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Primary malignant melanoma of uterine cervix: a suggestion of new scheme of treatment combination

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Chinese Journal of Cancer Research 2014年第3期26卷 351-354页

作者： Kyung-Jin Min Yeun-Sun Kim Jin-Hwa Hong Jae-Kwan Lee Dae-Sik Yang Department of Obstetrics and Gynaecology Korea University Medical Centre Department of Radiation Oncology Korea University Medical Centre

Historically, the lack of melanocytes in the vaginal and cervical mucus membranes has deterred the findings of primary melanomas. Mainly due to its rarity, difficulty to diagnose, and poor prognosis, there has been no absolute agreement on comprehensive treatment so far. In this case report, we present a case of a 46-year-old woman with primary malignant melanoma of uterine cervix. She underwent neo-adjuvant chemotherapy initially followed by a radical hysterectomy. After adjuvant concurrent chemo-radiation, the patient has been followed up for 24 months. So far, she has not shown any symptoms or signs of recurrence. Further studies with more cases based on variable combinations of treatment regimen have been on the way.

关键词： Malignant melanoma uterine cervix neo-adjuvant chemotherapy chemo-radiation

ROLE OF COLPOSCOPY IN THE DIAGNOSIS OF HUMAN PAPI- LLOMAVIRUS INFECTION OF THE uterine cervix

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Chinese Journal of Cancer Research 1993年第1期5卷 77-81页

作者：章文华孙建衡吴爱如刘炽明孙亚洲商铭张伟刘复生刘树范 Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 Cancer Institute Chinese Academy of Medical Sciences Beijing 100021 Cancer Institute Chinese Academy of Medical Sciences Beijing 100021mong 6706 women screened by cytology only 9 (0.13%) showed evidence of human pppillomavirus infection (HPVI). In 133 women examined by colposcopy for abnormal cytology or/ and suspected lestions on the cervix 41.(30. 8%) showed subclinical papillomavirus infection (SPI) while 17. 4% and 5. 3% showed HPVI by histopathology and cytology respectively. The conformation rate between colposcopy and pathology was 69. 6%. Sixty-nine specimens out of 133 colposcopy piled biopaies were assayed by HPV-DNA dot hybridization with 6B/11 16 18 probes to detect the presence of HPV-DNA In the cervical specimens. Thirty-nine (56.5%) gave a positive result. The colposcopic predictive value of positive result for HPVI was 76.7%. The difference between colposcopy (59%) and pathology (20. 5%) is statistically significant (P<0. 01). These results suggest that colposcopy is superior to cytology and hjstopathology for the detection of SPI in the cervix. In colposcopy HPV-DNA positive women aceto while epithelium was most common (28. 2%) . As it is difficult to differentiate SPI from cervical intraepithelial neoplasia especially the Grade Ⅰ lesion by colposcopy discrimination criteria are proposed together with the chief colposcopic features of SPI.

Among 6706 women screened by cytology, only 9 (0.13%) showed evidence of human pppillomavirus infection (HPVI). In 133 women examined by colposcopy for abnormal cytology or/ and suspected lestions on the cervix, 41.(30. 8%) showed subclinical papillomavirus infection (SPI), while 17. 4% and 5. 3% showed HPVI by histopathology and cytology, respectively. The conformation rate between colposcopy and pathology was 69. 6%. Sixty-nine specimens out of 133 colposcopy piled biopaies were assayed by HPV-DNA dot hybridization with 6B/11, 16, 18 probes to detect the presence of HPV-DNA In the cervical specimens. Thirty-nine (56.5%) gave a positive result. The colposcopic predictive value of positive result for HPVI was 76.7%. The difference between colposcopy (59%) and pathology (20. 5%) is statistically significant (Pcervix. In colposcopy HPV-DNA positive women, aceto while epithelium was most common (28. 2%) . As it is difficult to differentiate SPI from cervical intraepithelial neoplasia especially the Grade Ⅰ lesion by colposcopy, discrimination criteria are proposed together with the chief colposcopic features of SPI.

关键词： Papillomavirus DNA hybridization Colposcopy Condyloma uterine cervix Pathology Tumor virus infection.

