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validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 375-385页

作者： Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano Department of Gastroenterological Surgery II Hokkaido University Faculty of MedicineSapporoJapan Department of Surgery Cancer Center AmsterdamAmsterdam UMCLocation AMC University of AmsterdamAmsterdamthe Netherlands Department of Surgery Erasmus Medical CenterRotterdamthe Netherlands Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNYUSA

Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended.

关键词： Perihilar cholangiocarcinoma(PHCC) post operative mortality score post-hepatectomy liver failure score(PHLFS) validation study

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Validity and Reliability of a Mental Health Recovery Checklist for Young Adults

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International Journal of Mental Health Promotion 2024年第4期26卷 317-323页

作者： Brianna Cerrito Jamie Xiao Amie DiTomasso Amanda Fialk Jocelyn Bolin Research Department The DormNew York10023USA Department of Educational Psychology Ball State UniversityMuncie47306USA

The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occupation and school,physical health,mental health,spirituality,and social support systems.The Mental Health Recovery Checklist(MHRC)was developed at The Dorm,an intensive outpatient mental health treatment program for young adults in New York,NY,and Washington DC that services individuals between the ages of 18 and 35 years old.The present study is cross-sectional,as data were pulled from clients’records who were discharged between January 2018 and May 2023.Pearson Correlations and Cronbach’s alpha were used to determine scale reliability.To establish validity,an Exploratory Factor Analysis(EFA)was conducted to assess a single-factor model using Principal Axis Factoring.Cronbach’s alpha was high(α=0.88),indicating good reliability.In the EFA,all items loaded strongly on a single factor.The unidimensional structure revealed in the EFA highlights the interconnected nature of various life domains as they pertain to mental health recovery in young adults.Future research is warranted to explore whether there are additional dimensions of mental health recovery that have not been assessed in the present scale.

关键词： Mental health recovery young adult validation study mental health checklist

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validation of the Investigator 24plex QS Kit:a 6-dye multiplex PCR assay for forensic application in the Chinese Han population

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Forensic Sciences Research 2022年第2期7卷 172-180页

作者： Ruiyang Tao Chong Chen Xiang Sheng Ruocheng Xia Xiaochun Zhang Jingyi Zhang Zihao Yang Suhua Zhang Chengtao Li Institute of Forensic Medicine West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengduChina Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic SciencesMinistry of JusticeShanghaiChina College of Medicine and Forensics Xi’an Jiaotong University Health Science CenterXi’anChina QIAGEN HildenGermany Department of Forensic Medicine School of Basic Medical ScienceWenzhou Medical UniversityWenzhouChina Department of Forensic Science Medical School of Soochow UniversitySuzhouChina

The Investigator 24plex QS Kit(QIAGEN,Hilden,Germany)is a 6-dye fluorescent chemistry short tandem repeat(STR)polymerase chain reaction(PCR)amplification system that simultaneously amplifies 20 of the expanded Combined DNA Index System(CODIS)core STR loci,SE33,DYS391,and the standard sex-determining locus,amelogenin,as well as two special internal performance quality sensor controls(QS1 and QS2),which are included in the primer mix to check the PCR performance.This study was designed to be a pilot evaluation of this STR-PCR kit in a Chinese Han population regarding the PCR conditions,sensitivity,precision,accuracy,repeatability,reproducibility,and concordance;tolerance to PCR inhibitors;applicability to real“forensic-type”samples;species specificity;mixture,balance and stutter analyses,and utility in a population investigation.The exhaustive validation studies demonstrated that the Investigator 24plex QS system is accurate,sensitive and robust for STR genotyping.In addition,these genetic markers in the population data in our study indicated that they can also be useful for forensic identification and paternity testing in the Chinese Han population.

关键词： Forensic sciences forensic genetics short tandem repeat(STR)typing Investigator 24plex QS Kit validation study

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Forensic validation Studies of a Novel 35-InDel Multiplex Polymerase Chain Reaction System

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Journal of Forensic Science and Medicine 2023年第4期9卷 303-308,I0004-I0011页

作者： Tong Xie Hui Xu Congying Zhao Yating Fang Yongsong Zhou Qiong Lan Chunmei Shen Bofeng Zhu Department of Laboratory Medicine Guangzhou Key Laboratory of Forensic Multi-Omics for Precision IdentificationSchool of Forensic MedicineSouthern Medical UniversityGuangzhouChina Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Laboratory Medicine Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’anShaanxiChina

