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Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Military Medical Research 2021年第4期8卷 510-522页

作者： Shuai Wei Wei Wang Li Li Hao-Ye Meng Chun-Zhen Feng Yu-Ying Dong Xi-Chi Fang Qi-Qiang Dong Wen Jiang Hai-Li Xin Zhan-Zhen Li Xin Wang Institute of Orthopaedics Beijing Key Lab of Regenerative Medicine in OrthopaedicsChinese PLA General HospitalBeijing 100583China. Zhoushan Dinghai Guanghua Hospital Zhoushan 316000ZhejiangChina. Tianjin Hospital Tianjin UniversityTianjin 300211China. Geriatric Neurological Department of the Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijing 100853China. Department of Orthopedics Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000China. Department of Stomatology Chinese PLA General HospitalBeijing 100853China. Department of Plastic Surgery General Hospital of Taiyuan Iron and Steel Limited CompanyTaiyuan 030009China. Hand Microsurgery Department Shenzhen People’s HospitalShenzhen 518020GuangdongChina. Third Surgery Department Zhengzhou Renji HospitalZhengzhou 450000China. Department of Orthopedics the First Affiliated Hospital of Medical CollegeShihezi UniversityShiheziXinjiang 832000China. Pharmacy Department Chinese PLA General HospitalBeijing 100853China.

Background:vacuum sealing drainage(VSD)and epidermal growth factor(EGF)both play an important role in the treatment of *** study aims to explore the effects of the combination of VSD and EGF on wound healing and the optimal concentration and time of ***:We tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations(0,1,5,10,and 100ng/ml)and different EGF action times(2,10,and 30min).A full-thickness skin defect model was established using male,30-week-old Bama *** experiment included groups as follows:routine dressing change after covering with sterile auxiliary material(Control),continuous negative pressure drainage of the wound(VSD),continuous negative pressure drainage of the wound and injection of EGF 10min followed by removal by continuous lavage(V+E 10min),and continuous negative pressure drainage of the wound and injection of EGF 30min followed by removal by continuous lavage(V+E 30min).The wound healing rate,histological repair effect and collagen deposition were compared among the four ***:An EGF concentration of 10ng/ml and an action time of 10min had optimal effects on the proliferation and migration capacities of HaCaT and L929 *** drug dispersion effect was better than drug infusion after bolus injection effect,and the contact surface was *** with other groups,the V+E 10min group promoted wound healing to the greatest extent and obtained the best histological ***:A recombinant human epidermal growth factor(rhEGF)concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in *** combined with rhEGF kept in place for 10min and then washed,can promote wound healing better than the other treatments in vitro.

关键词： vacuum sealing drainage Epidermal growth factor Skin wound healing Full-thickness skin defect

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Novel Application of vacuum sealing drainage with Continuous Irrigation of Potassium Permanganate for Managing Infective Wounds of Gas Gangrene

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第4期35卷 563-568页

作者：胡宁吴星火刘融杨述华黄玮蒋电明吴强夏天邵增务叶哲伟 Department of Orthopaedic Surgery Institute for Orthopaedic Research and EducationThe First Affiliated Hospital of Chongqing Medical University Department of Orthopaedic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Orthopaedic Surgery Wuhan Puren HospitalWuhan University of Science and Technology

Summary： Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputa- tion. The aim of the present study was to use vacuum sealing drainage （VSD） with continuous irrigation of potassium permanganate to manage infective wounds of gas gangrene and observe its clinical effi- cacy. A total of 48 patients with open traumatic gas gangrene infection were included in this study. Am- putations were done for 27 patients, and limb salvage procedures were performed for the others. After amputation or aggressive debridement, the VSD system, including polyvinyl alcohol （PVA） foam dress- ing and polyurethane （PU） film, with continuous irrigation of 1：5000 potassium permanganate solutions, was applied to the wounds. During the follow-up, all the patients healed without recurrence within 8-18 months. There were four complications. Cardiac arrest during amputation surgery occurred in one pa- tient who suffered from severe septic shock. Emergent resuscitation was performed and the patient re- turned to stable condition. One patient suffered from mixed infection of Staphylococcal aureus, and a second-stage debridement was performed. One patient suffered from severe pain of the limb after the debridement. Exploratory operation was done and the possible reason was trauma of a local peripheral nerve. Three cases of crush syndrome had dialysis treatment for concomitant renal failure. In conclusion, VSD can convert open wound to closed wound, and evacuate necrotic tissues. Furthermore, potassium permanganate solutions help eliminate anaerobic microenviroument and achieve good therapeutic effect on gas gangrene and mixed infection. VSD with continuous irrigation of potassium permanganate is a novel, simple and feasible alternative for severe traumatic open wounds with gas gangrene infection.

