochondrial dysfunction further led to degeneration of highenergy-demanding Purkinje cells, which resulted in the pathogenesis of cerebellar ataxia. The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells. Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia, demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction, and suggested valproate as a potential therapeutic agent.

关键词： sorting nexin 14 cerebellar ataxia Purkinje cell degeneration mitochondrial dysfunction axonal transport valproate

Effect of levetiracetam and valproate on late‑onset post‑traumatic seizures

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Epileptologica 2023年第2期6卷 86-89页

作者： Yanli Wang Yiqi Wang Huifang Wang Xiaoping Du Jie Miao James X.Tao Meizhen Sun Department of Rehabilitation Shanxi Traditional Chinese Medical HospitalTaiyuan 030012China Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030012China Department of Neurology University of ChicagoChicagoIL 60601USA

Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury(TBI).Methods A total of 95 patients with TBI were recruited from 2017 to 2020.They were randomized into three groups:levetiracetam(LEV)group(n=30)receiving LEV treatment(500 mg,bid,po);valproate group(n=32)receiving sodium valproate(500 mg/d,once daily,po);and control group(n=33)receiving no anti-seizure medication.LEV and valproate were given to corresponding groups within seven days after TBI,and the administration lasted for one month.The incidence of epilepsy and adverse events were evaluated at 7 days and 12 months post-TBI.Results The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV,valproate,and control groups were 3.33%,12.50%and 15.63%,respectively.The cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups(Pvalproate group was not significantly different from that in the control group(P>0.05).Conclusions LEV can reduce the cumulative incidence of late post-traumatic seizures,whereas valproate can not.

关键词： Levetiracetam valproate Post-traumatic seizure

Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第3期14卷 480-484页

作者： Peng Wu Yue Hu Xiu-Juan Li Min Cheng Li Jiang Department of Neurology Children's Hospital of Chongqing Medical University Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing

Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown. A model of convulsive status epilepticus was established in Wistar rats by intraperitoneal injection of 3 mEq/kg lithium chloride, and intraperitoneal injection of pilocarpine 40 mg/kg after 18–20 hours. Sodium valproate(100, 200, 300, 400, 500, or 600 mg/kg) was intragastrically administered six times every day(4-hour intervals) for 5 days. To determine the best dosage, sodium valproate concentration was measured from the plasma. The effective concentration of sodium valproate in the plasma of the rats that received the 300-mg/kg intervention was 82.26 ± 11.23 μg/mL. Thus, 300 mg/kg was subsequently used as the intervention concentration of sodium valproate. The following changes were seen: Recording excitatory postsynaptic potentials in the CA1 region revealed high-frequency stimulation-induced long-term potentiation. Immunohistochemical staining for BrdU-positive cells in the brain revealed that sodium valproate intervention markedly increased the success rate and the duration of induced long-term potentiation in rats with convulsive status epilepticus. The intervention also reduced the number of newborn neurons in the subgranular area of the hippocampus and subventricular zone and inhibited the migration of newborn neurons to the dentate gyrus. These results indicate that sodium valproate can effectively inhibit the abnormal proliferation and migration of neural stem cells and newborn neurons after convulsive status epileptic

关键词： nerve regeneration status epilepticus sodium valproate long-term potentiation neural stem cells neurogenesis migration subgranular zone subventricular zone neural regeneration

在线全文

学校读者我要写书评

暂无评论

丙戊酸钠缓释片致中毒性表皮坏死溶解症一例

中华精神科杂志 2017年第5期50卷 397-398页

作者：吴为阁王文强范燕云厦门市仙岳医院儿童青少年心理科 361012 厦门大学附属中山医院消化内科

病例描述患者男,16岁,学生,因＂兴奋话多、言语夸大、乱发脾气3周＂于2015年10月8日入厦门市仙岳医院治疗.2015年9月15日患者无明显诱因出现兴奋,话多,内容夸大,要求多,索要钱财、抵押物品挥霍,不满足即大发脾气,毁物、持刀威胁欲自杀... 详细信息

病例描述患者男,16岁,学生,因＂兴奋话多、言语夸大、乱发脾气3周＂于2015年10月8日入厦门市仙岳医院治疗.2015年9月15日患者无明显诱因出现兴奋,话多,内容夸大,要求多,索要钱财、抵押物品挥霍,不满足即大发脾气,毁物、持刀威胁欲自杀被制止.患者整晚不眠、精力充沛,活动增多,对人热情,大量抽烟,并到处请人抽烟,易激惹,与老师发生冲突.入院前3d曾在我院门诊予丙戊酸钠缓释片（sodium valproate sustained-release tablets, VPA） 0.5 g每日2次,奥氮平5 mg每日1次进行治疗,但患者不予配合,家人难以管理,以＂躁狂发作＂强制收入我院.既往史、个人史、家族史均无特殊.