Background:A difficulty associated with forensic applications is the detection of degraded biological materials.Due to the large amplicon sizes of short tandem repeat alleles,valid genotyping results cannot be obtained from degraded biological materials.Recently,insertion/deletion(InDel)polymorphisms have been used in forensic applications for their widespread distributions in the human genome,short amplicon sizes,and low mutation rates.Purpose:Human identification InDel panels have mostly been designed for European populations.Therefore,our laboratory independently developed a multiplex polymerase chain reaction(PCR)system with 35 polymorphic InDel loci to be used for human identification in China.Forensic validation studies were conducted on this novel 35-InDel multiplex PCR system.Methods:The 35 InDel loci were screened in the database,and then used with the traditional PCR amplification and capillary electrophoresis platform combined with five-color fluorescence parallel detection technology.validation studies were performed on this novel panel,including accuracy,repeatability and reproducibility,species specificity,sensitivity,stability,forensic case sample detection,and mixture studies.In addition,forensic efficiency assessments were conducted in populations from different continents.Results:The data of validated studies indicated that the novel 35-InDel panel was accurate,stable,and efficient for forensic purposes.For human identification,the cumulative power of discrimination values for the these 35 InDel loci in East Asian,South Asian,European,American,and African populations were 0.999999999999995,0.999999999999995,0.999999999999971,0.9999999999999960,and 0.999999999998166,respectively.Conclusions:In this study,a set of 35 InDel loci were conducted in a multiplex amplification system for human identification of degraded DNA sample,and this new assay was efficient and stable.The present results suggested that the 35-InDel panel was a reliable tool for forensic use and could be efficiently used for human

关键词： 35-InDel panel human identification insertion/deletion polymorphism validation study

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validation of Peek Acuity application in pediatric screening programs in Paraguay

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1384-1389页

作者： Bryce de Venecia Yasmin Bradfield Ralph Moiler Trane Alicia Bareiro Miguel Scalamogna Department of Ophthalmology and Visual Sciences University of Wisconsin Madison Madison 53792 Wisconsin USA Fundacion Vision Calle Ingavi y Coronel Cazal DepartamentoSan Lorenzo 2300 Central Paraguay

AIM： To validate the Peek Acuity mobile phone application in pediatric populations and compare its utility, both economic and diagnostic, against conventional screening methods using a pediatric ophthalmologist examination as the gold standard.METHODS： A cohort of 393 subjects from Fernando de la Mora, Paraguay（ages 6-16 y） were enrolled in the study. Subjects were randomly assigned a starting screening modality among： Peek Acuity, a single line of tumbling E optotypes set at 20/40, and Spot Vision Screener. Once completing the first screening modality, the subjects completed the two remaining techniques. Referral criteria were established based on the most current American Association of Pediatric Ophthalmology and Strabismus（AAPOS） recommendations： 20/40 for Peek Acuity and the tumbling E, and refractive error detection for the Spot Vision Screener. Subjects that failed to achieve the cutoff for any of the three screening techniques or subjects that passed the screening but were randomly selected to perform a comprehensive eye exam to determine the false negative rate, were evaluated by a pediatric ophthalmologist. This evaluation was considered the gold standard, and included vision assessment by a Snellen chart, strabismus evaluation, and cycloplegic refraction with dilated fundoscopy.RESULTS： We obtained 48% sensitivity, 83% specificity, 43% positive predictive value, and 86% negative predictive value for Peek Acuity＇s ability to refer compared to evaluation by a pediatric ophthalmologist, failing to achieve a desired sensitivity for implementation. Peek Acuity trended to overestimate the subject＇s visual acuity, providing a higher visual acuity that would not indicate referral for a comprehensive eye examination. However, its high specificity accurately predicted a significant number of children who did not need further evaluation. When comparing the three screening methods, no single screening modality outperformed the others. Peek Acuity represented a technology that was economically feasible compared to

关键词： pediatric ophthalmology validation study screening mobile phone application

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Evaluation of joint awareness after acetabular fracture:validation of the Forgotten Joint Score according to the COSMIN checklist protocol

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World Journal of Orthopedics 2021年第2期12卷 69-81页

作者： Viola Freigang Johannes Weber Karolina Mueller Christian Pfeifer Michael Worlicek Volker Alt Florian Michael Baumann Department of Trauma Surgery Regensburg University Medical CenterRegensburg 93042Germany Center for Clinical Studies Regensburg University Medical CenterRegensburg 93042Germany

