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Mycobacterium smegmatis enhances shikonin-induced immunogenic cell death—an efficient in situ tumor vaccine strategy

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Journal of Biomedical Research 2024年第4期38卷 369-381页

作者： Zhaoye Qian Zhe Zhang Lanqi Cen Yaohua Ke Jie Shao Manman Tian Baorui Liu Department of Oncology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingJiangsu 210008China Department of Oncology the Affiliated Huai'an No.1 People's HospitalNanjing Medical UniversityHuai'anJiangsu 223000China Center of Clinical Oncology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of Oncology China Pharmaceutical University Nanjing Drum Tower HospitalNanjingJiangsu 210008China The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China Department of Oncology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China

Tumor vaccines are a promising avenue in cancer *** the progress in targeting specific immune epitopes,tumor cells lacking these epitopes can evade the ***,we aimed to construct an efficient in situ tumor vaccine called Vac-SM,utilizing shikonin(SKN)to induce immunogenic cell death(ICD)and Mycobacterium smegmatis as an immune adjuvant to enhance in situ tumor vaccine *** showed a dose-dependent and time-dependent cytotoxic effect on the tumor cell line and induced ICD in tumor cells as evidenced by the CCK-8 assay and the detection of the expression of relevant indicators,*** with the control group,the in situ Vac-SM injection in mouse subcutaneous metastatic tumors significantly inhibited tumor growth and distant tumor metastasis,while also improving survival *** smegmatis effectively induced maturation and activation of bone marrow-derived dendritic cells(DCs),and in vivo tumor-draining lymph nodes showed an increased maturation of DCs and a higher proportion of effector memory T-cell subsets with the Vac-SM treatment,based on flow cytometry analysis ***,the Vac-SM vaccine effectively induces ICD,improves antigen presentation by DCs,activates a specific systemic antitumor T-cell immune response,exhibits a favorable safety profile,and holds the promise for clinical translation for local tumor immunotherapy.

关键词： Mycobacterium smegmatis shikonin immunogenic cell death tumor vaccines immunogenicity cytotoxicity

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Compartmentalization of the inflammatory response during bacterial sepsis and severe COVID-19

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Journal of Intensive Medicine 2024年第3期4卷 326-340页

作者： Jean-Marc Cavaillon Benjamin G.Chousterman Tomasz Skirecki Institut Pasteur ParisFrance Department of Anesthesia and Critical Care Lariboisière University HospitalDMU ParabolAPHP NordParisFrance Inserm U942 University of ParisParisFrance Department of Translational Immunology and Experimental Intensive Care Centre of Postgraduate Medical EducationWarsawPoland

Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-organ failure and eventually to death. The host response to infection encompasses a large spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fighting the infectious agent and removing damaged tissues or cells, and the anti-inflammatory response aimed at controlling inflammation and initiating the healing process. Fine-tuning at the local and systemic levels is key to preventing local and remote injury due to immune system activation. Thus, during bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring. Immune cells (e.g., macrophages, neutrophils, natural killer cells, and T-lymphocytes), as well as endothelial cells, differ from one compartment to another and contribute to specific organ responses to sterile and microbial insult. Furthermore, tissue-specific microbiota influences the local and systemic response. A better understanding of the tissue-specific immune status, the organ immunity crosstalk, and the role of specific mediators during sepsis and COVID-19 can foster the development of more accurate biomarkers for better diagnosis and prognosis and help to define appropriate host-targeted treatments and vaccines in the context of precision medicine.

关键词： Acute respiratory distress syndrome Bone marrow Cytokines Lungs Mucosa vaccines

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Antimicrobial resistance containment in Africa:Moving beyond surveillance

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Biosafety and Health 2024年第1期6卷 50-58页

作者： Zikora Kizito Glory Anyaegbunam Ifeanyi Elibe Mba Yandev Doowuese Ngozi J.Anyaegbunam Toluwalase Mba Fetuata Aminat Aina Vincent NnamdigadiChigor Emeka Innocent Nweze Emmanuel A.Ezea Department of Microbiology Faculty of Biological SciencesUniversity of Nigeria Nsukka CampusEnugu 410001Nigeria Department of Pharmaceutical Microbiology Faculty of PharmacyUniversity of IbadanIbadan 20005Nigeria Department of Microbiology Federal University of Health SciencesOtukpo 970001Nigeria Measurement and Evaluation Unit Science Education Department University of Nigeria NsukkaEnugu 410001Nigeria Sumy State University Medical InstituteSumy Oblast 40000Ukraine Lead City University Hospital Lead CityIbadan 200255Nigeria Department of Microbiology College of Natural SciencesFederal University of AgricultureAbeokuta 111101Nigeria