关键词： vacuum sealing drainage potassium permanganate irrigation gas gangrene trauma

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Salvage of vascular graft infections via vacuum sealing drainage and rectus femoris muscle flap transposition: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2296-2301页

作者： Peng Zhang Fu-Lin Tao Qing-Hu Li Dong-Sheng Zhou Fan-Xiao Liu Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical *** aim of this report is to illustrate the novel vacuum sealing drainage(VSD)technique and rectus femoris muscle flap transposition for vascular graft infections,and to evaluate the prospective of future testing of this surgical *** SUMMARY We report the case of a 32-year-old male patient,who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft *** the VSD and muscle flap transposition,the groin wound and vascular graft infection were finally treated *** Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure,especially in consideration of treatable conditions.

关键词： Vascular graft Infection Muscle flap transposition Rectus femoris muscle flap vacuum sealing drainage Case report Trauma

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vacuum sealing drainage technique in the treatment of poor healing wounds after heart valve surgery:experience in cardiac nursing

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South China Journal of Cardiology 2014年第4期15卷 279-281页

作者： WU Hong-mei HUANG Zhi-feng ZHENG Shao-yi LAI Wen LIU Zu-an BIAN Hui-ning SUN Chuan-wei LI Han-hua MA Liang-hua CHEN Han-xi Department of Burns and Wound Repair Surgery Guangdong General Hospital Guangdong Academy of Medical Sciences

Background Poor wound healing or postoperative infection after open-heart surgery is most commonly seen. If not treated in time or the infection progresses, it can lead to sternal infection, even mediastinal and pericardial infection, causing a higher mortality rate. vacuum sealing drainage （VSD） is a new technology to promote wound healing. We studied the use of VSD technique in poor wound healing after heart valve surgery to see if it could achieve good therapeutic efficacy. Methods From 2013 October to 2014 October in Guang- dong General Hospital, 86 cases of the application of vacuum sealing drainage technique in the treatment of cardiac nonunion after valve replacement in patients with nursing observation. The treatment time, death rate and infection rate, etc were compared. Results Wound healing time of 86 patients receiving vacuum sealing drainage was 14.6 ± 3.6 days, and no patient died. Two patients came back to hospital for repair due to dehis- cence of the incision after discharge. Conclusion Nursing observation and drainage management were the key of VSD. VSD technique is worthy to be popularized clinically.

关键词： vacuum sealing drainage nursing heart valve surgery

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Application of vacuum sealing drainage technique in poor healing wounds after heart valve surgery

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South China Journal of Cardiology 2013年第2期14卷 122-126页

作者：黄志锋陈华德郑少逸赖文廖路妹刘族安卞徽宁孙传伟李汉华马亮华 Deparment of Burns Surgery Guangdong General Hospital Guangdong Academy Medical Sciences Panyu Dashi People's Hospital

Background： Poor healing wounds or postoperative infection after open-heart surgery are most commonly seen, especially in secondary surgery for heart diseases, with an incidence rate of 2.2% after a valve replacement surgery. If not treated in time or the infection progresses, it can lead to sternal infection, even mediastinal and pericardial infection, causing a higher mortality rate. It becomes a really troublesome and complicated case when a poor healing occurs in midsternal incision after the heart valve surgery and a higher medical cost may be needed. Methods From January 2009 to February 2013, 162 patients who underwent heart valve surgery through midsternal incision approach and had a poor healing of wound were observed for prospective randomized controlled trial. The patients were randomly assigned to a vacuum sealing drainage group （n = 81） who received vacuum sealing drainage for healing of the wound or a control group （n = 81） who received traditional treating for the infected wound. Their therapeutic effects, healing time and treatment costs, etc were compared. Results Two patients from the vacuum sealing drainage group came back to hospital for repair due to dehiscence of the incision after discharge, and no patient died. Six patients from the control group came back to hospital for repair due to dehiscence of the incision after discharge, two came back to hospital for surgery due to chronic osteomyelitis, and one patient died two weeks later after surgery due to severe chest infection. Wound healing time for vacuum sealing drainage group was 14.6 ± 3.6 days, which was significantly shorter than that of the control group （21.2 ± 7.8 days, P 〈 0.05）, while the medical costs showed no significant difference between the two groups （P 〉 0.05）. Seventy-eight patients （96.29%） in the vacuum sealing drainage group showed a good healing of the wound and sternum after a six-month follow-up. Conclusion The use of vacuum sealing drainage technique in poor-healing

关键词： vacuum sealing drainage heart valve heart operation poor healing wounds

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Consensus on the application of negative pressure wound therapy of diabetic foot wounds

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Burns & Trauma 2021年第1期9卷 421-432页