Clear Cell Carcinoma of the uterine cervix Arising from an Interstitial Cyst Complicated with Endometriosis: A Case Report

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Open Journal of Obstetrics and Gynecology 2021年第3期11卷 288-295页

作者： Kana Akagi Takako Tobiume Ayaka Kawamichi Yuichiro Koshida Yusuke Fujikami Eri Ogura Kenji Ban Hisanori Matsumoto Atsuhiko Okagaki Keiji Tatsumi Department of Obstetrics and Gynecology National Hospital Organization Osaka National Hospital Osaka Japan

Clear cell carcinoma (CCC) of the uterine cervix is rare, and its etiology is unclear, except for reports of prenatal diethylstilbestrol (DES) exposure. In this case report of a 78-year-old postmenopausal Japanese woman with pelvic endometriosis, cervical CCC presented as a deep interstitial tumor, strongly suggesting the patient suffered from cervical endometriosis for a long time. A cystic lesion without solid components was detected in the uterine cervix. Although the patient had regular gynecological examinations every 6 months, she presented 5 years later with a complaint of watery vaginal discharge. Ultrasonography and magnetic resonance imaging (MRI) detected a uterine cervical cystic mass with a solid component. Although no malignancy was confirmed preoperatively, surgery was performed under a high suspicion of cervical cancer. Intraoperative pathology revealed CCC in a solid tumor, so debulking surgery, including lymphadenectomy, was done. Endometrial tissue was found adjacent to the tumor, strongly suggesting the tumor arose from cervical endometriosis. Because endometriosis in ectopic sites carries a risk of carcinogenesis, as is the case in ovarian endometriosis, it may be recommended that a cervical cystic lesion with pelvic endometriosis should be followed up regularly for the early detection of uterine cancer.

关键词： Cancer Clear Cell Carcinoma Endometriosis uterine cervix

Clinical Significance of CENP-H Expression in uterine Cervical Cancer

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Clinical oncology and cancer researeh 2012年第3期9卷 192-196页

作者： Mei-ying Weng Lin Li Shun-jia Hong Shu-ying Feng Department of Obstetrics and Gynecology Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Objective This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H(CENP-H) in uterine cervical cancer(UCC). Methods The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method,with complete clinicopathologic data in all *** analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package. Results Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer *** analysis revealed a strong correlation between the CENP-H expression and the clinical classification(P=0.038) of the cervical *** expression increased with rise of the *** analysis of Cox proportional hazards regression model suggested that CENP-H expression(P=0.002) and tumor stage(P=0.001) were independent prognostic markers for the survival of UCC *** survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H(P=0.001). Conclusions CENP-H is likely to be a valuable marker for carcinogenesis and progression of *** might be used as the important diagnostic and prognostic marker for cervical carcinoma patients,especially for those at early stage.

关键词： uterine cervical cancer uterine cervix CENP-H immunohistochemistry tumor staging prognosis

宫颈原发性成熟性畸胎瘤2例临床病理分析并文献复习

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诊断病理学杂志 2023年第1期30卷 70-71,80页

作者：马紫瑜刘爱军朱逸飞安然刘振华朱红艳解放军总医院第七医学中心病理科北京100700

畸胎瘤是妇科常见的生殖细胞肿瘤,好发于卵巢,其中95%为成熟性囊性畸胎瘤[1]。性腺外畸胎瘤占生殖细胞肿瘤的2%~5%,较常发生于近中线部位。发生于宫颈的畸胎瘤罕见,其发生机制并不清楚。本研究报道2例原发于宫颈的成熟性畸胎瘤,并结合... 详细信息

畸胎瘤是妇科常见的生殖细胞肿瘤,好发于卵巢,其中95%为成熟性囊性畸胎瘤[1]。性腺外畸胎瘤占生殖细胞肿瘤的2%~5%,较常发生于近中线部位。发生于宫颈的畸胎瘤罕见,其发生机制并不清楚。本研究报道2例原发于宫颈的成熟性畸胎瘤,并结合近年来国内外相关文献对宫颈原发性畸胎瘤的临床病理特点进行讨论。1材料与方法1.1材料收集在解放军总医院第七医学中心会诊的2例原发于宫颈的成熟性畸胎瘤。

关键词：宫颈畸胎瘤 uterine cervix teratoma

A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature

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Oncology and Translational Medicine 2020年第3期6卷 131-133页

作者： Xiaoying Quan Zhihui Zhang Department of Medical Oncology the Sixth People's Hospital of ChengduChengdu 610051China Department of Lymphoma Sichuan Cancer Hospital and Research InstituteChengdu 610041China

Primary non-Hodgkin’s lymphoma of the uterine cervix is rarely ***,we report a case of"double-protein"expression in a primary uterine cervical diffuse large B-cell lymphoma that was detected based on cervical biopsies at Sichuan Cancer Hospital in December 2016 in a 53-year-old woman with a 1-month history of postmenopausal vaginal *** was diagnosed with stage IVA cervical cancer after workup and treated with six cycles of rituximab+cyclophosphamide+epirubicin+vindesine+*** showed a positive partial response after two cycles;however,response assessment revealed a progressive disease after six *** on the current condition,a treatment regimen comprising a combination of second-line chemotherapy and radiotherapy was advised for the ***,she discontinued her treatment because of various *** conclude that"double-protein"expression in primary uterine cervical diffuse large B-cell lymphoma is difficult to treat and has a poor ***,improving the diagnosis and treatment of this disease should be considered.

关键词： diffuse large B-cell lymphoma uterine cervix “double-protein”expression