BACKGROUND A fracture of the acetabulum is an uncommon,but serious injury.Established outcome tools do not reflect the patient’s perspective after fracture of the hip joint.Originally designed for post-arthroplasty patients,the Forgotten Joint Score(FJS)is a patient-reported outcome measurement(PROM)tool evaluating the diseasespecific health-related quality of life(HR-QoL).AIM To validate the FJS in patients after acetabular fracture.METHODS In a prospective mono-centric cohort study,we evaluated 100 patients at mean 5.2±3.6 years after a fracture of the acetabulum.The validation study followed the complete COSMIN checklist protocol.For calculation of convergent validity,we used the Tegner-Activity Scale,the Western Ontario and McMaster Universities Osteoarthritis Index,the EuroQol-5D,and a subjective rating of change as an anchor variable.RESULTS We confirmed good internal consistency with a Cronbach‘s alpha of 0.95.With an intraclass correlation coefficient of 0.99(95%CI:0.97,0.99),test-retest reliability of the FJS was excellent.Correlation coefficients between the questionnaires were moderate to high ranging from|0.56|to|0.83|(absolute value).No relevant floor or ceiling effects occurred.Standard error of measurement was 3.2 and smallest detectable change(SDC)was 8.8.Thus,changes greater than 8.8 points between two assessments denote a real change in FJS.CONCLUSION The FJS is a valid and reliable tool for evaluation of patient-reported outcome in posttraumatic condition after acetabular fracture.The SDC indicating a real clinical improvement was 8.8 points in the FJS.We could confirm responsiveness of the FJS and found no relevant floor-or ceiling effects.

关键词： Patient reported outcome measurement validation study Hip joint Forgotten Joint Score Acetabulum fracture COSMIN checklist

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Clinical and radiographic predictors in diagnosing sputum smear- negative pulmonary tuberculosis in HIV-negative patients： a cross- sectional study in China

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Chinese Medical Journal 2013年第19期126卷 3662-3667页

作者： LI Xin-xu JIANG Shi-wen ZHANG Hui JING Kuan-he WANG Li LI Wei-bin LIU Xiao-qiu YAO Hong-yan WANG Li-xia National Center for Tuberculosis Control and Prevention ChineseCenter for Disease Control and Prevention Beijing 102206 China Chongqing Institution of Tuberculosis Prevention and Treatment Chongqing 400050 China Liaoning Center for Disease Control and Prevention Shenyang110005 China Office of Epidemiology Chinese Center for Disease Control andPrevention Beijing 102206 China

Background In county-level tuberculosis （TB） dispensaries in China,the accurate diagnosis of sputum smear-negative pulmonary tuberculosis （SNPT） needs to be improved by developing and validating clinical and radiographic predictors.Methods The study was conducted simultaneously in three counties per province in Chongqing Municipality and Liaoning Province in China between May 2005 and May 2006.A total of 432 new SNPT patients who are HIV-negative and more than 15 years old diagnosed by expert panels in county-level TB dispensaries were recruited.Their sputum samples were collected for culture before anti-TB treatment,and the treatment outcomes （changes of X-rays） were followed up at the end of the 6th month.Results Of the 432 SNPT patients,sputum culture positive （9.7%） or culture negative with good changes of X-rays at the end of the 6th month （73.6%） was validated as SNPT.Four predictive variables were associated with validated SNPT in the multivariate logistic regression model：age ≤55 years old （odds ratio （OR） 5.66; 95% CI 2.69-11.91）,〉60 days of cough （OR 3.73; 95% CI 1.10-12.65）,≥10% of pulmonary consolidation in the lungs （OR 5.40; 95% CI 2.90-10.06）,and pulmonary consolidation in the upper lobe anterior segment （OR 3.00; 95% CI 1.57-5.72）.The area under the receiver operating characteristic curve of the model was 0.77 （95% CI 0.71-0.83）.Conclusion Four predictors of clinical and radiological characteristics that had a good diagnostic performance of SNPT deserve to be recommended as index indicators of SNPT diagnosis in county-level TB dispensaries in China.