Worldwide,infections caused by drug‐resistant pathogens constitute a significant challenge threatening therapeutic *** to the World Health Organization(WHO),antimicrobial resistance(AMR)ranks among the top 10 global public health *** with a high rate of multiple host adaptivity,significant genetic diversity(multiple lineages),high virulence factors,and genetic exchange have been isolated from various sources(humans,animals,and the environment)even without exposure to prior *** now,the source of AMR and how resistant clones are selected in the environment remain largely elusive,and potential anthropogenic transmission has been reported in different *** drug‐resistant pathogens,lineages,resistant clones,outbreak clusters,plasmid replicates,and genes that play a critical role in resistance dissemination have been *** of certain multidrug‐resistant(MDR)determinants has also been shown to enhance or support the propagation of *** far,significant advances have been made in understanding the burden of ***,overcoming AMR requires a holistic approach,as there is no single approach with sufficient precision to curb the *** strengthening AMR surveillance efforts is essential,as we have shown,there is also a need to intensify efforts to strengthen therapeutic interventions,especially in priority regions such as ***,we discussed the burden of AMR and the dissemination of AMR in humans,animals,and the environment(non‐medical drivers).We further delved into the big questions on Africa and discussed how therapeutic interventions involving vaccines and other viable biomaterials could be pivotal in reducing the burden of AMR to the barest minimum.

关键词： Antimicrobial resistance(AMR) Bacteria Surveillance One Health vaccines Africa

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Antigen epitopes of animal coronaviruses:a mini-review

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Animal Diseases 2024年第1期4卷 19-26页

作者： Mingjun Su Guanghui Zheng Xiangwen Xu Houhui Song Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics&Advanced TechnologyZhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health ManagementChina-Australia Joint Laboratory for Animal Health Big Data AnalyticsCollege of Animal Science and Technology&College of Veterinary Medicine of ZhejiangA&F University666 Wusu StreetLin'an DistrictHangzhou 311300Zhejiang ProvinceChina

Coronaviruses are widespread in nature and can infect mammals and poultry,making them a public health ***,prevention and control of emerging and re-emerging animal coronaviruses is a great *** mecha-nisms of virus-mediated immune responses have important implications for research on virus prevention and *** antigenic epitope is a chemical group capable of stimulating the production of antibodies or sensitized lympho-cytes,playing an important role in antiviral immune ***,it can shed light on the development of diagnos-tic methods and novel ***,we have reviewed advances in animal coronavirus antigenic epitope research,aiming to provide a reference for the prevention and control of animal and human coronaviruses.

关键词： Animal coronavirus Antigen epitope B-cell epitope T-cell epitope Immune responses vaccines

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Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya Sharma RB Jain Jitesh Satija Aditi Sharma Avani Sharma Sudhir Shekhawat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Biostatistician Ghaziabad 201014UPIndia

BACKGROUND Immunization is a key component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(P<0.001)were significant predictors of the immunization *** the study was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic vaccines Family health Routine immunization

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56 Years of the Marburg Virus—A Review of Therapeutics

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Open Journal of Epidemiology 2024年第2期14卷 273-283页

作者： Michael M. Toza Emmanuel Imangolwa Natalia Shakela Ferdinand Ndubi Hanzoma Hatwiko Christabel N. Hikaambo Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Department of Pharmaceutical Chemistry and Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Department of Physiological Sciences School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Background: The Marburg virus (MARV) is the causative agent of Marburg virus disease (MVD). This filovirus first appeared in 1967 and has since caused several outbreaks with case fatality rates between 23% and 90%. The earliest cases of MVD are thought to be caused by exposure to an infected animal, either a reservoir host (some bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as non-human primates. The virus is spread between people by direct contact with blood or other bodily fluids (including saliva, sweat, faeces, urine, tears, and breast milk) from infected individuals. Despite the high fatality rate, the Marburg virus has no vaccine or drug treatment. Recent outbreaks of the virus in 2023 in Tanzania and Equatorial Guinea have reignited the need to develop effective therapeutics, especially in the wake of the COVID-19 pandemic. Purpose: This review seeks to highlight the drug discovery efforts aimed at developing vaccines or possible treatments as potential therapeutics. Several existing antiviral agents are being probed, and vaccines are in pre-clinical and clinical stages. Natural products are also an important source of possible drugs or lead compounds and when coupled with computational techniques, these strategies offer possible therapeutics for the Marburg virus, especially in Africa, which has a high disease burden. Methods: Using the search engines Google Scholar and PubMed;keywords e.g. Marburg virus, Marburg treatments, Marburg virus drug discovery were utilized. Several results were yielded, and articles published in recent years were accepted into the final *** and Conclusion: This study shows there is a growing interest in therapeutics for the Marburg virus, especially with the recent outbreaks and pandemic preparedness. Initiatives that to support vaccine development and access like the MARVAC consort time are critical to fighting this public health threat.

