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Efficacy of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion

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Journal of Traditional Chinese Medicine 2022年第5期42卷 758-763页

作者： ZHANG Tiantian LI Guowen CHU Zhifeng LI Jie YU Lijun GAO Yuan WANG Huifeng Department of Pharmacy Shanghai Songjiang Fangta Hospital of TCMShanghai 201600China Department of Pharmacy Shanghai TCM-Integrated HospitalShanghai 200080China Department of Traditional Chinese Medicine Shanghai Songjiang Fangta Hospital of TCMShanghai 201600China

OBJECTIVE: To investigate the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding(AUB) in rats with incomplete abortion, and to study the possible mechanism. METHODS: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) were observed. RESULTS: Statistical analysis revealed that the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) to treat AUB in this study was 2∶1. CONCLUSION: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) on AUB.

关键词： uterine hemorrhage Qiancao(Radix Rubiae Cordifoliae) Haipiaoxiao(Endoconcha Sepiellae) herb pair weight ratio

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Studies on Relationship between Serum Nitric Oxide and Plasma Cyclic Guanosine Monophosphate and Prolonged Bleeding after Medical Abortion as well as Prophylaxis and Treatment of Bleeding with Traditional Chinese Medicine

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Journal of Reproduction and Contraception 1999年第4期10卷 220-226页

作者：廖玎玲谭布珍辛华贺晓菊

Objectives To study the relationship between serum nitric oxide (NO and plasma cyclic guanosine monophosphate (cGMP) and prolonged bleeding after medical abortion. Methods A total of 120 women having received medical abortions at random were recruited and divided into two groups: the one (Group A,n=60) taking 'Gong Fu Mixture(Uterus Recovering Mixture)' and the other (Group B,n=60) not taking it after abortion. On d 10, 20 and 30 after medical abortion, serum NO and plasma cGMP were tested before and after mifepristone administration and 10 d later by Gresis reaction method and radioimmunoassay respectively. Results NO concentration in serum and cGMP concentration in plasma decreased significantly after taking mifepristone given (P<0.05). Ten days later, the number of those with bleeding discontinuation in the group A was significantly greater than that in the group B (P<0.05). Serum NO level and plasma cGMP level in the group A decreased more significantly than those in the group B (P<0.05). Conclusion The slow decrease of serum NO and plasma cGMP is closely related to prolonged bleeding after medical abortion. “Gong Fu Mixture (uterus recovering mixture)” is effective in prevention and treatment of prolonged bleeding.

关键词： Mifepristone Induced abortion Nitric Oxide uterine hemorrhage Cyclic guanosine monophosphate

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Risk Stratification in Obstetrics: An Integrated Approach to Maternal Health

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 903-910页

作者： Taina Crespo Mendonca Bianca Beatriz Soares dos Reis Júlia Cruz Coelho Antônio de Oliveira Battistini Pestana Vitória Carolina Barreto Negri Alvaro Augusto Trigo Department of Medicine University of Franca Franca Brazil

Introduction: Prenatal care is crucial for maternal and fetal health, highlighting the importance of obstetric risk stratification. This enables personalized care, avoiding unnecessary interventions and reducing costs. Conditions such as first trimester bleeding, spontaneous abortion, gestational trophoblastic disease, and ectopic pregnancy require specific approaches. Early identification of these complications is vital, especially in urgent and emergency obstetric cases, which demand immediate hospital attention. Objective: Comprehensive review of first trimester pathologies and gestational hypertension, focusing on obstetric risks and personalized prenatal management. Methods: Literature review on bleeding and gestational hypertension. Results: The study provides a detailed analysis of pathologies associated with first trimester uterine bleeding and hypertensive disorders, focusing on obstetric risk stratification. The main causes of maternal and fetal mortality are hypertensive disorders, hemorrhages, infections, childbirth complications, and abortion. Spontaneous abortion is common, with different classifications, ranging from threatened to missed abortion. Infected abortion is a severe complication. Brazil has restrictive abortion laws, but many unsafe abortions occur, resulting in high public health costs. Pharmacological treatment with misoprostol is a safe option. Other pathologies include gestational trophoblastic disease, ectopic pregnancy, and placenta previa. Preeclampsia and eclampsia are severe conditions requiring immediate treatment to avoid complications. Conclusion: Early identification and management of obstetric risk factors, such as uterine bleeding, are essential for positive maternal and fetal outcomes. A multidisciplinary approach is fundamental.

关键词： Obstetrics Emergencies Hypertension Pregnancy-Induced uterine hemorrhage Pregnancy Trimester First

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A Survey on TCM Treatment of Drug-Induced Postabortal Colporrhagia

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Journal of Traditional Chinese Medicine 2000年第1期20卷 63-70页

作者：张艳王新中 The Affiliated Hospital of Guilin Municipal School of Traditional Chinese Medicine Guilin 541002Guangxi Province

Drug postabortal colporrhagia is one of the major problems that need to be solved in gynecoiatry. It is shown in the literature that TCM treatment of this disease has achieved quite good therapeutic effects. It is my opinion that the following works should be done for a better therapeutic effect: 1) study further the pathogeneses of the disease; 2) stipulate a unified criteria for typing, diagnosis and treatment; 3) develop specific prescriptions and new forms of preparation; and 4) further efforts should be also made on the other TCM therapies, such as acupuncture, physiotherapy, and massotherapy.

关键词： Abortifacient Agents Abortion, Induced Drugs, Chinese Herbal Female Humans uterine hemorrhage

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