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Salmonella Typhi:from a Human Pathogen to a vaccine vector

Cellular & Molecular Immunology 2008年第2期5卷 91-97页

作者： Victor Tunje Jeza Department of Immunology The State Key Laboratory of VirologyHubei Province Key Laboratory of Allergy and Immune-related DiseasesWuhan UniversitySchool of Medicine

Salmonella （S.） typhi is an important intracellular pathogen. Among the more than 2,300 closely-related Salmonella serovars bacteria recognized, S. typhi is the only one that is pathogenic exclusively for humans, in whom it causes typhoid or enteric fever. The pathogen has been around for many years and many studies have been done in an effort to combat it. Molecular and biologic features of S. typhi and host factors and immune responses involved in Salmonella invasion have been extensively studies. vaccines that have been developed most notably are Vi polysaccharide and Ty21a. However, as the results show, there is still a long way to go. It is also shown that multi-drug resistance has occurred to the few available antibiotics. More and more studies have shown that Salmonella can be used as a vaccine vector carrying antigens of other pathogens. This has been promising in that the immune system can be elicited in response to both the Salmonella bacteria and the antigen of the pathogen in question. This review aims to highlight some of the milestones attained in the fight against the disease from the time S. typhi was seen as a pathogen causing typhoid fever to the use of Salmonella as a vaccine vector. Cellular ＆ Molecular Immunology.

关键词： Salmonella typhi vaccine vector typhoid Vi polysaccharide Ty21a

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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

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Cellular & Molecular Immunology 2022年第2期19卷 234-244页

作者： Yeonsu Kim Xiaoyan Zheng Kathrin Eschke M.Zeeshan Chaudhry Federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On Julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte Stephan Ludwig Martin Messerle Carlos Guzman Ofer Mandelboim Michael Hust Stefan Pöhlmann Stipan Jonjić LukaČičin-Šain Department of Viral Immunology Helmholtz Centre for Infection Research(HZI)BraunschweigGermany Department of Biotechnology Institut für BiochemieBiotechnologie und BioinformatikTechnischen Universität BraunschweigBraunschweigGermany Oxford vaccine Group University of OxfordOxfordUK Center for Proteomics University of RijekaFaculty of MedicineRijekaCroatia Infection Biology Unit German Primate CenterGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany Department of Immunology Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael Infection Immunology Institute for Medical Microbiology and Hospital HygieneHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke-University MagdeburgMagdeburgGermanyImmune RegulationHelmholtz Centre for Infection ResearchBraunschweigGermany Department of Vaccinology and Applied Microbiology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute of Virology Medical University MünsterMünsterGermany Institute of Virology Hannover Medical School(MHH)HannoverGermany German Centre for Infection Research(DZIF) Hannover-Braunschweig SiteHannoverGermany Centre for Individualized Infection medicine(CiiM) a joint venture of HZI and MHHHannoverGermany

Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and *** remains a medical need for vaccines against these ***(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a ***,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous *** generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(S)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over ***,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T ***,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.

关键词： vaccine vector SARS-CoV-2 Influenza Cytomegalovirus humoral imunity

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Role of homologous recombination/recombineering on human adenovirus genome engineering:Not the only but the most competent solution

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Engineering Microbiology 2024年第1期4卷 90-107页

作者： Lisa-Marie Dawson Montaha Alshawabkeh Katrin Schröer Fatima Arakrak Anja Ehrhardt Wenli Zhang Virology and Microbiology Center for Biomedical Education and Research(ZBAF)School of MedicineFaculty of HealthWitten/Herdecke UniversityStockumer Str.1058453 WittenGermany

Adenoviruses typically cause mild illnesses,but severe diseases may occur primarily in immunodeficient individuals,particularly ***,adenoviruses have garnered significant interest as a versatile tool in gene therapy,tumor treatment,and vaccine vector *** the past two decades,the advent of recombineering,a method based on homologous recombination,has notably enhanced the utility of adenoviral vectors in therapeutic *** review summarizes recent advancements in the use of human adenoviral vectors in medicine and discusses the pivotal role of recombineering in the development of these ***,it highlights the current achievements and potential future impact of therapeutic adenoviral vectors.

关键词： Adenoviral vector Gene therapy Homologous recombination Oncolytic virus vaccine vector

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Application Progress of Recombinant Attenuated Listeria monocytogenes in Tumor Immunotherapy

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Animal Husbandry and Feed Science 2015年第6期7卷 349-353页

作者： Yin Xiaojiao Bai Lin Yang Xu Hubei Ecology Vocational College

Much progress of application of bacterial vaccine in treatment and prevention of tumor was acquired,which showed broad prospect in clinical study of animals and humans. Listeria monocytogenes( L. monocytogenes) was considered much important by virtue of its special characteristic of biology and immunology.L. monocytogenes was ingested by professional or part-time phagocytes,survived and proliferated in the phagocytes under synergism of toxic factor secreted by itself,meanwhile,the cellular and humoral immune response was induced. Antigenic gene of specific tumor was loaded in the attenuated L. monocytogenes,which can enhance immune response of host cells. Effective cell targeted to enter tumor tissue and acted on tumor cells to induce apoptosis of tumor cells. Tumor degenerated not easy to reappear. Therefore,recombinant attenuated L. monocytogenes was a safe and effective anti-cancer vaccine vector. Now the work of researchers mainly focuses on solving practical problem in clinical application. Biological characteristics of L. monocytogenes,feasibility and superiority of L. monocytogenes as targeted vaccine vector,problem and prospect of L. monocytogenes in clinical application of anti-tumor were reviewed in this paper.

关键词： Recombinant Listeria monocytogenes Anti-tumor vaccine vector

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