关键词： Marburg Virus vaccines Antivirals Viruses Drug Discovery

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Impact of COVID-19 pandemic on routine childhood vaccinations

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World Journal of Virology 2024年第2期13卷 1-4页

作者： Shi-Rong Lv Ming-Ke Wang Xue-Lu Yu Xin-Yue Li Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Routine pediatric vaccination is one of the most effective public health inter-ventions for the control of a number of fatal ***,during the coronavirus disease 2019 pandemic,routine pediatric vaccination rates were severely affected by disruptions of health services and vaccine confidence *** and the United Nations have taken measures to re-establish routine pediatric vaccination,while additional efforts are needed to catch up and develop plans to ensure routine vaccination services for the future pandemics.

关键词： vaccines Childhood immunizations COVID-19 SARS-CoV-2 Pandemic

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Corrigendum to “Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy” [Bioactive Mater. 16 107-119]

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Bioactive Materials 2023年第3期21卷 239-240页

作者： Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang Department of Biophysics School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu610054SichuanPR China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineNo.39 Shi-er-qiao RoadChengdu610072SichuanPR China Key Laboratory of Biorheological Science and Technology Ministry of EducationState and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030PR China

The authors regret that the published version of the above article contained two errors which were not identified during the proofing ***,Figure 2A and 6C have been *** authors apologize for these errors and state tha... 详细信息

关键词： Cor vaccines immunotherapy

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Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses

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Signal Transduction and Targeted Therapy 2022年第4期7卷 978-980页

作者： Xuenian Chen Tongfei Shi Chao Yang Fangman Chen Xuan He Kunbao Zhang Hanze Hu Lulu Cai Kam WLeong Dan Shao School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 511442China Institutes of Life Sciences School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong 510006China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Material and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

Dear Editor,The emergence of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection requires rapid development of vaccines matching the pace of virus *** the firstgeneration of nucleic acid vaccines have been successful,subunit vaccines carry far fewer safety concerns and also have shown promise in clinical trials.

关键词： vaccines protective acute

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Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology

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Acta Pharmaceutica Sinica B 2017年第4期7卷 532-540页

作者： Bing Cui Xuetao Cao Weiping Zou Yonghong Wan Ning Wang Yaohe Wang Pingping Li Fang Hua Yuying Liu Xiaowei Zhang Ke Li Xiaoxi Lv Bo Huang Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College National Key Laboratory of Medical Molecular Biology Department of ImmunologyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences Department of Surgery University of Michigan School of Medicine The University of Michigan Comprehensive Cancer Center University of Michigan Graduate Programs in Immunology and Tumor Biology University of Michigan Department of Pathology and Molecular Medicine Mc Master Immunology Research CentreMc Master University Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Laboratory for Cellular Biomechanics and Regenerative Medicine Department of Biomedical EngineeringSchool of Life Science and TechnologyHuazhong University of Science and Technology Center for Molecular Oncology Barts Cancer InstituteQueen Mary University of London School of Basic Medical Sciences Academy of Medical SciencesZhengzhou University Sino-British Research Centre for Molecular Oncology National Center for International Research in Cell and Gene TherapyZhengzhou University Diabetes Research Center of Chinese Academy of Medical Sciences Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Clinical Immunology Center Chinese Academy of Medical Sciences Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology

Immune cells play key roles in cancer and chronic inflammatory disease. A better understanding of the mechanisms and risks will help develop novel target therapies. At the 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology held in Beijing, China, on May 12, 2017, a number of speakers reported new findings and ongoing studies on immune-related diseases such as cancer, fibrotic disease, diabetes, and others. A considerably insightful overview was provided on cancer immunity, tumor microenvironments,and new immunotherapy for cancer. In addition, chronic inflammatory diseases were discussed. These findings may offer new insights into targeted immunotherapy.

关键词： Tumor Immunology Chromatin Exosomes Microparticles vaccines Oxidative stress Dormancy Protein quality control Inflammation

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