关键词：丙戊酸钠缓释片中毒性表皮坏死 valproate 溶解医院治疗精力充沛躁狂发作发脾气

Effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis status as well as inflammatory response in patients with intractable epilepsy

在线全文

学校读者我要写书评

暂无评论

Journal of Hainan Medical University 2018年第1期24卷 149-152页

作者： Wen Tang Mei-Mei Yang Ya-Ning Tang Department of Neurology Chengdu Fifth People's Hospital in Sichuan ProvinceChengduSichuan Province611130 Heart-and-lung Center the Fifth Hospital of Sichuan ProvinceChengduSichuan Province610031 Department of Pharmacy Chengdu Women and Children's Central Hospital in Sichuan ProvinceChengduSichuan Province610091

Objective: To investigate the effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis as well as inflammatory response in patients with intractable epilepsy. Methods: A total of 70 patients with intractable epilepsy who were treated in our hospital between August 2013 and October 2016 were divided into routine group (n=35) and study group (n=35) by random number table method, routine group received sodium valproate therapy and study group received lamotrigine combined with sodium valproate therapy. The differences in serum levels of neurotrophy indexes, nerve apoptosis indexes and inflammatory factors were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in serum levels of neurotrophy indexes, nerve apoptosis indexes and inflammatory factors between the two groups. After treatment, serum BDNF and NGF levels of study group were higher than those of routine group;serum Bcl-2, Fas and FasL levels of study group were lower than those of routine group whereas Bax level was higher than that of routine group;serum IL-1β, IL-6 and PGE2 levels of study group were lower than those of routine group. Conclusion: Lamotrigine combined with sodium valproate therapy can effectively increase the neurotrophy, inhibit the nerve apoptosis and reduce the systemic inflammatory response in patients with intractable epilepsy.

关键词： Intractable epilepsy Lamotrigine Sodium valproate Neurotrophy Apoptosis Inflammatory response

Effect of sodium valproate retard tablet on the oxidative stress system and cognitive function in patients with epilepsy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hainan Medical University 2017年第6期23卷 139-141页

作者： Jian-Feng Chen Mei-Hu Zhang Department of Neurology Dongguan Qishi HospitalGuangdong523500

Objective:To explore the effect of sodium valproate retard tablet on the oxidative stress system, cognitive function, and thyroid hormone level in patients with epilepsy.Methods:A total of 68 patients with epilepsy were included in the study and randomized into the treatment group and the control group with 34 cases in each group. The patients in the treatment group were given sodium valproate retard tablets, while the patients in the control group were given carbamazepine. The patients in the two groups were treated continuously for 6 months. The oxidative stress indicators and thyroid hormone level before and after treatment in the two groups were detected and compared. MMSE was used to evaluate the cognitive function in the two groups.Results: MPO, SOD, CAT, and GSH-Px levels after treatment in the two groups were significantly reduced when compared with before treatment, while MDA level was significantly elevated. The improvement of the above indicators after treatment in the treatment group was significantly superior to that in the control group. FT3 and FT4 levels after treatment in the control group were significantly reduced when compared with before treatment, but were significantly lower than those in the treatment group. MMSE score 3 and 6 months after treatment in the two groups was significantly elevated when compared with before treatment. MMSE score at each timing point after treatment in the treatment group was significantly higher than that in the control group.Conclusions: The sodium valproate has a small effect on the balance of oxidation and anti-oxidation in patients with epilepsy, and can significantly improve the cognitive function.

关键词： Epilepsy Sodium valproate retard tablet Oxidative stress Cognitive function Thyroid hormone

Comparisons of drug efficacy and time-effect among magnesium valproate,sustained-release magnesium valproate tablet and depakine chrono for epilepsy An experiment of determining cortical convulsive threshold in rats undergoing electrical stimulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2007年第12期2卷 732-735页

作者： Leiyu Geng Yuxi Liu Shurong Yan Jiali Xu Research Institute of Epilepsy Shanxi Medical University Taiyuan 030001 Shanxi Province China