关键词： validation study tuberculosis smear negative pulmonary/radiography

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MP-PIC simulation of circulating fluidized beds using an EMMS based drag model for Geldart B particles

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Particuology 2021年第6期19卷 76-90页

作者： Timo Dymala Tom Wytrwat Stefan Heinrich Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestr.1521073 HamburgGermany

In this study the multiphase particle-in-cell(MP-PIC)method is used for the simulation of two pilot-scale circulating fluidized beds(CFBs)with quartz sand belonging to Geldart’s group B as bed material.The simulations were performed using a homogeneous drag model as well as a structure dependent drag model based on the energy minimization multi-scale method(EMMS).The results are compared with experimental data from literature as well as experiments.The simulations with the EMMS based drag model show a good agreement of the time-averaged axial solids concentration,circulation rate and riser pressure drop.Furthermore,a lower grid sensitivity is observed compared to the homogeneous drag model.In contrast to the conventional drag model a dense bottom zone is predicted by the EMMS based drag model.An overprediction of the solid concentration in the dense bottom zone is presumably due to an overprediction of the cluster diameter that is calculated using an empirical cluster diameter correlation.This shows the necessity for a new meso-scale cluster correlation for the simulation of Geldart B particles.Furthermore,the results of the time-averaged radial solids concentration differ from the expectations of a core-annulus flow indicating that a mesh refinement at the walls is necessary.Finally,the importance of using a realistic particle size distribution is identified.

关键词： 3D-CFD simulation Circulating fluidized bed(CFB) Multiphase particle-in-cell method(MP-PIC) Energy minimizing multi-scale theory(EMMS) validation study

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Development of a Training Textbook for Countermeasures to “Verbal Abuse, Physical Assault, and Harassment in Pediatric Medical Settings”

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Health 2022年第1期14卷 63-69页

作者： Rie Wakimizu Hinako Kuwahara Yumiko Saito Makoto Saito Department of Child Health and Developmental Nursing Faculty of Medicine University of Tsukuba Ibaraki Japan Department of Nursing Toranomon Hospital Tokyo Japan Doctoral Program in Nursing Science Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Japan Department of Child Health Faculty of Medicine University of Tsukuba Ibaraki Japan

Background: Recently, abuse, assault, and harassment in pediatric medical settings have become more serious. We extracted typical problems from a nationwide simultaneous survey on abuse in the pediatric medical field and developed a training textbook to simulate or discuss these issues with colleagues. This study aimed to confirm the validity and usability of the contents of this training textbook. Methods: The textbook was mailed to the heads of 51 medical institutions affiliated with the Society of Ambulatory and General Pediatrics of Japan (SAGPJ) and the participants of the SAGPJ online workshop, who were asked to evaluate the textbook using a three-point scale to answer the following questions and provide opinions and impressions about the textbook. Q1. Do you think the whole content and structure of this textbook are useful? Q2. Would you use this textbook as a training textbook for all staff at your facility? A simple tabulation was performed on the evaluation using a three-point scale, while content analysis was performed on the opinions and impressions of the participants. Results: In response to Q1 and Q2, all 63 staff members from 55 facilities answered “3: Yes.” Opinions and impressions on the training textbook included “I think it can be used for workplace training” and “it is useful for exchanging various opinions among staff members and gaining a common opinion.” Conclusion: We developed a training textbook on abuse, assault, and harassment in pediatric medical settings based on a nationwide survey and confirmed the validity and usability of its contents.

关键词： Pediatric Safety Management Textbook validation study Workplace Violence

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Ten Rules of Foot Care—The Development of a Short Questionnaire for Patients with Diabetes

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Journal of Diabetes Mellitus 2021年第3期11卷 83-96页

作者： Ileana Antohe Alina Delia Popa Nursing Department Faculty of Medicine “Gr. T. Popa” University of Medicine and Pharmacy Ia&#351 i Romania

Objective: The aim of this study was to develop and validate a questionnaire for patients with diabetes to assess the foot self-care. Methods: A validation study was carried out in a sample of 200 patients with diabetes. Item analyses included the assessment of difficulty index, discrimination capacity and the correlation of items with the total score of the questionnaire. Factor analysis was used to test construct validity. Test-retest reliability was assessed with a sample of 31 patients. Criterion validity was determined by comparing the scores of patients with a history of foot ulcers with the scores of patients without this complication. Results: The internal consistency assessed by the Cronbach’s alpha (0.731) and test-retest reliability (r = 0.714, p = 0.001) for all sections were acceptable. Factor analysis revealed three factors: foot care, footwear and foot-damaging behavior, which explained 54.34% of the variance. All items had factor loading of greater than 0.4. Patients with diabetic neuropathy had a lower score after completing the foot care education questionnaire (Mann-Whitney U, p Conclusion: This questionnaire meets the reliability and validity conditions necessary for its application in our patients with diabetes.

关键词： Diabetes Mellitus Foot Care validation study Diabetic Foot Ulcers

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