作者： Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia Burn Institute of PLA Department of BurnsThe First Affiliated Hospital of Naval Medical UniversityNo.168 Changhai RoadYangpu DistrictShanghai200433China Fujian Burn Institute Fujian Medical University Union HospitalNo.29 Xinquan RoadGulou DistrictFuzhou350001China Department of Burns&Wound Care Center Second Affiliated Hospital of Zhejiang UniversityCollege of MedicineNo.88 Jiefang RoadShangcheng DistrictHangzhou310009China No.3 Department of Burns and Plastic Surgery and Wound Healing Center The Fourth Medical Center of Chinese PLA General HospitalNo 51 Fucheng RoadHaidian DistrictBeijing100048China Foot and Ankle Surgery Department Guangzhou Zhenggu Orthopedic HospitalNo.449 Dongfeng Middle RoadYuexiu DistrictGuangzhou510031China Department of Burns and Cutaneous Surgery The First Affiliated Hospital of Air Force Medical UniversityNo.127 West Changle RoadXincheng DistrictXi’an710032China Wound Healing Department PLA Strategic Support Force Characteristic Medical CenterNo.9 Anxiang North LaneChaoyang DistrictBeijing100101China Department of Peripheral Vascular Beijing University of Chinese MedicineDongzhimen HospitalHai Yun Cang on the 5thDongcheng DistrictBeijing100700China Department of Orthopedics Zhejiang University School of MedicineSir Run Run Shaw HospitalNo.3 East Qinchun RoadShangcheng DistrictHangzhou310016China Department of Burns The Fifth Hospital of HarbinNo.27 Jiankang RoadXiangfang District150030HarbinChina Institute of Burn Research State Key Laboratory of TraumaBurn and Combined InjurySouthwest HospitalThird Military Medical UniversityGaotanyan Street no.29Shapingba DistrictChongqing400038China Department of Burn Shanghai Jiaotong UniversitySchool of Medicine Affiliated Ruijin HospitalNo.197 Ruijin Road(No.2)Huangpu DistrictShanghai200025China Department of Burn Surgery the Third People’s Hospital of WuxiNo.585 North Xingyuan RoadWuxi214043China Innovation Center for Wound Rpair Diabetic Foot Care CenterDepartment of Endoc

Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been *** foot has become one of the main health-related killers due to its high disability and mortality *** pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its ***,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment *** 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound *** on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic *** consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot.

关键词： vacuum sealing drainage vacuum-assisted closure vacuum-assisted therapy Negative pressure wound therapy Topical negative pressure therapy Suction wound closure therapy Diabetic foot Diabetic ulcer Diabetic wound

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Postoperative infection of the skull base surgical site due to suppurative parotitis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4991-4997页

作者： Yong Zhao Yang Zhao Li-Qin Zhang Guo-Dong Feng Department of Otorhinolaryngology-Head and Neck Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Paraganglioma occurring at the lateral skull base is a rare *** is the primary treatment of benign *** infection of the surgical site at the lateral skull base is very dangerous and hard to *** SUMMARY A 30-year-old man with a 1-year history of left-side progressive hearing loss,tinnitus,facial palsy,and choking failed conventional treatment and is the focus of this case *** revealed a mass around the left jugular foramen that was approximately 47 mm×38 mm×34 mm in size and had eroded the bone of the vertebral and horizontal segments of the internal carotid *** tumor breached the meninges and occupied the cerebella pontine region.A two-stage surgery was designed for the resection of the *** the first-stage,the epidural portion of the mass was *** abdominal fat and the temporal muscle flap were transposed within the surgical *** surgery was successful;however,25 d after surgery,he developed suppurative parotitis,and the infection spread to the surgical site at the skull ***-spectrum antibiotics were used,and debridement was *** that,the wound was cleaned *** months after the first-stage surgery,the wound was still unclosed,and there was intermittent purulent exudation within the surgical *** sealing drainage(VSD)was used,and the wound healed in a *** year after the first surgery,the second-stage of the operation was performed to remove the intracranial portion of the *** of the tumor was not detected after a 6-month *** After a lateral skull base surgery,suppurative parotitis can spread into the operative cavity leading to infection of the surgical *** can help to effectively heal the infected wound.A two-stage surgical approach offers a safer option for removing the lateral skull base paraganglioma that involves the meninges.

关键词： Postoperative infection Lateral skull base Suppurative parotitis vacuum sealing drainage Two-stage surgery Case report

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Experience of VSD in the treatment of foot tophi rupture with severe infection wounds

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Chinese Journal of Plastic and Reconstructive Surgery 2019年第2期1卷 5-11页

作者： Peng WANG Yong-jing HE Ji-hua WANG Wei-qi YANG Li-kun ZHU Department of Plastic Surgery Second Affiliated HospitalKunming Medical UniversityYunnan Province650101China

Objective Investigate the clinical effects of vacuum sealing drainage(VSD)in the treatment of 11 cases of foot tophi rupture with severely infected *** From January 2017 to January 2019,11 patients with foot tophi rupture and severe infection were enrolled in our *** were 9 males and 2 females,aged from 27 to 68 years *** patients were treated with VSD after *** treatment time was 7d-42d,with an average of *** All patients were followed up for 6 months after VSD *** the wounds healed well without *** VSD is used to treat foot tophus rupture with severe infection of *** is easy to operate and satisfactory in clinical results.

关键词： vacuum sealing drainage foot tophi rupture severe infection wound healing

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