BACKGROUND： Scholars have investigated the differences in drug metabolism and pharmacodynamics between valproate and its sustained-release tablets only from the angle of pharmaceutical sciences or clinical practice. Whether the fact that differences in drug efficacy and time-effect of different doses of valproate and different types of sustained-release valproate tablets at the same concentration can be quantitatively reflected by determining the changes in convulsive threshold pre- and post-administration in rat models of determining the convulsive threshold developed by direct cortical electrical stimulation remains unclear. OBJECTIVE： This study aimed to compare the drug efficacy and time-effect among magnesium valproate, sustained-release magnesium valproate tablet and depakine chrono in the treatment of epilepsy by determining the convulsive threshold of rat models created by direct cortical electrical stimulation, and human serum drug concentration before and after administration. DESIGN： A controlled observational experiment. SETTING： Research Institute of Epilepsy, Shanxi Medical University. MATERIALS： Adult health male SD rats of clean grade, weighing 200 - 220 g, provided by the Laboratory Animal Center of Shanxi Medical University. The protocol was carried out in accordance with requests from Animal Ethics Committees for guidance. Magnesium valproate （Lot No. 041004） and sustained-release magnesium valproate tablet （Lot No. 050501） were produced in Hunan Xiangzhong Pharmaceutical Co., Ltd. METHODS： This study was carried out in the Laboratory for Epilepsy, Shanxi Medical University between June and August 2005. （1）All the SD rats were created into models for determining cortical convulsive threshold. They were randomly divided into 4 groups with 20 rats in each： magnesium valproate tablet group, sustained-release magnesium valproate tablet group, depakine chrono group and control group. After being modeled, the rats in the first 3 groups were intragastrically administrated with magnesium valp

关键词： epilepsy valproate convulsive threshold serum drug concentration

Population pharmacokinetic/pharmacodynamic modeling of valproate in Chinese children with epilepsy

在线全文

学校读者我要写书评

暂无评论

Population pharmacokinetic/pharmacodynamic modeling of valpr...

Needs monitoring with quetiapine

中国药理学会临床药理学专业委员会会议暨第十次全国临床药...

作者： JIANG De-chun~(1,2) WANG Li~2 WANG Yu-qin~1 LU Wei~(3,4) BAI Xiang-rong~1 1 Department of Pharmacy,Xuan-wu Hospital,Capital Medical University,Beijing 100083,Chinta 2 Department of Pediatrics,First Hospital,Peking University,Beijing 100083,China 3 Department of Pharmaceuties,School of Pharmaceutical Science,Peking University,Beijing 100083,China 4 State Key Lab.of Natural and Biomimetic Drugs,Beijing 100083,China

AIM:To establish a population pharmacokinetic/pharma- codynamic(PK/PD)model for valproate(VPA)in chil- dren with epilepsy in China,and promote reasonable use of antiepileptie drug in clinical practice. METHODS:Sparse data of VPA serum concentrations from 417 pediatric children were collected.These patients were divided into three groups:Population PK-Index group,n=317;Population PK-Valid group,n=100;115 of the total 417 subjects were also included in the Population PD group.Population PK parameters of VPA were estimated based on the data from population PK-Index group.In the validation procedure,the serum concentra- tions of VPA from the population PK-Valid group were pre- dicted by base and final models respectively.To assess the accuracy and precision of the predictions,mean prediction error(MPE),mean square(t prediction error(MSPE), root mean squared prediction error(RMSPE),weight-resi- dues(WRES)and its 95% confidence intervals(95%CI) were all calculated,then compared between the two mode- Is.For population PD group,’all of the 115 patients were VPA monotherapy.Efficacy of epilepsy treatment was di- vided into 5 grades according to the percentage of seizure frequency decreased(PSFD%).The value of PSFD% 100%,75%-100%,50%-75%,25%-50%,or less than 25 % are corresponding to grade 1 to 5.For pop- ulation PD group,the quantitative relationship between the VPA serum concentrations and the probability for its effica- cy score was characterized by logistic regression. RESULTS:Population PK of VPA was described by one- compartment model with first order absorption.In the final model,K,V/F,CL/F are0.251+2.24·(1-HS)(/ h),2.88+0.157·WT(L),0.106+0.0157· AGE(L/h),respectively.The final model was validated internally and externally.Logistic regression showed that VPA serum concentrations and corresponding peak proba- bility for its efficacy were(25μg/mL,grade 5,50%), (32 μg/mL,grade 4,32.3%),(50 μg/mL,grade 3, 26.3%),(67 μg/mL,grade 2,36.5%),and(78 μg,/mL,grade 1,50% ),respectively. CONCLUSION:The population PK/PD model of V

关键词： population pharmacokinetics/pharmacodynamics valproate epileptic children Bayesian approach NONMEM individualized dosage regimen

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第1期132卷 113-114页

作者： Pugazhenthan Thangaraju Sajitha Venkatesan Vineet Kumar Chadha Department of Pharmacology All India Institute of Medical SciencesRaipurChhattisgarh 492099India Clinical Division Central Leprosy Teaching and Research InstituteChengalpattuTamilnadu 603001India

To the Editor:We read with great interest regarding the article on "Acute Pancreatitis Associated with valproate Treatment."By Quan et al^[1] published in your esteemed journal.

关键词： Acute Pancreatitis Associated valproate Treatment quetiapine